Analyze bioequivalence study data with industrial strength. Sample size could be determined for various crossover designs, such as 2x2 design, 2x4 design, 4x4 design, Balaam design, Two-sequence dual design, and William design. Reference: Chow SC, Liu JP. Design and Analysis of Bioavailability and Bioequivalence Studies. 3rd ed. (2009, ISBN:978-1-58488-668-6).

This is an implementation of design methods for binomial reliability demonstration tests (BRDTs) with failure count data. The acceptance decision uncertainty of BRDT has been quantified and the impacts of the uncertainty on related reliability assurance activities such as reliability growth (RG) and warranty services (WS) are evaluated. This package is associated with the work from the published paper "Optimal Binomial Reliability Demonstration Tests Design under Acceptance Decision Uncertainty" by Suiyao Chen et al. (2020) <doi:10.1080/08982112.2020.1757703>.

This package provides tools for bioinformatics modeling using recursive transformer-inspired architectures, autoencoders, random forests, XGBoost, and stacked ensemble models. Includes utilities for cross-validation, calibration, benchmarking, and threshold optimization in predictive modeling workflows. The methodology builds on ensemble learning (Breiman 2001 <doi:10.1023/A:1010933404324>), gradient boosting (Chen and Guestrin 2016 <doi:10.1145/2939672.2939785>), autoencoders (Hinton and Salakhutdinov 2006 <doi:10.1126/science.1127647>), and recursive transformer efficiency approaches such as Mixture-of-Recursions (Bae et al. 2025 <doi:10.48550/arXiv.2507.10524>).

This package provides a two-step Bayesian approach for mode inference following Cross, Hoogerheide, Labonne and van Dijk (2024) <doi:10.1016/j.econlet.2024.111579>). First, a mixture distribution is fitted on the data using a sparse finite mixture (SFM) Markov chain Monte Carlo (MCMC) algorithm. The number of mixture components does not have to be known; the size of the mixture is estimated endogenously through the SFM approach. Second, the modes of the estimated mixture at each MCMC draw are retrieved using algorithms specifically tailored for mode detection. These estimates are then used to construct posterior probabilities for the number of modes, their locations and uncertainties, providing a powerful tool for mode inference.

Fitting Bayesian multiple and mixed-effect regression models for circular data based on the projected normal distribution. Both continuous and categorical predictors can be included. Sampling from the posterior is performed via an MCMC algorithm. Posterior descriptives of all parameters, model fit statistics and Bayes factors for hypothesis tests for inequality constrained hypotheses are provided. See Cremers, Mulder & Klugkist (2018) <doi:10.1111/bmsp.12108> and Nuñez-Antonio & Guttiérez-Peña (2014) <doi:10.1016/j.csda.2012.07.025>.

Implementations of Bayesian parametric, nonparametric and semiparametric procedures for univariate and multivariate time series. The package is based on the methods presented in C. Kirch et al (2018) <doi:10.1214/18-BA1126>, A. Meier (2018) <https://opendata.uni-halle.de//handle/1981185920/13470> and Y. Tang et al (2023) <doi:10.48550/arXiv.2303.11561>. It was supported by DFG grants KI 1443/3-1 and KI 1443/3-2.

This package provides functions to construct efficient block designs for 3-level factorial experiments in block size 3. The designs ensure the estimation of all main effects and two-factor interactions in minimum number of replications. For more details, see Dey and Mukerjee (2012) <doi:10.1016/j.spl.2012.06.014> and Dash, S., Parsad, R. and Gupta, V.K. (2013) <doi:10.1007/s40003-013-0059-5>.

Allows users to easily visualize data from the BLS (United States of America Bureau of Labor Statistics) <https://www.bls.gov>. Currently unemployment data series U1-U6 are available. Not affiliated with the Bureau of Labor Statistics or United States Government.

This package produces an economic evaluation of a sample of suitable variables of cost and effectiveness / utility for two or more interventions, e.g. from a Bayesian model in the form of MCMC simulations. This package computes the most cost-effective alternative and produces graphical summaries and probabilistic sensitivity analysis, see Baio et al (2017) <doi:10.1007/978-3-319-55718-2>.

The BACCO bundle of packages is replaced by the BACCO package, which provides a vignette that illustrates the constituent packages (emulator, approximator, calibrator) in use.

This package provides functions to compute pair-wise dissimilarities (distance matrices) and multiple-site dissimilarities, separating the turnover and nestedness-resultant components of taxonomic (incidence and abundance based), functional and phylogenetic beta diversity.

Maleknia et al. (2020) <doi:10.1101/2020.01.13.905448>. A novel pathway enrichment analysis package based on Bayesian network to investigate the topology features of the pathways. firstly, 187 kyoto encyclopedia of genes and genomes (KEGG) human non-metabolic pathways which their cycles were eliminated by biological approach, enter in analysis as Bayesian network structures. The constructed Bayesian network were optimized by the Least Absolute Shrinkage Selector Operator (lasso) and the parameters were learned based on gene expression data. Finally, the impacted pathways were enriched by Fisherâ s Exact Test on significant parameters.

Computes Bayesian A- and D-optimal block designs under the linear mixed effects model settings using block/array exchange algorithm of Debusho, Gemechu and Haines (2018) <doi:10.1080/03610918.2018.1429617> and Gemechu, Debusho and Haines (2025) <doi:10.5539/ijsp.v14n1p50> where the interest is in a comparison of all possible elementary treatment contrasts. The package also provides an optional method of using the graphical user interface (GUI) R package tcltk to ensure that it is user friendly.

Fit Bayesian models with a focus on the spatial econometric models.

Data on multiple individuals through time are often sampled at times that differ between persons. Irregular observation times can severely complicate the statistical analysis of the data. The broken stick model approximates each subjectâ s trajectory by one or more connected line segments. The times at which segments connect (breakpoints) are identical for all subjects and under control of the user. A well-fitting broken stick model effectively transforms individual measurements made at irregular times into regular trajectories with common observation times. Specification of the model requires three variables: time, measurement and subject. The model is a special case of the linear mixed model, with time as a linear B-spline and subject as the grouping factor. The main assumptions are: subjects are exchangeable, trajectories between consecutive breakpoints are straight, random effects follow a multivariate normal distribution, and unobserved data are missing at random. The package contains functions for fitting the broken stick model to data, for predicting curves in new data and for plotting broken stick estimates. The package supports two optimization methods, and includes options to structure the variance-covariance matrix of the random effects. The analyst may use the software to smooth growth curves by a series of connected straight lines, to align irregularly observed curves to a common time grid, to create synthetic curves at a user-specified set of breakpoints, to estimate the time-to-time correlation matrix and to predict future observations. See <doi:10.18637/jss.v106.i07> for additional documentation on background, methodology and applications.

Producing probabilistic projections of net migration rate for all countries of the world or for subnational units using a Bayesian hierarchical model by Azose an Raftery (2015) <doi:10.1007/s13524-015-0415-0>.

This package provides tools for statistical analysis using the binscatter methods developed by Cattaneo, Crump, Farrell and Feng (2024a) <doi:10.48550/arXiv.1902.09608>, Cattaneo, Crump, Farrell and Feng (2024b) <https://nppackages.github.io/references/Cattaneo-Crump-Farrell-Feng_2024_NonlinearBinscatter.pdf> and Cattaneo, Crump, Farrell and Feng (2024c) <doi:10.48550/arXiv.1902.09615>. Binscatter provides a flexible way of describing the relationship between two variables based on partitioning/binning of the independent variable of interest. binsreg(), binsqreg() and binsglm() implement binscatter least squares regression, quantile regression and generalized linear regression respectively, with particular focus on constructing binned scatter plots. They also implement robust (pointwise and uniform) inference of regression functions and derivatives thereof. binstest() implements hypothesis testing procedures for parametric functional forms of and nonparametric shape restrictions on the regression function. binspwc() implements hypothesis testing procedures for pairwise group comparison of binscatter estimators. binsregselect() implements data-driven procedures for selecting the number of bins for binscatter estimation. All the commands allow for covariate adjustment, smoothness restrictions and clustering.

From R 4.5.0, the datasets package includes the penguins and penguins_raw data sets popularised in the palmerpenguins package. basepenguins takes files that use the palmerpenguins package and converts them to work with the versions from datasets ('R >= 4.5.0). It does this by removing calls to library(palmerpenguins) and making the necessary changes to column names. Additionally, it provides helper functions to define new files paths for saving the output and a directory of example files to experiment with.

Primarily created as an easy and understanding way to do basic sequences surrounding the central dogma of molecular biology.

Prevents and detects information leakage in biomedical machine learning. Provides leakage-resistant split policies (subject-grouped, batch-blocked, study leave-out, time-ordered), guarded preprocessing (train-only imputation, normalization, filtering, feature selection), cross-validated fitting with common learners, permutation-gap auditing, batch and fold association tests, and duplicate detection.

This package provides an alternative approach to aoristic analyses for archaeological datasets by fitting Bayesian parametric growth models and non-parametric random-walk Intrinsic Conditional Autoregressive (ICAR) models on time frequency data (Crema (2024)<doi:10.1111/arcm.12984>). It handles event typo-chronology based timespans defined by start/end date as well as more complex user-provided vector of probabilities.

Frequentist inference on adaptively generated data. The methods implemented are based on Zhan et al. (2021) <doi:10.48550/arXiv.2106.02029> and Hadad et al. (2021) <doi:10.48550/arXiv.1911.02768>. For illustration, several functions for simulating non-contextual and contextual adaptive experiments using Thompson sampling are also supplied.

Creating spatially or environmentally separated folds for cross-validation to provide a robust error estimation in spatially structured environments; Investigating and visualising the effective range of spatial autocorrelation in continuous raster covariates and point samples to find an initial realistic distance band to separate training and testing datasets spatially described in Valavi, R. et al. (2019) <doi:10.1111/2041-210X.13107>.

This package implements an S3 class based on data.table to store and process efficiently ethomics (high-throughput behavioural) data.