This package implements the kernel method of test equating as defined in von Davier, A. A., Holland, P. W. and Thayer, D. T. (2004) <doi:10.1007/b97446> and Andersson, B. and Wiberg, M. (2017) <doi:10.1007/s11336-016-9528-7> using the CB, EG, SG, NEAT CE/PSE and NEC designs, supporting Gaussian, logistic and uniform kernels and unsmoothed and pre-smoothed input data.

An easy-to-use ndjson (newline-delimited JSON') logger. It provides a set of wrappers for base R's message(), warning(), and stop() functions that maintain identical functionality, but also log the handler message to an ndjson log file. No change in existing code is necessary to use this package, and only a few additional adjustments are needed to fully utilize its potential.

This package provides a nonparametric method to approximate Laplacian graph spectra of a network with ordered vertices. This provides a computationally efficient algorithm for obtaining an accurate and smooth estimate of the graph Laplacian basis. The approximation results can then be used for tasks like change point detection, k-sample testing, and so on. The primary reference is Mukhopadhyay, S. and Wang, K. (2018, Technical Report).

Estimates of coefficients of lasso penalized linear regression and generalized linear models subject to non-negativity constraints on the parameters using multiplicative iterative algorithm. Entire regularization path for a sequence of lambda values can be obtained. Functions are available for creating plots of regularization path, cross validation and estimating coefficients at a given lambda value. There is also provision for obtaining standard error of coefficient estimates.

This package provides a network-guided penalized regression framework that integrates network characteristics from Gaussian graphical models with partial penalization, accounting for both network structure (hubs and non-hubs) and clinical covariates in high-dimensional omics data, including transcriptomics and proteomics. The full methodological details can be found in our recent preprint by Ahn S and Oh EJ (2025) <doi:10.48550/arXiv.2505.22986>.

Provide principally an eponymic function that numerically computes the Le Cam's one-step estimator for an independent and identically distributed sample. One-step estimation is asymptotically efficient (see L. Le Cam (1956) <https://projecteuclid.org/euclid.bsmsp/1200501652>) and can be computed faster than the maximum likelihood estimator for large observation samples, see e.g. Brouste et al. (2021) <doi:10.32614/RJ-2021-044>.

Calculates profile repeatability for replicate stress response curves, or similar time-series data. Profile repeatability is an individual repeatability metric that uses the variances at each timepoint, the maximum variance, the number of crossings (lines that cross over each other), and the number of replicates to compute the repeatability score. For more information see Reed et al. (2019) <doi:10.1016/j.ygcen.2018.09.015>.

The purpose of PH1XBAR is to build a Phase I Shewhart control chart for the basic Shewhart, the variance components and the ARMA models in R for subgrouped and individual data. More details can be found: Yao and Chakraborti (2020) <doi: 10.1002/qre.2793>, Yao and Chakraborti (2021) <doi: 10.1080/08982112.2021.1878220>, and Yao et al. (2023) <doi: 10.1080/00224065.2022.2139783>.

This package provides a set of functions for taking qualitative GIS data, hand drawn on a map, and converting it to a simple features object. These tools are focused on data that are drawn on a map that contains some type of polygon features. For each area identified on the map, the id numbers of these polygons can be entered as vectors and transformed using qualmap.

This package performs two-sample comparisons using the restricted mean survival time (RMST) as a summary measure of the survival time distribution. Three kinds of between-group contrast metrics (i.e., the difference in RMST, the ratio of RMST and the ratio of the restricted mean time lost (RMTL)) are computed. It performs an ANCOVA-type covariate adjustment as well as unadjusted analyses for those measures.

This package provides a flexible moving average algorithm for modeling drug exposure in pharmacoepidemiology studies as presented in the article: Ouchi, D., Giner-Soriano, M., Gómez-Lumbreras, A., Vedia Urgell, C.,Torres, F., & Morros, R. (2022). "Automatic Estimation of the Most Likely Drug Combination in Electronic Health Records Using the Smooth Algorithm : Development and Validation Study." JMIR medical informatics, 10(11), e37976. <doi:10.2196/37976>.

Decompose a time series into seasonal, trend, and remainder components using an implementation of Seasonal Decomposition of Time Series by Loess (STL) that provides several enhancements over the STL method in the stats package. These enhancements include handling missing values, providing higher order (quadratic) loess smoothing with automated parameter choices, frequency component smoothing beyond the seasonal and trend components, and some basic plot methods for diagnostics.

This package contains an R Markdown template for a clinical trial protocol adhering to the SPIRIT statement. The SPIRIT (Standard Protocol Items for Interventional Trials) statement outlines recommendations for a minimum set of elements to be addressed in a clinical trial protocol. Also contains functions to create a xml document from the template and upload it to clinicaltrials.gov<https://www.clinicaltrials.gov/> for trial registration.

It allows to quickly perform permutation-based closed testing by sum-based global tests, and construct lower confidence bounds for the TDP, simultaneously over all subsets of hypotheses. As a main feature, it produces simultaneous lower confidence bounds for the proportion of active voxels in different clusters for fMRI cluster analysis. Details may be found in Vesely, Finos, and Goeman (2020) <arXiv:2102.11759>.

For each string in a set of strings, determine a unique tag that is a substring of fixed size k unique to that string, if it has one. If no such unique substring exists, the least frequent substring is used. If multiple unique substrings exist, the lexicographically smallest substring is used. This lexicographically smallest substring of size k is called the "UniqTag" of that string.

Comparison of variance - covariance patterns using relative principal component analysis (relative eigenanalysis), as described in Le Maitre and Mitteroecker (2019) <doi:10.1111/2041-210X.13253>. Also provides functions to compute group covariance matrices, distance matrices, and perform proportionality tests. A worked sample on the body shape of cichlid fishes is included, based on the dataset from Kerschbaumer et al. (2013) <doi:10.5061/dryad.fc02f>.

This package uses a statistical framework for rapid and accurate detection of aneuploid cells with local copy number deletion or amplification. Our method uses an EM algorithm with mixtures of Poisson distributions while incorporating cytogenetics information (e.g., regional deletion or amplification) to guide the classification (partCNV). When applicable, we further improve the accuracy by integrating a Hidden Markov Model for feature selection (partCNVH).

The package allows for predicting whether a coiled coil sequence (amino acid sequence plus heptad register) is more likely to form a dimer or more likely to form a trimer. Additionally to the prediction itself, a prediction profile is computed which allows for determining the strengths to which the individual residues are indicative for either class. Prediction profiles can also be visualized as curves or heatmaps.

PanomiR is a package to detect miRNAs that target groups of pathways from gene expression data. This package provides functionality for generating pathway activity profiles, determining differentially activated pathways between user-specified conditions, determining clusters of pathways via the PCxN package, and generating miRNAs targeting clusters of pathways. These function can be used separately or sequentially to analyze RNA-Seq data.

This package does k-nearest neighbor based statistics and visualizations with flow and mass cytometery data. This gives tSNE maps"fold change" functionality and provides a data quality metric by assessing manifold overlap between fcs files expected to be the same. Other applications using this package include imputation, marker redundancy, and testing the relative information loss of lower dimension embeddings compared to the original manifold.

EBImage provides general purpose functionality for image processing and analysis. In the context of (high-throughput) microscopy-based cellular assays, EBImage offers tools to segment cells and extract quantitative cellular descriptors. This allows the automation of such tasks using the R programming language and facilitates the use of other tools in the R environment for signal processing, statistical modeling, machine learning and visualization with image data.

This package provides a set of tools for creation, manipulation, and modeling of tensors with arbitrary number of modes. A tensor in the context of data analysis is a multidimensional array. rTensor does this by providing a S4 class Tensor that wraps around the base array class. rTensor provides common tensor operations as methods, including matrix unfolding, summing/averaging across modes, calculating the Frobenius norm, and taking the inner product between two tensors. Familiar array operations are overloaded, such as index subsetting via [ and element-wise operations. rTensor also implements various tensor decomposition, including CP, GLRAM, MPCA, PVD, and Tucker. For tensors with 3 modes, rTensor also implements transpose, t-product, and t-SVD, as defined in Kilmer et al. (2013). Some auxiliary functions include the Khatri-Rao product, Kronecker product, and the Hadamard product for a list of matrices.

Model adsorption behavior using classical isotherms, including Langmuir, Freundlich, Brunauerâ Emmettâ Teller (BET), and Temkin models. The package supports parameter estimation through both linearized and non-linear fitting techniques and generates high-quality plots for model diagnostics. It is intended for environmental scientists, chemists, and researchers working on adsorption phenomena in soils, water treatment, and material sciences. Functions are compatible with base R and ggplot2 for visualization.

Make some distributions from the C++ library Boost available in R'. In addition, the normal-inverse Gaussian distribution and the generalized inverse Gaussian distribution are provided. The distributions are represented by R6 classes. The method to sample from the generalized inverse Gaussian distribution is the one given in "Random variate generation for the generalized inverse Gaussian distribution" Luc Devroye (2012) <doi:10.1007/s11222-012-9367-z>.