This package is an R package designed for QC, analysis, and exploration of single cell RNA-seq data. It easily enables widely-used analytical techniques, including the identification of highly variable genes, dimensionality reduction; PCA, ICA, t-SNE, standard unsupervised clustering algorithms; density clustering, hierarchical clustering, k-means, and the discovery of differentially expressed genes and markers.

The r-nleqslv package solves a system of nonlinear equations using a Broyden or a Newton method with a choice of global strategies such as line search and trust region. There are options for using a numerical or user supplied Jacobian, for specifying a banded numerical Jacobian and for allowing a singular or ill-conditioned Jacobian.

This package provides a method to refit and correct the diploid region in copy number profiles. It uses a clustering algorithm to identify pathology-specific normal (diploid) chromosomes and then use their copy number signal to refit the whole profile. The package is composed by three functions: DRrefit (the main function), ComputeNormalChromosome and PlotCluster.

The hdxmsqc package enables us to analyse and visualise the quality of HDX-MS experiments. Either as a final quality check before downstream analysis and publication or as part of a interative procedure to determine the quality of the data. The package builds on the QFeatures and Spectra packages to integrate with other mass-spectrometry data.

Plots simulation results of clinical trials. Its main feature is allowing users to simultaneously investigate the impact of several simulation input dimensions through dynamic filtering of the simulation results. A more detailed description of the app can be found in Meyer et al. <DOI:10.1016/j.softx.2023.101347> or the vignettes on GitHub'.

This package provides functions for data augmentation using the Bayesian discount prior method for single arm and two-arm clinical trials, as described in Haddad et al. (2017) <doi:10.1080/10543406.2017.1300907>. The discount power prior methodology was developed in collaboration with the The Medical Device Innovation Consortium (MDIC) Computer Modeling & Simulation Working Group.

Easily launch, track, and control functions as background-parallel jobs. Includes robust utilities for job status, error handling, resource monitoring, and result collection. Designed for scalable workflows in interactive and automated settings (local or remote). Integrates with multiple backends; supports flexible automation pipelines and live job tracking. For more information, see <https://anirbanshaw24.github.io/bakerrr/>.

Querying, extracting, and processing large-scale network data from Neo4j databases using the Neo4j Bolt <https://neo4j.com/docs/bolt/current/bolt/> protocol. This interface supports efficient data retrieval, batch processing for large datasets, and seamless conversion of query results into R data frames, making it ideal for bioinformatics, computational biology, and other graph-based applications.

This package performs a Correspondence Analysis (CA) on a contingency table and creates a scatterplot of the row and column points on the selected dimensions. Optionally, the function can add segments to the plot to visualize significant associations between row and column categories on the basis of positive (unadjusted) standardized residuals larger than a given threshold.

This package performs forward and backward stepwise regression for the proportional subdistribution hazards model in competing risks (Fine & Gray 1999). Procedure uses AIC, BIC and BICcr as selection criteria. BICcr has a penalty of k = log(n*), where n* is the number of primary events. This version includes improved handling of factors, interactions, and polynomial terms.

Estimation of population size of migratory caribou herds based on large scale aggregations monitored by radio telemetry. It implements the methodology found in the article by Rivest et al. (1998) about caribou abundance estimation. It also includes a function based on the Lincoln-Petersen Index as applied to radio telemetry data by White and Garrott (1990).

This model fitting tool incorporates cyclic coordinate descent and majorization-minimization approaches to fit a variety of regression models found in large-scale observational healthcare data. Implementations focus on computational optimization and fine-scale parallelization to yield efficient inference in massive datasets. Please see: Suchard, Simpson, Zorych, Ryan and Madigan (2013) <doi:10.1145/2414416.2414791>.

This package provides functions to analyze the spatial distribution of biodiversity, in particular categorical analysis of neo- and paleo-endemism (CANAPE) as described in Mishler et al (2014) <doi:10.1038/ncomms5473>. canaper conducts statistical tests to determine the types of endemism that occur in a study area while accounting for the evolutionary relationships of species.

Calculates the dutch air quality index (LKI). This index was created on the basis of scientific studies of the health effects of air pollution. From these studies it can be deduced at what concentrations a certain percentage of the population can be affected. For more information see: <https://www.rivm.nl/bibliotheek/rapporten/2014-0050.pdf>.

This package performs alignment, PCA, and modeling of multidimensional and unidimensional functions using the square-root velocity framework (Srivastava et al., 2011 <doi:10.48550/arXiv.1103.3817> and Tucker et al., 2014 <DOI:10.1016/j.csda.2012.12.001>). This framework allows for elastic analysis of functional data through phase and amplitude separation.

This package provides high-level access to neuroimaging data from standard software packages like FreeSurfer <http://freesurfer.net/> on the level of subjects and groups. Load morphometry data, surfaces and brain parcellations based on atlases. Mask data using labels, load data for specific atlas regions only, and visualize data and statistical results directly in R'.

This package provides classes for GeoJSON to make working with GeoJSON easier. Includes S3 classes for GeoJSON classes with brief summary output, and a few methods such as extracting and adding bounding boxes, properties, and coordinate reference systems; working with newline delimited GeoJSON'; and serializing to/from Geobuf binary GeoJSON format.

This package provides a suite of diagnostic tools for hierarchical (multilevel) linear models. The tools include not only leverage and traditional deletion diagnostics (Cook's distance, covratio, covtrace, and MDFFITS) but also convenience functions and graphics for residual analysis. Models can be fit using either lmer in the lme4 package or lme in the nlme package.

This package provides a fresh take on iterators in R. Designed to be cross-compatible with the iterators package, but using the nextOr method will offer better performance as well as more compact code. With batteries included: includes a collection of iterator constructors and combinators ported and refined from the iterators', itertools', and itertools2 packages.

This package provides a collection of Irucka Embry's miscellaneous USGS functions (processing .exp and .psf files, statistical error functions, "+" dyadic operator for use with NA, creating ADAPS and QW spreadsheet files, calculating saturated enthalpy). Irucka created these functions while a Cherokee Nation Technology Solutions (CNTS) United States Geological Survey (USGS) Contractor and/or USGS employee.

This package provides a Comprehensive tool for almost all existing multiple testing methods for multiple families. The package summarizes the existing methods for multiple families multiple testing procedures (MTPs) such as double FDR, group Benjamini-Hochberg (GBH) procedure and average FDR controlling procedure. The package also provides some novel multiple testing procedures using selective inference idea.

This package provides routines for plotting linkage and association results along a chromosome, with marker names displayed along the top border. There are also routines for generating BED and BedGraph custom tracks for viewing in the UCSC genome browser. The data reformatting program Mega2 uses this package to plot output from a variety of programs.

Growing collection of helper functions for point pattern analysis. Most functions are designed to work with the spatstat (<http://spatstat.org>) package. The focus of most functions are either null models or summary functions for spatial point patterns. For a detailed description of all null models and summary functions, see Wiegand and Moloney (2014, ISBN:9781420082548).

Implementation of penalized regression with second-generation p-values for variable selection. The algorithm can handle linear regression, GLM, and Cox regression. S3 methods print(), summary(), coef(), predict(), and plot() are available for the algorithm. Technical details can be found at Zuo et al. (2021) <doi:10.1080/00031305.2021.1946150>.