CARD is a reference-based deconvolution method that estimates cell type composition in spatial transcriptomics based on cell type specific expression information obtained from a reference scRNA-seq data. A key feature of CARD is its ability to accommodate spatial correlation in the cell type composition across tissue locations, enabling accurate and spatially informed cell type deconvolution as well as refined spatial map construction. CARD relies on an efficient optimization algorithm for constrained maximum likelihood estimation and is scalable to spatial transcriptomics with tens of thousands of spatial locations and tens of thousands of genes.

This package ADAMgui is a graphical user interface (GUI) for the ADAM package. The ADAMgui package provides two shiny-based applications that allows the user to study the output of the ADAM package files through different plots. It's possible, for example, to choose a specific group of functionally associated genes (GFAG) and observe the gene expression behavior with the plots created with the GFAGtargetUi function. Features such as differential expression and fold change can be easily seen with aid of the plots made with the GFAGpathUi function.

Mail is an internet library for Ruby that is designed to handle email generation, parsing and sending. The purpose of this library is to provide a single point of access to handle all email functions, including sending and receiving emails. All network type actions are done through proxy methods to Net::SMTP, Net::POP3 etc.

Mail has been designed with a very simple object oriented system that really opens up the email messages you are parsing, if you know what you are doing, you can fiddle with every last bit of your email directly.

Model selection and parameter tuning procedures for a class of random network models. The model selection can be done by a general cross-validation framework called ECV from Li et. al. (2016) <arXiv:1612.04717> . Several other model-based and task-specific methods are also included, such as NCV from Chen and Lei (2016) <arXiv:1411.1715>, likelihood ratio method from Wang and Bickel (2015) <arXiv:1502.02069>, spectral methods from Le and Levina (2015) <arXiv:1507.00827>. Many network analysis methods are also implemented, such as the regularized spectral clustering (Amini et. al. 2013 <doi:10.1214/13-AOS1138>) and its degree corrected version and graphon neighborhood smoothing (Zhang et. al. 2015 <arXiv:1509.08588>). It also includes the consensus clustering of Gao et. al. (2014) <arXiv:1410.5837>, the method of moments estimation of nomination SBM of Li et. al. (2020) <arxiv:2008.03652>, and the network mixing method of Li and Le (2021) <arxiv:2106.02803>. It also includes the informative core-periphery data processing method of Miao and Li (2021) <arXiv:2101.06388>. The work to build and improve this package is partially supported by the NSF grants DMS-2015298 and DMS-2015134.

This toolkit implements a numerical solution algorithm to invert a quality of life measure from observed data. Unlike the traditional Rosen-Roback measure, this measure accounts for mobility frictionsâ generated by idiosyncratic tastes and local ties â and trade frictions â generated by trade costs and non-tradable services, thereby reducing non-classical measurement error. The QoL measure is based on Ahlfeldt, Bald, Roth, Seidel (2024) <https://econpapers.repec.org/RePEc:boc:bocode:s459382> "Measuring Quality of Life under Spatial Frictions". When using this programme or the toolkit in your work, please cite the paper.

Providing the functions for communicating with Amazon Web Services(AWS) Elastic Compute Cloud(EC2) and Elastic Container Service(ECS). The functions will have the prefix ecs_ or ec2_ depending on the class of the API. The request will be sent via the REST API and the parameters are given by the function argument. The credentials can be set via aws_set_credentials'. The EC2 documentation can be found at <https://docs.aws.amazon.com/AWSEC2/latest/APIReference/Welcome.html> and ECS can be found at <https://docs.aws.amazon.com/AmazonECS/latest/APIReference/Welcome.html>.

Concept drift refers to the change in the data distribution or in the relationships between variables over time. drifter calculates distances between variable distributions or variable relations and identifies both types of drift. Key functions are: calculate_covariate_drift() checks distance between corresponding variables in two datasets, calculate_residuals_drift() checks distance between residual distributions for two models, calculate_model_drift() checks distance between partial dependency profiles for two models, check_drift() executes all checks against drift. drifter is a part of the DrWhy.AI universe (Biecek 2018) <arXiv:1806.08915>.

Descriptive analysis is essential for publishing medical articles. This package provides an easy way to conduct the descriptive analysis. 1. Both numeric and factor variables can be handled. For numeric variables, normality test will be applied to choose the parametric and nonparametric test. 2. Both two or more groups can be handled. For groups more than two, the post hoc test will be applied, Tukey for the numeric variables and FDR for the factor variables. 3. T test, ANOVA or Fisher test can be forced to apply. 4. Mean and standard deviation can be forced to display.

Developed by CDC/ATSDR (Centers for Disease Control and Prevention/ Agency for Toxic Substances and Disease Registry), Social Vulnerability Index (SVI) serves as a tool to assess the resilience of communities by taking into account socioeconomic and demographic factors. Provided with year(s), region(s) and a geographic level of interest, findSVI retrieves required variables from US census data and calculates SVI for communities in the specified area based on CDC/ATSDR SVI documentation. Reference for the calculation methods: Flanagan BE, Gregory EW, Hallisey EJ, Heitgerd JL, Lewis B (2011) <doi:10.2202/1547-7355.1792>.

Guild AI is an open-source tool for managing machine learning experiments. It's for scientists, engineers, and researchers who want to run scripts, compare results, measure progress, and automate machine learning workflow. Guild AI is a light weight, external tool that runs locally. It works with any framework, doesn't require any changes to your code, or access to any web services. Users can easily record experiment metadata, track model changes, manage experiment artifacts, tune hyperparameters, and share results. Guild AI combines features from Git', SQLite', and Make to provide a lab notebook for machine learning.

Nonparametric tests for clustered data in pre-post intervention design documented in Cui and Harrar (2021) <doi:10.1002/bimj.201900310> and Harrar and Cui (2022) <doi:10.1016/j.jspi.2022.05.009>. Other than the main test results mentioned in the reference paper, this package also provides a function to calculate the sample size allocations for the input long format data set, and also a function for adjusted/unadjusted confidence intervals calculations. There are also functions to visualize the distribution of data across different intervention groups over time, and also the adjusted/unadjusted confidence intervals.

Snow water equivalent is modeled with the process based models delta.snow and HS2SWE and empirical regression, which use relationships between density and diverse at-site parameters. The methods are described in Winkler et al. (2021) <doi:10.5194/hess-25-1165-2021>, Magnusson et al. (2025) <doi:10.1016/j.coldregions.2025.104435>, Guyennon et al. (2019) <doi:10.1016/j.coldregions.2019.102859>, Pistocchi (2016) <doi:10.1016/j.ejrh.2016.03.004>, Jonas et al. (2009) <doi:10.1016/j.jhydrol.2009.09.021> and Sturm et al. (2010) <doi:10.1175/2010JHM1202.1>.

An add-on to the party package, with a faster implementation of the partial-conditional permutation importance for random forests. The standard permutation importance is implemented exactly the same as in the party package. The conditional permutation importance can be computed faster, with an option to be backward compatible to the party implementation. The package is compatible with random forests fit using the party and the randomForest package. The methods are described in Strobl et al. (2007) <doi:10.1186/1471-2105-8-25> and Debeer and Strobl (2020) <doi:10.1186/s12859-020-03622-2>.

Regression analysis using common models in seed temperature studies, such as the Gaussian model (Martins, JF, Barroso, AAM, & Alves, PLCA (2017) <doi:10.1590/s0100-83582017350100039>), quadratic (Nunes, AL, Sossmeier, S, Gotz, AP, & Bispo, NB (2018) <doi: 10.17265/2161-6264/2018.06.002>) and others with potential for use, such as those implemented in the drc package (Ritz, C, Baty, F, Streibig, JC, & Gerhard, D (2015). <doi:10.1371/journal.pone.0146021>), in the estimation of the ideal and cardinal temperature for the occurrence of plant seed germination. The functions return graphs with the equations automatically.

Two versions of sample variance plots, Sv-plot1 and Sv-plot2, will be provided illustrating the squared deviations from sample variance. Besides indicating the contribution of squared deviations for the sample variability, these plots are capable of detecting characteristics of the distribution such as symmetry, skewness and outliers. A remarkable graphical method based on Sv-plot2 can determine the decision on testing hypotheses over one or two population means. In sum, Sv-plots will be appealing visualization tools. Complete description of this methodology can be found in the article, Wijesuriya (2020) <doi:10.1080/03610918.2020.1851716>.

This package provides methods for anonymisation of spatial datasets while preserving spatial structure and relationships. Original coordinates or raster geometries are transformed using randomized or predefined vertical shifts, horizontal shifts, and rotations. Compatible with point-based data in matrix', data.frame', or sf formats, as well as terra raster objects. Supports reversible anonymisation workflows, hash-based validation, shapefile export, and consistent tangling across related datasets using stored transformation sequences. Approach informed by the De-Identification Decision Making Framework (CM Oâ Keefe, S Otorepec, M Elliot, E Mackey, and K Oâ Hara 2017) <doi:10.4225/08/59c169433efd4>.

This package detects significant differentially methylated regions (for both qualitative and quantitative traits), using a scan statistic with underlying Poisson heuristics. The scan statistic will depend on a sequence of window sizes (# of CpGs within each window) and on a threshold for each window size. This threshold can be calculated by three different means: i) analytically using Siegmund et.al (2012) solution (preferred), ii) an important sampling as suggested by Zhang (2008), and a iii) full MCMC modeling of the data, choosing between a number of different options for modeling the dependency between each CpG.

StabMap performs single cell mosaic data integration by first building a mosaic data topology, and for each reference dataset, traverses the topology to project and predict data onto a common embedding. Mosaic data should be provided in a list format, with all relevant features included in the data matrices within each list object. The output of stabMap is a joint low-dimensional embedding taking into account all available relevant features. Expression imputation can also be performed using the StabMap embedding and any of the original data matrices for given reference and query cell lists.

The `TrIdent` R package automates the analysis of transductomics data by detecting, classifying, and characterizing read coverage patterns associated with potential transduction events. Transductomics is a DNA sequencing-based method for the detection and characterization of transduction events in pure cultures and complex communities. Transductomics relies on mapping sequencing reads from a viral-like particle (VLP)-fraction of a sample to contigs assembled from the metagenome (whole-community) of the same sample. Reads from bacterial DNA carried by VLPs will map back to the bacterial contigs of origin creating read coverage patterns indicative of ongoing transduction.

This package performs simulation-based inference as an alternative to the delta method for obtaining valid confidence intervals and p-values for regression post-estimation quantities, such as average marginal effects and predictions at representative values. This framework for simulation-based inference is especially useful when the resulting quantity is not normally distributed and the delta method approximation fails. The methodology is described in King, Tomz, and Wittenberg (2000) <doi:10.2307/2669316>. clarify is meant to replace some of the functionality of the archived package Zelig'; see the vignette "Translating Zelig to clarify" for replicating this functionality.

This package provides R-implementation of Decision forest algorithm, which combines the predictions of multiple independent decision tree models for a consensus decision. In particular, Decision Forest is a novel pattern-recognition method which can be used to analyze: (1) DNA microarray data; (2) Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (SELDI-TOF-MS) data; and (3) Structure-Activity Relation (SAR) data. In this package, three fundamental functions are provided, as (1)DF_train, (2)DF_pred, and (3)DF_CV. run Dforest() to see more instructions. Weida Tong (2003) <doi:10.1021/ci020058s>.

This package provides tools for exploration of R package dependencies. The main deepdep() function allows to acquire deep dependencies of any package and plot them in an elegant way. It also adds some popularity measures for the packages e.g. in the form of download count through the cranlogs package. Uses the CRAN metadata database <http://crandb.r-pkg.org> and Bioconductor metadata <https://bioconductor.org>. Other data acquire functions are: get_dependencies(), get_downloads() and get_description(). The deepdep_shiny() function runs shiny application that helps to produce a nice deepdep plot.

Analysis of temporal changes (i.e. dynamics) of ecological entities, defined as trajectories on a chosen multivariate space, by providing a set of trajectory metrics and visual representations [De Caceres et al. (2019) <doi:10.1002/ecm.1350>; and Sturbois et al. (2021) <doi:10.1016/j.ecolmodel.2020.109400>]. Includes functions to estimate metrics for individual trajectories (length, directionality, angles, ...) as well as metrics to relate pairs of trajectories (dissimilarity and convergence). Functions are also provided to estimate the ecological quality of ecosystem with respect to reference conditions [Sturbois et al. (2023) <doi:10.1002/ecs2.4726>].

Manages a file system cache. Regular files can be moved or copied to the cache folder. Sub-folders can be created in order to organize the files. Files can be located inside the cache using a glob function. Text contents can be easily stored in and retrieved from the cache using dedicated functions. It can be used for an application or a package, as a global cache, or as a per-user cache, in which case the standard OS user cache folder will be used (e.g.: on Linux $HOME/.cache/R/my_app_or_pkg_cache_folder).