Allows the user to execute interactively radial data envelopment analysis models. The user has the ability to upload a data frame, select the input/output variables, choose the technology assumption to adopt and decide whether to run an input or an output oriented model. When the model is executed a set of results are displayed which include efficiency scores, peers determination, scale efficiencies evaluation and slacks calculation. Fore more information about the theoretical background of the package, please refer to Bogetoft & Otto (2011) <doi:10.1007/978-1-4419-7961-2>.

This package performs fragment analysis using genetic data coming from capillary electrophoresis machines. These are files with FSA extension which stands for FASTA-type file, and .txt files from Beckman CEQ 8000 system, both contain DNA fragment intensities read by machinery. In addition to visualization, it performs automatic scoring of SSRs (Sample Sequence Repeats; a type of genetic marker very common across the genome) and other type of PCR markers (standing for Polymerase Chain Reaction) in biparental populations such as F1, F2, BC (backcross), and diversity panels (collection of genetic diversity).

This package provides functions to assess the calibration of logistic regression models with the GiViTI (Gruppo Italiano per la Valutazione degli interventi in Terapia Intensiva, Italian Group for the Evaluation of the Interventions in Intensive Care Units - see <http://www.giviti.marionegri.it/>) approach. The approach consists in a graphical tool, namely the GiViTI calibration belt, and in the associated statistical test. These tools can be used both to evaluate the internal calibration (i.e. the goodness of fit) and to assess the validity of an externally developed model.

Audits ggplot2 visualizations for accessibility issues, misleading practices, and readability problems. Checks for color accessibility concerns including colorblind-unfriendly palettes, misleading scale manipulations such as truncated axes and dual y-axes, text readability issues like small fonts and overlapping labels, and general accessibility barriers. Provides comprehensive audit reports with actionable suggestions for improvement. Color vision deficiency simulation uses methods from the colorspace package Zeileis et al. (2020) <doi:10.18637/jss.v096.i01>. Contrast calculations follow WCAG 2.1 guidelines (W3C 2018 <https://www.w3.org/WAI/WCAG21/Understanding/contrast-minimum>).

We implemented multiple tests based on the restricted mean time lost (RMTL) for general factorial designs as described in Munko et al. (2024) <doi:10.48550/arXiv.2409.07917>. Therefore, an asymptotic test and a permutation test are incorporated with a Wald-type test statistic. The asymptotic test takes the asymptotic exact dependence structure of the test statistics into account to gain more power. Furthermore, confidence intervals for RMTL contrasts can be calculated and plotted and a stepwise extension that can improve the power of the multiple tests is available.

Fits tumor-zone-specific conditional cell-density networks from registered three-dimensional multiplex imaging. An anisotropic Matern-3/2 Gaussian process is estimated per variable and zone using a Vecchia likelihood on spatially balanced anchors; predictions at all selected cells yield residual covariance sufficient statistics. Gaussian maximum likelihood then fits a shared-plus-zone factor covariance model. A matched section-wise planar fit uses the same selected cells and covariance estimator. This extends the spatially informed cell-density analysis of Bhadury et al. (2026) <doi:10.1038/s41598-026-35341-8>.

Assists researchers in choosing Key Opinion Leaders (KOLs) in a network to help disseminate or encourage adoption of an innovation by other network members. Potential KOL teams are evaluated using the ABCDE framework (Neal et al., 2025 <doi:10.31219/osf.io/3vxy9_v1>). This framework which considers: (1) the team members Availability, (2) the Breadth of the team's network coverage, (3) the Cost of recruiting a team of a given size, and (4) the Diversity of the team's members, (5) which are pooled into a single Evaluation score.

An interface to Neptune. A metadata store for MLOps, built for teams that run a lot of experiments. It gives you a single place to log, store, display, organize, compare, and query all your model-building metadata. Neptune is used for: â ¢ Experiment tracking: Log, display, organize, and compare ML experiments in a single place. â ¢ Model registry: Version, store, manage, and query trained models, and model building metadata. â ¢ Monitoring ML runs live: Record and monitor model training, evaluation, or production runs live For more information see <https://neptune.ai/>.

The functions allow for the numerical evaluation of some commonly used entropy measures, such as Shannon entropy, Rényi entropy, Havrda and Charvat entropy, and Arimoto entropy, at selected parametric values from several well-known and widely used probability distributions. Moreover, the functions also compute the relative loss of these entropies using the truncated distributions. Related works include: Awad, A. M., & Alawneh, A. J. (1987). Application of entropy to a life-time model. IMA Journal of Mathematical Control and Information, 4(2), 143-148. <doi:10.1093/imamci/4.2.143>.

It is a single cell active pathway analysis tool based on the graph neural network (F. Scarselli (2009) <doi:10.1109/TNN.2008.2005605>; Thomas N. Kipf (2017) <arXiv:1609.02907v4>) to construct the gene-cell association network, infer pathway activity scores from different single cell modalities data, integrate multiple modality data on the same cells into one pathway activity score matrix, identify cell phenotype activated gene modules and parse association networks of gene modules under multiple cell phenotype. In addition, abundant visualization programs are provided to display the results.

This package implements the Welch-Satterthwaite approximation for differences of non-standardized t-distributed random variables in both univariate and multivariate settings. The package provides methods for computing effective degrees of freedom and scale parameters, as well as distribution functions for the approximated difference distribution. The methodology extends the classical Welch-Satterthwaite framework from variance combinations to t-distribution differences through careful moment matching. Methods build on the classical Welch-Satterthwaite approach described in Welch (1947) <doi:10.1093/biomet/34.1-2.28> and Satterthwaite (1946) <doi:10.2307/3002019>.

This package provides a collection of functions designed for analyzing deconvolution of the bulk sample(s) using an atlas of reference omic signature profiles and a user-selected model. Users are given the option to create or extend a reference atlas and,also simulate the desired size of the bulk signature profile of the reference cell types. The package includes the cell-type-specific methylation atlas and, Illumina Epic B5 probe ids that can be used in deconvolution. Additionally, we included BSmeth2Probe, to make mapping WGBS data to their probe IDs easier.

This package implements importance sampling from the truncated multivariate normal using the Geweke-Hajivassiliou-Keane (GHK) simulator. Unlike Gibbs sampling which can get stuck in one truncation sub-region depending on initial values, this package allows truncation based on disjoint regions that are created by truncation of absolute values. The GHK algorithm uses simple Cholesky transformation followed by recursive simulation of univariate truncated normals hence there are also no convergence issues. Importance sample is returned along with sampling weights, based on which, one can calculate integrals over truncated regions for multivariate normals.

Fit pharmacokinetic/pharmacodynamic (PK/PD) models to aggregate-level data (mean vector and covariance matrix per study) rather than individual-level data, for meta-analysis across studies. Integrates with the nlmixr2'/'rxode2 ecosystem via four estimation methods: a First-Order ('FO') analytical estimator, a Monte Carlo (MC) estimator, a Gauss-Hermite quadrature ('GH') estimator, and an Iterative Reweighting Monte Carlo ('IRMC') estimator. Methods are based on Välitalo (2021) <doi:10.1007/s10928-021-09760-1>; software described in van de Beek et al. (2025) <doi:10.1007/s10928-025-10011-w>.

This package provides the low level utilities on which the DescToolsX ecosystem is built. Covered are data manipulation and reshaping, predicates for data inspection and validation, vector and string operations, handling of labels and metadata, and routines from number theory and combinatorics. All functions share a common naming and argument scheme and are implemented as S3 generics wherever several input types are meaningful, with performance critical parts written in C++. The package is self contained and can be used on its own, independently of the higher level packages of the suite.

Computes conditional multivariate t probabilities, random deviates, and densities. It can also be used to create missing values at random in a dataset, resulting in a missing at random (MAR) mechanism. Inbuilt in the package are the Expectation-Maximization (EM), Monte Carlo EM, and Stochastic EM algorithms for imputation of missing values in datasets assuming the multivariate t distribution. See Kinyanjui, Tamba, Orawo, and Okenye (2020)<doi:10.3233/mas-200493>, and Kinyanjui, Tamba, and Okenye(2021)<http://www.ceser.in/ceserp/index.php/ijamas/article/view/6726/0> for more details.

Automatic generation of finite state machine models of dynamic decision-making that both have strong predictive power and are interpretable in human terms. We use an efficient model representation and a genetic algorithm-based estimation process to generate simple deterministic approximations that explain most of the structure of complex stochastic processes. We have applied the software to empirical data, and demonstrated it's ability to recover known data-generating processes by simulating data with agent-based models and correctly deriving the underlying decision models for multiple agent models and degrees of stochasticity.

This package provides a set of functions to quantify the relationship between development rate and temperature and to build phenological models. The package comprises a set of models and estimated parameters borrowed from a literature review in ectotherms. The methods and literature review are described in Rebaudo et al. (2018) <doi:10.1111/2041-210X.12935>, Rebaudo and Rabhi (2018) <doi:10.1111/eea.12693>, and Regnier et al. (2021) <doi:10.1093/ee/nvab115>. An example can be found in Rebaudo et al. (2017) <doi:10.1007/s13355-017-0480-5>.

This package provides a comprehensive toolkit for single-cell annotation with the CellMarker2.0 database (see Xia Li, Peng Wang, Yunpeng Zhang (2023) <doi: 10.1093/nar/gkac947>). Streamlines biological label assignment in single-cell RNA-seq data and facilitates transcriptomic analysis, including preparation of TCGA<https://portal.gdc.cancer.gov/> and GEO<https://www.ncbi.nlm.nih.gov/geo/> datasets, differential expression analysis and visualization of enrichment analysis results. Additional utility functions support various bioinformatics workflows. See Wei Cui (2024) <doi: 10.1101/2024.09.14.609619> for more details.

This package provides an automated workflow for Principal Component Analysis (PCA) that simplifies multivariate data analysis by performing essential preprocessing, statistical tests, component extraction, and visualization in a single function call. The package automatically standardizes variables, computes correlation matrices, performs Kaiser-Meyer-Olkin (KMO) and Bartlett's tests, determines the optimal number of principal components using multiple selection criteria, generates component loadings and scores, and produces publication-ready tables and graphical outputs for researchers and students. Methodological background is described in Shankar et al. (2024) <doi:10.1007/s12665-024-11985-5>.

The Delphi Epidata API provides real-time access to epidemiological surveillance data for influenza, COVID-19', and other diseases for the USA at various geographical resolutions, both from official government sources such as the Center for Disease Control (CDC) and Google Trends and private partners such as Facebook and Change Healthcare'. It is built and maintained by the Carnegie Mellon University Delphi research group. To cite this API: David C. Farrow, Logan C. Brooks, Aaron Rumack', Ryan J. Tibshirani', Roni Rosenfeld (2015). Delphi Epidata API. <https://github.com/cmu-delphi/delphi-epidata>.

This package implements functions and instruments for regression model building and its application to forecasting. The main scope of the package is in variables selection and models specification for cases of time series data. This includes promotional modelling, selection between different dynamic regressions with non-standard distributions of errors, selection based on cross validation, solutions to the fat regression model problem and more. Models developed in the package are tailored specifically for forecasting purposes. So as a results there are several methods that allow producing forecasts from these models and visualising them.

This package provides a statistical learning method that tries to find the best set of predictors and interactions between predictors for modeling binary or quantitative response data in a decision tree. Several search algorithms and ensembling techniques are implemented allowing for finetuning the method to the specific problem. Interactions with quantitative covariables can be properly taken into account by fitting local regression models. Moreover, a variable importance measure for assessing marginal and interaction effects is provided. Implements the procedures proposed by Lau et al. (2024, <doi:10.1007/s10994-023-06488-6>).

Fast binning of multiple variables using parallel processing. A summary of all the variables binned is generated which provides the information value, entropy, an indicator of whether the variable follows a monotonic trend or not, etc. It supports rebinning of variables to force a monotonic trend as well as manual binning based on pre specified cuts. The cut points of the bins are based on conditional inference trees as implemented in the partykit package. The conditional inference framework is described by Hothorn T, Hornik K, Zeileis A (2006) <doi:10.1198/106186006X133933>.