This package generates pathway scores from expression data for single samples after training on a reference cohort. The score is generated by taking the expression of a gene set (pathway) from a reference cohort and performing linear discriminant analysis to distinguish samples in the cohort that have the pathway augmented and not. The separating hyperplane is then used to score new samples.

svaNUMT contains functions for detecting NUMT events from structural variant calls. It takes structural variant calls in GRanges of breakend notation and identifies NUMTs by nuclear-mitochondrial breakend junctions. The main function reports candidate NUMTs if there is a pair of valid insertion sites found on the nuclear genome within a certain distance threshold. The candidate NUMTs are reported by events.

XAItest is an R Package that identifies features using eXplainable AI (XAI) methods such as SHAP or LIME. This package allows users to compare these methods with traditional statistical tests like t-tests, empirical Bayes, and Fisher's test. Additionally, it includes simThresh, a system that enables the comparison of feature importance with p-values by incorporating calibrated simulated data.

This package provides functions for species distribution modeling, calibration and evaluation, ensemble of models, ensemble forecasting and visualization. The package permits to run consistently up to 10 single models on a presence/absences (resp presences/pseudo-absences) dataset and to combine them in ensemble models and ensemble projections. Some bench of other evaluation and visualisation tools are also available within the package.

This package provides a matrix of agreement patterns and counts for record pairs is the input for the procedure. An EM algorithm is used to impute plausible values for missing record pairs. A second EM algorithm, incorporating possible correlations between per-field agreement, is used to estimate posterior probabilities that each pair is a true match - i.e. constitutes the same individual.

This package provides tools for the analysis, visualization, and manipulation of dynamical, social (Saqr et al. (2024) <doi:10.1007/978-3-031-54464-4_10>) and complex networks (Saqr et al. (2025) <doi:10.1145/3706468.3706513>). The package supports multiple network formats and offers flexible tools for heterogeneous, multi-layer, and hierarchical network analysis with simple syntax and extensive toolset.

Convex Partition is a black-box optimisation algorithm for single objective real-parameters functions. The basic principle is to progressively estimate and exploit a regression tree similar to a CART (Classification and Regression Tree) of the objective function. For more details see de Paz (2024) <doi:10.1007/978-3-031-62836-8_3> and Loh (2011) <doi:10.1002/widm.8> .

This package provides tools to fit sample selection models in case of discrete response variables, through a parametric formulation which represents a natural extension of the well-known Heckman selection model are provided in the package. The response variable can be of Bernoulli, Poisson or Negative Binomial type. The sample selection mechanism allows to choose among a Normal, Logistic or Gumbel distribution.

This package provides benchmark datasets and foundational tools for Symbolic Data Analysis (SDA). The package includes functions for constructing symbolic data objects from classical data, converting among different interval-valued data formats, managing interval-valued, histogram-valued, modal-valued, and multi-valued data, and performing basic descriptive statistics. It is designed to support teaching, methodological research, and the development of SDA techniques.

The Economic Policy Institute (<https://www.epi.org/>) provides researchers, media, and the public with easily accessible, up-to-date, and comprehensive historical data on the American labor force. It is compiled from Economic Policy Institute analysis of government data sources. Use it to research wages, inequality, and other economic indicators over time and among demographic groups. Data is usually updated monthly.

On import, the XML information is converted to a dataframe that reflects the hierarchical XML structure. Intuitive functions allow to navigate within this transparent XML data structure (without any knowledge of XPath'). flatXML also provides tools to extract data from the XML into a flat dataframe that can be used to perform statistical operations. It also supports converting dataframes to XML.

This package implements fast change point detection algorithm based on the paper "Sequential Gradient Descent and Quasi-Newton's Method for Change-Point Analysis" by Xianyang Zhang, Trisha Dawn <https://proceedings.mlr.press/v206/zhang23b.html>. The algorithm is based on dynamic programming with pruning and sequential gradient descent. See Li and Zhang (2026) <doi:10.18637/jss.v116.i06> for details.

Fit linear mixed-effects models using restricted (or residual) maximum likelihood (REML) and with generalized inverse matrices to specify covariance structures for random effects. In particular, the package is suited to fit quantitative genetic mixed models, often referred to as animal models'. Implements the average information algorithm as the main tool to maximize the restricted log-likelihood, but with other algorithms available.

Utilities to cost and evaluate Australian tax policy, including fast projections of personal income tax collections, high-performance tax and transfer calculators, and an interface to common indices from the Australian Bureau of Statistics. Written to support Grattan Institute's Australian Perspectives program, and related projects. Access to the Australian Taxation Office's sample files of personal income tax returns is assumed.

Some basic functions to implement belief functions including: transformation between belief functions using the method introduced by Philippe Smets <arXiv:1304.1122>, evidence combination, evidence discounting, decision-making, and constructing masses. Currently, thirteen combination rules and six decision rules are supported. It can also be used to generate different types of random masses when working on belief combination and conflict management.

Interactive dendrogram that enables the user to select and color clusters, to zoom and pan the dendrogram, and to visualize the clustered data not only in a built-in heat map, but also in GGobi interactive plots and user-supplied plots. This is a backport of Qt-based idendro (<https://github.com/tsieger/idendro>) to base R graphics and Tcl/Tk GUI.

Visualization of multi-dimensional data arising in multi-objective optimization, including plots of the empirical attainment function (EAF), M. López-Ibáñez, L. Paquete, and T. Stützle (2010) <doi:10.1007/978-3-642-02538-9_9>, and symmetric Vorob'ev expectation and deviation, M. Binois, D. Ginsbourger, O. Roustant (2015) <doi:10.1016/j.ejor.2014.07.032>, among others.

Computes the prime implicants or a minimal disjunctive normal form for a logic expression presented by a truth table or a logic tree. Has been particularly developed for logic expressions resulting from a logic regression analysis, i.e. logic expressions typically consisting of up to 16 literals, where the prime implicants are typically composed of a maximum of 4 or 5 literals.

This package performs maximum a posteriori Bayesian estimation of individual pharmacokinetic parameters from a model defined in mrgsolve', typically for model-based therapeutic drug monitoring. Internally computes an objective function value from model and data, performs optimization and returns predictions in a convenient format. The performance of the package was described by Le Louedec et al (2021) <doi:10.1002/psp4.12689>.

An efficient data integration method is provided for multiple spatial transcriptomics data with non-cluster-relevant effects such as the complex batch effects. It unifies spatial factor analysis simultaneously with spatial clustering and embedding alignment, requiring only partially shared cell/domain clusters across datasets. More details can be referred to Wei Liu, et al. (2023) <doi:10.1038/s41467-023-35947-w>.

This package provides functions for data normalization and transformation in preprocessing stages. Implements scaling methods (min-max, Z-score, L2 normalization) and power transformations (Box-Cox, Yeo-Johnson). Box-Cox transformation is described in Box and Cox (1964) <doi:10.1111/j.2517-6161.1964.tb00553.x>, Yeo-Johnson transformation in Yeo and Johnson (2000) <doi:10.1093/biomet/87.4.954>.

Calculates the right-tail probability of quadratic forms of Gaussian variables using the skewness-kurtosis ratio matching method, modified Liu-Tang-Zhang method and Satterthwaite-Welch method. The technical details can be found in Hong Zhang, Judong Shen and Zheyang Wu (2022) "A fast and accurate approximation to the distributions of quadratic forms of Gaussian variables" <doi:10.1080/10618600.2021.2000423>.

User-friendly framework that enables the training and the evaluation of species distribution models (SDMs). The package implements functions for data driven variable selection and model tuning and includes numerous utilities to display the results. All the functions used to select variables or to tune model hyperparameters have an interactive real-time chart displayed in the RStudio viewer pane during their execution.

Extends the classical SSIM method proposed by Wang', Bovik', Sheikh', and Simoncelli'(2004) <doi:10.1109/TIP.2003.819861>. for irregular lattice-based maps and raster images. The geographical SSIM method incorporates well-developed geographically weighted summary statistics'('Brunsdon', Fotheringham and Charlton 2002) <doi:10.1016/S0198-9715(01)00009-6> with an adaptive bandwidth kernel function for irregular lattice-based maps.