This package provides computational tools to generate efficient blocked and unblocked fractional factorial designs for two-level and three-level factors using the generalized Minimum Aberration (MA) criterion and related optimization algorithms. Methodological foundations include the general theory of minimum aberration as described by Cheng and Tang (2005) <doi:10.1214/009053604000001228>, and the catalogue of three-level regular fractional factorial designs developed by Xu (2005) <doi:10.1007/s00184-005-0408-x>. The main functions dol2() and dol3() generate blocked two-level and three-level fractional factorial designs, respectively, using beam search, optimization-based ranking, confounding assessment, and structured output suitable for complete factorial situations.

Adjusting the bias due to residual confounding (often called treatment selection bias) in estimating the treatment effect in a proportional hazard model, as described in Williamson et al. (2022) <doi:10.1158/1078-0432.ccr-21-2468>.

This package provides a practical tool for estimating the burden of common communicable diseases in settlements of displaced populations. An online version of the tool can be found at <http://who-refugee-bod.ecdf.ed.ac.uk/shiny/app/>. Estimates of burden of disease aim to synthesize data about cause-specific morbidity and mortality through a systematic approach that enables evidence-based decisions and comparisons across settings. The focus of this tool is on four acute communicable diseases and syndromes, including Acute respiratory infections, Acute diarrheal diseases, Acute jaundice syndrome and Acute febrile illnesses.

Statistical classification and regression have been popular among various fields and stayed in the limelight of scientists of those fields. Examples of the fields include clinical trials where the statistical classification of patients is indispensable to predict the clinical courses of diseases. Considering the negative impact of diseases on performing daily tasks, correctly classifying patients based on the clinical information is vital in that we need to identify patients of the high-risk group to develop a severe state and arrange medical treatment for them at an opportune moment. Deep learning - a part of artificial intelligence - has gained much attention, and research on it burgeons during past decades: see, e.g, Kazemi and Mirroshandel (2018) <DOI:10.1016/j.artmed.2017.12.001>. It is a veritable technique which was originally designed for the classification, and hence, the Buddle package can provide sublime solutions to various challenging classification and regression problems encountered in the clinical trials. The Buddle package is based on the back-propagation algorithm - together with various powerful techniques such as batch normalization and dropout - which performs a multi-layer feed-forward neural network: see Krizhevsky et. al (2017) <DOI:10.1145/3065386>, Schmidhuber (2015) <DOI:10.1016/j.neunet.2014.09.003> and LeCun et al. (1998) <DOI:10.1109/5.726791> for more details. This package contains two main functions: TrainBuddle() and FetchBuddle(). TrainBuddle() builds a feed-forward neural network model and trains the model. FetchBuddle() recalls the trained model which is the output of TrainBuddle(), classifies or regresses given data, and make a final prediction for the data.

Bayesian optimal design with futility and efficacy stopping boundaries (BOP2-FE) is a novel statistical framework for single-arm Phase II clinical trials. It enables early termination for efficacy when interim data are promising, while explicitly controlling Type I and Type II error rates. The design supports a variety of endpoint structures, including single binary endpoints, nested endpoints, co-primary endpoints, and joint monitoring of efficacy and toxicity. The package provides tools for enumerating stopping boundaries prior to trial initiation and for conducting simulation studies to evaluate the designâ s operating characteristics. Users can flexibly specify design parameters to suit their specific applications. For methodological details, refer to Xu et al. (2025) <doi:10.1080/10543406.2025.2558142>.

This package provides tools for optimal and approximate state estimation as well as network inference of Partially-Observed Boolean Dynamical Systems.

This package provides comprehensive tools for Bayesian model diagnostics and comparison. Includes prior sensitivity analysis, posterior predictive checks (Gelman et al. (2013) <doi:10.1201/b16018>), advanced model comparison using Pareto-smoothed importance sampling leave-one-out cross-validation (Vehtari et al. (2017) <doi:10.1007/s11222-016-9696-4>), convergence diagnostics, and prior elicitation tools. Integrates with brms (Burkner (2017) <doi:10.18637/jss.v080.i01>), rstan', and rstanarm packages for comprehensive Bayesian workflow diagnostics.

Developed for the following tasks. 1- Simulating and computing the maximum likelihood estimator for the Birnbaum-Saunders (BS) distribution, 2- Computing the Bayesian estimator for the parameters of the BS distribution based on reference prior proposed by Xu and Tang (2010) <doi:10.1016/j.csda.2009.08.004> and conjugate prior. 3- Computing the Bayesian estimator for the BS distribution based on conjugate prior. 4- Computing the Bayesian estimator for the BS distribution based on Jeffrey prior given by Achcar (1993) <doi:10.1016/0167-9473(93)90170-X> 5- Computing the Bayesian estimator for the BS distribution under progressive type-II censoring scheme.

This package implements the Bayesian Augmented Control (BAC, a.k.a. Bayesian historical data borrowing) method under clinical trial setting by calling Just Another Gibbs Sampler ('JAGS') software. In addition, the BACCT package evaluates user-specified decision rules by computing the type-I error/power, or probability of correct go/no-go decision at interim look. The evaluation can be presented numerically or graphically. Users need to have JAGS 4.0.0 or newer installed due to a compatibility issue with rjags package. Currently, the package implements the BAC method for binary outcome only. Support for continuous and survival endpoints will be added in future releases. We would like to thank AbbVie's Statistical Innovation group and Clinical Statistics group for their support in developing the BACCT package.

This package provides a suite of open-source R functions designed to produce standard metrics for forest management and ecology from forest inventory data. The overarching goal is to minimize potential inconsistencies introduced by the algorithms used to compute and summarize core forest metrics. Learn more about the purpose of the package and the specific algorithms used in the package at <https://github.com/kearutherford/BerkeleyForestsAnalytics>.

Runs hierarchical linear Bayesian models. Samples from the posterior distributions of model parameters in JAGS (Just Another Gibbs Sampler; Plummer, 2017, <http://mcmc-jags.sourceforge.net>). Computes Bayes factors for group parameters of interest with the Savage-Dickey density ratio (Wetzels, Raaijmakers, Jakab, Wagenmakers, 2009, <doi:10.3758/PBR.16.4.752>).

Algorithms for computing and generating plots with and without error bars for Bayesian cluster validity index (BCVI) (O. Preedasawakul, and N. Wiroonsri, A Bayesian Cluster Validity Index, Computational Statistics & Data Analysis, 202, 108053, 2025. <doi:10.1016/j.csda.2024.108053>) based on several underlying cluster validity indexes (CVIs) including Calinski-Harabasz, Chou-Su-Lai, Davies-Bouldin, Dunn, Pakhira-Bandyopadhyay-Maulik, Point biserial correlation, the score function, Starczewski, and Wiroonsri indices for hard clustering, and Correlation Cluster Validity, the generalized C, HF, KWON, KWON2, Modified Pakhira-Bandyopadhyay-Maulik, Pakhira-Bandyopadhyay-Maulik, Tang, Wiroonsri-Preedasawakul, Wu-Li, and Xie-Beni indices for soft clustering. The package is compatible with K-means, fuzzy C means, EM clustering, and hierarchical clustering (single, average, and complete linkage). Though BCVI is compatible with any underlying existing CVIs, we recommend users to use either WI or WP as the underlying CVI.

This package provides datasets and functions used for analysis and visualizations in the Bayes Rules! book (<https://www.bayesrulesbook.com>). The package contains a set of functions that summarize and plot Bayesian models from some conjugate families and another set of functions for evaluation of some Bayesian models.

Model agnostic tool for decomposition of predictions from black boxes. Break Down Table shows contributions of every variable to a final prediction. Break Down Plot presents variable contributions in a concise graphical way. This package work for binary classifiers and general regression models.

This package implements the Bayesian FDR control described by Newton et al. (2004), <doi:10.1093/biostatistics/5.2.155>. Allows optimisation and visualisation of expected error rates based on tail posterior probability tests. Based on code written by Catalina Vallejos for BASiCS, see Beyond comparisons of means: understanding changes in gene expression at the single-cell level Vallejos et al. (2016) <doi:10.1186/s13059-016-0930-3>.

Regression for data too large to fit in memory. This package functions exactly like the biglm package, but works with later versions of R.

Some elementary matrix algebra tools are implemented to manage block matrices or partitioned matrix, i.e. "matrix of matrices" (http://en.wikipedia.org/wiki/Block_matrix). The block matrix is here defined as a new S3 object. In this package, some methods for "matrix" object are rewritten for "blockmatrix" object. New methods are implemented. This package was created to solve equation systems with block matrices for the analysis of environmental vector time series . Bugs/comments/questions/collaboration of any kind are warmly welcomed.

Response surface methods for drug synergy analysis. Available methods include generalized and classical Loewe formulations as well as Highest Single Agent methodology. Response surfaces can be plotted in an interactive 3-D plot and formal statistical tests for presence of synergistic effects are available. Implemented methods and tests are described in the article "BIGL: Biochemically Intuitive Generalized Loewe null model for prediction of the expected combined effect compatible with partial agonism and antagonism" by Koen Van der Borght, Annelies Tourny, Rytis Bagdziunas, Olivier Thas, Maxim Nazarov, Heather Turner, Bie Verbist & Hugo Ceulemans (2017) <doi:10.1038/s41598-017-18068-5>.

This package provides a Bayesian version of the analysis of variance based on a three-component Gaussian mixture for which a Gibbs sampler produces posterior draws. For details about the Bayesian ANOVA based on Gaussian mixtures, see Kelter (2019) <arXiv:1906.07524>.

Calculates the necessary quantities to perform Bayesian multigroup equivalence testing. Currently the package includes the Bayesian models and equivalence criteria outlined in Pourmohamad and Lee (2023) <doi:10.1002/sta4.645>, but more models and equivalence testing features may be added over time.

Calculates nonparametric pointwise confidence intervals for the survival distribution for right censored data, and for medians [Fay and Brittain <DOI:10.1002/sim.6905>]. Has two-sample tests for dissimilarity (e.g., difference, ratio or odds ratio) in survival at a fixed time, and differences in medians [Fay, Proschan, and Brittain <DOI:10.1111/biom.12231>]. Basically, the package gives exact inference methods for one- and two-sample exact inferences for Kaplan-Meier curves (e.g., generalizing Fisher's exact test to allow for right censoring), which are especially important for latter parts of the survival curve, small sample sizes or heavily censored data. Includes mid-p options.

Various supervised and unsupervised binning tools including using entropy, recursive partition methods and clustering.

This package implements two algorithms of detecting Bull and Bear markets in stock prices: the algorithm of Pagan and Sossounov (2002, <doi:10.1002/jae.664>) and the algorithm of Lunde and Timmermann (2004, <doi:10.1198/073500104000000136>). The package also contains functions for printing out the dating of the Bull and Bear states of the market, the descriptive statistics of the states, and functions for plotting the results. For the sake of convenience, the package includes the monthly and daily data on the prices (not adjusted for dividends) of the S&P 500 stock market index.

This package provides functions to plot and help understand positive and negative predictive values (PPV and NPV), and their relationship with sensitivity, specificity, and prevalence. See Akobeng, A.K. (2007) <doi:10.1111/j.1651-2227.2006.00180.x> for a theoretical overview of the technical concepts and Navarrete et al. (2015) for a practical explanation about the importance of their understanding <doi:10.3389/fpsyg.2015.01327>.