Combines taxonomic classifications of high-throughput 16S rRNA gene sequences with reference proteomes of archaeal and bacterial taxa to generate amino acid compositions of community reference proteomes. Calculates chemical metrics including carbon oxidation state ('Zc'), stoichiometric oxidation and hydration state ('nO2 and nH2O'), H/C, N/C, O/C, and S/C ratios, grand average of hydropathicity ('GRAVY'), isoelectric point ('pI'), protein length, and average molecular weight of amino acid residues. Uses precomputed reference proteomes for archaea and bacteria derived from the Genome Taxonomy Database ('GTDB'). Also includes reference proteomes derived from the NCBI Reference Sequence ('RefSeq') database and manual mapping from the RDP Classifier training set to RefSeq taxonomy as described by Dick and Tan (2023) <doi:10.1007/s00248-022-01988-9>. Processes taxonomic classifications in RDP Classifier format or OTU tables in phyloseq-class objects from the Bioconductor package phyloseq'.

This package provides core computational operations in C++ via RcppArmadillo', enabling faster performance than pure R, improved numerical stability, and parallel execution with OpenMP where available. On systems without OpenMP support, the package automatically falls back to single-threaded execution with no user configuration required. For efficient model selection, it integrates with CVST to provide sequential-testing cross-validation and additionally supports restricted maximum likelihood (REML) for continuous optimization of the regularization parameter. The package offers a unified interface for exact kernel ridge regression and three scalable approximationsâ Nyström, Pivoted Cholesky, and Random Fourier Featuresâ allowing analyses with substantially larger sample sizes than are feasible with exact KRR. It also integrates with the tidymodels ecosystem via the parsnip model specification krr_reg', and the S3 method tunable.krr_reg(). To understand the theoretical background, one can refer to Wainwright (2019) <doi:10.1017/9781108627771>.

Goodness-of-fit tests for an arbitrary user-specified continuous distribution under Type-II right- or left-censoring. Implements the transformation-based method of Lin, Huang and Balakrishnan (2008) <doi:10.1109/TR.2008.2005860>, which uses a property of order statistics due to Malmquist (1950) to convert an r-out-of-n Type-II censored uniform sample into a complete sample of size r, alongside the earlier transformation of Michael and Schucany (1979) <doi:10.1080/00401706.1979.10489813>. Also implements the direct (untransformed) censored-sample statistics of Barr and Davidson (1973) <doi:10.1080/00401706.1973.10489108> and Pettitt and Stephens (1976) <doi:10.1093/biomet/63.2.291>, and the modified-statistic maximum-likelihood procedure of Chen and Balakrishnan (1995) for testing composite hypotheses. General background on empirical-distribution-function goodness-of-fit methods follows D'Agostino and Stephens (1986, ISBN:982-0-8247-7487-5).

This package provides methods for simultaneous clustering and dimensionality reduction such as: Double k-means, Reduced k-means, Factorial k-means, Clustering with Disjoint PCA but also methods for exclusively dimensionality reduction: Disjoint PCA, Disjoint FA. The statistical methods implemented refer to the following articles: de Soete G., Carroll J. (1994) "K-means clustering in a low-dimensional Euclidean space" <doi:10.1007/978-3-642-51175-2_24> ; Vichi M. (2001) "Double k-means Clustering for Simultaneous Classification of Objects and Variables" <doi:10.1007/978-3-642-59471-7_6> ; Vichi M., Kiers H.A.L. (2001) "Factorial k-means analysis for two-way data" <doi:10.1016/S0167-9473(00)00064-5> ; Vichi M., Saporta G. (2009) "Clustering and disjoint principal component analysis" <doi:10.1016/j.csda.2008.05.028> ; Vichi M. (2017) "Disjoint factor analysis with cross-loadings" <doi:10.1007/s11634-016-0263-9>.

Runs ecological niche models over all combinations of user-defined settings (i.e., tuning), performs cross validation to evaluate models, and returns data tables to aid in selection of optimal model settings that balance goodness-of-fit and model complexity. Also has functions to partition data spatially (or not) for cross validation, to plot multiple visualizations of results, to run null models to estimate significance and effect sizes of performance metrics, and to calculate range overlap between model predictions, among others. The package was originally built for Maxent models (Phillips et al. 2006, Phillips et al. 2017), but the current version allows possible extensions for any modeling algorithm. The extensive vignette, which guides users through most package functionality but unfortunately has a file size too big for CRAN, can be found here on the package's Github Pages website: <https://jamiemkass.github.io/ENMeval/articles/ENMeval-2.0-vignette.html>.

Easily explore data by plotting graphs with a few lines of code. Use these ggplot() wrappers to quickly draw graphs of scatter/dots with box-whiskers, violins or SD error bars, data distributions, before-after graphs, factorial ANOVA and more. Customise graphs in many ways, for example, by choosing from colour blind-friendly palettes (12 discreet, 3 continuous and 2 divergent palettes). Use the simple code for ANOVA as ordinary (lm()) or mixed-effects linear models (lmer()), including randomised-block or repeated-measures designs, and fit non-linear outcomes as a generalised additive model (gam) using mgcv(). Obtain estimated marginal means and perform post-hoc comparisons on fitted models (via emmeans()). Also includes small datasets for practising code and teaching basics before users move on to more complex designs. See vignettes for details on usage <https://grafify.shenoylab.com/>. Citation: <doi:10.5281/zenodo.5136508>.

This package provides functions to compute p-values based on permutation tests. Regression, ANOVA and ANCOVA, omnibus F-tests, marginal unilateral and bilateral t-tests are available. Several methods to handle nuisance variables are implemented (Kherad-Pajouh, S., & Renaud, O. (2010) <doi:10.1016/j.csda.2010.02.015> ; Kherad-Pajouh, S., & Renaud, O. (2014) <doi:10.1007/s00362-014-0617-3> ; Winkler, A. M., Ridgway, G. R., Webster, M. A., Smith, S. M., & Nichols, T. E. (2014) <doi:10.1016/j.neuroimage.2014.01.060>). An extension for the comparison of signals issued from experimental conditions (e.g. EEG/ERP signals) is provided. Several corrections for multiple testing are possible, including the cluster-mass statistic (Maris, E., & Oostenveld, R. (2007) <doi:10.1016/j.jneumeth.2007.03.024>) and the threshold-free cluster enhancement (Smith, S. M., & Nichols, T. E. (2009) <doi:10.1016/j.neuroimage.2008.03.061>).

This package contains performance analysis metrics of track records including entropy-based correlation and dynamic beta based on a state/space algorithm. The normalized sample entropy method has been implemented which produces accurate entropy estimation even on smaller datasets. On a separate stream, trades from the five major assets classes and also functionality to use pricing curves, rating tables, Credit Support Annex and add-on tables. The implementation follows an object oriented logic whereby each trade inherits from more abstract classes while also the curves/tables are objects. Furthermore, odds calculators and P&L back-testing functionality has been implemented for the most widely used betting/trading strategies including martingale, DAlembert', Labouchere and Fibonacci. Back testing has also been included for the EuroMillions', the EuroJackpot', the UK Lotto, the Set For Life and the UK ThunderBall lotteries. Furthermore, some basic functionality about climate risk has been included.

BioNERO aims to integrate all aspects of biological network inference in a single package, including data preprocessing, exploratory analyses, network inference, and analyses for biological interpretations. BioNERO can be used to infer gene coexpression networks (GCNs) and gene regulatory networks (GRNs) from gene expression data. Additionally, it can be used to explore topological properties of protein-protein interaction (PPI) networks. GCN inference relies on the popular WGCNA algorithm. GRN inference is based on the "wisdom of the crowds" principle, which consists in inferring GRNs with multiple algorithms (here, CLR, GENIE3 and ARACNE) and calculating the average rank for each interaction pair. As all steps of network analyses are included in this package, BioNERO makes users avoid having to learn the syntaxes of several packages and how to communicate between them. Finally, users can also identify consensus modules across independent expression sets and calculate intra and interspecies module preservation statistics between different networks.

Automatic fixed rank kriging for (irregularly located) spatial data using a class of basis functions with multi-resolution features and ordered in terms of their resolutions. The model parameters are estimated by maximum likelihood (ML) and the number of basis functions is determined by Akaike's information criterion (AIC). For spatial data with either one realization or independent replicates, the ML estimates and AIC are efficiently computed using their closed-form expressions when no missing value occurs. Details regarding the basis function construction, parameter estimation, and AIC calculation can be found in Tzeng and Huang (2018) <doi:10.1080/00401706.2017.1345701>. For data with missing values, the ML estimates are obtained using the expectation- maximization algorithm. Apart from the number of basis functions, there are no other tuning parameters, making the method fully automatic. Users can also include a stationary structure in the spatial covariance, which utilizes LatticeKrig package.

Fits high dimensional penalized generalized linear mixed models using the Monte Carlo Expectation Conditional Minimization (MCECM) algorithm. The purpose of the package is to perform variable selection on both the fixed and random effects simultaneously for generalized linear mixed models. The package supports fitting of Binomial, Gaussian, and Poisson data with canonical links, and supports penalization using the MCP, SCAD, or LASSO penalties. The MCECM algorithm is described in Rashid et al. (2020) <doi:10.1080/01621459.2019.1671197>. The techniques used in the minimization portion of the procedure (the M-step) are derived from the procedures of the ncvreg package (Breheny and Huang (2011) <doi:10.1214/10-AOAS388>) and grpreg package (Breheny and Huang (2015) <doi:10.1007/s11222-013-9424-2>), with appropriate modifications to account for the estimation and penalization of the random effects. The ncvreg and grpreg packages also describe the MCP, SCAD, and LASSO penalties.

The Row-column designs are widely recommended for experimental situations when there are two well-identified factors that are cross-classified representing known sources of variability. These designs are expected to result a gain in accuracy of estimating treatment comparisons in an experiment as they eliminate the effects of the row and column factors. However, these designs are not readily available when the number of treatments is more than the levels of row and column blocking factors. This package named iRoCoDe generates row-column designs with incomplete rows and columns, by amalgamating two incomplete block designs (D1 and D2). The selection of D1 and D2 (the input designs) can be done from the available incomplete block designs, viz., balanced incomplete block designs/ partially balanced incomplete block designs/ t-designs. (Mcsorley, J.P., Phillips, N.C., Wallis, W.D. and Yucas, J.L. (2005).<doi:10.1007/s10623-003-6149-9>).

This package provides a Bayesian analysis for Q methodology, alongside the classical one. Models the forced Q sort as an ordered partition of the statements through an exact rank-order likelihood (the design quotas fix the partition margins, so the likelihood of the observed sorting event is exact), fits it by a parameter-expanded Gibbs sampler in R with no compiled code and a convergence gate on rotation-invariant functionals, resolves rotational ambiguity via the MatchAlign post-processing of Poworoznek et al. (2025) <doi:10.1214/25-BA1544>, and returns the familiar Q tables as posterior summaries: credible intervals for bounded participant loadings, flag probabilities with an explicit unclassified state, quota-respecting factor arrays, distinguishing and consensus statements judged against a posterior critical difference and a grid-width equivalence region, one posterior false-discovery rule for all published claims, and a two-signal posterior-predictive workflow for the number of factors.

This package provides tools for performing consensus clustering on multiple imputed datasets. The package supports a range of clustering algorithms across imputations, including hierarchical methods (e.g., Ward, single, complete, average) and partition-based approaches such as k-means, k-medoids (PAM), fuzzy clustering, model-based clustering ('mclust'), and methods for mixed or categorical data (k-modes and k-prototypes). A co-assignment matrix is constructed to quantify agreement between partitions, and consensus solutions are derived via hierarchical clustering applied to the resulting dissimilarity matrix. Additional functions are provided for validation and visualization of clustering results, facilitating robust analysis in the presence of missing data. Consensus clustering framework is based on Monti et al. (2003) <doi:10.1023/A:1023949509487>, rank aggregation methods follow Pihur et al. (2007) <doi:10.1093/bioinformatics/btm158>, and the PAC (Proportion of Ambiguous Clustering) metric is based on Senbabaoglu et al. (2014) <doi:10.1038/srep06207>.

This package implements the self-validated elastic-net and relaxed elastic-net ensemble modeling and multi-response optimization workflow described in Karl (2026) <doi:10.1016/j.chemolab.2026.105660>. Self-validated ensemble models (SVEM; Lemkus et al. (2021) <doi:10.1016/j.chemolab.2021.104439>) are fitted for small-sample design-of-experiments and related workflows using glmnet (Friedman et al. (2010) <doi:10.18637/jss.v033.i01>). Fractional random-weight bootstraps with anti-correlated validation copies are used to tune penalty paths by validation-weighted AIC/BIC. Supports Gaussian and binomial responses, deterministic expansion helpers for shared factor spaces, prediction with bootstrap uncertainty, and a random-search optimizer that respects mixture constraints and combines multiple responses via desirability functions. Also includes a permutation-based whole-model test for Gaussian SVEM fits (Karl (2024) <doi:10.1016/j.chemolab.2024.105122>). Package code was drafted with assistance from generative AI tools.

The cfTools R package provides methods for cell-free DNA (cfDNA) methylation data analysis to facilitate cfDNA-based studies. Given the methylation sequencing data of a cfDNA sample, for each cancer marker or tissue marker, we deconvolve the tumor-derived or tissue-specific reads from all reads falling in the marker region. Our read-based deconvolution algorithm exploits the pervasiveness of DNA methylation for signal enhancement, therefore can sensitively identify a trace amount of tumor-specific or tissue-specific cfDNA in plasma. cfTools provides functions for (1) cancer detection: sensitively detect tumor-derived cfDNA and estimate the tumor-derived cfDNA fraction (tumor burden); (2) tissue deconvolution: infer the tissue type composition and the cfDNA fraction of multiple tissue types for a plasma cfDNA sample. These functions can serve as foundations for more advanced cfDNA-based studies, including cancer diagnosis and disease monitoring.

Easy application of Bayesian inference for functional responses via brms'. This package allows to fit various FR models for single- and multi-prey experiments by providing nonlinear prediction functions for brms'. It uses dynamical prediction models to correct for prey depletion. The brms framework facilitates statistical modeling and enables users to conveniently incorporate covariates such as temperature gradients, experimental treatment variables, or random effects that account for grouping in experimental units. Default brms functions make it easy to perform model checking, model comparison and hypothesis testing. Potential statistical issues with data from feeding trials, such as overdispersion, can be resolved by effortlessly switching between likelihood functions. This package, together with its tutorials, should provide students and researchers with a comprehensive and integrated statistical framework for easily testing their hypotheses on trophic interactions. References: Rosenbaum and Rall (2018) <doi:10.1111/2041-210X.13039>; Rosenbaum et al. (2024) <doi:10.1111/2041-210X.14372>.

This package provides a collection of synthetic datasets simulating sales transactions from a fictional company. The dataset includes various related tables that contain essential business and operational data, useful for analyzing sales performance and other business insights. Key tables included in the package are: - "sales": Contains data on individual sales transactions, including order details, pricing, quantities, and customer information. - "customer": Stores customer-specific details such as demographics, geographic location, occupation, and birthday. - "store": Provides information about stores, including location, size, status, and operational dates. - "orders": Contains details about customer orders, including order and delivery dates, store, and customer data. - "product": Contains data on products, including attributes such as product name, category, price, cost, and weight. - "calendar": A time-based table that includes date-related attributes like year, month, quarter, day, and working day indicators. This dataset is ideal for practicing data analysis, performing time-series analysis, creating reports, or simulating business intelligence scenarios.

Download and process public education data from INEP (Instituto Nacional de Estudos e Pesquisas Educacionais Anà sio Teixeira). Provides functions to access microdata from the School Census (Censo Escolar), ENEM (Exame Nacional do Ensino Médio), SAEB (Sistema de Avaliação da Educação Básica), Higher Education Census (Censo da Educação Superior), ENADE (Exame Nacional de Desempenho dos Estudantes), ENCCEJA (Exame Nacional para Certificação de Competências de Jovens e Adultos), IDD (Indicador de Diferença entre os Desempenhos Observado e Esperado), CPC (Conceito Preliminar de Curso), IGC (à ndice Geral de Cursos), CAPES graduate education data, FUNDEB (Fundo de Manutencao e Desenvolvimento da Educacao Basica), IDEB (à ndice de Desenvolvimento da Educação Básica), and other educational datasets. Returns data in tidy format ready for analysis. Data source: INEP Open Data Portal <https://www.gov.br/inep/pt-br/acesso-a-informacao/dados-abertos>.

Translates a BNF (Backus-Naur Form) specification of a context-free language into an R grammar object which consists of the start symbol, the symbol table, the production table, and a short production table. The short production table is non-recursive. The grammar object contains the file name from which it was generated (without a path). In addition, it provides functions to determine the type of a symbol (isTerminal() and isNonterminal()) and functions to access the production table (rules() and derives()). For the BNF specification, see Backus, John et al. (1962) "Revised Report on the Algorithmic Language ALGOL 60". (ALGOL60 standards page <http://www.algol60.org/2standards.htm>, html-edition <https://www.masswerk.at/algol60/report.htm>) A preprocessor for macros which expand to standard BNF is included. The grammar compiler is an extension of the APL2 implementation in Geyer-Schulz, Andreas (1997, ISBN:978-3-7908-0830-X).

This package performs (simultaneous) inferences for ratios of linear combinations of coefficients in the general linear model, linear mixed model, and for quantiles in a one-way layout. Multiple comparisons and simultaneous confidence interval estimations can be performed for ratios of treatment means in the normal one-way layout with homogeneous and heterogeneous treatment variances, according to Dilba et al. (2007) <https://cran.r-project.org/doc/Rnews/Rnews_2007-1.pdf> and Hasler and Hothorn (2008) <doi:10.1002/bimj.200710466>. Confidence interval estimations for ratios of linear combinations of linear model parameters like in (multiple) slope ratio and parallel line assays can be carried out. Moreover, it is possible to calculate the sample sizes required in comparisons with a control based on relative margins. For the simple two-sample problem, functions for a t-test for ratio-formatted hypotheses and the corresponding confidence interval are provided assuming homogeneous or heterogeneous group variances.

This package provides an extensible formula system to quickly and easily create production quality tables. The processing steps are a formula parser, statistical content generation from data as defined by formula, followed by rendering into a table. Each step of the processing is separate and user definable thus creating a set of composable building blocks for highly customizable table generation. A user is not limited by any of the choices of the package creator other than the formula grammar. For example, one could chose to add a different S3 rendering function and output a format not provided in the default package, or possibly one would rather have Gini coefficients for their statistical content in a resulting table. Routines to achieve New England Journal of Medicine style, Lancet style and Hmisc::summaryM() statistics are provided. The package contains rendering for HTML5, Rmarkdown and an indexing format for use in tracing and tracking are provided.

This package provides a modular and extendable approach to extract (micro)saccades from gaze samples via an ensemble of methods. Although there is an agreement about a general definition of a saccade, the more specific details are harder to agree upon. Therefore, there are numerous algorithms that extract saccades based on various heuristics, which differ in the assumptions about velocity, acceleration, etc. The package uses three methods (Engbert and Kliegl (2003) <doi:10.1016/S0042-6989(03)00084-1>, Otero-Millan et al. (2014)<doi:10.1167/14.2.18>, and Nyström and Holmqvist (2010) <doi:10.3758/BRM.42.1.188>) to label individual samples and then applies a majority vote approach to identify saccades. The package includes three methods but can be extended via custom functions. It also uses a modular approach to compute velocity and acceleration from noisy samples. Finally, you can obtain methods votes per gaze sample instead of saccades.

An interface to WordNet using the Jawbone Java API to WordNet. WordNet (<https://wordnet.princeton.edu/>) is a large lexical database of English. Nouns, verbs, adjectives and adverbs are grouped into sets of cognitive synonyms (synsets), each expressing a distinct concept. Synsets are interlinked by means of conceptual-semantic and lexical relations. Please note that WordNet(R) is a registered tradename. Princeton University makes WordNet available to research and commercial users free of charge provided the terms of their license (<https://wordnet.princeton.edu/license-and-commercial-use>) are followed, and proper reference is made to the project using an appropriate citation (<https://wordnet.princeton.edu/citing-wordnet>). The WordNet database files need to be made available separately, either via package wordnetDicts from <https://datacube.wu.ac.at>, installing system packages where available, or direct download from <https://wordnetcode.princeton.edu/3.0/WNdb-3.0.tar.gz>.