This package provides a minimal-dependency R client for OpenAI'-compatible text-to-speech APIs (see <https://developers.openai.com/api/reference/resources/audio>). Supports OpenAI', ElevenLabs', local servers ('Chatterbox', LM Studio', OpenWebUI', AnythingLLM'), and the chatterbox package for in-process synthesis. Provides a unified interface for speech synthesis, voice cloning, and voice design with backend-specific parameters.

Ecological niche model estimation using ellipsoidal geometry under an M hypothesis. Fits nine likelihood families (presence-only, weighted, inverse-probability-weighted, skew-normal, skew-normal-weighted, skew-t, skew-t-weighted, ncst, and ncst-weighted) via multi-start optimisation with Sobol sequences. Methods for the optimisation of ellipses parameters are as described in Jimenez et al. (2022) <doi:10.1016/j.ecolmodel.2021.109823>.

This package provides functions for designing multiple dependent state sampling inspection plans for time-truncated life tests. The package determines the minimum sample size required to satisfy a specified consumer's risk constraint and evaluates the probability of acceptance under different quality and termination ratios. Users can directly provide failure probabilities, allowing the sampling plan to be applied to different lifetime distributions without requiring distribution-specific functions. Provide operating characteristic analysis, sample size analysis, and graphical comparison with single sampling inspection plans. Aslam et al. (2016) <doi:10.1080/08982112.2015.1068331>; Rao et al. (2020) <doi:10.1080/25742558.2020.1857915>; Balamurali et al. (2017) <doi:10.1080/07474946.2016.1275459>; Saha et al. (2021) <doi:10.1080/21681015.2021.1893843>; Tripathi et al. (2020) <doi:10.1007/s40745-020-00267-z>; Tripathi et al. (2023) <doi:10.1007/s41872-023-00221-x>.

Indirect method for the estimation of reference intervals (RIs) using Real-World Data ('RWD') and methods for comparing and verifying RIs. Estimates RIs by applying advanced statistical methods to routine diagnostic test measurements, which include both pathological and non-pathological samples, to model the distribution of non-pathological samples. This distribution is then used to derive reference intervals and support RI verification, i.e., deciding if a specific RI is suitable for the local population. The package also provides functions for printing and plotting algorithm results. See ?refineR for a detailed description of features. Version 1.0 of the algorithm is described in Ammer et al. (2021) <doi:10.1038/s41598-021-95301-2>. Additional guidance is in Ammer et al. (2023) <doi:10.1093/jalm/jfac101>. The verification method is described in Beck et al. (2025) <doi:10.1515/cclm-2025-0728>.

EBImage provides general purpose functionality for image processing and analysis. In the context of (high-throughput) microscopy-based cellular assays, EBImage offers tools to segment cells and extract quantitative cellular descriptors. This allows the automation of such tasks using the R programming language and facilitates the use of other tools in the R environment for signal processing, statistical modeling, machine learning and visualization with image data.

SpNeigh provides methods for neighborhood-aware analysis of spatial transcriptomics data. It supports boundary detection, spatial weighting (centroid- and boundary-based), spatially informed differential expression using spline-based models, and spatial enrichment analysis via the Spatial Enrichment Index (SEI). Designed for compatibility with Seurat objects, SpatialExperiment objects and spatial data frames, SpNeigh enables interpretable, publication-ready analysis of spatial gene expression patterns.

This package provides a function for estimating the parameters of Structural Bayesian Vector Autoregression models with the method developed by Baumeister and Hamilton (2015) <doi:10.3982/ECTA12356>, Baumeister and Hamilton (2017) <doi:10.3386/w24167>, and Baumeister and Hamilton (2018) <doi:10.1016/j.jmoneco.2018.06.005>. Functions for plotting impulse responses, historical decompositions, and posterior distributions of model parameters are also provided.

This package provides a tool for the preparation and enrichment of health datasets for analysis (Toner et al. (2023) <doi:10.1093/gigascience/giad030>). Provides functionality for assessing data quality and for improving the reliability and machine interpretability of a dataset. eHDPrep also enables semantic enrichment of a dataset where metavariables are discovered from the relationships between input variables determined from user-provided ontologies.

This package provides a shiny'-based graphical user interface for the earth package, enabling interactive building and exploration of Multivariate Adaptive Regression Splines (MARS) models. Features include data import from CSV and Excel files, automatic detection of categorical variables, interactive control of interaction terms via an allowed matrix, comprehensive model diagnostics with variable importance and partial dependence plots, and publication-quality report generation via Quarto'.

Solves a least squares system Ax~=b (dim(A)=(m,n) with m >= n) with a precondition matrix B: BAx=Bb (dim(B)=(n,m)). Implemented method is based on GMRES (Saad, Youcef; Schultz, Martin H. (1986). "GMRES: A Generalized Minimal Residual Algorithm for Solving Nonsymmetric Linear Systems" <doi:10.1137/0907058>) with callback functions, i.e. no explicit A, B or b are required.

This package provides tools for manipulating, visualizing, and exporting raster images in R. Designed as an educational resource for students learning the basics of remote sensing, the package provides user-friendly functions to apply color ramps, export RGB composites, and create multi-frame visualizations. Built on top of the terra and ggplot2 packages. See <https://github.com/ducciorocchini/imageRy> for more details and examples.

This package provides a collection of methods for large scale single mediator hypothesis testing. The six included methods for testing the mediation effect are Sobel's test, Max P test, joint significance test under the composite null hypothesis, high dimensional mediation testing, divide-aggregate composite null test, and Sobel's test under the composite null hypothesis. Du et al (2023) <doi:10.1002/gepi.22510>.

Estimates Variable Length Markov Chains (VLMC) models and VLMC with covariates models from discrete sequences. Supports model selection via information criteria and simulation of new sequences from an estimated model. See Bühlmann, P. and Wyner, A. J. (1999) <doi:10.1214/aos/1018031204> for VLMC and Zanin Zambom, A., Kim, S. and Lopes Garcia, N. (2022) <doi:10.1111/jtsa.12615> for VLMC with covariates.

An interface to the Apache OpenNLP tools (version 1.5.3). The Apache OpenNLP library is a machine learning based toolkit for the processing of natural language text written in Java. It supports the most common NLP tasks, such as tokenization, sentence segmentation, part-of-speech tagging, named entity extraction, chunking, parsing, and coreference resolution. See <https://opennlp.apache.org/> for more information.

Applies an objective Bayesian method to the Mb capture-recapture model to estimate the population size N. The Mb model is a class of capture-recapture methods used to account for variations in capture probability due to animal behavior. Under the Mb formulation, the initial capture of an animal may effect the probability of subsequent captures due to their becoming "trap happy" or "trap shy.".

Simple method of purging independent variables of mediating effects. First, regress the direct variable on the indirect variable. Then, used the stored residuals as the new purged (direct) variable in the updated specification. This purging process allows for use of a new direct variable uncorrelated with the indirect variable. Please cite the method and/or package using Waggoner, Philip D. (2018) <doi:10.1177/1532673X18759644>.

This package provides tools for analyzing and understanding the file contents of large shiny application directories. The package extracts key information about render functions, reactive functions, and their inputs from app files, organizing them into structured data frames for easy reference. This streamlines the onboarding process for new contributors and helps identify areas for optimization in complex shiny codebases with multiple files and sourcing chains.

Implementation of SAPEVO-M, a Group Ordinal Method for Multiple Criteria Decision-Making (MCDM). SAPEVO-M is an acronym for Simple Aggregation of Preferences Expressed by Ordinal Vectors Group Decision Making. This method provides alternatives ranking given decision makers preferences: criteria preferences and alternatives preferences for each criterion.This method is described in Gomes et al. (2020) <doi: 10.1590/0101-7438.2020.040.00226524 >.

An implementation of self-exciting point process model for information cascades, which occurs when many people engage in the same acts after observing the actions of others (e.g. post resharings on Facebook or Twitter). It provides functions to estimate the infectiousness of an information cascade and predict its popularity given the observed history. See <http://snap.stanford.edu/seismic/> for more information and datasets.

Detects spatial and temporal groups in GPS relocations (Robitaille et al. (2019) <doi:10.1111/2041-210X.13215>). It can be used to convert GPS relocations to gambit-of-the-group format to build proximity-based social networks, and perform data-stream randomization methods suitable for GPS data. Also provides measures of intragroup social dynamics including distance and direction to leaders, centroids and nearest neighbours.

Computation of approximate potentials for both gradient and non gradient fields. It is known from physics that only gradient fields, also known as conservative, have a well defined potential function. Here we present an algorithm, based on the classical Helmholtz decomposition, to obtain an approximate potential function for non gradient fields. More information in Rodrà guez-Sánchez (2020) <doi:10.1371/journal.pcbi.1007788>.

This tool takes longitudinal dataset as input and analyzes if there is significant change of the features over time (a proxy for treatments), while detects and controls for covariates simultaneously. LongDat is able to take in several data types as input, including count, proportion, binary, ordinal and continuous data. The output table contains p values, effect sizes and covariates of each feature, making the downstream analysis easy.

The package allows for predicting whether a coiled coil sequence (amino acid sequence plus heptad register) is more likely to form a dimer or more likely to form a trimer. Additionally to the prediction itself, a prediction profile is computed which allows for determining the strengths to which the individual residues are indicative for either class. Prediction profiles can also be visualized as curves or heatmaps.

PanomiR is a package to detect miRNAs that target groups of pathways from gene expression data. This package provides functionality for generating pathway activity profiles, determining differentially activated pathways between user-specified conditions, determining clusters of pathways via the PCxN package, and generating miRNAs targeting clusters of pathways. These function can be used separately or sequentially to analyze RNA-Seq data.