Evaluates acute lymphoblastic leukemia maintenance therapy practice at patient and cohort level.

Constructs sparse adjacency matrices from spatial coordinates, feature measurements, class labels, and temporal indices. Supports nearest-neighbor graphs, heat-kernel weights, graph Laplacians, diffusion operators, and bilateral smoothers for graph-based data analysis, following spectral graph methods in von Luxburg (2007) <doi:10.1007/s11222-007-9033-z>, diffusion maps in Coifman and Lafon (2006) <doi:10.1016/j.acha.2006.04.006>, and bilateral filtering in Tomasi and Manduchi (1998) <doi:10.1109/ICCV.1998.710815>.

This package provides nine computational algorithms for dimensionality reduction via Principal Component Analysis (PCA), built using an object-oriented (S3) architecture. The package includes classical and modern methods: Singular Value Decomposition (SVD) based on Eckart and Young (1936) <doi:10.1007/BF02288367>, Power Iteration based on Hotelling (1933) <doi:10.1037/h0071325>, QR Algorithm based on Francis (1961) <doi:10.1093/comjnl/4.3.265>, Jacobi Algorithm based on Jacobi (1846) <doi:10.1515/crll.1846.30.51>, Arnoldi Iteration based on Arnoldi (1951) <doi:10.1090/qam/42792>, NIPALS based on Wold (1975) <doi:10.1017/S0021900200047604>, Alternating Least Squares (ALS) based on Kolda and Bader (2009) <doi:10.1137/07070111X>, Probabilistic PCA (PPCA) with EM Algorithm based on Tipping and Bishop (1999) <doi:10.1111/1467-9868.00196>, and Generalized Hebbian Algorithm (GHA) based on Sanger (1989) <doi:10.1016/0893-6080(89)90044-0>.

This package provides a powerful tool for automating the early detection of disease outbreaks in time series data. aeddo employs advanced statistical methods, including hierarchical models, in an innovative manner to effectively characterize outbreak signals. It is particularly useful for epidemiologists, public health professionals, and researchers seeking to identify and respond to disease outbreaks in a timely fashion. For a detailed reference on hierarchical models, consult Henrik Madsen and Poul Thyregod's book (2011), ISBN: 9781420091557.

Set of tools for statistical analysis, visualization, and reporting of agroindustrial and agricultural experiments. The package provides functions to perform one-way and two-way ANOVA with post-hoc tests (Tukey HSD and Duncan MRT), Welch ANOVA for heteroscedastic data, and the Games-Howell post-hoc test as a robust alternative when variance homogeneity fails. Normality of residuals is assessed with the Shapiro-Wilk test and homoscedasticity with the Fligner-Killeen test; the appropriate statistical path is selected automatically based on these diagnostics. Coefficients of variation and statistical power (via one-way ANOVA power analysis) are reported alongside the post-hoc letter display. High-level wrappers allow automated multi-variable analysis with optional clustering by one or two experimental factors, with support for custom level ordering and relabeling. Results are returned as ggplot2 boxplots with mean and letter annotations, wide-format summary tables ready for publication or LaTeX rendering, and structured decision summaries for rapid agronomic interpretation. Direct export to Excel spreadsheets and high-resolution image tables is also supported. Functions follow methods widely used in agronomy, field trials, and plant breeding. Key references: Tukey (1949) <doi:10.2307/3001913>; Duncan (1955) <doi:10.2307/3001478>; Welch (1951) <doi:10.2307/2332579>; Games and Howell (1976) <doi:10.2307/2529858>; Shapiro and Wilk (1965) <doi:10.2307/2333709>; Fligner and Killeen (1976) <doi:10.2307/2529096>; Cohen (1988, ISBN:9781138892899); Wickham (2016, ISBN:9783319242750) for ggplot2'; see also agricolae <https://CRAN.R-project.org/package=agricolae> and rstatix <https://CRAN.R-project.org/package=rstatix>. Version en espanol: Conjunto de herramientas para el analisis estadistico, visualizacion y generacion de reportes en ensayos agroindustriales y agricolas. Incluye ANOVA univariado y bifactorial con pruebas post-hoc (Tukey HSD y Duncan MRT), ANOVA de Welch para datos heterocedasticos y la prueba post-hoc de Games-Howell como alternativa robusta cuando falla la homogeneidad de varianzas. La normalidad de residuos se evalua con la prueba de Shapiro-Wilk y la homogeneidad de varianzas con la prueba de Fligner-Killeen; la ruta estadistica apropiada se selecciona automaticamente segun estos diagnosticos. Se reportan coeficientes de variacion y potencia estadistica junto con las letras de separacion de medias. Los envoltorios de alto nivel permiten analisis multivariable automatizado con agrupamiento opcional por uno o dos factores experimentales, con soporte para orden y etiquetado personalizado de niveles. Los resultados se devuelven como boxplots con anotaciones de medias y letras, tablas resumen en formato ancho listas para publicacion o renderizado en LaTeX, y resumenes de decision para interpretacion agronomica rapida. Tambien se soporta exportacion directa a Excel e imagenes de alta resolucion para informes tecnicos.

This package provides tools to study sorting patterns in matching markets and to estimate the affinity matrix of both the bipartite one-to-one matching model without frictions and with Transferable Utility by Dupuy and Galichon (2014) <doi:10.1086/677191> and its unipartite variant by Ciscato', Galichon and Gousse (2020) <doi:10.1086/704611>. It also contains all the necessary tools to implement the saliency analysis, to run rank tests of the affinity matrix and to build tables and plots summarizing the findings.

This package performs approximate unconditional and permutation testing for 2x2 contingency tables. Motivated by testing for disease association with rare genetic variants in case-control studies. When variants are extremely rare, these tests give better control of Type I error than standard tests.

In order to make Arrow Database Connectivity ('ADBC <https://arrow.apache.org/adbc/>) accessible from R, an interface compliant with the DBI package is provided, using driver back-ends that are implemented in the adbcdrivermanager framework. This enables interacting with database systems using the Arrow data format, thereby offering an efficient alternative to ODBC for analytical applications.

This package provides the alpha-adjustment correction from "Benjamini, Y., & Hochberg, Y. (1995) <doi:10.1111/j.2517-6161.1995.tb02031.x> Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal statistical society: series B (Methodological), 57(1), 289-300". For researchers interested in using the exact mathematical formulas and procedures as used in the original paper.

Pair of simple convenience functions to convert a vector of birth dates to age and age distributions. These functions may be helpful when related age and custom age distributions are desired given a vector of birth dates.

The centralized empirical cumulative average deviation function is utilized to develop both Ada-plot and Uda-plot as alternatives to Ad-plot and Ud-plot introduced by the author. Analogous to Ad-plot, Ada-plot can identify symmetry, skewness, and outliers of the data distribution. The Uda-plot is as exceptional as Ud-plot in assessing normality. The d-value that quantifies the degree of proximity between the Uda-plot and the graph of the estimated normal density function helps guide to make decisions on confirmation of normality. Extreme values in the data can be eliminated using the 1.5IQR rule to create its robust version if user demands. Full description of the methodology can be found in the article by Wijesuriya (2025a) <doi:10.1080/03610926.2025.2558108>. Further, the development of Ad-plot and Ud-plot is contained in both article and the adplots R package by Wijesuriya (2025b & 2025c) <doi:10.1080/03610926.2024.2440583> and <doi:10.32614/CRAN.package.adplots>.

This package provides a (mildly) opinionated set of functions to help assess medication adherence for researchers working with medication claims data. Medication adherence analyses have several complex steps that are often convoluted and can be time-intensive. The focus is to create a set of functions using "tidy principles" geared towards transparency, speed, and flexibility while working with adherence metrics. All functions perform exactly one task with an intuitive name so that a researcher can handle details (often achieved with vectorized solutions) while we handle non-vectorized tasks common to most adherence calculations such as adjusting fill dates and determining episodes of care. The methodologies in referenced in this package come from Canfield SL, et al (2019) "Navigating the Wild West of Medication Adherence Reporting in Specialty Pharmacy" <doi:10.18553/jmcp.2019.25.10.1073>.

The AHP method (Analytic Hierarchy Process) is a multi-criteria decision-making method addressing choice and outranking problems. The method enables to perform the analysis of alternatives in each type of criterion and then provides a global performance of each alternative in the decision context. The main difference of this package is the possibility of evaluating the alternatives using quantitative data, by numerical representation, and qualitative data, using the Saaty scale, providing preference relation between variables by a pairwise evaluation.

Computes and integrates daily potential evapotranspiration (PET) and a soil water balance model. It allows users to estimate and predict the wet season calendar, including onset, cessation, and duration, based on an agroclimatic approach for a specified period. This functionality helps in managing agricultural water resources more effectively. For detailed methodologies, users can refer to Allen et al. (1998, ISBN:92-5-104219-5); Allen (2005, ISBN:9780784408056); Doorenbos and Pruitt (1975, ISBN:9251002797); Guo et al. (2016) <doi:10.1016/j.envsoft.2015.12.019>; Hargreaves and Samani (1985) <doi:10.13031/2013.26773>; Priestley and Taylor (1972) <https://journals.ametsoc.org/view/journals/apme/18/7/1520-0450_1979_018_0898_tptema_2_0_co_2.xml>.

NBMiner is an implementation of the model-based mining algorithm for mining NB-frequent itemsets and NB-precise rules. Michael Hahsler (2006) <doi:10.1007/s10618-005-0026-2>.

Generate code for use with the Optical Mark Recognition free software Auto Multiple Choice (AMC). More specifically, this package provides functions that use as input the question and answer texts, and output the LaTeX code for AMC.

Penalized variable selection tools for the Cox proportional hazards model with interval censored and possibly left truncated data. It performs variable selection via penalized nonparametric maximum likelihood estimation with an adaptive lasso penalty. The optimal thresholding parameter can be searched by the package based on the profile Bayesian information criterion (BIC). The asymptotic validity of the methodology is established in Li et al. (2019 <doi:10.1177/0962280219856238>). The unpenalized nonparametric maximum likelihood estimation for interval censored and possibly left truncated data is also available.

Static code compilation of a shiny app given an R function (into ui.R and server.R files or into a shiny app object). See examples at <https://github.com/alekrutkowski/autoshiny>.

Computation of adherence to medications from Electronic Health care Data and visualization of individual medication histories and adherence patterns. The package implements a set of S3 classes and functions consistent with current adherence guidelines and definitions. It allows the computation of different measures of adherence (as defined in the literature, but also several original ones), their publication-quality plotting, the estimation of event duration and time to initiation, the interactive exploration of patient medication history and the real-time estimation of adherence given various parameter settings. It scales from very small datasets stored in flat CSV files to very large databases and from single-thread processing on mid-range consumer laptops to parallel processing on large heterogeneous computing clusters. It exposes a standardized interface allowing it to be used from other programming languages and platforms, such as Python.

It fits a univariate left, right, or interval censored linear regression model with autoregressive errors, considering the normal or the Student-t distribution for the innovations. It provides estimates and standard errors of the parameters, predicts future observations, and supports missing values on the dependent variable. References used for this package: Schumacher, F. L., Lachos, V. H., & Dey, D. K. (2017). Censored regression models with autoregressive errors: A likelihood-based perspective. Canadian Journal of Statistics, 45(4), 375-392 <doi:10.1002/cjs.11338>. Schumacher, F. L., Lachos, V. H., Vilca-Labra, F. E., & Castro, L. M. (2018). Influence diagnostics for censored regression models with autoregressive errors. Australian & New Zealand Journal of Statistics, 60(2), 209-229 <doi:10.1111/anzs.12229>. Valeriano, K. A., Schumacher, F. L., Galarza, C. E., & Matos, L. A. (2024). Censored autoregressive regression models with Studentâ t innovations. Canadian Journal of Statistics, 52(3), 804-828 <doi:10.1002/cjs.11804>.

Enables sampling from arbitrary distributions if the log density is known up to a constant; a common situation in the context of Bayesian inference. The implemented sampling algorithm was proposed by Vihola (2012) <DOI:10.1007/s11222-011-9269-5> and achieves often a high efficiency by tuning the proposal distributions to a user defined acceptance rate.

Facilitates estimating, visualizing, and testing average dose-response functions (ADRFs) for characterizing the causal effect of a continuous (i.e., non-discrete) treatment or exposure. Includes support for frequentist and Bayesian regression models, analytical and bootstrap inference, and characterization of subgroup effects.

Grafts the extinct bird species from the Avotrex database (Sayol et al., in review) on to the BirdTree phylogenies <https://birdtree.org>, using a set of different commands.

Autoregressive-based decomposition of a time series based on the approach in West (1997). Particular cases include the extraction of trend and seasonal components.