This package provides quantitative variant callers for detecting subclonal mutations in ultra-deep (>=100x coverage) sequencing experiments. The deepSNV algorithm is used for a comparative setup with a control experiment of the same loci and uses a beta-binomial model and a likelihood ratio test to discriminate sequencing errors and subclonal SNVs. The shearwater algorithm computes a Bayes classifier based on a beta-binomial model for variant calling with multiple samples for precisely estimating model parameters - such as local error rates and dispersion - and prior knowledge, e.g. from variation data bases such as COSMIC.

ANCOMBC is a package containing differential abundance (DA) and correlation analyses for microbiome data. Specifically, the package includes Analysis of Compositions of Microbiomes with Bias Correction(ANCOM-BC) and Analysis of Composition of Microbiomes (ANCOM) for DA analysis, and Sparse Estimation of Correlations among Microbiomes (SECOM) for correlation analysis. Microbiome data are typically subject to two sources of biases: unequal sampling fractions (sample-specific biases) and differential sequencing efficiencies (taxon-specific biases). Methodologies included in the ANCOMBC package were designed to correct these biases and construct statistically consistent estimators.

This package provides a tool to provide an easy, intuitive and consistent access to information contained in various R models, like model formulas, model terms, information about random effects, data that was used to fit the model or data from response variables. The package mainly revolves around two types of functions: Functions that find (the names of) information, starting with find_, and functions that get the underlying data, starting with get_. The package has a consistent syntax and works with many different model objects, where otherwise functions to access these information are missing.

Functionality for working with virtual machines (VMs) in Microsoft's Azure cloud: <https://azure.microsoft.com/en-us/services/virtual-machines/>. Includes facilities to deploy, startup, shutdown, and cleanly delete VMs and VM clusters. Deployment configurations can be highly customised, and can make use of existing resources as well as creating new ones. A selection of predefined configurations is provided to allow easy deployment of commonly used Linux and Windows images, including Data Science Virtual Machines. With a running VM, execute scripts and install optional extensions. Part of the AzureR family of packages.

This package provides a practical tool for estimating the burden of common communicable diseases in settlements of displaced populations. An online version of the tool can be found at <http://who-refugee-bod.ecdf.ed.ac.uk/shiny/app/>. Estimates of burden of disease aim to synthesize data about cause-specific morbidity and mortality through a systematic approach that enables evidence-based decisions and comparisons across settings. The focus of this tool is on four acute communicable diseases and syndromes, including Acute respiratory infections, Acute diarrheal diseases, Acute jaundice syndrome and Acute febrile illnesses.

This package provides functions for training an optimal decision tree classifier, making predictions and generating latex code for plotting. Works for two-class and multi-class classification problems. The algorithm seeks the optimal Boolean rule consisting of multiple variables to split a node, resulting in shorter trees. Use bsnsing() to build a tree, predict() to make predictions and plot() to plot the tree into latex and PDF. See Yanchao Liu (2022) <arXiv:2205.15263> for technical details. Source code and more data sets are at <https://github.com/profyliu/bsnsing/>.

Maximum likelihood estimation, random values generation, density computation and other functions for the bivariate Poisson distribution. References include: Kawamura K. (1984). "Direct calculation of maximum likelihood estimator for the bivariate Poisson distribution". Kodai Mathematical Journal, 7(2): 211--221. <doi:10.2996/kmj/1138036908>. Kocherlakota S. and Kocherlakota K. (1992). "Bivariate discrete distributions". CRC Press. <doi:10.1201/9781315138480>. Karlis D. and Ntzoufras I. (2003). "Analysis of sports data by using bivariate Poisson models". Journal of the Royal Statistical Society: Series D (The Statistician), 52(3): 381--393. <doi:10.1111/1467-9884.00366>.

This package creates spatially or environmentally separated, or group-preserving, training and testing folds for k-fold, leave-group-out, and leave-one-out cross-validation. Provides spatial blocking, clustering, buffering, and nearest-neighbour distance-matching methods, together with tools to visualise folds, summarise fold sizes and class balance, and assess trainâ test separation and environmental novelty. Also estimates spatial autocorrelation ranges in point samples and continuous raster covariates to provide an initial distance scale for designing spatial folds. Methods are described in Valavi, R. et al. (2019) <doi:10.1111/2041-210X.13107>.

We propose to determine the correction of the significance level after multiple coding of an explanatory variable in Generalized Linear Model. The different methods of correction of the p-value are the Single step Bonferroni procedure, and resampling based methods developed by P.H.Westfall in 1993. Resampling methods are based on the permutation and the parametric bootstrap procedure. If some continuous, and dichotomous transformations are performed this package offers an exact correction of the p-value developed by B.Liquet & D.Commenges in 2005. The naive method with no correction is also available.

Demonstration code showing how (univariate) kernel density estimates are computed, at least conceptually, and allowing users to experiment with different kernels, should they so wish. The method used follows directly the definition, but gains efficiency by replacing the observations by frequencies in a very fine grid covering the sample range. A canonical reference is B. W. Silverman, (1998) <doi: 10.1201/9781315140919>. NOTE: the density function in the stats package uses a more sophisticated method based on the fast Fourier transform and that function should be used if computational efficiency is a prime consideration.

This package creates publication-ready forest plots from any tabular data containing point estimates and confidence intervals. Suitable for visualising results from regression models, meta-analyses, subgroup analyses, or any comparative study. Supports group and subgroup headings, summary estimates displayed as diamonds, grouped estimates with automatic colour and shape mapping, vertical dodging of multiple estimates within the same row, customisable text columns alongside the plot, and optional row striping. Provides a helper to export plots to PDF, PNG, SVG, or TIFF. Built on tinyplot for clean, consistent visual styling with a minimal dependency footprint.

This presents a comprehensive set of tools for the analysis and visualization of drug formulation data. It includes functions for statistical analysis, regression modeling, hypothesis testing, and comparative analysis to assess the impact of formulation parameters on drug release and other critical attributes. Additionally, the package offers a variety of data visualization functions, such as scatterplots, histograms, and boxplots, to facilitate the interpretation of formulation data. With its focus on usability and efficiency, this package aims to streamline the drug formulation process and aid researchers in making informed decisions during formulation design and optimization.

Read and write PNG images with arrays, rasters, native rasters, numeric arrays, integer arrays, raw vectors and indexed values. This PNG encoder exposes configurable internal options enabling the user to select a speed-size tradeoff. For example, disabling compression can speed up writing PNG by a factor of 50. Multiple image formats are supported including raster, native rasters, and integer and numeric arrays at color depths of 1, 2, 3 or 4. 16-bit images are also supported. This implementation uses the libspng C library which is available from <https://github.com/randy408/libspng/>.

Detects central processing unit and graphics processing unit hardware and reports the apparent availability of CUDA', Metal', ROCm', and OpenCL compute backends. Detection uses operating-system information, documented platform interfaces, and optional command-line utilities, without requiring a GPU framework, Python', or a vendor software development kit. Backend interpretation follows the official CUDA <https://docs.nvidia.com/cuda/cuda-driver-api/>, Metal <https://developer.apple.com/documentation/metal>, ROCm <https://rocm.docs.amd.com/>, and OpenCL <https://registry.khronos.org/OpenCL/> documentation. Missing hardware, drivers, libraries, and utilities are handled safely.

Four datasets are provided here from the Intendo game Super Jetroid'. It is data from the 2015 year of operation and it comprises a revenue table ('all_revenue'), a daily users table ('users_daily'), a user summary table ('user_summary'), and a table with data on all user sessions ('all_sessions'). These core datasets come in different sizes, and, each of them has a variant that was intentionally made faulty (totally riddled with errors and inconsistencies). This suite of tables is useful for testing with packages that focus on data validation and data documentation.

This package provides a set of tools to i) identify geographic areas with significant change over time in drug utilization, and ii) characterize common change over time patterns among the time series for multiple geographic areas. For reference, see below: 1. Song, J., Carey, M., Zhu, H., Miao, H., Ram´ırez, J. C., & Wu, H. (2018) <doi:10.1504/IJCBDD.2018.10011910> 2. Wu, S., Wu, H. (2013) <doi:10.1186/1471-2105-14-6> 3. Carey, M., Wu, S., Gan, G. & Wu, H. (2016) <doi:10.1016/j.idm.2016.07.001>.

This package provides tools for multilevel descriptive statistics and data preparation. Computes within-group and between-group correlations (via variance decomposition or two-level structural equation modeling), intraclass correlation coefficients (ICCs), and descriptive statistics for nested data (e.g., repeated measurements per person), supporting both frequentist (via lme4 or lavaan') and Bayesian (via brms') estimation. Results are formatted according to APA standards and can be exported as tables using gt or tinytable'. Also includes functions for decomposing variables into within-group and between-group components for use in Random Effects Within-Between (REWB) models.

An implementation of the alternating expectation conditional maximization (AECM) algorithm for matrix-variate variance gamma (MVVG) and normal-inverse Gaussian (MVNIG) linear models. These models are designed for settings of multivariate analysis with clustered non-uniform observations and correlated responses. The package includes fitting and prediction functions for both models, and an example dataset from a periodontal on Gullah-speaking African Americans, with responses in gaad_res, and covariates in gaad_cov. For more details on the matrix-variate distributions used, see Gallaugher & McNicholas (2019) <doi:10.1016/j.spl.2018.08.012>.

Mass measurement corrections and uncertainties using calibration data, as recommended by EURAMET's guideline No. 18 (2015) ISBN:978-3-942992-40-4 . The package provides classes, functions, and methods for storing information contained in calibration certificates and converting balance readings to both conventional mass and real mass. For the latter, the Magnitude of the Air Buoyancy Correction factor employs models (such as the CIMP-2007 formula revised by Picard, Davis, Gläser, and Fujii (2008) <doi:10.1088/0026-1394/45/2/004>) to estimate the local air density using measured environmental conditions.

This package provides a toolbox for continuous norming of psychological and educational tests, supporting regression-based norming where norms can vary as a continuous function of age or another norm predictor. Norms are estimated using Generalized Additive Models for Location, Scale, and Shape (GAMLSS), enabling flexible modelling of the full score distribution in a normative sample. The package supports applications in psychometrics and psychological testing, and includes functions for model selection, reliability estimation, norm calculation, including confidence intervals, and sample size planning. For more details, see Timmerman et al. (2021) <doi:10.1037/met0000348>.

Retrieve and analyze biomedical literature from PubMed and the wider NIH'/'NLM data stack through a single, PMID-centered interface. A PubMed search resolves to a set of PMIDs, which can be used to retrieve article metadata and abstracts, author affiliations, iCite citation data and links, PubTator3 entity and relation annotations, and open-access full text from PMC'. A local analysis layer operates on the retrieved tables, supporting corpus expansion through citation links, citation network construction, sentence-level entity co-occurrence, inspection of relation evidence, and MeSH descriptor keyness.

This package provides a unified and user-friendly framework for applying the principal sufficient dimension reduction methods for both linear and nonlinear cases. The package has an extendable power by varying loss functions for the support vector machine, even for an user-defined arbitrary function, unless those are convex and differentiable everywhere over the support (Li et al. (2011) <doi:10.1214/11-AOS932>). Also, it provides a real-time sufficient dimension reduction update procedure using the principal least squares support vector machine (Artemiou et al. (2021) <doi:10.1016/j.patcog.2020.107768>).

This package provides a collection of (wrapper) functions the creator found useful for quickly placing data summaries and formatted regression results into .Rnw or .Rmd files. Functions for generating commonly used graphics, such as receiver operating curves or Bland-Altman plots, are also provided by qwraps2'. qwraps2 is an updated version of a package qwraps'. The original version qwraps was never submitted to CRAN but can be found at <https://github.com/dewittpe/qwraps/>. The implementation and limited scope of the functions within qwraps2 <https://github.com/dewittpe/qwraps2/> is fundamentally different from qwraps'.

This package provides functions aiming to facilitate the analysis of the structure of animal acoustic signals in R'. warbleR makes use of the basic sound analysis tools from the packages tuneR and seewave', and offers new tools for exploring and quantifying acoustic signal structure. The package allows users to organize and manipulate multiple sound files, create spectrograms of complete recordings or individual signals in different formats, run several measures of acoustic structure, and characterize different structural levels in acoustic signals (Araya-Salas and Smith-Vidaurre 2017 <doi:10.1111/2041-210X.12624>).