An implementation of Simultaneous Truth and Performance Level Estimation (STAPLE) <doi:10.1109/TMI.2004.828354>. This method is used when there are multiple raters for an object, typically an image, and this method fuses these ratings into one rating. It uses an expectation-maximization method to estimate this rating and the individual specificity/sensitivity for each rater.

This package provides utility functions to help researchers implement best practices for their coding projects. Includes tools for reading and cleaning data files, initializing R projects with a standard folder structure, creating Quarto documents from a reproducible template, detecting the execution context across interactive, Quarto, and script-based workflows, and splitting data frames into group-level output files.

This package provides a streamlined workflow for UK Biobank cloud-based analysis on the Research Analysis Platform (RAP). Includes tools for phenotype extraction and decoding, variable derivation, survival and association analysis, genetic risk score computation, and publication-quality visualization. For details on the UK Biobank resource, see Bycroft et al. (2018) <doi:10.1038/s41586-018-0579-z>.

This dataset was collected using a new four-arm within-study comparison design. The study aimed to examine the impact of a mathematics training intervention and a vocabulary study session on post-test scores in mathematics and vocabulary, respectively. The innovative four-arm within-study comparison design facilitates both experimental and quasi-experimental identification of average causal effects.

Various tools for handling fuzzy measures, calculating Shapley value and interaction index, Choquet and Sugeno integrals, as well as fitting fuzzy measures to empirical data are provided. Construction of fuzzy measures from empirical data is done by solving a linear programming problem by using lpsolve package, whose source in C adapted to the R environment is included. The description of the basic theory of fuzzy measures is in the manual in the Doc folder in this package. Please refer to the following: [1] <https://personal-sites.deakin.edu.au/~gleb/fmtools.html> [2] G. Beliakov, H. Bustince, T. Calvo, A Practical Guide to Averaging', Springer, (2016, ISBN: 978-3-319-24753-3). [3] G. Beliakov, S. James, J-Z. Wu, Discrete Fuzzy Measures', Springer, (2020, ISBN: 978-3-030-15305-2).

This package Provides a variety of functions for producing simple weighted statistics, such as weighted Pearson's correlations, partial correlations, Chi-Squared statistics, histograms, and t-tests. Also now includes some software for quickly recoding survey data and plotting point estimates from interaction terms in regressions (and multiply imputed regressions). NOTE: Weighted partial correlation calculations pulled to address a bug.

For tree ensembles such as random forests, regularized random forests and gradient boosted trees, this package provides functions for: extracting, measuring and pruning rules; selecting a compact rule set; summarizing rules into a learner; calculating frequent variable interactions; formatting rules in latex code. Reference: Interpreting tree ensembles with inTrees (Houtao Deng, 2019, <doi:10.1007/s41060-018-0144-8>).

This package provides a port of the web-based software DAGitty for analyzing structural causal models (also known as directed acyclic graphs or DAGs). This package computes covariate adjustment sets for estimating causal effects, enumerates instrumental variables, derives testable implications (d-separation and vanishing tetrads), generates equivalent models, and includes a simple facility for data simulation.

After the clustering step of a single-cell RNAseq experiment, this package aims to suggest labels/cell types for the clusters, on the basis of similarity to a reference dataset. It requires a table of read counts per cell per gene, and a list of the cells belonging to each of the clusters, (for both test and reference data).

Messina is a collection of algorithms for constructing optimally robust single-gene classifiers, and for identifying differential expression in the presence of outliers or unknown sample subgroups. The methods have application in identifying lead features to develop into clinical tests (both diagnostic and prognostic), and in identifying differential expression when a fraction of samples show unusual patterns of expression.

This package enables automated selection of group specific signature, especially for rare population. The package is developed for generating specifc lists of signature genes based on Term Frequency-Inverse Document Frequency (TF-IDF) modified methods. It can also be used as a new gene-set scoring method or data transformation method. Multiple visualization functions are implemented in this package.

The package generally provides methods for gene set enrichment analysis of high-throughput RNA-Seq data by integrating differential expression and splicing. It uses negative binomial distribution to model read count data, which accounts for sequencing biases and biological variation. Based on permutation tests, statistical significance can also be achieved regarding each gene's differential expression and splicing, respectively.

This package provides a collection of Japanese text processing tools for filling Japanese iteration marks, Japanese character type conversions, segmentation by phrase, and text normalization which is based on rules for the Sudachi morphological analyzer and the NEologd (Neologism dictionary for MeCab'). These features are specific to Japanese and are not implemented in ICU (International Components for Unicode).

This wrapper package for mgcv makes it easier to create high-performing Generalized Additive Models (GAMs). With its central function autogam(), by entering just a dataset and the name of the outcome column as inputs, AutoGAM tries to automate the procedure of configuring a highly accurate GAM which performs at reasonably high speed, even for large datasets.

Computes the cosine-correlation coefficient for measuring the degree of linear dependence among variables in a multidimensional context. The package implements the generalized cosine-correlation theorem for p-1 variables, providing a quantitative assessment of interrelationships within experimental frameworks. This methodology extends classical correlation measures to higher-dimensional spaces using a dimensional exploration approach based on time scale calculus.

Package to fit diffusion-based IRT models to response and response time data. Models are fit using marginal maximum likelihood. Parameter restrictions (fixed value and equality constraints) are possible. In addition, factor scores (person drift rate and person boundary separation) can be estimated. Model fit assessment tools are also available. The traditional diffusion model can be estimated as well.

The amplitude-dependent autoregressive time series model (EXPAR) proposed by Haggan and Ozaki (1981) <doi:10.2307/2335819> was improved by incorporating the moving average (MA) framework for capturing the variability efficiently. Parameters of the EXPARMA model can be estimated using this package. The user is provided with the best fitted EXPARMA model for the data set under consideration.

This package provides tools to work with the Flexible Dirichlet distribution. The main features are an E-M algorithm for computing the maximum likelihood estimate of the parameter vector and a function based on conditional bootstrap to estimate its asymptotic variance-covariance matrix. It contains also functions to plot graphs, to generate random observations and to handle compositional data.

This package provides a simple and flexible tool designed to create enriched figures and tables by providing a way to add text around them through predefined or custom layouts. Any input which is convertible to grob is supported, like ggplot', gt or flextable'. Based on R grid graphics, for more details see Paul Murrell (2018) <doi:10.1201/9780429422768>.

This package provides semiparametric sufficient dimension reduction for central mean subspaces for heterogeneous data defined by combinations of binary factors (such as chronic conditions). Subspaces are estimated to be hierarchically nested to respect the structure of subpopulations with overlapping characteristics. This package is an implementation of the proposed methodology of Huling and Yu (2021) <doi:10.1111/biom.13546>.

Estimates treatment effects using covariate adjustment methods in Randomized Clinical Trials (RCT) motivated by higher-order influence functions (HOIF). Provides point estimates, oracle bias, variance, and approximate variance for HOIF-adjusted estimators. For methodology details, see Zhao et al. (2024) <doi:10.48550/arXiv.2411.08491> and Gu et al. (2025) <doi:10.48550/arXiv.2512.20046>.

This package provides diagnostic tools for understanding and debugging data frame joins. Analyzes key columns before joining to detect duplicates, mismatches, encoding issues, and other common problems. Explains unexpected row count changes and provides safe join wrappers with cardinality enforcement. Concepts and diagnostics build on tidy data principles as described in Wickham (2014) <doi:10.18637/jss.v059.i10>.

Implementations several algorithms for kernel k-means. The default OTQT algorithm is a fast alternative to standard implementations of kernel k-means, particularly in cases with many clusters. For a small number of clusters, the implemented MacQueen method typically performs the fastest. For more details and performance evaluations, see Berlinski and Maitra (2025) <doi:10.1002/sam.70032>.

Implementation of the KCMeans regression estimator studied by Wiemann (2023) <arXiv:2311.17021> for expectation function estimation conditional on categorical variables. Computation leverages the unconditional KMeans implementation in one dimension using dynamic programming algorithm of Wang and Song (2011) <doi:10.32614/RJ-2011-015>, allowing for global solutions in time polynomial in the number of observed categories.