This tool computes the probability of detection (POD) curve and the limit of detection (LOD), i.e. the number of copies of the target DNA sequence required to ensure a 95 % probability of detection (LOD95). Other quantiles of the LOD can be specified. This is a reimplementation of the mathematical-statistical modelling of the validation of qualitative polymerase chain reaction (PCR) methods within a single laboratory as provided by the commercial tool PROLab <http://quodata.de/>. The modelling itself has been described by Uhlig et al. (2015) <doi:10.1007/s00769-015-1112-9>.

The overall performance of soil ecosystem services and productivity greatly relies on soil health, making it a crucial indicator. The evaluation of soil physical, chemical, and biological parameters is necessary to determine the overall soil quality index. In our package, three commonly used methods, including linear scoring, regression-based, and principal component-based soil quality indexing, are employed to calculate the soil quality index. This package has been developed using concept of Bastida et al. (2008) and Doran and Parkin (1994) <doi:10.1016/j.geoderma.2008.08.007> <doi:10.2136/sssaspecpub35.c1>.

This package provides an interface to a large number of classification and regression techniques. These techniques include machine-readable parameter descriptions. There is also an experimental extension for survival analysis, clustering and general, example-specific cost-sensitive learning. Also included:

• Generic resampling, including cross-validation, bootstrapping and subsampling;

• Hyperparameter tuning with modern optimization techniques, for single- and multi-objective problems;

• Filter and wrapper methods for feature selection;

• Extension of basic learners with additional operations common in machine learning, also allowing for easy nested resampling.

Most operations can be parallelized.

Package ACV (short for Affine Cross-Validation) offers an improved time-series cross-validation loss estimator which utilizes both in-sample and out-of-sample forecasting performance via a carefully constructed affine weighting scheme. Under the assumption of stationarity, the estimator is the best linear unbiased estimator of the out-of-sample loss. Besides that, the package also offers improved versions of Diebold-Mariano and Ibragimov-Muller tests of equal predictive ability which deliver more power relative to their conventional counterparts. For more information, see the accompanying article Stanek (2021) <doi:10.2139/ssrn.3996166>.

This package provides a comprehensive suite for assessing multivariate normality using six statistical tests (Mardia, Henzeâ Zirkler, Henzeâ Wagner, Royston, Doornikâ Hansen, Energy). Also includes univariate diagnostics, bivariate density visualization, robust outlier detection, power transformations (e.g., Boxâ Cox, Yeoâ Johnson), and imputation strategies ("mean", "median", "mice") for handling missing data. Bootstrap resampling is supported for selected tests to improve p-value accuracy in small samples. Diagnostic plots are available via both ggplot2 and interactive plotly visualizations. See Korkmaz et al. (2014) <https://journal.r-project.org/articles/RJ-2014-031/RJ-2014-031.pdf>.

Sequential Poisson sampling is a variation of Poisson sampling for drawing probability-proportional-to-size samples with a given number of units, and is commonly used for price-index surveys. This package gives functions to draw stratified sequential Poisson samples according to the method by Ohlsson (1998, ISSN:0282-423X), as well as other order sample designs by Rosén (1997, <doi:10.1016/S0378-3758(96)00186-3>), and generate approximate bootstrap replicate weights according to the generalized bootstrap method by Beaumont and Patak (2012, <doi:10.1111/j.1751-5823.2011.00166.x>).

This is a set of minimization tools (maximum likelihood estimation and least square fitting) to solve examples in the Johan Gabrielsson and Dan Weiner's book "Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications" 5th ed. (ISBN:9198299107). Examples include linear and nonlinear compartmental model, turn-over model, single or multiple dosing bolus/infusion/oral models, allometry, toxicokinetics, reversible metabolism, in-vitro/in-vivo extrapolation, enterohepatic circulation, metabolite modeling, Emax model, inhibitory model, tolerance model, oscillating response model, enantiomer interaction model, effect compartment model, drug-drug interaction model, receptor occupancy model, and rebound phenomena model.

RealtimeKit is a D-Bus system service that changes the scheduling policy of user processes/threads to SCHED_RR (realtime scheduling mode) on request. It is intended to be used as a secure mechanism to allow real-time scheduling to be used by normal user processes.

RealtimeKit enforces strict policies when handing out real-time priority and includes a canary-based watchdog that automatically demotes all real-time threads to SCHED_OTHER should the system overload. The daemon runs as an unprivileged user and uses capabilities, resource limits, and chroot to minimize its security impact.

This package provides an implementation of the Ordered Forest estimator as developed in Lechner & Okasa (2019) <arXiv:1907.02436>. The Ordered Forest flexibly estimates the conditional probabilities of models with ordered categorical outcomes (so-called ordered choice models). Additionally to common machine learning algorithms the orf package provides functions for estimating marginal effects as well as statistical inference thereof and thus provides similar output as in standard econometric models for ordered choice. The core forest algorithm relies on the fast C++ forest implementation from the ranger package (Wright & Ziegler, 2017) <arXiv:1508.04409>.

This package implements Bayesian multiple-membership multilevel models with parameterizable weight functions via JAGS to model how lower-level units jointly shape higher-level outcomes (micro-macro link) across a range of outcome types (e.g., linear, logit, and survival models). Supports estimation and comparison of alternative aggregation mechanisms, allows weight matrices to be endogenized through parameters and covariates, and accommodates complex dependence structures that extend beyond traditional multilevel frameworks. For details, see Rosche (2026) "A Multilevel Model for Coalition Governments. Uncovering Party-Level Dependencies Within and Between Governments" <doi:10.31235/osf.io/4bafr_v2>.

This data management package provides some helper classes for publicly available data sources (HMD, DESTATIS) in Demography. Similar to ideas developed in the Bioconductor project <https://bioconductor.org> we strive to encapsulate data in easy to use S4 objects. If original data is provided in a text file, the resulting S4 object contains all information from that text file. But the information is somehow structured (header, footer, etc). Further the classes provide methods to make a subset for selected calendar years or selected regions. The resulting subset objects still contain the original header and footer information.

It fits a robust linear quantile regression model using a new family of zero-quantile distributions for the error term. Missing values and censored observations can be handled as well. This family of distribution includes skewed versions of the Normal, Student's t, Laplace, Slash and Contaminated Normal distribution. It also performs logistic quantile regression for bounded responses as shown in Galarza et.al.(2020) <doi:10.1007/s13571-020-00231-0>. It provides estimates and full inference. It also provides envelopes plots for assessing the fit and confidences bands when several quantiles are provided simultaneously.

This package provides tools to fit Rasch models (RM), linear logistic test models (LLTM), rating scale model (RSM), linear rating scale models (LRSM), partial credit models (PCM), and linear partial credit models (LPCM). Missing values are allowed in the data matrix. Additional features are the ML estimation of the person parameters, Andersen's LR-test, item-specific Wald test, Martin-Loef-Test, nonparametric Monte-Carlo Tests, itemfit and personfit statistics including infit and outfit measures, ICC and other plots, automated stepwise item elimination, and a simulation module for various binary data matrices.

This package provides a number of functions to facilitate extracting information in YAML fragments from one or multiple files, optionally structuring the information in a data.tree'. YAML (recursive acronym for "YAML ain't Markup Language") is a convention for specifying structured data in a format that is both machine- and human-readable. YAML therefore lends itself well for embedding (meta)data in plain text files, such as Markdown files. This principle is implemented in yum with minimal dependencies (i.e. only the yaml packages, and the data.tree package can be used to enable additional functionality).

This is a complete suite to estimate models based on moment conditions. It includes the two step Generalized method of moments (Hansen 1982; <doi:10.2307/1912775>), the iterated GMM and continuous updated estimator (Hansen, Eaton and Yaron 1996; <doi:10.2307/1392442>) and several methods that belong to the Generalized Empirical Likelihood family of estimators (Smith 1997; <doi:10.1111/j.0013-0133.1997.174.x>, Kitamura 1997; <doi:10.1214/aos/1069362388>, Newey and Smith 2004; <doi:10.1111/j.1468-0262.2004.00482.x>, and Anatolyev 2005 <doi:10.1111/j.1468-0262.2005.00601.x>).

This package provides a novel decision tree algorithm in the hypothesis testing framework. The algorithm examines the distribution difference between two child nodes over all possible binary partitions. The test statistic of the hypothesis testing is equivalent to the generalized energy distance, which enables the algorithm to be more powerful in detecting the complex structure, not only the mean difference. It is applicable for numeric, nominal, ordinal explanatory variables and the response in general metric space of strong negative type. The algorithm has superior performance compared to other tree models in type I error, power, prediction accuracy, and complexity.

This package provides functions to identify plausible and replicable factor structures for a set of variables via k-fold cross validation. The process combines the exploratory and confirmatory factor analytic approach to scale development (Flora & Flake, 2017) <doi:10.1037/cbs0000069> with a cross validation technique that maximizes the available data (Hastie, Tibshirani, & Friedman, 2009) <isbn:978-0-387-21606-5>. Also available are functions to determine k by drawing on power analytic techniques for covariance structures (MacCallum, Browne, & Sugawara, 1996) <doi:10.1037/1082-989X.1.2.130>, generate model syntax, and summarize results in a report.

This shows how NONMEM (Beal SL, Sheiner LB, Boeckmann AJ, Bauer RJ. NONMEM 7.5 Users Guides. Icon plc, 2020) software works. NONMEM classical estimation methods such as First Order (FO) approximation', First Order Conditional Estimation (FOCE)', and Laplacian approximation are explained. Functions are also provided for post-run processing of NONMEM output files, generating PDF or Markdown diagnostic reports including objective function value analysis, parameter estimates, prediction and residual diagnostics, empirical Bayes estimate (EBE) analysis, input data summary, and individual pharmacokinetic parameter distributions. Helper utilities for building NONMEM-ready datasets from SDTM-style source tables are also included.

The Structural Topic and Sentiment-Discourse (STS) model allows researchers to estimate topic models with document-level metadata that determines both topic prevalence and sentiment-discourse. The sentiment-discourse is modeled as a document-level latent variable for each topic that modulates the word frequency within a topic. These latent topic sentiment-discourse variables are controlled by the document-level metadata. The STS model can be useful for regression analysis with text data in addition to topic modelingâ s traditional use of descriptive analysis. The method was developed in Chen and Mankad (2025) <doi:10.1287/mnsc.2022.00261>.

This package provides a collection of integrated tools designed to seamlessly interact with each other for the analysis of biogenic silica bSi in inland and marine sediments. These tools share common data representations and follow a consistent API design. The primary goal of the bSi package is to simplify the installation process, facilitate data loading, and enable the analysis of multiple samples for biogenic silica fluxes. This package is designed to enhance the efficiency and coherence of the entire bSi analytic workflow, from data loading to model construction and visualization tailored towards reconstructing productivity in aquatic ecosystems.

This package produces statistical indicators of the impact of migration on the socio-demographic composition of an area. Three measures can be used: ratios, percentages and the Duncan index of dissimilarity. The input data files are assumed to be in an origin-destination matrix format, with each cell representing a flow count between an origin and a destination area. Columns are expected to represent origins, and rows are expected to represent destinations. The first row and column are assumed to contain labels for each area. See Rodriguez-Vignoli and Rowe (2018) <doi:10.1080/00324728.2017.1416155> for technical details.

The aim of the package is two-fold: (i) To implement the MMD method for attribution of individuals to sources using the Hamming distance between multilocus genotypes. (ii) To select informative genetic markers based on information theory concepts (entropy, mutual information and redundancy). The package implements the functions introduced by Perez-Reche, F. J., Rotariu, O., Lopes, B. S., Forbes, K. J. and Strachan, N. J. C. Mining whole genome sequence data to efficiently attribute individuals to source populations. Scientific Reports 10, 12124 (2020) <doi:10.1038/s41598-020-68740-6>. See more details and examples in the README file.

This package provides a collection of privacy-preserving distributed algorithms (PDAs) for conducting federated statistical learning across multiple data sites. The PDA framework includes models for various tasks such as regression, trial emulation, causal inference, design-specific analysis, and clustering. The PDA algorithms run on a lead site and only require summary statistics from collaborating sites, with one or few iterations. The package can be used together with the online data transfer system (<https://pda-ota.pdamethods.org/>) for safe and convenient collaboration. For more information, please visit our software websites: <https://github.com/Penncil/pda>, and <https://pdamethods.org/>.

This package provides methods for decomposing seasonal data: STR (a Seasonal-Trend time series decomposition procedure based on Regression) and Robust STR. In some ways, STR is similar to Ridge Regression and Robust STR can be related to LASSO. They allow for multiple seasonal components, multiple linear covariates with constant, flexible and seasonal influence. Seasonal patterns (for both seasonal components and seasonal covariates) can be fractional and flexible over time; moreover they can be either strictly periodic or have a more complex topology. The methods provide confidence intervals for the estimated components. The methods can also be used for forecasting.