Analysis of dyadic network and relational data using additive and multiplicative effects (AME) models. The basic model includes regression terms, the covariance structure of the social relations model (Warner, Kenny and Stoto (1979) <DOI:10.1037/0022-3514.37.10.1742>, Wong (1982) <DOI:10.2307/2287296>), and multiplicative factor models (Hoff(2009) <DOI:10.1007/s10588-008-9040-4>). Several different link functions accommodate different relational data structures, including binary/network data, normal relational data, zero-inflated positive outcomes using a tobit model, ordinal relational data and data from fixed-rank nomination schemes. Several of these link functions are discussed in Hoff, Fosdick, Volfovsky and Stovel (2013) <DOI:10.1017/nws.2013.17>. Development of this software was supported in part by NIH grant R01HD067509.

The adapted pair correlation function transfers the concept of the pair correlation function from point patterns to patterns of objects of finite size and irregular shape (e.g. lakes within a country). The pair correlation function describes the spatial distribution of objects, e.g. random, aggregated or regularly spaced. This is a reimplementation of the method suggested by Nuske et al. (2009) <doi:10.1016/j.foreco.2009.09.050> using the library GEOS <doi:10.5281/zenodo.11396894>.

Multivariate tools to analyze comparative data, i.e. a phylogeny and some traits measured for each taxa. The package contains functions to represent comparative data, compute phylogenetic proximities, perform multivariate analysis with phylogenetic constraints and test for the presence of phylogenetic autocorrelation. The package is described in Jombart et al (2010) <doi:10.1093/bioinformatics/btq292>.

This package provides tools for the multiscale spatial analysis of multivariate data. Several methods are based on the use of a spatial weighting matrix and its eigenvector decomposition (Moran's Eigenvectors Maps, MEM). Several approaches are described in the review Dray et al (2012) <doi:10.1890/11-1183.1>.

This package implements the Adaptive Multiple Importance Sampling (AMIS) algorithm, as described by Retkute et al. (2021, <doi:10.1214/21-AOAS1486>), to estimate key epidemiological parameters by combining outputs from a geostatistical model of infectious diseases (such as prevalence, incidence, or relative risk) with a disease transmission model. Utilising the resulting posterior distributions, the package enables forward projections at the local level.

Schema definitions and read, write and validation tools for data formatted in accordance with the AIRR Data Representation schemas defined by the AIRR Community <http://docs.airr-community.org>.

This package provides an algebra over probability distributions enabling composition, sampling, and automatic simplification to closed forms. Supports normal, exponential, multivariate normal, and empirical distributions with operations like addition and subtraction that automatically simplify when mathematical identities apply (e.g., the sum of independent normal distributions is normal). Uses S3 classes for distributions and R6 for support objects.

This package contains some tools for testing, analyzing time series data and fitting popular time series models such as ARIMA, Moving Average and Holt Winters, etc. Most functions also provide nice and clear outputs like SAS does, such as identify, estimate and forecast, which are the same statements in PROC ARIMA in SAS.

Automated methods to assemble population PK (pharmacokinetic) and PKPD (pharmacodynamic) datasets for analysis in NONMEM (non-linear mixed effects modeling) by Bauer (2019) <doi:10.1002/psp4.12404>. The package includes functions to build datasets from SDTM (study data tabulation module) <https://www.cdisc.org/standards/foundational/sdtm>, ADaM (analysis dataset module) <https://www.cdisc.org/standards/foundational/adam>, or other dataset formats. The package will combine population datasets, add covariates, and create documentation to support regulatory submission and internal communication.

The archdata package provides several types of data that are typically used in archaeological research. It provides all of the data sets used in "Quantitative Methods in Archaeology Using R" by David L Carlson, one of the Cambridge Manuals in Archaeology.

This package provides a systematic framework for neural networkâ based model selection and forecasting using single hidden layer feed-forward networks. It evaluates all possible combinations of predictor variables and hidden layer configurations, selecting the optimal model based on predictive accuracy criteria such as root mean squared error (RMSE) and mean absolute percentage error (MAPE). Predictors are automatically standardized, and model performance is assessed using out-of-sample validation. The package is designed for empirical modelling and forecasting in economics, agriculture, trade, climate, and related applied research domains where nonlinear relationships and robust predictive performance are of primary interest.

We provide a stage-wise selection method using genetic algorithm which can perform fast interaction selection in high-dimensional linear regression models with two-way interaction effects under strong, weak, or no heredity condition. Ye, C.,and Yang,Y. (2019) <doi:10.1109/TIT.2019.2913417>.

Estimate the causal treatment effect for subjects that can adhere to one or both of the treatments. Given longitudinal data with missing observations, consistent causal effects are calculated. Unobserved potential outcomes are estimated through direct integration as described in: Qu et al., (2019) <doi:10.1080/19466315.2019.1700157> and Zhang et. al., (2021) <doi:10.1080/19466315.2021.1891965>.

Create Tables for Reporting Clinical Trials. Calculates descriptive statistics and hypothesis tests, arranges the results in a table ready for reporting with LaTeX, HTML or Word.

Use Monte-Carlo and K-fold cross-validation coupled with machine- learning classification algorithms to perform population assignment, with functionalities of evaluating discriminatory power of independent training samples, identifying informative loci, reducing data dimensionality for genomic data, integrating genetic and non-genetic data, and visualizing results.

ACE (Advanced Cohort Engine) is a powerful tool that allows constructing cohorts of patients extremely quickly and efficiently. This package is designed to interface directly with an instance of ACE search engine and facilitates API queries and data dumps. Prerequisite is a good knowledge of the temporal language to be able to efficiently construct a query. More information available at <https://shahlab.stanford.edu/start>.

Given the parameters of a distribution, the package uses the concept of alpha-outliers by Davies and Gather (1993) to flag outliers in a data set. See Davies, L.; Gather, U. (1993): The identification of multiple outliers, JASA, 88 423, 782-792, <doi:10.1080/01621459.1993.10476339> for details.

This package contains functions carrying out adaptive procedures using mixed scaling approach to establish bioequivalence for in-vitro permeation test (IVPT) data. Currently, the package provides procedures based on parallel replicate design and balanced data, according to the U.S. Food and Drug Administration's "Draft Guidance on Acyclovir" <https://www.accessdata.fda.gov/drugsatfda_docs/psg/Acyclovir_topical%20cream_RLD%2021478_RV12-16.pdf>. Potvin et al. (2008) <doi:10.1002/pst.294> provides the basis for our adaptive design (see Method B). For a comprehensive overview of the method, refer to Lim et al. (2023) <doi:10.1002/pst.2333>. This package reflects the views of the authors and should not be construed to represent the views or policies of the U.S. Food and Drug Administration.

The Ata method (Yapar et al. (2019) <doi:10.15672/hujms.461032>), an alternative to exponential smoothing (described in Yapar (2016) <doi:10.15672/HJMS.201614320580>, Yapar et al. (2017) <doi:10.15672/HJMS.2017.493>), is a new univariate time series forecasting method which provides innovative solutions to issues faced during the initialization and optimization stages of existing forecasting methods. Forecasting performance of the Ata method is superior to existing methods both in terms of easy implementation and accurate forecasting. It can be applied to non-seasonal or seasonal time series which can be decomposed into four components (remainder, level, trend and seasonal). This methodology performed well on the M3 and M4-competition data. This package was written based on Ali Sabri Taylanâ s PhD dissertation.

Process results generated by Antares', a powerful open source software developed by RTE (Réseau de Transport dâ à lectricité) to simulate and study electric power systems (more information about Antares here: <https://github.com/AntaresSimulatorTeam/Antares_Simulator>). This package provides functions to create new columns like net load, load factors, upward and downward margins or to compute aggregated statistics like economic surpluses of consumers, producers and sectors.

Adjusts output of cranlogs package to account for CRAN'-wide daily automated downloads and re-downloads caused by package updates.

Using sparse precision matricies and Choleski factorization simulates data that is auto-regressive.

This package implements a framework for creating boxplots where the whisker lengths are determined by formal multiple testing procedures, making them adaptive to sample size and data characteristics. The function bh_boxplot() generates boxplots that control the False Discovery Rate (FDR) via the Benjamini-Hochberg procedure, and the function holm_boxplot() generates boxplots that control the Family-Wise Error Rate (FWER) via the Holm procedure. The methods are based on the framework in Gang, Lin, and Tong (2025) <doi:10.48550/arXiv.2510.20259>.

This package provides a function to calibrate variant effect scores against evidence strength categories defined by the American College of Medical Genetics and Genomics (ACMG) and the Association for Molecular Pathology (AMP) guidelines. The method computes likelihood ratios of pathogenicity via kernel density estimation of pathogenic and benign score distributions, and derives score intervals corresponding to ACMG/AMP evidence levels. This enables researchers and clinical geneticists to interpret functional and computational variant scores in a reproducible and standardised manner. For details, see Badonyi and Marsh (2025) <doi:10.1093/bioinformatics/btaf503>.