The notion of spreading activation is a prevalent metaphor in the cognitive sciences. This package provides the tools for cognitive scientists and psychologists to conduct computer simulations that implement spreading activation in a network representation. The algorithmic method implemented in spreadr subroutines follows the approach described in Vitevitch, Ercal, and Adagarla (2011, Frontiers), who viewed activation as a fixed cognitive resource that could spread among nodes that were connected to each other via edges or connections (i.e., a network). See Vitevitch, M. S., Ercal, G., & Adagarla, B. (2011). Simulating retrieval from a highly clustered network: Implications for spoken word recognition. Frontiers in Psychology, 2, 369. <doi:10.3389/fpsyg.2011.00369> and Siew, C. S. Q. (2019). spreadr: A R package to simulate spreading activation in a network. Behavior Research Methods, 51, 910-929. <doi: 10.3758/s13428-018-1186-5>.

Best Orthogonalized Subset Selection (BOSS) is a least-squares (LS) based subset selection method, that performs best subset selection upon an orthogonalized basis of ordered predictors, with the computational effort of a single ordinary LS fit. This package provides a highly optimized implementation of BOSS and estimates a heuristic degrees of freedom for BOSS, which can be plugged into an information criterion (IC) such as AICc in order to select the subset from candidates. It provides various choices of IC, including AIC, BIC, AICc, Cp and GCV. It also implements the forward stepwise selection (FS) with no additional computational cost, where the subset of FS is selected via cross-validation (CV). CV is also an option for BOSS. For details see: Tian, Hurvich and Simonoff (2021), "On the Use of Information Criteria for Subset Selection in Least Squares Regression", <arXiv:1911.10191>.

Many Fitbit users, and R-friendly Fitbit users especially, have found themselves curious about their Fitbit data. Fitbit aggregates a large amount of personal data, much of which is interesting for personal research and to satisfy curiosity, and is even potentially useful in medical settings. The goal of fitbitr is to make interfacing with the Fitbit API as streamlined as possible, to make it simple for R users of all backgrounds and comfort levels to analyze their Fitbit data and do whatever they want with it! Currently, fitbitr includes methods for pulling data on activity, sleep, and heart rate, but this list is likely to grow in the future as the package gains more traction and more requests for new methods to be implemented come in. You can find details on the Fitbit API at <https://dev.fitbit.com/build/reference/web-api/>.

Implementation of the Interval Testing Procedure for functional data in different frameworks (i.e., one or two-population frameworks, functional linear models) by means of different basis expansions (i.e., B-spline, Fourier, and phase-amplitude Fourier). The current version of the package requires functional data evaluated on a uniform grid; it automatically projects each function on a chosen functional basis; it performs the entire family of multivariate tests; and, finally, it provides the matrix of the p-values of the previous tests and the vector of the corrected p-values. The functional basis, the coupled or uncoupled scenario, and the kind of test can be chosen by the user. The package provides also a plotting function creating a graphical output of the procedure: the p-value heat-map, the plot of the corrected p-values, and the plot of the functional data.

This small collection of functions provides what we call elemental graphics for display of analysis of variance results, David C. Hoaglin, Frederick Mosteller and John W. Tukey (1991, ISBN:978-0-471-52735-0), Paul R. Rosenbaum (1989) <doi:10.2307/2684513>, Robert M. Pruzek and James E. Helmreich <https://jse.amstat.org/v17n1/helmreich.html>. The term elemental derives from the fact that each function is aimed at construction of graphical displays that afford direct visualizations of data with respect to the fundamental questions that drive the particular analysis of variance methods. These functions can be particularly helpful for students and non-statistician analysts. But these methods should be quite generally helpful for work-a-day applications of all kinds, as they can help to identify outliers, clusters or patterns, as well as highlight the role of non-linear transformations of data.

The theoretical covariance between pairs of markers is calculated from either paternal haplotypes and maternal linkage disequilibrium (LD) or vise versa. A genetic map is required. Grouping of markers is based on the correlation matrix and a representative marker is suggested for each group. Employing the correlation matrix, optimal sample size can be derived for association studies based on a SNP-BLUP approach. The implementation relies on paternal half-sib families and biallelic markers. If maternal half-sib families are used, the roles of sire/dam are swapped. Multiple families can be considered. Wittenburg, Bonk, Doschoris, Reyer (2020) "Design of Experiments for Fine-Mapping Quantitative Trait Loci in Livestock Populations" <doi:10.1186/s12863-020-00871-1>. Carlson, Eberle, Rieder, Yi, Kruglyak, Nickerson (2004) "Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium" <doi:10.1086/381000>.

This package provides functions for dimension reduction through the seeded canonical correlation analysis are provided. A classical canonical correlation analysis (CCA) is one of useful statistical methods in multivariate data analysis, but it is limited in use due to the matrix inversion for large p small n data. To overcome this, a seeded CCA has been proposed in Im, Gang and Yoo (2015) \doi10.1002/cem.2691. The seeded CCA is a two-step procedure. The sets of variables are initially reduced by successively projecting cov(X,Y) or cov(Y,X) onto cov(X) and cov(Y), respectively, without loss of information on canonical correlation analysis, following Cook, Li and Chiaromonte (2007) \doi10.1093/biomet/asm038 and Lee and Yoo (2014) \doi10.1111/anzs.12057. Then, the canonical correlation is finalized with the initially-reduced two sets of variables.

This package provides estimation methods for markets in equilibrium and disequilibrium. Supports the estimation of an equilibrium and four disequilibrium models with both correlated and independent shocks. Also provides post-estimation analysis tools, such as aggregation, marginal effect, and shortage calculations. See Karapanagiotis (2024) <doi:10.18637/jss.v108.i02> for an overview of the functionality and examples. The estimation methods are based on full information maximum likelihood techniques given in Maddala and Nelson (1974) <doi:10.2307/1914215>. They are implemented using the analytic derivative expressions calculated in Karapanagiotis (2020) <doi:10.2139/ssrn.3525622>. Standard errors can be estimated by adjusting for heteroscedasticity or clustering. The equilibrium estimation constitutes a case of a system of linear, simultaneous equations. Instead, the disequilibrium models replace the market-clearing condition with a non-linear, short-side rule and allow for different specifications of price dynamics.

The goal of the SwimmeR package is to provide means of acquiring, and then analyzing, data from swimming (and diving) competitions. To that end SwimmeR allows results to be read in from .html sources, like Hy-Tek real time results pages, .pdf files, ISL results, Omega results, and (on a development basis) .hy3 files. Once read in, SwimmeR can convert swimming times (performances) between the computationally useful format of seconds reported to the 100ths place (e.g. 95.37), and the conventional reporting format (1:35.37) used in the swimming community. SwimmeR can also score meets in a variety of formats with user defined point values, convert times between courses ('LCM', SCM', SCY') and draw single elimination brackets, as well as providing a suite of tools for working cleaning swimming data. This is a developmental package, not yet mature.

This package implements a suite of methods to preprocess data from PTR-TOF-MS instruments (HDF5 format) and generates the sample by features table of peak intensities in addition to the sample and feature metadata (as a singl<e ExpressionSet object for subsequent statistical analysis). This package also permit usefull tools for cohorts management as analyzing data progressively, visualization tools and quality control. The steps include calibration, expiration detection, peak detection and quantification, feature alignment, missing value imputation and feature annotation. Applications to exhaled air and cell culture in headspace are described in the vignettes and examples. This package was used for data analysis of Gassin Delyle study on adults undergoing invasive mechanical ventilation in the intensive care unit due to severe COVID-19 or non-COVID-19 acute respiratory distress syndrome (ARDS), and permit to identfy four potentiel biomarquers of the infection.

Computation of various confidence intervals (Altman et al. (2000), ISBN:978-0-727-91375-3; Hedderich and Sachs (2018), ISBN:978-3-662-56657-2) including bootstrapped versions (Davison and Hinkley (1997), ISBN:978-0-511-80284-3) as well as Hsu (Hedderich and Sachs (2018), ISBN:978-3-662-56657-2), permutation (Janssen (1997), <doi:10.1016/S0167-7152(97)00043-6>), bootstrap (Davison and Hinkley (1997), ISBN:978-0-511-80284-3), intersection-union (Sozu et al. (2015), ISBN:978-3-319-22005-5) and multiple imputation (Barnard and Rubin (1999), <doi:10.1093/biomet/86.4.948>) t-test; furthermore, computation of intersection-union z-test as well as multiple imputation Wilcoxon tests. Graphical visualization by volcano and Bland-Altman plots (Bland and Altman (1986), <doi:10.1016/S0140-6736(86)90837-8>; Shieh (2018), <doi:10.1186/s12874-018-0505-y>).

Sample size estimation for bio-equivalence trials is supported through a simulation-based approach that extends the Two One-Sided Tests (TOST) procedure. The methodology provides flexibility in hypothesis testing, accommodates multiple treatment comparisons, and accounts for correlated endpoints. Users can model complex trial scenarios, including parallel and crossover designs, intra-subject variability, and different equivalence margins. Monte Carlo simulations enable accurate estimation of power and type I error rates, ensuring well-calibrated study designs. The statistical framework builds on established methods for equivalence testing and multiple hypothesis testing in bio-equivalence studies, as described in Schuirmann (1987) <doi:10.1007/BF01068419>, Mielke et al. (2018) <doi:10.1080/19466315.2017.1371071>, Shieh (2022) <doi:10.1371/journal.pone.0269128>, and Sozu et al. (2015) <doi:10.1007/978-3-319-22005-5>. Comprehensive documentation and vignettes guide users through implementation and interpretation of results.

This package provides a set of functions allowing to implement the SpiceFP approach which is iterative. It involves transformation of functional predictors into several candidate explanatory matrices (based on contingency tables), to which relative edge matrices with contiguity constraints are associated. Generalized Fused Lasso regression are performed in order to identify the best candidate matrix, the best class intervals and related coefficients at each iteration. The approach is stopped when the maximal number of iterations is reached or when retained coefficients are zeros. Supplementary functions allow to get coefficients of any candidate matrix or mean of coefficients of many candidates. The methods in this package are describing in Girault Gnanguenon Guesse, Patrice Loisel, Bénedicte Fontez, Thierry Simonneau, Nadine Hilgert (2021) "An exploratory penalized regression to identify combined effects of functional variables -Application to agri-environmental issues" <https://hal.archives-ouvertes.fr/hal-03298977>.

The "ussher" data set is drawn from original chronological textual historic events. Commonly known as James Ussher's Annals of the World, the source text was originally written in Latin in 1650, and published in English translation in 1658.The data are classified by index, year, epoch (or one of the 7 ancient "Ages of the World"), Biblical source book if referenced (rarely), as well as alternate dating mechanisms, such as "Anno Mundi" (age of the world) or "Julian Period" (dates based upon the Julian calendar). Additional file "usshfull" includes variables that may be of further interest to historians, such as Southern Kingdom and Northern Kingdom discrepant dates, and the original amalgamated dating mechanic used by Ussher in the original text. The raw data can also be called using "usshraw", as described in: Ussher, J. (1658) <https://archive.org/stream/AnnalsOfTheWorld/Annals_djvu.txt>.

Data Analysis using Bootstrap-Coupled ESTimation. Estimation statistics is a simple framework that avoids the pitfalls of significance testing. It uses familiar statistical concepts: means, mean differences, and error bars. More importantly, it focuses on the effect size of one's experiment/intervention, as opposed to a false dichotomy engendered by P values. An estimation plot has two key features: 1. It presents all datapoints as a swarmplot, which orders each point to display the underlying distribution. 2. It presents the effect size as a bootstrap 95% confidence interval on a separate but aligned axes. Estimation plots are introduced in Ho et al., Nature Methods 2019, 1548-7105. <doi:10.1038/s41592-019-0470-3>. The free-to-view PDF is located at <https://www.nature.com/articles/s41592-019-0470-3.epdf?author_access_token=Euy6APITxsYA3huBKOFBvNRgN0jAjWel9jnR3ZoTv0Pr6zJiJ3AA5aH4989gOJS_dajtNr1Wt17D0fh-t4GFcvqwMYN03qb8C33na_UrCUcGrt-Z0J9aPL6TPSbOxIC-pbHWKUDo2XsUOr3hQmlRew%3D%3D>.

Estimation and comparison of the performances of diagnostic tests in multi-reader multi-case studies where true case statuses (or ground truths) are known and one or more readers provide test ratings for multiple cases. Reader performance metrics are provided for area under and expected utility of ROC curves, likelihood ratio of positive or negative tests, and sensitivity and specificity. ROC curves can be estimated empirically or with binormal or binormal likelihood-ratio models. Statistical comparisons of diagnostic tests are based on the ANOVA model of Obuchowski-Rockette and the unified framework of Hillis (2005) <doi:10.1002/sim.2024>. The ANOVA can be conducted with data from a full factorial, nested, or partially paired study design; with random or fixed readers or cases; and covariances estimated with the DeLong method, jackknifing, or an unbiased method. Smith and Hillis (2020) <doi:10.1117/12.2549075>.

This package provides a set of functions useful in the analysis of 3D genomic interactions. It includes the import of standard HiC data formats into R and HiC normalisation procedures. The main objective of this package is to improve the visualization and quantification of the analysis of HiC contacts through aggregation. The package allows to import 1D genomics data, such as peaks from ATACSeq, ChIPSeq, to create potential couples between features of interest under user-defined parameters such as distance between pairs of features of interest. It allows then the extraction of contact values from the HiC data for these couples and to perform Aggregated Peak Analysis (APA) for visualization, but also to compare normalized contact values between conditions. Overall the package allows to integrate 1D genomics data with 3D genomics data, providing an easy access to HiC contact values.

Build and use B-splines for interpolation and regression. In case of regression, equality constraints as well as monotonicity and/or positivity of B-spline weights can be imposed. Moreover, knot positions can be on regular grid or be part of optimized parameters too (in addition to the spline weights). For this end, bspline is able to calculate Jacobian of basis vectors as function of knot positions. User is provided with functions calculating spline values at arbitrary points. These functions can be differentiated and integrated to obtain B-splines calculating derivatives/integrals at any point. B-splines of this package can simultaneously operate on a series of curves sharing the same set of knots. bspline is written with concern about computing performance that's why the basis and Jacobian calculation is implemented in C++. The rest is implemented in R but without notable impact on computing speed.

This package provides functions for implementing the novel algorithm CASCORE, which is designed to detect latent community structure in graphs with node covariates. This algorithm can handle models such as the covariate-assisted degree corrected stochastic block model (CADCSBM). CASCORE specifically addresses the disagreement between the community structure inferred from the adjacency information and the community structure inferred from the covariate information. For more detailed information, please refer to the reference paper: Yaofang Hu and Wanjie Wang (2022) <arXiv:2306.15616>. In addition to CASCORE, this package includes several classical community detection algorithms that are compared to CASCORE in our paper. These algorithms are: Spectral Clustering On Ratios-of Eigenvectors (SCORE), normalized PCA, ordinary PCA, network-based clustering, covariates-based clustering and covariate-assisted spectral clustering (CASC). By providing these additional algorithms, the package enables users to compare their performance with CASCORE in community detection tasks.

This data contains a large variety of information on players and their current attributes on Fantasy Premier League <https://fantasy.premierleague.com/>. In particular, it contains a `next_gw_points` (next gameweek points) value for each player given their attributes in the current week. Rows represent player-gameweeks, i.e. for each player there is a row for each gameweek. This makes the data suitable for modelling a player's next gameweek points, given attributes such as form, total points, and cost at the current gameweek. This data can therefore be used to create Fantasy Premier League bots that may use a machine learning algorithm and a linear programming solver (for example) to return the best possible transfers and team to pick for each gameweek, thereby fully automating the decision making process in Fantasy Premier League. This function simply supplies the required data for such a task.

This package provides constrained joint maximum likelihood estimation algorithms for item factor analysis (IFA) based on multidimensional item response theory models. So far, we provide functions for exploratory and confirmatory IFA based on the multidimensional two parameter logistic (M2PL) model for binary response data. Comparing with traditional estimation methods for IFA, the methods implemented in this package scale better to data with large numbers of respondents, items, and latent factors. The computation is facilitated by multiprocessing OpenMP API. For more information, please refer to: 1. Chen, Y., Li, X., & Zhang, S. (2018). Joint Maximum Likelihood Estimation for High-Dimensional Exploratory Item Factor Analysis. Psychometrika, 1-23. <doi:10.1007/s11336-018-9646-5>; 2. Chen, Y., Li, X., & Zhang, S. (2019). Structured Latent Factor Analysis for Large-scale Data: Identifiability, Estimability, and Their Implications. Journal of the American Statistical Association, <doi: 10.1080/01621459.2019.1635485>.

This package provides a multi-core R package that contains a set of tools based on copula graphical models for accomplishing the three interrelated goals in genetics and genomics in an unified way: (1) linkage map construction, (2) constructing linkage disequilibrium networks, and (3) exploring high-dimensional genotype-phenotype network and genotype- phenotype-environment interactions networks. The netgwas package can deal with biparental inbreeding and outbreeding species with any ploidy level, namely diploid (2 sets of chromosomes), triploid (3 sets of chromosomes), tetraploid (4 sets of chromosomes) and so on. We target on high-dimensional data where number of variables p is considerably larger than number of sample sizes (p >> n). The computations is memory-optimized using the sparse matrix output. The netgwas implements the methodological developments in Behrouzi and Wit (2017) <doi:10.1111/rssc.12287> and Behrouzi and Wit (2017) <doi:10.1093/bioinformatics/bty777>.

The GENESIS package provides methodology for estimating, inferring, and accounting for population and pedigree structure in genetic analyses. The current implementation provides functions to perform PC-AiR (Conomos et al., 2015, Gen Epi) and PC-Relate (Conomos et al., 2016, AJHG). PC-AiR performs a Principal Components Analysis on genome-wide SNP data for the detection of population structure in a sample that may contain known or cryptic relatedness. Unlike standard PCA, PC-AiR accounts for relatedness in the sample to provide accurate ancestry inference that is not confounded by family structure. PC-Relate uses ancestry representative principal components to adjust for population structure/ancestry and accurately estimate measures of recent genetic relatedness such as kinship coefficients, IBD sharing probabilities, and inbreeding coefficients. Additionally, functions are provided to perform efficient variance component estimation and mixed model association testing for both quantitative and binary phenotypes.

This package provides a statistical ecosystem modelling package, taking many features of the ecosystem into account. Gadget works by running an internal model based on many parameters, and then comparing the data from the output of this model to real data to get a goodness-of-fit likelihood score. These parameters can then be adjusted, and the model re-run, until an optimum is found, which corresponds to the model with the lowest likelihood score. Gadget allows the user to include a number of features into an ecosystem model: One or more species, each of which may be split into multiple stocks; multiple areas with migration between areas; predation between and within species; maturation; reproduction and recruitment; multiple commercial and survey fleets taking catches from the populations. For more details see <https://gadget-framework.github.io/gadget2/>. This is the C++ Gadget2 runtime, making it available for R.