This package provides tools to visualize ordination results in R by adding covariance-based ellipses, centroids, vectors, and confidence regions to plots created with ggplot2'. The package extends the vegan framework and supports Principal Component Analysis (PCA), Redundancy Analysis (RDA), and Non-metric Multidimensional Scaling (NMDS). Ellipses can represent either group dispersion (standard deviation, SD) or centroid precision (standard error, SE), following Wang et al. (2015) <doi:10.1371/journal.pone.0118537>. Robust estimators of covariance are implemented, including the Minimum Covariance Determinant (MCD) method of Hubert et al. (2018) <doi:10.1002/wics.1421>. This approach reduces the influence of outliers. barrel is particularly useful for multivariate ecological datasets, promoting reproducible, publication-quality ordination graphics with minimal effort.

Box-Cox-type transformations for linear and logistic models with random effects using non-parametric profile maximum likelihood estimation, as introduced in Almohaimeed (2018) <http://etheses.dur.ac.uk/12831/> and Almohaimeed and Einbeck (2022) <doi:10.1177/1471082X20966919>. The main functions are optim.boxcox() for linear models with random effects and boxcoxtype() for logistic models with random effects.

Bayesian MCPMod (Fleischer et al. (2022) <doi:10.1002/pst.2193>) is an innovative method that improves the traditional MCPMod by systematically incorporating historical data, such as previous placebo group data. This package offers functions for simulating, analyzing, and evaluating Bayesian MCPMod trials with normally and binary distributed endpoints. It enables the assessment of trial designs incorporating historical data across various true dose-response relationships and sample sizes. Robust mixture prior distributions, such as those derived with the Meta-Analytic-Predictive approach (Schmidli et al. (2014) <doi:10.1111/biom.12242>), can be specified for each dose group. Resulting mixture posterior distributions are used in the Bayesian Multiple Comparison Procedure and modeling steps. The modeling step also includes a weighted model averaging approach (Pinheiro et al. (2014) <doi:10.1002/sim.6052>). Estimated dose-response relationships can be bootstrapped and visualized.

This package provides tools to design best-worst scaling designs (i.e., balanced incomplete block designs) and to analyze data from these designs, using aggregate and individual methods such as: difference scores, Louviere, Lings, Islam, Gudergan, & Flynn (2013) <doi:10.1016/j.ijresmar.2012.10.002>; analytical estimation, Lipovetsky & Conklin (2014) <doi:10.1016/j.jocm.2014.02.001>; empirical Bayes, Lipovetsky & Conklin (2015) <doi:10.1142/S1793536915500028>; Elo, Hollis (2018) <doi:10.3758/s13428-017-0898-2>; and network-based measures.

The proposed event-driven approach for Bayesian two-stage single-arm phase II trial design is a novel clinical trial design and can be regarded as an extension of the Simonâ s two-stage design with the time-to-event endpoint. This design is motivated by cancer clinical trials with immunotherapy and molecularly targeted therapy, in which time-to-event endpoint is often a desired endpoint.

Package for Bayesian Variable Selection and Model Averaging in linear models and generalized linear models using stochastic or deterministic sampling without replacement from posterior distributions. Prior distributions on coefficients are from Zellner's g-prior or mixtures of g-priors corresponding to the Zellner-Siow Cauchy Priors or the mixture of g-priors from Liang et al (2008) <DOI:10.1198/016214507000001337> for linear models or mixtures of g-priors from Li and Clyde (2019) <DOI:10.1080/01621459.2018.1469992> in generalized linear models. Other model selection criteria include AIC, BIC and Empirical Bayes estimates of g. Sampling probabilities may be updated based on the sampled models using sampling w/out replacement or an efficient MCMC algorithm which samples models using a tree structure of the model space as an efficient hash table. See Clyde, Ghosh and Littman (2010) <DOI:10.1198/jcgs.2010.09049> for details on the sampling algorithms. Uniform priors over all models or beta-binomial prior distributions on model size are allowed, and for large p truncated priors on the model space may be used to enforce sampling models that are full rank. The user may force variables to always be included in addition to imposing constraints that higher order interactions are included only if their parents are included in the model. This material is based upon work supported by the National Science Foundation under Division of Mathematical Sciences grant 1106891. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.

This package provides a chemical speciation and toxicity prediction model for the toxicity of metals to aquatic organisms. The Biotic Ligand Model (BLM) engine was originally programmed in PowerBasic by Robert Santore and others. The main way the BLM can be used is to predict the toxicity of a metal to an organism with a known sensitivity (i.e., it is known how much of that metal must accumulate on that organism's biotic ligand to cause a physiological effect in a certain percentage of the population, such as a 20% loss in reproduction or a 50% mortality rate). The second way the BLM can be used is to estimate the chemical speciation of the metal and other constituents in water, including estimating the amount of metal accumulated to an organism's biotic ligand during a toxicity test. In the first application of the BLM, the amount of metal associated with a toxicity endpoint, or regulatory limit will be predicted, while in the second application, the amount of metal is known and the portions of that metal that exist in various forms will be determined. This version of the engine has been re-structured to perform the calculations in a different way that will make it more efficient in R, while also making it more flexible and easier to maintain in the future. Because of this, it does not currently match the desktop model exactly, but we hope to improve this comparability in the future.

Compute multivariate location, scale, and correlation estimates based on Tukey's biweight M-estimator.

This package provides a curated collection of biodiversity and species-related datasets (birds, plants, reptiles, turtles, mammals, bees, marine data and related biological measurements), together with small utilities to load and explore them. The package gathers data sourced from public repositories (including Kaggle and well-known ecological/biological R packages) and standardizes access for researchers, educators, and data analysts working on biodiversity, biogeography, ecology and comparative biology. It aims to simplify reproducible workflows by packaging commonly used example datasets and metadata so they can be easily inspected, visualized, and used for teaching, testing, and prototyping analyses.

This package provides a toolbox for analyzing and simulating large networks based on hierarchical exponential-family random graph models (HERGMs).'bigergm implements the estimation for large networks efficiently building on the lighthergm and hergm packages. Moreover, the package contains tools for simulating networks with local dependence to assess the goodness-of-fit.

Biostatistical and clinical data analysis, including descriptive statistics, exploratory data analysis, sample size and power calculations, statistical inference, and data visualization. Normality tests are implemented following Mishra et al. (2019) <doi:10.4103/aca.ACA_157_18>, omnibus test procedures are based on Blanca et al. (2017) <doi:10.3758/s13428-017-0918-2> and Field et al. (2012, ISBN:9781446200469), while sample size and power calculation methods follow Chow et al. (2017) <doi:10.1201/9781315183084>.

Whitening is the first step of almost all blind source separation (BSS) methods. A fast implementation of whitening for BSS is implemented to serve as a lightweight dependency for packages providing BSS methods.

Adjust the Gamma regression models from a Bayesian perspective described by Cepeda and Urdinola (2012) <doi:10.1080/03610918.2011.600500>, modeling the parameters of mean and shape and using different link functions for the parameter associated to the mean. And calculates different adjustment statistics such as the Akaike information criterion and Bayesian information criterion.

Selecting linear and generalized linear models for large data sets using modified stepwise procedure and modern selection criteria (like modifications of Bayesian Information Criterion). Selection can be performed on data which exceed RAM capacity. Bogdan et al., (2004) <doi:10.1534/genetics.103.021683>.

Script search, corner, genetic optimization, permutation tests, write expect test.

This package provides a developing software suite for multiple change-point and change-point-type feature detection/estimation (data segmentation) in data sequences.

This package implements variable selection for high dimensional datasets with a binary response variable using the EM algorithm. Both probit and logit models are supported. Also included is a useful function to generate high dimensional data with correlated variables.

Estimation of association between disease or death counts (e.g. COVID-19) and socio-environmental risk factors using a zero-inflated Bayesian spatiotemporal model. Non-spatiotemporal models and/or models without zero-inflation are also included for comparison. Functions to produce corresponding maps are also included. See Chakraborty et al. (2022) <doi:10.1007/s13253-022-00487-1> for more details on the method.

Application of genome prediction for a continuous variable, focused on genotype by environment (GE) genomic selection models (GS). It consists a group of functions that help to create regression kernels for some GE genomic models proposed by Jarquà n et al. (2014) <doi:10.1007/s00122-013-2243-1> and Lopez-Cruz et al. (2015) <doi:10.1534/g3.114.016097>. Also, it computes genomic predictions based on Bayesian approaches. The prediction function uses an orthogonal transformation of the data and specific priors present by Cuevas et al. (2014) <doi:10.1534/g3.114.013094>.

This package provides tools for 3D imaging, mostly for biology/microscopy. Read and write TIFF stacks. Functions for segmentation, filtering and analyzing 3D point patterns.

Supervised learning using Boltzmann Bayes model inference, which extends naive Bayes model to include interactions. Enables classification of data into multiple response groups based on a large number of discrete predictors that can take factor values of heterogeneous levels. Either pseudo-likelihood or mean field inference can be used with L2 regularization, cross-validation, and prediction on new data. <doi:10.18637/jss.v101.i05>.

This package implements regression models for binary data on the absolute risk scale. These models are applicable to cohort and population-based case-control data.

This package provides classes and functions to work with biological sequences (DNA, RNA and amino acid sequences). Implements S3 infrastructure to work with biological sequences as described in Keck (2020) <doi:10.1111/2041-210X.13490>. Provides a collection of functions to perform biological conversion among classes (transcription, translation) and basic operations on sequences (detection, selection and replacement based on positions or patterns). The package also provides functions to import and export sequences from and to other package formats.

Description: Provides streamlined tools for retrieving sequences from NCBI, performing sequence alignments (pairwise and multiple), and building phylogenetic trees. Implements the Needleman-Wunsch algorithm for global alignment (Needleman & Wunsch (1970) <doi:10.1016/0022-2836(70)90057-4>), Smith-Waterman for local alignment (Smith & Waterman (1981) <doi:10.1016/0022-2836(81)90087-5>), and Neighbor-Joining for tree construction (Saitou & Nei (1987) <doi:10.1093/oxfordjournals.molbev.a040454>).