This package provides a toolbox for programming Clinical Data Interchange Standards Consortium (CDISC) compliant Analysis Data Model (ADaM) datasets in R. ADaM datasets are a mandatory part of any New Drug or Biologics License Application submitted to the United States Food and Drug Administration (FDA). Analysis derivations are implemented in accordance with the "Analysis Data Model Implementation Guide" (CDISC Analysis Data Model Team, 2021, <https://www.cdisc.org/standards/foundational/adam>).

In tumor tissue, underlying genomic instability can lead to DNA copy number alterations, e.g., copy number gains or losses. Sporadic copy number alterations occur randomly throughout the genome, whereas recurrent alterations are observed in the same genomic region across multiple independent samples, perhaps because they provide a selective growth advantage. This package implements the DiNAMIC procedure for assessing the statistical significance of recurrent DNA copy number aberrations (Bioinformatics (2011) 27(5) 678 - 685).

Clustered or multilevel data structures are common in the assessment of differential item functioning (DIF), particularly in the context of large-scale assessment programs. This package allows users to implement extensions of the Mantel-Haenszel DIF detection procedures in the presence of multilevel data based on the work of Begg (1999) <doi:10.1111/j.0006-341X.1999.00302.x>, Begg & Paykin (2001) <doi:10.1080/00949650108812115>, and French & Finch (2013) <doi:10.1177/0013164412472341>.

The purpose of the package is to enable an R function interface into the Statistics Denmark Databank API mainly for research purposes. The Statistics Denmark Databank API has four endpoints, see here for more information and testing the API in their console: <https://www.dst.dk/en/Statistik/brug-statistikken/muligheder-i-statistikbanken/api>. This package mimics the structure of the API and provides four main functions to match the functionality of the API endpoints.

Discrete splines are a class of univariate piecewise polynomial functions which are analogous to splines, but whose smoothness is defined via divided differences rather than derivatives. Tools for efficient computations relating to discrete splines are provided here. These tools include discrete differentiation and integration, various matrix computations with discrete derivative or discrete spline bases matrices, and interpolation within discrete spline spaces. These techniques are described in Tibshirani (2020) <doi:10.48550/arXiv.2003.03886>.

Fit the hierarchical and non-hierarchical Bayesian measurement models proposed by Bullock, Imai, and Shapiro (2011) <DOI:10.1093/pan/mpr031> to analyze endorsement experiments. Endorsement experiments are a survey methodology for eliciting truthful responses to sensitive questions. This methodology is helpful when measuring support for socially sensitive political actors such as militant groups. The model is fitted with a Markov chain Monte Carlo algorithm and produces the output containing draws from the posterior distribution.

Fit and visualize the results of a Bayesian analysis of networks commonly found in psychology. The package supports fitting cross-sectional network models fitted using the packages BDgraph', bgms and BGGM'. The package provides the parameter estimates, posterior inclusion probabilities, inclusion Bayes factor, and the posterior density of the parameters. In addition, for BDgraph and bgms it allows to assess the posterior structure space. Furthermore, the package comes with an extensive suite for visualizing results.

This package contains regional Floristic Quality Assessment databases that have been approved or approved with reservations by the U.S. Army Corps of Engineers (USACE). Paired with the fqacalc R package, these data sets allow for Floristic Quality Assessment metrics to be calculated. For information on FQA see Spyreas (2019) <doi:10.1002/ecs2.2825>. Both packages were developed for the USACE by the U.S. Army Engineer Research and Development Center's Environmental Laboratory.

Turn irregular polygons (such as geographical regions) into regular or hexagonal grids. This package enables the generation of regular (square) and hexagonal grids through the package sp and then assigns the content of the existing polygons to the new grid using the Hungarian algorithm, Kuhn (1955) (<doi:10.1007/978-3-540-68279-0_2>). This prevents the need for manual generation of hexagonal grids or regular grids that are supposed to reflect existing geography.

European Commission's Labour Market Policy (LMP) database (<https://webgate.ec.europa.eu/empl/redisstat/databrowser/explore/all/lmp?lang=en&display=card&sort=category>) provides information on labour market interventions, which are government actions to help and support the unemployed and other disadvantaged groups in the transition from unemployment or inactivity to work. It covers the EU countries and Norway. This package provides functions for downloading and importing the LMP data and metadata (codelists).

This package provides methods for estimating borders of uniform distribution on the interval (one-dimensional) and on the elliptical domain (two-dimensional) under measurement errors. For one-dimensional case, it also estimates the length of underlying uniform domain and tests the hypothesized length against two-sided or one-sided alternatives. For two-dimensional case, it estimates the area of underlying uniform domain. It works with numerical inputs as well as with pictures in JPG format.

This package provides a causal mediation framework for single-cell data that incorporates two key features ('MedZIsc', pronounced Magics): (1) zero-inflation using beta regression and (2) overdispersed expression counts using negative binomial regression. This approach also includes a screening step based on penalized and marginal models to handle high-dimensionality. Full methodological details are available in our recent preprint by Ahn S and Li Z (2025) <doi:10.48550/arXiv.2505.22986>.

This package provides a set of tools for testing networks. It includes functions for univariate and multivariate conditional uniform graph and quadratic assignment procedure testing, and network regression. The package is a complement to Multimodal Political Networks (2021, ISBN:9781108985000), and includes various datasets used in the book. Built on the manynet package, all functions operate with matrices, edge lists, and igraph', network', and tidygraph objects, and on one-mode and two-mode (bipartite) networks.

This package provides functions for normalizing psychometric test scores. The normalization aims at correcting the metrological properties of the psychometric tests such as the ceiling and floor effects and the curvilinearity (unequal interval scaling). Functions to compute and plot predictions in the natural scale of the psychometric test from the estimates of a linear mixed model estimated on the normalized scores are also provided. See Philipps et al (2014) <doi:10.1159/000365637> for details.

This package provides tools to process raster data and apply Otsu-based thresholding for burned area mapping and other image segmentation tasks. Implements the method described by Otsu (1979) <doi:10.1109/TSMC.1979.4310076>, a data-driven technique that determines an optimal threshold by maximizing the inter-class variance of pixel intensities. It includes validation functions to assess segmentation accuracy against reference data using standard accuracy metrics such as precision, recall, and F1-score.

An R implementation of the cross-platform, language-independent "port4me" algorithm (<https://github.com/HenrikBengtsson/port4me>), which (1) finds a free Transmission Control Protocol ('TCP') port in [1024,65535] that the user can open, (2) is designed to work in multi-user environments, (3), gives different users, different ports, (4) gives the user the same port over time with high probability, (5) gives different ports for different software tools, and (6) requires no configuration.

This package provides tools developed to facilitate the establishment of the rank and social hierarchy for gregarious animals by the Si method developed by Kondo & Hurnik (1990)<doi:10.1016/0168-1591(90)90125-W>. It is also possible to determine the number of agonistic interactions between two individuals, sociometric and dyadics matrix from dataset obtained through electronic bins. In addition, it is possible plotting the results using a bar plot, box plot, and sociogram.

Perform association test within linear mixed model framework using score test integrated with Empirical Bayes for genome-wide association study. Firstly, score test was conducted for each marker under linear mixed model framework, taking into account the genetic relatedness and population structure. And then all the potentially associated markers were selected with a less stringent criterion. Finally, all the selected markers were placed into a multi-locus model to identify the true quantitative trait nucleotide.

This package contains more modern tools for causal inference using regression standardization. Four general classes of models are implemented; generalized linear models, conditional generalized estimating equation models, Cox proportional hazards models, and shared frailty gamma-Weibull models. Methodological details are described in Sjölander, A. (2016) <doi:10.1007/s10654-016-0157-3>. Also includes functionality for doubly robust estimation for generalized linear models in some special cases, and the ability to implement custom models.

Archimax copulas are a mixture of Archimedean and EV copulas. This package provides definitions of several parametric families of generator and dependence function, computes CDF and PDF, estimates parameters, tests for goodness of fit, generates random sample and checks copula properties for custom constructs. In the 2-dimensional case explicit formulas for density are used, contrary to higher dimensions when all derivatives are linearly approximated. Several non-archimax families (normal, FGM, Plackett) are provided as well.

This package provides an R interface to Extreme Gradient Boosting, which is an efficient implementation of the gradient boosting framework from Chen and Guestrin (2016). The package includes efficient linear model solver and tree learning algorithms. The package can automatically do parallel computation on a single machine. It supports various objective functions, including regression, classification and ranking. The package is made to be extensible, so that users are also allowed to define their own objectives easily.

This package provides the basic functionality to interact with the Collatz conjecture. The parameterisation uses the same (P,a,b) notation as Conway's generalisations. Besides the function and reverse function, there is also functionality to retrieve the hailstone sequence, the "stopping time"/"total stopping time", or tree-graph. The only restriction placed on parameters is that both P and a can't be 0. For further reading, see <https://en.wikipedia.org/wiki/Collatz_conjecture>.

This package provides a collection of functions that have been developed to assist experimenter in modeling chemical degradation kinetic data. The selection of the appropriate degradation model and parameter estimation is carried out automatically as far as possible and is driven by a rigorous statistical interpretation of the results. The package integrates already available goodness-of-fit statistics for nonlinear models. In addition it allows data fitting with the nonlinear first-order multi-target (FOMT) model.

Computes the Extended Chen-Poisson (ecp) distribution, survival, density, hazard, cumulative hazard and quantile functions. It also allows to generate a pseudo-random sample from this distribution. The corresponding graphics are available. Functions to obtain measures of skewness and kurtosis, k-th raw moments, conditional k-th moments and mean residual life function were added. For details about ecp distribution, see Sousa-Ferreira, I., Abreu, A.M. & Rocha, C. (2023). <doi:10.57805/revstat.v21i2.405>.