This package provides methods and functions to analyze the quantitative or qualitative performance for diagnostic assays, and outliers detection, reader precision and reference range are discussed. Most of the methods and algorithms refer to CLSI (Clinical & Laboratory Standards Institute) recommendations and NMPA (National Medical Products Administration) guidelines. In additional, relevant plots are constructed by ggplot2'.

This package provides functionality to produce graphs of sampling distributions of test statistics from a variety of common statistical tests. With only a few keystrokes, the user can conduct a hypothesis test and visualize the test statistic and corresponding p-value through the shading of its sampling distribution. Initially created for statistics at Middlebury College.

Predicting the structure of a graph including new nodes and edges using a time series of graphs. Flux balance analysis, a linear and integer programming technique used in biochemistry is used with time series prediction methods to predict the graph structure at a future time point Kandanaarachchi (2024) <doi:10.48550/arXiv.2401.04280>.

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the rxode2 package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

The openFDA API facilitates access to Federal Drug Agency (FDA) data on drugs, devices, foodstuffs, tobacco, and more with httr2'. This package makes the API easily accessible, returning objects which the user can convert to JSON data and parse. Kass-Hout TA, Xu Z, Mohebbi M et al. (2016) <doi:10.1093/jamia/ocv153>.

Access a variety of PubMed data through a single, user-friendly interface, including abstracts <https://pubmed.ncbi.nlm.nih.gov/>, bibliometrics from iCite <https://icite.od.nih.gov/>, pubtations from PubTator3 <https://www.ncbi.nlm.nih.gov/research/pubtator3/>, and full-text records from PMC <https://www.ncbi.nlm.nih.gov/pmc/>.

Programs for Martinussen and Scheike (2006), `Dynamic Regression Models for Survival Data', Springer Verlag. Plus more recent developments. Additive survival model, semiparametric proportional odds model, fast cumulative residuals, excess risk models and more. Flexible competing risks regression including GOF-tests. Two-stage frailty modelling. PLS for the additive risk model. Lasso in the ahaz package.

The diffUTR package provides a uniform interface and plotting functions for limma/edgeR/DEXSeq -powered differential bin/exon usage. It includes in addition an improved version of the limma::diffSplice method. Most importantly, diffUTR further extends the application of these frameworks to differential UTR usage analysis using poly-A site databases.

metaCCA performs multivariate analysis of a single or multiple GWAS based on univariate regression coefficients. It allows multivariate representation of both phenotype and genotype. metaCCA extends the statistical technique of canonical correlation analysis to the setting where original individual-level records are not available, and employs a covariance shrinkage algorithm to achieve robustness.

The genome is divided into non-overlapping fixed-sized bins, number of sequence reads in each counted, adjusted with a simultaneous two-dimensional loess correction for sequence mappability and GC content, and filtered to remove spurious regions in the genome. Downstream steps of segmentation and calling are also implemented via packages DNAcopy and CGHcall, respectively.

This package contains various routines for drawing ellipses and ellipse-like confidence regions, implementing the plots described in Murdoch and Chow (1996), A graphical display of large correlation matrices, The American Statistician 50, 178-180. There are also routines implementing the profile plots described in Bates and Watts (1988), Nonlinear Regression Analysis and its Applications.

This package implements a general framework for finite mixtures of regression models using the EM algorithm. FlexMix provides the E-step and all data handling, while the M-step can be supplied by the user to easily define new models. Existing drivers implement mixtures of standard linear models, generalized linear models and model-based clustering.

This package provides a regular expression toolkit for regex-base with compile-time checking of regular expression syntax, data types for matches and captures, a text replacement toolkit, portable options, high-level AWK-like tools for building text processing apps, regular expression macros with parsers and test bench, comprehensive documentation, tutorials and copious examples.

The 6581 SID chip is the sound chip used in the Commodore 64 computer. reMID is a MIDI implementation of the 6581 SID chip using the reSID library to provide a virtual SID-based synthesizer, controllable in real-time via MIDI. It includes support for scripted instruments that allow complex sonic control of the chip.

Indirect method for the estimation of reference intervals using Real-World Data ('RWD'). It takes routine measurements of diagnostic tests, containing pathological and non-pathological samples as input and uses sophisticated statistical methods to derive a model describing the distribution of the non-pathological samples. This distribution can then be used to derive reference intervals. Furthermore, the package offers functions for printing and plotting the results of the algorithm. See ?refineR for a more comprehensive description of the features. Version 1.0 of the algorithm is described in detail in Ammer et al. (2021) <doi:10.1038/s41598-021-95301-2>. Additional guidance on the usage of the algorithm is given in Ammer et al. (2023) <doi:10.1093/jalm/jfac101>.

Processes standard recommendation datasets (e.g., a user-item rating matrix) as input and generates rating predictions and lists of recommended items. Standard algorithm implementations which are included in this package are the following: Global/Item/User-Average baselines, Weighted Slope One, Item-Based KNN, User-Based KNN, FunkSVD, BPR and weighted ALS. They can be assessed according to the standard offline evaluation methodology (Shani, et al. (2011) <doi:10.1007/978-0-387-85820-3_8>) for recommender systems using measures such as MAE, RMSE, Precision, Recall, F1, AUC, NDCG, RankScore and coverage measures. The package (Coba, et al.(2017) <doi: 10.1007/978-3-319-60042-0_36>) is intended for rapid prototyping of recommendation algorithms and education purposes.

Plots simulation results of clinical trials. Its main feature is allowing users to simultaneously investigate the impact of several simulation input dimensions through dynamic filtering of the simulation results. A more detailed description of the app can be found in Meyer et al. <DOI:10.1016/j.softx.2023.101347> or the vignettes on GitHub'.

This package provides functions for data augmentation using the Bayesian discount prior method for single arm and two-arm clinical trials, as described in Haddad et al. (2017) <doi:10.1080/10543406.2017.1300907>. The discount power prior methodology was developed in collaboration with the The Medical Device Innovation Consortium (MDIC) Computer Modeling & Simulation Working Group.

Querying, extracting, and processing large-scale network data from Neo4j databases using the Neo4j Bolt <https://neo4j.com/docs/bolt/current/bolt/> protocol. This interface supports efficient data retrieval, batch processing for large datasets, and seamless conversion of query results into R data frames, making it ideal for bioinformatics, computational biology, and other graph-based applications.

Estimation of population size of migratory caribou herds based on large scale aggregations monitored by radio telemetry. It implements the methodology found in the article by Rivest et al. (1998) about caribou abundance estimation. It also includes a function based on the Lincoln-Petersen Index as applied to radio telemetry data by White and Garrott (1990).

This package provides tools for performing cross-validation (CV). The main function is a general purpose wrapper that performs k-fold CV for any tuning parameter in any supervised learning method. The package also has a function that computes the loss incurred by a set of predictions for a variety of loss functions and model families.

This package performs a Correspondence Analysis (CA) on a contingency table and creates a scatterplot of the row and column points on the selected dimensions. Optionally, the function can add segments to the plot to visualize significant associations between row and column categories on the basis of positive (unadjusted) standardized residuals larger than a given threshold.

This package provides functions to analyze the spatial distribution of biodiversity, in particular categorical analysis of neo- and paleo-endemism (CANAPE) as described in Mishler et al (2014) <doi:10.1038/ncomms5473>. canaper conducts statistical tests to determine the types of endemism that occur in a study area while accounting for the evolutionary relationships of species.

This model fitting tool incorporates cyclic coordinate descent and majorization-minimization approaches to fit a variety of regression models found in large-scale observational healthcare data. Implementations focus on computational optimization and fine-scale parallelization to yield efficient inference in massive datasets. Please see: Suchard, Simpson, Zorych, Ryan and Madigan (2013) <doi:10.1145/2414416.2414791>.