This package provides a comprehensive framework for representing, analyzing, and visualizing genomic interactions, particularly focusing on gene-enhancer relationships. The package extends the GenomicRanges infrastructure to handle paired genomic regions with specialized methods for chromatin interaction data from Hi-C, Promoter Capture Hi-C (PCHi-C), and single-cell ATAC-seq experiments. Key features include conversion from common interaction formats, annotation of promoters and enhancers, distance-based analyses, interaction strength metrics, statistical modeling using CHiCANE methodology, and tailored visualization tools. The package aims to standardize the representation of genomic interaction data while providing domain-specific functions not available in general genomic interaction packages.

Unifies the implementations of several Network Zoo methods (netzoo, netzoo.github.io) into a single package by creating interfaces between network inference and network analysis methods. Currently, the package has 3 methods for network inference including PANDA and its optimized implementation OTTER (network reconstruction using multiple lines of biological evidence), LIONESS (single-sample network inference), and EGRET (genotype-specific networks). Network analysis methods include CONDOR (community detection), ALPACA (differential community detection), CRANE (significance estimation of differential modules), MONSTER (estimation of network transition states). In addition, YARN allows to process gene expression data for tissue-specific analyses and SAMBAR infers missing mutation data based on pathway information.

Calculations of the most common metrics of automated advertisement and plotting of them with trend and forecast. Calculations and description of metrics is taken from different RTB platforms support documentation. Plotting and forecasting is based on packages forecast', described in Rob J Hyndman and George Athanasopoulos (2021) "Forecasting: Principles and Practice" <https://otexts.com/fpp3/> and Rob J Hyndman et al "Documentation for forecast'" (2003) <https://pkg.robjhyndman.com/forecast/>, and ggplot2', described in Hadley Wickham et al "Documentation for ggplot2'" (2015) <https://ggplot2.tidyverse.org/>, and Hadley Wickham, Danielle Navarro, and Thomas Lin Pedersen (2015) "ggplot2: Elegant Graphics for Data Analysis" <https://ggplot2-book.org/>.

Bootstrap based goodness-of-fit tests. It allows to perform rigorous statistical tests to check if a chosen model family is correct based on the marked empirical process. The implemented algorithms are described in (Dikta and Scheer (2021) <doi:10.1007/978-3-030-73480-0>) and can be applied to generalized linear models without any further implementation effort. As far as certain linearity conditions are fulfilled the resampling scheme are also applicable beyond generalized linear models. This is reflected in the software architecture which allows to reuse the resampling scheme by implementing only certain interfaces for models that are not supported natively by the package.

This package provides several novel exact hypothesis tests with minimal assumptions on the errors. The tests are exact, meaning that their p-values are correct for the given sample sizes (the p-values are not derived from asymptotic analysis). The test for stochastic inequality is for ordinal comparisons based on two independent samples and requires no assumptions on the errors. The other tests include tests for the mean and variance of a single sample and comparing means in independent samples. All these tests only require that the data has known bounds (such as percentages that lie in [0,100]. These bounds are part of the input.

High Dynamic Range (HDR) images support a large range in luminosity between the lightest and darkest regions of an image. To capture this range, data in HDR images is often stored as floating point numbers and in formats that capture more data and channels than standard image types. This package supports reading and writing two types of HDR images; PFM (Portable Float Map) and OpenEXR images. HDR images can be converted to lower dynamic ranges (for viewing) using tone-mapping. A number of tone-mapping algorithms are included which are based on Reinhard (2002) "Photographic tone reproduction for digital images" <doi:10.1145/566654.566575>.

Extracts features from amplification curve data of quantitative Polymerase Chain Reactions (qPCR) according to Pabinger et al. 2014 <doi:10.1016/j.bdq.2014.08.002> for machine learning purposes. Helper functions prepare the amplification curve data for processing as functional data (e.g., Hausdorff distance) or enable the plotting of amplification curve classes (negative, ambiguous, positive). The hookreg() and hookregNL() functions of Burdukiewicz et al. (2018) <doi:10.1016/j.bdq.2018.08.001> can be used to predict amplification curves with an hook effect-like curvature. The pcrfit_single() function can be used to extract features from an amplification curve.

This package implements the density-preserving modification to t-SNE and UMAP described by Narayan et al. (2020) <doi:10.1101/2020.05.12.077776>. den-SNE and densMAP aim to enable more accurate visual interpretation of high-dimensional datasets by producing lower-dimensional embeddings that accurately represent the heterogeneity of the original high-dimensional space, enabling the identification of homogeneous and heterogeneous cell states. This accuracy is accomplished by including in the optimisation process a term which considers the local density of points in the original high-dimensional space. This can help to create visualisations that are more representative of heterogeneity in the original high-dimensional space.

This package contains functions to compute the nonparametric maximum likelihood estimator (MLE) for the bivariate distribution of (X,Y), when realizations of (X,Y) cannot be observed directly. To be more precise, we consider the situation where we observe a set of rectangles that are known to contain the unobservable realizations of (X,Y). We compute the MLE based on such a set of rectangles. The methods can also be used for univariate censored data (see data set cosmesis), and for censored data with competing risks (see data set menopause). The package also provides functions to visualize the observed data and the MLE.

msqrob2 provides a robust linear mixed model framework for assessing differential abundance in MS-based Quantitative proteomics experiments. Our workflows can start from raw peptide intensities or summarised protein expression values. The model parameter estimates can be stabilized by ridge regression, empirical Bayes variance estimation and robust M-estimation. msqrob2's hurde workflow can handle missing data without having to rely on hard-to-verify imputation assumptions, and, outcompetes state-of-the-art methods with and without imputation for both high and low missingness. It builds on QFeature infrastructure for quantitative mass spectrometry data to store the model results together with the raw data and preprocessed data.

Our pipeline, MICSQTL, utilizes scRNA-seq reference and bulk transcriptomes to estimate cellular composition in the matched bulk proteomes. The expression of genes and proteins at either bulk level or cell type level can be integrated by Angle-based Joint and Individual Variation Explained (AJIVE) framework. Meanwhile, MICSQTL can perform cell-type-specic quantitative trait loci (QTL) mapping to proteins or transcripts based on the input of bulk expression data and the estimated cellular composition per molecule type, without the need for single cell sequencing. We use matched transcriptome-proteome from human brain frontal cortex tissue samples to demonstrate the input and output of our tool.

This package implements Collective And Point Anomaly (CAPA) Fisch, Eckley, and Fearnhead (2022) <doi:10.1002/sam.11586>, Multi-Variate Collective And Point Anomaly (MVCAPA) Fisch, Eckley, and Fearnhead (2021) <doi:10.1080/10618600.2021.1987257>, Proportion Adaptive Segment Selection (PASS) Jeng, Cai, and Li (2012) <doi:10.1093/biomet/ass059>, and Bayesian Abnormal Region Detector (BARD) Bardwell and Fearnhead (2015) <doi:10.1214/16-BA998>. These methods are for the detection of anomalies in time series data. Further information regarding the use of this package along with detailed examples can be found in Fisch, Grose, Eckley, Fearnhead, and Bardwell (2024) <doi:10.18637/jss.v110.i01>.

This package implements fast, exact bootstrap Principal Component Analysis and Singular Value Decompositions for high dimensional data, as described in <doi:10.1080/01621459.2015.1062383> (see also <doi:10.48550/arXiv.1405.0922>). For data matrices that are too large to operate on in memory, users can input objects with class ff (see the ff package), where the actual data is stored on disk. In response, this package will implement a block matrix algebra procedure for calculating the principal components (PCs) and bootstrap PCs. Depending on options set by the user, the parallel package can be used to parallelize the calculation of the bootstrap PCs.

Several implementations of non-parametric stable bootstrap-based techniques to determine the numbers of components for Partial Least Squares linear or generalized linear regression models as well as and sparse Partial Least Squares linear or generalized linear regression models. The package collects techniques that were published in a book chapter (Magnanensi et al. 2016, The Multiple Facets of Partial Least Squares and Related Methods', <doi:10.1007/978-3-319-40643-5_18>) and two articles (Magnanensi et al. 2017, Statistics and Computing', <doi:10.1007/s11222-016-9651-4>) and (Magnanensi et al. 2021, Frontiers in Applied Mathematics and Statistics', <doi:10.3389/fams.2021.693126>).

This package provides tools to calibrate, validate, and make predictions with the General Unified Threshold model of Survival adapted for Bee species. The model is presented in the publication from Baas, J., Goussen, B., Miles, M., Preuss, T.G., Roessing, I. (2022) <doi:10.1002/etc.5423> and Baas, J., Goussen, B., Taenzler, V., Roeben, V., Miles, M., Preuss, T.G., van den Berg, S., Roessink, I. (2024) <doi:10.1002/etc.5871>, and is based on the GUTS framework Jager, T., Albert, C., Preuss, T.G. and Ashauer, R. (2011) <doi:10.1021/es103092a>. The authors are grateful to Bayer A.G. for its financial support.

Copernicus Atmosphere Monitoring Service (CAMS) radiations service provides time series of global, direct, and diffuse irradiations on horizontal surface, and direct irradiation on normal plane for the actual weather conditions as well as for clear-sky conditions. The geographical coverage is the field-of-view of the Meteosat satellite, roughly speaking Europe, Africa, Atlantic Ocean, Middle East. The time coverage of data is from 2004-02-01 up to 2 days ago. Data are available with a time step ranging from 15 min to 1 month. For license terms and to create an account, please see <http://www.soda-pro.com/web-services/radiation/cams-radiation-service>.

This package provides functions for loading large (10M+ lines) CSV and other delimited files, similar to read.csv, but typically faster and using less memory than the standard R loader. While not entirely general, it covers many common use cases when the types of columns in the CSV file are known in advance. In addition, the package provides a class int64', which represents 64-bit integers exactly when reading from a file. The latter is useful when working with 64-bit integer identifiers exported from databases. The CSV file loader supports common column types including integer', double', string', and int64', leaving further type transformations to the user.

Testing and documenting code that communicates with remote databases can be painful. Although the interaction with R is usually relatively simple (e.g. data(frames) passed to and from a database), because they rely on a separate service and the data there, testing them can be difficult to set up, unsustainable in a continuous integration environment, or impossible without replicating an entire production cluster. This package addresses that by allowing you to make recordings from your database interactions and then play them back while testing (or in other contexts) all without needing to spin up or have access to the database your code would typically connect to.

Traditional phasing programs are limited to diploid organisms. Our method modifies Li and Stephens algorithm with Markov chain Monte Carlo (MCMC) approaches, and builds a generic framework that allows haplotype searches in a multiple infection setting. This package is primarily developed as part of the Pf3k project, which is a global collaboration using the latest sequencing technologies to provide a high-resolution view of natural variation in the malaria parasite Plasmodium falciparum. Parasite DNA are extracted from patient blood sample, which often contains more than one parasite strain, with unknown proportions. This package is used for deconvoluting mixed haplotypes, and reporting the mixture proportions from each sample.

Computes a series of indices commonly used in the fields of economic geography, economic complexity, and evolutionary economics to describe the location, distribution, spatial organization, structure, and complexity of economic activities. Functions include basic spatial indicators such as the location quotient, the Krugman specialization index, the Herfindahl or the Shannon entropy indices but also more advanced functions to compute different forms of normalized relatedness between economic activities or network-based measures of economic complexity. Most of the functions use matrix calculus and are based on bipartite (incidence) matrices consisting of region - industry pairs. These are described in Balland (2017) <http://econ.geo.uu.nl/peeg/peeg1709.pdf>.

The R4EPIs project <https://r4epi.github.io/sitrep/> seeks to provide a set of standardized tools for analysis of outbreak and survey data in humanitarian aid settings. This package currently provides standardized data dictionaries from Medecins Sans Frontieres Operational Centre Amsterdam for outbreak scenarios (Acute Jaundice Syndrome, Cholera, Diphtheria, Measles, Meningitis) and surveys (Retrospective mortality and access to care, Malnutrition, Vaccination coverage and Event Based Surveillance) - as described in the following <https://scienceportal.msf.org/assets/standardised-mortality-surveys?utm_source=chatgpt.com>. In addition, a data generator from these dictionaries is provided. It is also possible to read in any Open Data Kit format data dictionary.

This package provides a suite of convenient tools for social network analysis geared toward students, entry-level users, and non-expert practitioners. â ideanetâ features unique functions for the processing and measurement of sociocentric and egocentric network data. These functions automatically generate node- and system-level measures commonly used in the analysis of these types of networks. Outputs from these functions maximize the ability of novice users to employ network measurements in further analyses while making all users less prone to common data analytic errors. Additionally, â ideanetâ features an R Shiny graphic user interface that allows novices to explore network data with minimal need for coding.

Automatic disaggregation of small-area population estimates by demographic groups (e.g., age, sex, race, marital status, educational level, etc) along with the estimates of uncertainty, using advanced Bayesian statistical modelling approaches based on integrated nested Laplace approximation (INLA) Rue et al. (2009) <doi:10.1111/j.1467-9868.2008.00700.x> and stochastic partial differential equation (SPDE) methods Lindgren et al. (2011) <doi:10.1111/j.1467-9868.2011.00777.x>. The package implements hierarchical Bayesian modeling frameworks for small area estimation as described in Leasure et al. (2020) <doi:10.1073/pnas.1913050117> and Nnanatu et al. (2025) <doi:10.1038/s41467-025-59862-4>.

This package performs predictions of totals and weighted sums, or finite population block kriging, on spatial data using the methods in Ver Hoef (2008) <doi:10.1007/s10651-007-0035-y>. The primary outputs are an estimate of the total, mean, or weighted sum in the region, an estimated prediction variance, and a plot of the predicted and observed values. This is useful primarily to users with ecological data that are counts or densities measured on some sites in a finite area of interest. Spatial prediction for the total count or average density in the entire region can then be done using the functions in this package.