The package generally provides methods for gene set enrichment analysis of high-throughput RNA-Seq data by integrating differential expression and splicing. It uses negative binomial distribution to model read count data, which accounts for sequencing biases and biological variation. Based on permutation tests, statistical significance can also be achieved regarding each gene's differential expression and splicing, respectively.

This package Provides a variety of functions for producing simple weighted statistics, such as weighted Pearson's correlations, partial correlations, Chi-Squared statistics, histograms, and t-tests. Also now includes some software for quickly recoding survey data and plotting point estimates from interaction terms in regressions (and multiply imputed regressions). NOTE: Weighted partial correlation calculations pulled to address a bug.

For tree ensembles such as random forests, regularized random forests and gradient boosted trees, this package provides functions for: extracting, measuring and pruning rules; selecting a compact rule set; summarizing rules into a learner; calculating frequent variable interactions; formatting rules in latex code. Reference: Interpreting tree ensembles with inTrees (Houtao Deng, 2019, <doi:10.1007/s41060-018-0144-8>).

R is a language and environment for statistical computing and graphics. It provides a variety of statistical techniques, such as linear and nonlinear modeling, classical statistical tests, time-series analysis, classification and clustering. It also provides robust support for producing publication-quality data plots. A large amount of 3rd-party packages are available, greatly increasing its breadth and scope.

The GNU Privacy Guard is a complete implementation of the OpenPGP standard. It is used to encrypt and sign data and communication. It features powerful key management and the ability to access public key servers. It includes several libraries: libassuan (IPC between GnuPG components), libgpg-error (centralized GnuPG error values), and libskba (working with X.509 certificates and CMS data).

Balancing quasi-experimental field research for effects of covariates is fundamental for drawing causal inference. Propensity Score Matching deals with this issue but current techniques are restricted to binary treatment variables. Moreover, they provide several solutions without providing a comprehensive framework on choosing the best model. The MAGMA R-package addresses these restrictions by offering nearest neighbor matching for two to four groups. It also includes the option to match data of a 2x2 design. In addition, MAGMA includes a framework for evaluating the post-matching balance. The package includes functions for the matching process and matching reporting. We provide a tutorial on MAGMA as vignette. More information on MAGMA can be found in Feuchter, M. D., Urban, J., Scherrer V., Breit, M. L., and Preckel F. (2022) <https://osf.io/p47nc/>.

Routines for re-scaling isotope maps using known-origin tissue isotope data, assigning origin of unknown samples, and summarizing and assessing assignment results. Methods are adapted from Wunder (2010, in ISBN:9789048133536) and Vander Zanden, H. B. et al. (2014) <doi:10.1111/2041-210X.12229> as described in Ma, C. et al. (2020) <doi:10.1111/2041-210X.13426>.

Linear and nonlinear regression analysis common in agricultural science articles (Archontoulis & Miguez (2015). <doi:10.2134/agronj2012.0506>). The package includes polynomial, exponential, gaussian, logistic, logarithmic, segmented, non-parametric models, among others. The functions return the model coefficients and their respective p values, coefficient of determination, root mean square error, AIC, BIC, as well as graphs with the equations automatically.

When many possible multiplier method estimates of a target population are available, a weighted sum of estimates from each back-calculated path can be achieved with this package. Variance-minimizing weights are used and with any admissible tree-structured data. The methodological basis used to create this package can be found in Flynn (2023) <http://hdl.handle.net/2429/86174>.

This package provides color palettes based on crayon colors since the early 1900s. Colors are based on various crayon colors, sets, and promotional palettes, most of which can be found at <https://en.wikipedia.org/wiki/List_of_Crayola_crayon_colors>. All palettes are discrete palettes and are not necessarily color-blind friendly. Provides scales for ggplot2 for discrete coloring.

This package provides a copula based clustering algorithm that finds clusters according to the complex multivariate dependence structure of the data generating process. The updated version of the algorithm is described in Di Lascio, F.M.L. and Giannerini, S. (2019). "Clustering dependent observations with copula functions". Statistical Papers, 60, p.35-51. <doi:10.1007/s00362-016-0822-3>.

Browser cookies are name-value pairs that are saved in a user's browser by a website. Cookies allow websites to persist information about the user and their use of the website. Here we provide tools for working with cookies in shiny apps, in part by wrapping the js-cookie JavaScript library <https://github.com/js-cookie/js-cookie>.

Functionality for manipulating values of associative maps. The package is a dependency for mvp-type packages that use the STL map class: it traps plausible idiom that is ill-defined (implementation-specific) and returns an informative error, rather than returning a possibly incorrect result. To cite the package in publications please use Hankin (2022) <doi:10.48550/ARXIV.2210.03856>.

Deep Gaussian mixture models as proposed by Viroli and McLachlan (2019) <doi:10.1007/s11222-017-9793-z> provide a generalization of classical Gaussian mixtures to multiple layers. Each layer contains a set of latent variables that follow a mixture of Gaussian distributions. To avoid overparameterized solutions, dimension reduction is applied at each layer by way of factor models.

Fast estimation algorithms to implement the Quantile Regression with Selection estimator and the multiplicative Bootstrap for inference. This estimator can be used to estimate models that feature sample selection and heterogeneous effects in cross-sectional data. For more details, see Arellano and Bonhomme (2017) <doi:10.3982/ECTA14030> and Pereda-Fernández (2024) <doi:10.48550/arXiv.2402.16693>.

Implementation of dynamic principal component analysis (DPCA), simulation of VAR and VMA processes and frequency domain tools. These frequency domain methods for dimensionality reduction of multivariate time series were introduced by David Brillinger in his book Time Series (1974). We follow implementation guidelines as described in Hormann, Kidzinski and Hallin (2016), Dynamic Functional Principal Component <doi:10.1111/rssb.12076>.

This package performs analysis of variance testing procedures for univariate and multivariate functional data (Cuesta-Albertos and Febrero-Bande (2010) <doi:10.1007/s11749-010-0185-3>, Gorecki and Smaga (2015) <doi:10.1007/s00180-015-0555-0>, Gorecki and Smaga (2017) <doi:10.1080/02664763.2016.1247791>, Zhang et al. (2018) <doi:10.1016/j.csda.2018.05.004>).

Creation of an input model (fitted distribution) via the frequentist model averaging (FMA) approach and generate random-variates from the distribution specified by "myfit" which is the fitted input model via the FMA approach. See W. X. Jiang and B. L. Nelson (2018), "Better Input Modeling via Model Averaging," Proceedings of the 2018 Winter Simulation Conference, IEEE Press, 1575-1586.

Identifying spatially variable genes is critical in linking molecular cell functions with tissue phenotypes. This package implemented a granularity-based dimension-agnostic tool for the identification of spatially variable genes. The detailed description of this method is available at Wang, J. and Li, J. et al. 2023 (Wang, J. and Li, J. (2023), <doi:10.1038/s41467-023-43256-5>).

Simulating species migration and range dynamics under stable or changing environmental conditions based on a simple, raster-based, deterministic or stochastic migration model. KISSMig runs on binary or quantitative suitability maps, which are pre-calculated with niche-based habitat suitability models (also called ecological niche models (ENMs) or species distribution models (SDMs)). Nobis & Normand (2014), <doi:10.1111/ecog.00930>.

This package provides a Momentumized, Adaptive, Dual Averaged Gradient Method for Stochastic Optimization algorithm. MADGRAD is a best-of-both-worlds optimizer with the generalization performance of stochastic gradient descent and at least as fast convergence as that of Adam, often faster. A drop-in optim_madgrad() implementation is provided based on Defazio et al (2020) <arxiv:2101.11075>.

Computes the Owen's T function or the bivariate normal integral using one of the following: modified Euler's arctangent series, tetrachoric series, or Vasicek's series. For the methods, see Komelj, J. (2023) <doi:10.4236/ajcm.2023.134026> (or reprint <arXiv:2312.00011> with better typography) and Vasicek, O. A. (1998) <doi:10.21314/JCF.1998.015>.

Bland (2009) <doi:10.1136/bmj.b3985> recommended to base study sizes on the width of the confidence interval rather the power of a statistical test. The goal of presize is to provide functions for such precision based sample size calculations. For a given sample size, the functions will return the precision (width of the confidence interval), and vice versa.

Collection of model estimation, and model plotting functions related to the STEPCAM family of community assembly models. STEPCAM is a STEPwise Community Assembly Model that infers the relative contribution of Dispersal Assembly, Habitat Filtering and Limiting Similarity from a dataset consisting of the combination of trait and abundance data. See also <doi:10.1890/14-0454.1> for more information.