Import, create and assemble data needed to fit spatial-statistical stream-network models using the SSN2 package for R'. Streams, observations, and prediction locations are represented as simple features and specific tools provided to define topological relationships between features; calculate the hydrologic distances (with flow-direction preserved) and the spatial additive function used to weight converging stream segments; and export the topological, spatial, and attribute information to an `SSN` (spatial stream network) object, which can be efficiently stored, accessed and analysed in R'. A detailed description of methods used to calculate and format the spatial data can be found in Peterson, E.E. and Ver Hoef, J.M., (2014) <doi:10.18637/jss.v056.i02>.

This data set provides information on the fate of passengers on the fatal maiden voyage of the ocean liner "Titanic", summarized according to economic status (class), sex, age and survival. Whereas the base R Titanic data found by calling data("Titanic") is an array resulting from cross-tabulating 2201 observations, these data sets are the individual non-aggregated observations and formatted in a machine learning context with a training sample, a testing sample, and two additional data sets that can be used for deeper machine learning analysis. These data sets are also the data sets downloaded from the Kaggle competition and thus lowers the barrier to entry for users new to R or machine learing.

treekoR is a novel framework that aims to utilise the hierarchical nature of single cell cytometry data to find robust and interpretable associations between cell subsets and patient clinical end points. These associations are aimed to recapitulate the nested proportions prevalent in workflows inovlving manual gating, which are often overlooked in workflows using automatic clustering to identify cell populations. We developed treekoR to: Derive a hierarchical tree structure of cell clusters; quantify a cell types as a proportion relative to all cells in a sample (%total), and, as the proportion relative to a parent population (%parent); perform significance testing using the calculated proportions; and provide an interactive html visualisation to help highlight key results.

This package provides Bayesian probabilistic methods for record linkage and entity resolution across multiple datasets using the Comprehensive Hit Or Miss Probabilistic Entity Resolution (CHOMPER) model. The package implements three main inference approaches: (1) Evolutionary Variational Inference for record Linkage (EVIL), (2) Coordinate Ascent Variational Inference (CAVI), and (3) Markov Chain Monte Carlo (MCMC) with split and merge process. The model supports both discrete and continuous fields, and it performs locally-varying hit mechanism for the attributes with multiple truths. It also provides tools for performance evaluation based on either approximated variational factors or posterior samples. The package is designed to support parallel computing with multi-threading support for EVIL to estimate the linkage structure faster.

Diagnostic and prognostic models are typically evaluated with measures of accuracy that do not address clinical consequences. Decision-analytic techniques allow assessment of clinical outcomes, but often require collection of additional information may be cumbersome to apply to models that yield a continuous result. Decision curve analysis is a method for evaluating and comparing prediction models that incorporates clinical consequences, requires only the data set on which the models are tested, and can be applied to models that have either continuous or dichotomous results. See the following references for details on the methods: Vickers (2006) <doi:10.1177/0272989X06295361>, Vickers (2008) <doi:10.1186/1472-6947-8-53>, and Pfeiffer (2020) <doi:10.1002/bimj.201800240>.

This package provides a complete workflow for large-scale, two-condition high-throughput drug screening (HTS). It compares drug sensitivity between any two experimental conditions - for example irradiated versus non-irradiated cells, cancer versus normal cell lines, or treated versus untreated samples - across many plates and experiments. The package covers the full pipeline: control-based normalisation, plate-level quality-control metrics (Z-factor, Z-prime, signal-to-background, signal-to-noise and strictly standardised mean difference), replicate-consistency checks, four-parameter logistic dose-response fitting with area under the curve (AUC) estimation, differential (delta) AUC scoring with within-plate standardisation, cut-off and sigma-based hit selection, and publication-ready heatmap, scatter and quality-control visualisations.

Analysis of temporal changes (i.e. dynamics) of ecological entities, defined as trajectories on a chosen multivariate space, by providing a set of trajectory metrics and visual representations [De Caceres et al. (2019) <doi:10.1002/ecm.1350>; and Sturbois et al. (2021) <doi:10.1016/j.ecolmodel.2020.109400>; Djeghri et al. (2026a) <doi:10.1002/ecm.70058>; Djeghri et al. (2026b) <doi:10.24072/pcjournal.736>]. Includes functions to estimate metrics for individual trajectories (length, directionality, angles, ...) as well as metrics to relate pairs of trajectories (dissimilarity and convergence). Functions are also provided to estimate the ecological quality of ecosystem with respect to reference conditions [Sturbois et al. (2023) <doi:10.1002/ecs2.4726>].

Open source data allows for reproducible research and helps advance our knowledge. The purpose of this package is to collate open source ophthalmic data sets curated for direct use. This is real life data of people with intravitreal injections with anti-vascular endothelial growth factor (anti-VEGF), due to age-related macular degeneration or diabetic macular edema. Associated publications of the data sets: Fu et al. (2020) <doi:10.1001/jamaophthalmol.2020.5044>, Moraes et al (2020) <doi:10.1016/j.ophtha.2020.09.025>, Fasler et al. (2019) <doi:10.1136/bmjopen-2018-027441>, Arpa et al. (2020) <doi:10.1136/bjophthalmol-2020-317161>, Kern et al. 2020, <doi:10.1038/s41433-020-1048-0>.

Genotyping assays for bi-allelic markers (e.g. SNPs) produce signal intensities for the two alleles. fitPoly assigns genotypes (allele dosages) to a collection of polyploid samples based on these signal intensities. fitPoly replaces the older package fitTetra that was limited (a.o.) to only tetraploid populations whereas fitPoly accepts any ploidy level. Reference: Voorrips RE, Gort G, Vosman B (2011) <doi:10.1186/1471-2105-12-172>. New functions added on conversion of data from SNP array software formats, drawing of XY-scatterplots with or without genotype colors, checking against expected F1 segregation patterns, comparing results from two different assays (probes) for the same SNP, recovery from a saveMarkerModels() crash.

This package provides methods for correcting heaping (digit preference) in survey data at the individual record level. Age heaping, where respondents disproportionately report ages ending in 0 or 5, is a common phenomenon that can distort demographic analyses. Unlike traditional smoothing methods that only correct aggregated statistics, this package corrects individual values by replacing a calculated proportion of heaped observations with draws from fitted truncated distributions (log-normal, normal, or uniform). Supports 5-year and 10-year heaping patterns, single heap correction, survey weights, and optional covariate-conditional (model-based) correction via quantile regression forests or linear models to preserve relationships. A multiple-imputation wrapper repeats the correction to propagate the added uncertainty into downstream inference.

Network meta-analysis for survival outcome data often involves several studies only involve dichotomized outcomes (e.g., the numbers of event and sample sizes of individual arms). To combine these different outcome data, Woods et al. (2010) <doi:10.1186/1471-2288-10-54> proposed a Bayesian approach using complicated hierarchical models. Besides, frequentist approaches have been alternative standard methods for the statistical analyses of network meta-analysis, and the methodology has been well established. We proposed an easy-to-implement method for the network meta-analysis based on the frequentist framework in Noma and Maruo (2025) <doi:10.1101/2025.01.23.25321051>. This package involves some convenient functions to implement the simple synthesis method.

Set of functions that improves the graphical presentations of the functions: wave.correlation and spin.correlation (waveslim package, Whitcher 2012) and the wave.multiple.correlation and wave.multiple.cross.correlation (wavemulcor package, Fernandez-Macho 2012b). The plot outputs (heatmaps) can be displayed in the screen or can be saved as PNG or JPG images or as PDF or EPS formats. The W2CWM2C package also helps to handle the (input data) multivariate time series easily as a list of N elements (times series) and provides a multivariate data set (dataexample) to exemplify its use. A description of the package was published in a scientific paper: Polanco-Martinez and Fernandez-Macho (2014), <doi:10.1109/MCSE.2014.96>.

This package provides functions are designed to facilitate access to and utility with large scale, publicly available environmental data in R. The package contains functions for downloading raw data files from web URLs (download_data()), processing the raw data files into clean spatial objects (process_covariates()), and extracting values from the spatial data objects at point and polygon locations (calculate_covariates()). These functions call a series of source-specific functions which are tailored to each data sources/datasets particular URL structure, data format, and spatial/temporal resolution. The functions are tested, versioned, and open source and open access. For sum_edc() method details, see Messier, Akita, and Serre (2012) <doi:10.1021/es203152a>.

Chemical analysis of proteins based on their amino acid compositions. Amino acid compositions can be read from FASTA files and used to calculate chemical metrics including carbon oxidation state and stoichiometric hydration state, as described in Dick et al. (2020) <doi:10.5194/bg-17-6145-2020>. Other properties that can be calculated include protein length, grand average of hydropathy (GRAVY), isoelectric point (pI), molecular weight (MW), standard molal volume (V0), and metabolic costs (Akashi and Gojobori, 2002 <doi:10.1073/pnas.062526999>; Wagner, 2005 <doi:10.1093/molbev/msi126>; Zhang et al., 2018 <doi:10.1038/s41467-018-06461-1>). A database of amino acid compositions of human proteins derived from UniProt is provided.

Given a multivariate dataset and some knowledge about the dependencies between its features, it is customary to fit a statistical model to the features to infer parameters of interest. Such a procedure implicitly assumes that the sample is exchangeable. This package provides a flexible non-parametric test of this exchangeability assumption, allowing the user to specify the feature dependencies by hand as long as features can be grouped into disjoint independent sets. This package also allows users to test a dual hypothesis, which is, given that the sample is exchangeable, does a proposed grouping of the features into disjoint sets also produce statistically independent sets of features? See Aw, Spence and Song (2023) for the accompanying paper.

This is a method for Allele-specific DNA Copy Number profiling for whole-Exome sequencing data. Given the allele-specific coverage and site biases at the variant loci, this program segments the genome into regions of homogeneous allele-specific copy number. It requires, as input, the read counts for each variant allele in a pair of case and control samples, as well as the site biases. For detection of somatic mutations, the case and control samples can be the tumor and normal sample from the same individual. The implemented method is based on the paper: Chen, H., Jiang, Y., Maxwell, K., Nathanson, K. and Zhang, N. (under review). Allele-specific copy number estimation by whole Exome sequencing.

This package implements the online Bayesian inference framework for joint state and parameter estimation in a stochastic Susceptible-Exposed-Infectious-Recovered (SEIR) epidemic model with a time-varying transmission rate. The log-transmission rate is modelled as a latent Ornstein-Uhlenbeck (OU) process with exact Gaussian discrete-time transitions. Inference is performed via the nested particle filter (NPF) of Crisan and Miguez (2018) <doi:10.3150/17-BEJ954>, which maintains an outer particle layer over the OU hyperparameters and, for each outer particle, an inner bootstrap filter over epidemic states. The Cori-style renewal-equation estimator follows Cori et al. (2013) <doi:10.1093/aje/kwt133>. The package also provides utilities for simulation, posterior summarisation, and forecasting.

This package provides an exact Goodness-of-Fit test for multinomial data with fixed probabilities. It can be used to determine whether a set of counts fits a given expected ratio. To see whether a set of observed counts fits an expectation, one can examine all possible outcomes with xmulti() or a random sample of them with xmonte() and find the probability of an observation deviating from the expectation by at least as much as the observed. As a measure of deviation from the expected, one can use the log-likelihood ratio, the multinomial probability, or the classic chi-square statistic. A histogram of the test statistic can also be plotted and compared with the asymptotic curve.

Interactions between proteins occur in many, if not most, biological processes. Most proteins perform their functions in networks associated with other proteins and other biomolecules. This fact has motivated the development of a variety of experimental methods for the identification of protein interactions. This variety has in turn ushered in the development of numerous different computational approaches for modeling and predicting protein interactions. Sometimes an experiment is aimed at identifying proteins closely related to some interesting proteins. A network based statistical learning method is used to infer the putative functions of proteins from the known functions of its neighboring proteins on a PPI network. This package identifies such proteins often involved in the same or similar biological functions.

Highly efficient functions for estimating various rank (centrality) measures of nodes in bipartite graphs (two-mode networks). Includes methods for estimating HITS, CoHITS, BGRM, and BiRank with implementation primarily inspired by He et al. (2016) <doi:10.1109/TKDE.2016.2611584>. Also provides easy-to-use tools for efficiently estimating PageRank in one-mode graphs, incorporating or removing edge-weights during rank estimation, projecting two-mode graphs to one-mode, and for converting edgelists and matrices to sparseMatrix format. Best of all, the package's rank estimators can work directly with common formats of network data including edgelists (class data.frame, data.table, or tbl_df) and adjacency matrices (class matrix or dgCMatrix).

Emissions are the mass of pollutants released into the atmosphere. Air quality models need emissions data, with spatial and temporal distribution, to represent air pollutant concentrations. This package, eixport, creates inputs for the air quality models WRF-Chem Grell et al (2005) <doi:10.1016/j.atmosenv.2005.04.027>, MUNICH Kim et al (2018) <doi:10.5194/gmd-11-611-2018> , BRAMS-SPM Freitas et al (2005) <doi:10.1016/j.atmosenv.2005.07.017> and RLINE Snyder et al (2013) <doi:10.1016/j.atmosenv.2013.05.074>. See the eixport website (<https://atmoschem.github.io/eixport/>) for more information, documentations and examples. More details in Ibarra-Espinosa et al (2018) <doi:10.21105/joss.00607>.

Fit occupancy models in Stan via brms'. The full variety of brms formula-based effects structures are available to use in multiple classes of occupancy model, including single-season models, models with data augmentation for never-observed species, dynamic (multiseason) models with explicit colonization and extinction processes, and dynamic models with autologistic occupancy dynamics. Formulas can be specified for all relevant distributional terms, including detection and one or more of occupancy, colonization, extinction, and autologistic depending on the model type. Several important forms of model post-processing are provided. References: Bürkner (2017) <doi:10.18637/jss.v080.i01>; Carpenter et al. (2017) <doi:10.18637/jss.v076.i01>; Socolar & Mills (2023) <doi:10.1101/2023.10.26.564080>.

This package implements the five-parameter Generalized Kumaraswamy ('gkw') distribution proposed by Carrasco, Ferrari and Cordeiro (2010) <doi:10.48550/arXiv.1004.0911> and its seven nested sub-families for modeling bounded continuous data on the unit interval (0,1). The gkw distribution extends the Kumaraswamy distribution described by Jones (2009) <doi:10.1016/j.stamet.2008.04.001>. Provides density, distribution, quantile, and random generation functions, along with analytical log-likelihood, gradient, and Hessian functions implemented in C++ via RcppArmadillo for maximum computational efficiency. Suitable for modeling proportions, rates, percentages, and indices exhibiting complex features such as asymmetry, or heavy tails and other shapes not adequately captured by standard distributions like simple Beta or Kumaraswamy.

This package provides a self-contained, static build of the HDF5 (Hierarchical Data Format 5) C library (release 2.2.0) for R package developers. Designed for use in the LinkingTo field, it enables zero-dependency integration by building the library entirely from source during installation. Additionally, it compiles and internally links a comprehensive suite of advanced compression filters and their HDF5 plugins (Zstd, LZ4, Blosc/Blosc2, Snappy, ZFP, Bzip2, LZF, Bitshuffle, szip, and gzip). These plugins are integrated out-of-the-box, allowing downstream packages to utilize high-performance compression directly through the standard HDF5 API while keeping the underlying third-party headers fully encapsulated. HDF5 is developed by The HDF Group <https://www.hdfgroup.org/>.