This package provides tools for the calculation of effect sizes (standardised mean difference) and mean difference in pre-post controlled studies, including robust imputation of missing variances (standard deviation of changes) and correlations (Pearson correlation coefficient). The main function metacor_dual() implements several methods for imputing missing standard deviation of changes or Pearson correlation coefficient, and generates transparent imputation reports. Designed for meta-analyses with incomplete summary statistics. For details on the methods, see Higgins et al. (2023) and Fu et al. (2013).

This package provides a method that analyzes quality control metrics from multi-sample genomic sequencing studies and nominates poor quality samples for exclusion. Per sample quality control data are transformed into z-scores and aggregated. The distribution of aggregated z-scores are modelled using parametric distributions. The parameters of the optimal model, selected either by goodness-of-fit statistics or user-designation, are used for outlier nomination. Two implementations of the Cosine Similarity Outlier Detection algorithm are provided with flexible parameters for dataset customization.

The algorithm combines the most predictive variable, such as count of the main International Classification of Diseases (ICD) codes, and other Electronic Health Record (EHR) features (e.g. health utilization and processed clinical note data), to obtain a score for accurate risk prediction and disease classification. In particular, it normalizes the surrogate to resemble gaussian mixture and leverages the remaining features through random corruption denoising. Background and details about the method can be found at Yu et al. (2018) <doi:10.1093/jamia/ocx111>.

Displays provenance graphically for provenance collected by the rdt or rdtLite packages, or other tools providing compatible PROV JSON output. The exact format of the JSON created by rdt and rdtLite is described in <https://github.com/End-to-end-provenance/ExtendedProvJson>. More information about rdtLite and associated tools is available at <https://github.com/End-to-end-provenance/> and Barbara Lerner, Emery Boose, and Luis Perez (2018), Using Introspection to Collect Provenance in R, Informatics, <doi: 10.3390/informatics5010012>.

Cluster-independent method based on topology structure of gene co-expression network for identifying feature gene sets, extracting cellular subpopulations, and elucidating intrinsic relationships among these subpopulations. Without prior cell clustering, SifiNet circumvents potential inaccuracies in clustering that may influence subsequent analyses. This method is introduced in Qi Gao, Zhicheng Ji, Liuyang Wang, Kouros Owzar, Qi-Jing Li, Cliburn Chan, Jichun Xie "SifiNet: a robust and accurate method to identify feature gene sets and annotate cells" (2024) <doi:10.1093/nar/gkae307>.

We build an Susceptible-Infectious-Recovered (SIR) model where the rate of infection is the sum of the household rate and the community rate. We estimate the posterior distribution of the parameters using the Metropolis algorithm. Further details may be found in: F Scott Dahlgren, Ivo M Foppa, Melissa S Stockwell, Celibell Y Vargas, Philip LaRussa, Carrie Reed (2021) "Household transmission of influenza A and B within a prospective cohort during the 2013-2014 and 2014-2015 seasons" <doi:10.1002/sim.9181>.

This package provides functions for automated noncompartmental pharmacokinetic (NCA) analysis using concentration-time data. The package estimates pharmacokinetic parameters including area under the concentration-time curve (AUC), area under the first moment curve (AUMC), maximum concentration (Cmax), time to maximum concentration (Tmax), terminal elimination rate constant (Kel), elimination half-life, clearance, volume of distribution, and mean residence time (MRT). It supports automatic terminal phase selection, bootstrap confidence intervals, and publication-ready concentration-time profiles. Methods are based on Gibaldi and Perrier (1982, ISBN:9780824710422).

This package provides functions to compute compositional turnover using zeta-diversity, the number of species shared by multiple assemblages. The package includes functions to compute zeta-diversity for a specific number of assemblages and to compute zeta-diversity for a range of numbers of assemblages. It also includes functions to explain how zeta-diversity varies with distance and with differences in environmental variables between assemblages, using generalised linear models, linear models with negative constraints, generalised additive models,shape constrained additive models, and I-splines.

This package provides connections to the epiviz web app (http://epiviz.cbcb.umd.edu) for interactive visualization of genomic data. Objects in R/bioc interactive sessions can be displayed in genome browser tracks or plots to be explored by navigation through genomic regions. Fundamental Bioconductor data structures are supported (e.g., GenomicRanges and RangedSummarizedExperiment objects), while providing an easy mechanism to support other data structures (through package epivizrData). Visualizations (using d3.js) can be easily added to the web app as well.

Collection of procedures to perform Bayesian analysis on a variety of factor models. Currently, it includes: "Bayesian Exploratory Factor Analysis" (befa) from G. Conti, S. Frühwirth-Schnatter, J.J. Heckman, R. Piatek (2014) <doi:10.1016/j.jeconom.2014.06.008>, an approach to dedicated factor analysis with stochastic search on the structure of the factor loading matrix. The number of latent factors, as well as the allocation of the manifest variables to the factors, are not fixed a priori but determined during MCMC sampling.

Easy access to data from Brazil's population censuses. The package provides a simple and efficient way to download and read the data sets and the documentation of all the population censuses taken in and after 1960 in the country. The package is built on top of the Arrow platform <https://arrow.apache.org/docs/r/>, which allows users to work with larger-than-memory census data using dplyr familiar functions. <https://arrow.apache.org/docs/r/articles/arrow.html#analyzing-arrow-data-with-dplyr>.

This package provides methods to compute verifiable false discovery rate (FDR) diagnostic checks for workflows based on target-decoy competition and related confidence measures. Implements calibration, stability and tail diagnostics, including tail support, threshold elasticity, posterior error probability (PEP) reliability, and equal-chance checks. If you used this package in your research, please cite the associated preprint <doi:10.64898/2026.04.16.718468>. Detailed examples of using this package can also be found on the GitHub repository (<https://github.com/Jacky11/diagFDR>).

This package provides facilities to read, write and validate geographic metadata defined with ISO TC211 / OGC ISO geographic information metadata standards, and encoded using the ISO 19139 and ISO 19115-3 (XML) standard technical specifications. This includes ISO 19110 (Feature cataloguing), 19115 (dataset metadata), 19119 (service metadata) and 19136 (GML). Other interoperable schemas from the OGC are progressively supported as well, such as the Sensor Web Enablement (SWE) Common Data Model, the OGC GML Coverage Implementation Schema (GMLCOV), or the OGC GML Referenceable Grid (GMLRGRID).

This package provides icon geometries for ggplot2', using vector icon sets from the icons package. Icons can be drawn as points in place of ordinary markers, styled with the usual colour, size, alpha and angle aesthetics, and mapped from discrete values or passed through directly. Icons also appear in legend keys, as fixed-position annotations, and as axis, strip and legend labels. Pictograms extend this to isotype-style unit charts, waffle/percentage charts and rating widgets, encoding a value as a grid of repeated icons.

Studies that report shifts in species distributions may be biased by the shape of the study area. The main functionality of this package is to calculate the Latitudinal Bias Index (LBI) for any given shape. The LBI is bounded between +1 (100% probability to exclusively record latitudinal shifts, i.e., range shifts data sampled along a perfectly South-North oriented straight line) and -1 (100% probability to exclusively record longitudinal shifts, i.e., range shifts data sampled along a perfectly East-West oriented straight line).

Fits multivariate (Brownian Motion, Early Burst, ACDC, Ornstein-Uhlenbeck and Shifts) models of continuous traits evolution on trees and time series. mvMORPH also proposes high-dimensional multivariate comparative tools (linear models using Generalized Least Squares and multivariate tests) based on penalized likelihood and Empirical Bayes approaches. See Clavel et al. (2015) <DOI:10.1111/2041-210X.12420>, Clavel et al. (2019) <DOI:10.1093/sysbio/syy045>, Clavel & Morlon (2020) <DOI:10.1093/sysbio/syaa010>, and Montoya et al. (2026) <DOI:10.1093/sysbio/syag051>.

Nonparametric Failure Time (NFT) Bayesian Additive Regression Trees (BART): Time-to-event Machine Learning with Heteroskedastic Bayesian Additive Regression Trees (HBART) and Low Information Omnibus (LIO) Dirichlet Process Mixtures (DPM). An NFT BART model is of the form Y = mu + f(x) + sd(x) E where functions f and sd have BART and HBART priors, respectively, while E is a nonparametric error distribution due to a DPM LIO prior hierarchy. See the following for a description of the model at <doi:10.1111/biom.13857>.

This package provides functions for estimating ploidy levels and detecting aneuploidy in individuals using allele intensities or allele count data from high-throughput genotyping platforms, including single nucleotide polymorphism (SNP) arrays and sequencing-based technologies. Implements method described in Taniguti et al. (2025) <doi:10.1002/tpg2.70044> an extended version of the PennCNV signal standardization method by Wang et al. (2007) <doi:10.1101/gr.6861907> for higher ploidy levels. Computes B-allele frequencies (BAF), z-scores, and identifies copy number variation patterns.

This package provides tools for calculating disclosure risk measures for microdata, including record-level and file-level measures. The record-level disclosure risk is estimated primarily using exhaustive tabulation. The file-level disclosure risk is estimated by fitting loglinear models on the observed sample counts in cells formed by key variables and their interactions. Funded by the National Center for Education Statistics. See Skinner and Shlomo (2008) <doi:10.1198/016214507000001328> for a description of the file-level risk measures and the loglinear model approach.

Simultaneous tests and confidence intervals are provided for one-way experimental designs with one or many normally distributed, primary response variables (endpoints). Differences (Hasler and Hothorn, 2011 <doi:10.2202/1557-4679.1258>) or ratios (Hasler and Hothorn, 2012 <doi:10.1080/19466315.2011.633868>) of means can be considered. Various contrasts can be chosen, unbalanced sample sizes are allowed as well as heterogeneous variances (Hasler and Hothorn, 2008 <doi:10.1002/bimj.200710466>) or covariance matrices (Hasler, 2014 <doi:10.1515/ijb-2012-0015>).

This package implements an algorithm for Latent Dirichlet Allocation (LDA), Blei et al. (2003) <https://www.jmlr.org/papers/volume3/blei03a/blei03a.pdf>, using style conventions from the tidyverse', Wickham et al. (2019)<doi:10.21105/joss.01686>, and tidymodels', Kuhn et al.<https://tidymodels.github.io/model-implementation-principles/>. Fitting is done via warpLDA', a Metropolis-Hastings sampler, Chen et al. (2016) <doi:10.48550/arXiv.1510.08628>. Also implements several novel features for LDA such as guided models and transfer learning.

Easily override the default visual choices in ggplot2 to make your time series plots look more like the Wall Street Journal. Specific theme design choices include omitting x-axis grid lines and displaying sparse light grey y-axis grid lines. Additionally, this allows to label the y-axis scales with your units only displayed on the top-most number, while also removing the bottom most number (unless specifically overridden). The goal is visual simplicity, because who has time to waste looking at a cluttered graph?

This package provides a collection of tools for cancer genomic data clustering analyses, including those for single cell RNA-seq. Cell clustering and feature gene selection analysis employ Bayesian (and maximum likelihood) non-negative matrix factorization (NMF) algorithm. Input data set consists of RNA count matrix, gene, and cell bar code annotations. Analysis outputs are factor matrices for multiple ranks and marginal likelihood values for each rank. The package includes utilities for downstream analyses, including meta-gene identification, visualization, and construction of rank-based trees for clusters.

This package manages a file system cache. Regular files can be moved or copied to the cache folder. Sub-folders can be created in order to organize the files. Files can be located inside the cache using a glob function. Text contents can be easily stored in and retrieved from the cache using dedicated functions. It can be used for an application or a package, as a global cache, or as a per-user cache, in which case the standard OS user cache folder will be used.