This package provides functions to identify Homozygous-by-Descent (HBD) segments associated with runs of homozygosity (ROH) and to estimate individual autozygosity (or inbreeding coefficient). HBD segments and autozygosity are assigned to multiple HBD classes with a model-based approach relying on a mixture of exponential distributions. The rate of the exponential distribution is distinct for each HBD class and defines the expected length of the HBD segments. These HBD classes are therefore related to the age of the segments (longer segments and smaller rates for recent autozygosity / recent common ancestor). The functions allow to estimate the parameters of the model (rates of the exponential distributions, mixing proportions), to estimate global and local autozygosity probabilities and to identify HBD segments with the Viterbi decoding. The method is fully described in Druet and Gautier (2017) <doi:10.1111/mec.14324> and Druet and Gautier (2022) <doi:10.1016/j.tpb.2022.03.001>.

LLVM is a compiler infrastructure designed for compile-time, link-time, runtime, and idle-time optimization of programs from arbitrary programming languages. It currently supports compilation of C and C++ programs, using front-ends derived from GCC 4.0.1. A new front-end for the C family of languages is in development. The compiler infrastructure includes mirror sets of programming tools as well as libraries with equivalent functionality.

Combination of results for meta-analysis using significance and effect size only. P-values and fold-change are combined to obtain a global significance on each metabolite. Produces a volcano plot summarising the relevant results from meta-analysis. Vote-counting reports for metabolites. And explore plot to detect discrepancies between studies at a first glance. Methodology is described in the Llambrich et al. (2021) <doi:10.1093/bioinformatics/btab591>.

Twelve confidence intervals for one binomial proportion or a vector of binomial proportions are computed. The confidence intervals are: Jeffreys, Wald, Wald corrected, Wald, Blyth and Still, Agresti and Coull, Wilson, Score, Score corrected, Wald logit, Wald logit corrected, Arcsine and Exact binomial. References include, among others: Vollset, S. E. (1993). "Confidence intervals for a binomial proportion". Statistics in Medicine, 12(9): 809-824. <doi:10.1002/sim.4780120902>.

This package provides a first-principle, phylogeny-aware comparative genomics tool for investigating associations between terms used to annotate genomic components (e.g., Pfam IDs, Gene Ontology terms,) with quantitative or rank variables such as number of cell types, genome size, or density of specific genomic elements. See the project website for more information, documentation and examples, and <doi:10.1016/j.patter.2023.100728> for the full paper.

An intuitive, cross-platform graphical data analysis system. It uses menus and dialogs to guide the user efficiently through the data manipulation and analysis process, and has an excel like spreadsheet for easy data frame visualization and editing. Deducer works best when used with the Java based R GUI JGR, but the dialogs can be called from the command line. Dialogs have also been integrated into the Windows Rgui.

Spatial analyses involving binning require that every bin have the same area, but this is impossible using a rectangular grid laid over the Earth or over any projection of the Earth. Discrete global grids use hexagons, triangles, and diamonds to overcome this issue, overlaying the Earth with equally-sized bins. This package provides utilities for working with discrete global grids, along with utilities to aid in plotting such data.

An implementation of 14 parsimonious mixture models for model-based clustering or model-based classification. Gaussian, Student's t, generalized hyperbolic, variance-gamma or skew-t mixtures are available. All approaches work with missing data. Celeux and Govaert (1995) <doi:10.1016/0031-3203(94)00125-6>, Browne and McNicholas (2014) <doi:10.1007/s11634-013-0139-1>, Browne and McNicholas (2015) <doi:10.1002/cjs.11246>.

This package provides a collection of machine learning helper functions, particularly assisting in the Exploratory Data Analysis phase. Makes heavy use of the data.table package for optimal speed and memory efficiency. Highlights include a versatile bin_data() function, sparsify() for converting a data.table to sparse matrix format with one-hot encoding, fast evaluation metrics, and empirical_cdf() for calculating empirical Multivariate Cumulative Distribution Functions.

This package provides tools to help convert credit risk data at two timepoints into traditional credit state migration (aka, "transition") matrices. At a higher level, migrate is intended to help an analyst understand how risk moved in their credit portfolio over a time interval. References to this methodology include: 1. Schuermann, T. (2008) <doi:10.1002/9780470061596.risk0409>. 2. Perederiy, V. (2017) <doi:10.48550/arXiv.1708.00062>.

Format numbers and plots for publication; includes the removal of leading zeros, standardization of number of digits, addition of affixes, and a p-value formatter. These tools combine the functionality of several base functions such as paste()', format()', and sprintf() into specific use case functions that are named in a way that is consistent with usage, making their names easy to remember and easy to deploy.

Simulate DNA sequences for the node substitution model. In the node substitution model, substitutions accumulate additionally during a speciation event, providing a potential mechanistic explanation for substitution rate variation. This package provides tools to simulate such a process, simulate a reference process with only substitutions along the branches, and provides tools to infer phylogenies from alignments. More information can be found in Janzen (2021) <doi:10.1093/sysbio/syab085>.

Likelihood based optimal partitioning and indicator species analysis. Finding the best binary partition for each species based on model selection, with the possibility to take into account modifying/confounding variables as described in Kemencei et al. (2014) <doi:10.1556/ComEc.15.2014.2.6>. The package implements binary and multi-level response models, various measures of uncertainty, Lorenz-curve based thresholding, with native support for parallel computations.

Computes nonparametric p-values for the potential class memberships of new observations as well as cross-validated p-values for the training data. The p-values are based on permutation tests applied to an estimated Bayesian likelihood ratio, using a plug-in statistic for the Gaussian model, k nearest neighbors', weighted nearest neighbors or penalized logistic regression'. Additionally, it provides graphical displays and quantitative analyses of the p-values.

Generates multivariate data with count and continuous variables with a pre-specified correlation matrix. The count and continuous variables are assumed to have Poisson and normal marginals, respectively. The data generation mechanism is a combination of the normal to anything principle and a connection between Poisson and normal correlations in the mixture. The details of the method are explained in Yahav et al. (2012) <DOI:10.1002/asmb.901>.

Complex graphical representations of data are best explored using interactive elements. parcats adds interactive graphing capabilities to the easyalluvial package. The plotly.js parallel categories diagrams offer a good framework for creating interactive flow graphs that allow manual drag and drop sorting of dimensions and categories, highlighting single flows and displaying mouse over information. The plotly.js dependency is quite heavy and therefore is outsourced into a separate package.

Hexadecimal codes are typically used to represent colors in R. Connecting these codes to their colors requires practice or memorization. palette provides a vctrs class for working with color palettes, including printing and plotting functions. The goal of the class is to place visual representations of color palettes directly on or, at least, next to their corresponding character representations. Palette extensions also are provided for data frames using pillar'.

For a single, known pathogen phylogeny, provides functions for enumeration of the set of compatible epidemic transmission trees, and for uniform sampling from that set. Optional arguments allow for incomplete sampling with a known number of missing individuals, multiple sampling, and known infection time limits. Always assumed are a complete transmission bottleneck and no superinfection or reinfection. See Hall and Colijn (2019) <doi:10.1093/molbev/msz058> for methodology.

Different multiple testing procedures for correlation tests are implemented. These procedures were shown to theoretically control asymptotically the Family Wise Error Rate (Roux (2018) <https://tel.archives-ouvertes.fr/tel-01971574v1>) or the False Discovery Rate (Cai & Liu (2016) <doi:10.1080/01621459.2014.999157>). The package gather four test statistics used in correlation testing, four FWER procedures with either single step or stepdown versions, and four FDR procedures.

martini deals with the low power inherent to GWAS studies by using prior knowledge represented as a network. SNPs are the vertices of the network, and the edges represent biological relationships between them (genomic adjacency, belonging to the same gene, physical interaction between protein products). The network is scanned using SConES, which looks for groups of SNPs maximally associated with the phenotype, that form a close subnetwork.

Identifies motifs that are significantly co-enriched from enhancer-promoter interaction data. While enhancer-promoter annotation is commonly used to define groups of interaction anchors, spatzie also supports co-enrichment analysis between preprocessed interaction anchors. Supports BEDPE interaction data derived from genome-wide assays such as HiC, ChIA-PET, and HiChIP. Can also be used to look for differentially enriched motif pairs between two interaction experiments.

This package provides functions for handling and analyzing immune receptor repertoire data, such as produced by the CellRanger V(D)J pipeline. This includes reading the data into R, merging it with paired single-cell data, quantifying clonotype abundances, calculating diversity metrics, and producing common plots. It implements the E-M Algorithm for clonotype assignment, along with other methods, which makes use of ambiguous cells for improved quantification.

This package can be used to predict the r-species accumulation curve (r-SAC), which is the number of species represented at least r times as a function of the sampling effort. When r = 1, the curve is known as the species accumulation curve, or the library complexity curve in high-throughput genomic sequencing. The package includes both parametric and nonparametric methods, as described by Deng C, et al. (2018).

This package provides a fast implementation of a key-value store. Environments are commonly used as key-value stores, but every time a new key is used, it is added to R's global symbol table, causing a small amount of memory leakage. This can be problematic in cases where many different keys are used. Fastmap avoids this memory leak issue by implementing the map using data structures in C++.