This package provides methods to unify the different ways of creating predictive models and their different predictive formats for classification and regression. It includes methods such as K-Nearest Neighbors Schliep, K. P. (2004) <doi:10.5282/ubm/epub.1769>, Decision Trees Leo Breiman, Jerome H. Friedman, Richard A. Olshen, Charles J. Stone (2017) <doi:10.1201/9781315139470>, ADA Boosting Esteban Alfaro, Matias Gamez, Noelia Garcà a (2013) <doi:10.18637/jss.v054.i02>, Extreme Gradient Boosting Chen & Guestrin (2016) <doi:10.1145/2939672.2939785>, Random Forest Breiman (2001) <doi:10.1023/A:1010933404324>, Neural Networks Venables, W. N., & Ripley, B. D. (2002) <ISBN:0-387-95457-0>, Support Vector Machines Bennett, K. P. & Campbell, C. (2000) <doi:10.1145/380995.380999>, Bayesian Methods Gelman, A., Carlin, J. B., Stern, H. S., & Rubin, D. B. (1995) <doi:10.1201/9780429258411>, Linear Discriminant Analysis Venables, W. N., & Ripley, B. D. (2002) <ISBN:0-387-95457-0>, Quadratic Discriminant Analysis Venables, W. N., & Ripley, B. D. (2002) <ISBN:0-387-95457-0>, Logistic Regression Dobson, A. J., & Barnett, A. G. (2018) <doi:10.1201/9781315182780> and Penalized Logistic Regression Friedman, J. H., Hastie, T., & Tibshirani, R. (2010) <doi:10.18637/jss.v033.i01>.

Adaptive Sparse Multi-block Partial Least Square, a supervised algorithm, is an extension of the Sparse Multi-block Partial Least Square, which allows different quantiles to be used in different blocks of different partial least square components to decide the proportion of features to be retained. The best combinations of quantiles can be chosen from a set of user-defined quantiles combinations by cross-validation. By doing this, it enables us to do the feature selection for different blocks, and the selected features can then be further used to predict the outcome. For example, in biomedical applications, clinical covariates plus different types of omics data such as microbiome, metabolome, mRNA data, methylation data, copy number variation data might be predictive for patients outcome such as survival time or response to therapy. Different types of data could be put in different blocks and along with survival time to fit the model. The fitted model can then be used to predict the survival for the new samples with the corresponding clinical covariates and omics data. In addition, Adaptive Sparse Multi-block Partial Least Square Discriminant Analysis is also included, which extends Adaptive Sparse Multi-block Partial Least Square for classifying the categorical outcome.

Estimation and inference using the Generalized Maximum Entropy (GME) and Generalized Cross Entropy (GCE) framework, a flexible method for solving ill-posed inverse problems and parameter estimation under uncertainty (Golan, Judge, and Miller (1996, ISBN:978-0471145925) "Maximum Entropy Econometrics: Robust Estimation with Limited Data"). The package includes routines for generalized cross entropy estimation of linear models including the implementation of a GME-GCE two steps approach. Diagnostic tools, and options to incorporate prior information through support and prior distributions are available (Macedo, Cabral, Afreixo, Macedo and Angelelli (2025) <doi:10.1007/978-3-031-97589-9_21>). In particular, support spaces can be defined by the user or be internally computed based on the ridge trace or on the distribution of standardized regression coefficients. Different optimization methods for the objective function can be used. An adaptation of the normalized entropy aggregation (Macedo and Costa (2019) <doi:10.1007/978-3-030-26036-1_2> "Normalized entropy aggregation for inhomogeneous large-scale data") and a two-stage maximum entropy approach for time series regression (Macedo (2022) <doi:10.1080/03610918.2022.2057540>) are also available. Suitable for applications in econometrics, health, signal processing, and other fields requiring robust estimation under data constraints.

This package provides researchers and educators with easy-to-learn, user friendly tools for calculating key spatial statistics and for applying simple as well as advanced methods of spatial analysis on real data. These include: Local Pearson and Geographically Weighted Pearson Correlation Coefficients; Spatial Inequality Measures (Gini coefficient, Spatial Gini, Location Quotient (LQ) and Focal Location Quotient); Spatial Autocorrelation indices (Global and Local Moran's I); several Geographically Weighted Regression techniques, including the Geographically Weighted Zero-Inflated Poisson Regression; tools for computing variables used in Spatial Interaction Models; and other spatial analysis tools (other geographically weighted statistics). The local correlation tools were originally developed to test for local multicollinearity among the explanatory variables of local regression models and can also be used to examine the local association between pairs of variables. The package also contains functions for measuring the significance of each statistic calculated, mainly based on Monte Carlo simulations, and comes with two example datasets, one of which is a spatial data frame referring to the municipalities of Greece. Methods are described in Kalogirou (2012) <doi:10.1007/s10037-011-0061-y>, Kalogirou (2016) <doi:10.1111/gean.12092>, and Rey and Smith (2013) <doi:10.1007/s12076-012-0086-z>.

This package provides a collection of tools to handle microsatellite data of any ploidy (and samples of mixed ploidy) where allele copy number is not known in partially heterozygous genotypes. It can import and export data in ABI GeneMapper', Structure', ATetra', Tetrasat'/'Tetra', GenoDive', SPAGeDi', POPDIST', STRand', and binary presence/absence formats. It can calculate pairwise distances between individuals using a stepwise mutation model or infinite alleles model, with or without taking ploidies and allele frequencies into account. These distances can be used for the calculation of clonal diversity statistics or used for further analysis in R. Allelic diversity statistics and Polymorphic Information Content are also available. polysat can assist the user in estimating the ploidy of samples, and it can estimate allele frequencies in populations, calculate pairwise or global differentiation statistics based on those frequencies, and export allele frequencies to SPAGeDi and adegenet'. Functions are also included for assigning alleles to isoloci in cases where one pair of microsatellite primers amplifies alleles from two or more independently segregating isoloci. polysat is described by Clark and Jasieniuk (2011) <doi:10.1111/j.1755-0998.2011.02985.x> and Clark and Schreier (2017) <doi:10.1111/1755-0998.12639>.

This package implements the stacked-imputation workflow for conditional inference trees ('ctree') described in Sherlock et al. (2026) <doi:10.1080/00273171.2026.2661244>. When data contain missing values, multiply imputed datasets (e.g., from mice') are stacked vertically and a single ctree is fit on the combined data. To correct for the artificially inflated sample size introduced by stacking, every node-level test statistic is divided by the number of imputations M, the node-level p-values are recomputed from the chi-squared reference distribution ctree uses (including its multiplicity adjustment across candidate splitting variables), and the tree is compressed bottom-up (the Stack/M correction). Degrees of freedom are derived for each node and each candidate variable, so univariate, bivariate and higher-dimensional outcomes are all handled, as are unordered factor predictors, whose degrees of freedom depend on how many levels remain in a node. The result is a single interpretable tree that incorporates imputation uncertainty without requiring pooling of structurally different trees. Also exports stack_imputations(), rescale_statistic(), prune_stackM(), node_table() and report_ctreeMI() as standalone utilities. The underlying ctree algorithm is provided by partykit (Hothorn & Zeileis, 2015; Hothorn, Hornik & Zeileis, 2006 <doi:10.1198/106186006X133933>).

Offers a flexible and user-friendly interface for visualizing conditional effects from a broad range of regression models, including mixed-effects and generalized additive (mixed) models. Compatible model types include lm(), rlm(), glm(), glm.nb(), betareg(), and gam() (from mgcv'); nonlinear models via nls(); generalized least squares via gls(); and survival models via coxph() (from survival'). Mixed-effects models with random intercepts and/or slopes can be fitted using lmer(), glmer(), glmer.nb(), glmmTMB(), or gam() (from mgcv', via smooth terms). Plots are rendered using base R graphics with extensive customization options. Approximate confidence intervals for nls() and betareg() models are computed using the delta method. Robust standard errors for rlm() are computed using the sandwich estimator (Zeileis 2004) <doi:10.18637/jss.v011.i10>. For beta regression using betareg', see Cribari-Neto and Zeileis (2010) <doi:10.18637/jss.v034.i02>. For mixed-effects models with lme4', see Bates et al. (2015) <doi:10.18637/jss.v067.i01>. For models using glmmTMB', see Brooks et al. (2017) <doi:10.32614/RJ-2017-066>. Methods for generalized additive models using mgcv follow Wood (2017) <doi:10.1201/9781315370279>.

Several functions are provided for dose-response (or concentration-response) characterization from omics data. DRomics is especially dedicated to omics data obtained using a typical dose-response design, favoring a great number of tested doses (or concentrations) rather than a great number of replicates (no need of replicates). DRomics provides functions 1) to check, normalize and or transform data, 2) to select monotonic or biphasic significantly responding items (e.g. probes, metabolites), 3) to choose the best-fit model among a predefined family of monotonic and biphasic models to describe each selected item, 4) to derive a benchmark dose or concentration and a typology of response from each fitted curve. In the available version data are supposed to be single-channel microarray data in log2, RNAseq data in raw counts, or already pretreated continuous omics data (such as metabolomic data) in log scale. In order to link responses across biological levels based on a common method, DRomics also handles apical data as long as they are continuous and follow a normal distribution for each dose or concentration, with a common standard error. For further details see Delignette-Muller et al (2023) <DOI:10.24072/pcjournal.325> and Larras et al (2018) <DOI:10.1021/acs.est.8b04752>.

This package provides functions to calculate Biological Condition Gradient (BCG) using input files with one row per sample with metric values and site classes as columns. A second file with the BCG Rules (example included) to define the memberships is also needed. The three main functions convert metric scores to metric memberships following fuzzy set BCG Rules (BCG.Level.Assignment), combine metric memberships to level memberships according to BCG Rules (BCG.Level.Membership), and then assign a BCG primary and secondary level based on level memberships (BCG.Level.Assignment). Originally developed as a package for use with BCG for Puget Lowland/Willamette Valley but has been further enhanced for use with multiple communities (benthic macroinvertebrates, fish, periphyton, or coral) and different rule sets. Oregon and Washington reference - "Stamp, J. and J. Gerritsen. 2018. Calibration of the Biological Condition Gradient (BCG) for Macroinvertebrate Assemblages in Puget Lowland/Willamette Valley Freshwater Wadeable Streams. Prepared by Tetra Tech for the US EPA Office of Water, Office of Science and Technology and US EPA Region 10." BCG process documentation - "USEPA. 2016. A Practitionerâ s Guide to the Biological Condition Gradient - A Framework to Describe Incremental Change in Aquatic Ecosystems. EPA 842-R-16-001. Office of Science and Technology, Washington, DC 20460.".

It is used to construct run sequences with minimum changes for half replicate of two level factorial run order. Experimenter can save time and resources by minimizing the number of changes in levels of individual factor and therefore the total number of changes. It consists of the function minimal_hrtlf(). This technique can be employed to any half replicate of two level factorial run order where the number of factors are greater than two. In Design of Experiments (DOE) theory, two level of a factor can be represented as integers e.g. - 1 for low and 1 for high. User is expected to enter total number of factors to be considered in the experiment. minimal_hrtlf() provides the required run sequences for the input number of factors. The output also gives the number of changes of each factor along with total number of changes in the run sequence. Due to restricted randomization the minimally changed run sequences of half replicate of two level factorial run order will be affected by trend effect. The output also provides the Trend Factor value of the run order. Trend factor value will lies between 0 to 1. Higher the values, lesser the influence of trend effects on the run order.

This package provides a versatile package that provides implementation of various methods of Functional Data Analysis (FDA) and Empirical Dynamics. The core of this package is Functional Principal Component Analysis (FPCA), a key technique for functional data analysis, for sparsely or densely sampled random trajectories and time courses, via the Principal Analysis by Conditional Estimation (PACE) algorithm. This core algorithm yields covariance and mean functions, eigenfunctions and principal component (scores), for both functional data and derivatives, for both dense (functional) and sparse (longitudinal) sampling designs. For sparse designs, it provides fitted continuous trajectories with confidence bands, even for subjects with very few longitudinal observations. PACE is a viable and flexible alternative to random effects modeling of longitudinal data. There is also a Matlab version (PACE) that contains some methods not available on fdapace and vice versa. Updates to fdapace were supported by grants from NIH Echo and NSF DMS-1712864 and DMS-2014626. Please cite our package if you use it (You may run the command citation("fdapace") to get the citation format and bibtex entry). References: Wang, J.L., Chiou, J., Müller, H.G. (2016) <doi:10.1146/annurev-statistics-041715-033624>; Chen, K., Zhang, X., Petersen, A., Müller, H.G. (2017) <doi:10.1007/s12561-015-9137-5>.

Fit generalized linear mixed models (GLMMs) with normal random effects using first-order Laplace, fully exponential Laplace (FEL) with mean-only corrections, and FEL with mean and variance-diagonal corrections in the E-step of an expectation-maximization (EM) algorithm. The current development version provides a matrix-based interface (y, X, Z) and supports binary logit and probit, and Poisson log-link models. An EM framework is used to update fixed effects, random effects, and a single variance component tau^2 for G = tau^2 I, with staged approximations (Laplace -> FEL mean-only -> FEL full) for efficiency and stability. A pseudo-likelihood engine glmmFEL_pl() implements the working-response / working-weights linearization approach of Wolfinger and O'Connell (1993) <doi:10.1080/00949659308811554>, and is adapted from the implementation used in the RealVAMS package (Broatch, Green, and Karl (2018)) <doi:10.32614/RJ-2018-033>. The FEL implementation follows Karl, Yang, and Lohr (2014) <doi:10.1016/j.csda.2013.11.019> and related work (e.g., Tierney, Kass, and Kadane (1989) <doi:10.1080/01621459.1989.10478824>; Rizopoulos, Verbeke, and Lesaffre (2009) <doi:10.1111/j.1467-9868.2008.00704.x>; Steele (1996) <doi:10.2307/2532845>). Package code was drafted with assistance from generative AI tools.

Download geospatial data available from several federated data sources (mainly sources maintained by the US Federal government). Currently, the package enables extraction from nine datasets: The National Elevation Dataset digital elevation models (<https://www.usgs.gov/3d-elevation-program> 1 and 1/3 arc-second; USGS); The National Hydrography Dataset (<https://www.usgs.gov/national-hydrography/national-hydrography-dataset>; USGS); The Soil Survey Geographic (SSURGO) database from the National Cooperative Soil Survey (<https://websoilsurvey.sc.egov.usda.gov/>; NCSS), which is led by the Natural Resources Conservation Service (NRCS) under the USDA; the Global Historical Climatology Network (<https://www.ncei.noaa.gov/products/land-based-station/global-historical-climatology-network-daily>; GHCN), coordinated by National Climatic Data Center at NOAA; the Daymet gridded estimates of daily weather parameters for North America, version 4, available from the Oak Ridge National Laboratory's Distributed Active Archive Center (<https://daymet.ornl.gov/>; DAAC); the International Tree Ring Data Bank; the National Land Cover Database (<https://www.mrlc.gov/>; NLCD); the Cropland Data Layer from the National Agricultural Statistics Service (<https://www.nass.usda.gov/Research_and_Science/Cropland/SARS1a.php>; NASS); and the PAD-US dataset of protected area boundaries (<https://www.usgs.gov/programs/gap-analysis-project/science/pad-us-data-overview>; USGS).

This package implements generalized statistical point prediction and prediction intervals for future failure times under various hybrid censoring schemes. Supported censoring schemes include Type-I, Type-II, Generalized Type-I, Generalized Type-II, Unified, Progressive Type-I, and Progressive Type-II hybrid censoring schemes. Available prediction methods include Best Unbiased Predictor (BUP), Conditional Median Predictor (CMP), Maximum Likelihood Predictor (MLP), equal-tailed classical prediction intervals, Highest Conditional Density (HCD) prediction intervals, and Bayesian prediction intervals. Algorithms accept user-defined continuous probability density functions, cumulative distribution functions, quantile functions, or survival functions along with estimated parameter values. Methodological foundations are based on Balakrishnan, Cramer, and Kundu (2023, ISBN:978-0123983879), Shafay and Balakrishnan (2012) <doi:10.1080/03610918.2011.579367> for Type-I hybrid censoring, Balakrishnan and Shafay (2012) <doi:10.1080/03610926.2010.543300> for Type-II hybrid censoring, Shafay (2017) <doi:10.1080/03610926.2016.1200093> for Generalized Type-I hybrid censoring, Shafay (2016) <doi:10.1080/00949655.2015.1096361> for Generalized Type-II hybrid censoring, Mohie El-Din, Nagy, and Shafay (2017) <doi:10.18576/jsap/060113> for Unified hybrid censoring, Ebrahimi (1992) <doi:10.1109/24.126685>, Valiollahi, Asgharzadeh, and Kundu (2017) <doi:10.1214/15-BJPS302>, and Asgharzadeh, Valiollahi, and Kundu (2015) <doi:10.1080/00949655.2013.848451>.

According to a phenomenon known as "the wisdom of the crowds," combining point estimates from multiple judges often provides a more accurate aggregate estimate than using a point estimate from a single judge. However, if the judges use shared information in their estimates, the simple average will over-emphasize this common component at the expense of the judgesâ private information. Asa Palley & Ville Satopää (2021) "Boosting the Wisdom of Crowds Within a Single Judgment Problem: Selective Averaging Based on Peer Predictions" <https://papers.ssrn.com/sol3/Papers.cfm?abstract_id=3504286> proposes a procedure for calculating a weighted average of the judgesâ individual estimates such that resulting aggregate estimate appropriately combines the judges collective information within a single estimation problem. The authors use both simulation and data from six experimental studies to illustrate that the weighting procedure outperforms existing averaging-like methods, such as the equally weighted average, trimmed average, and median. This aggregate estimate -- know as "the knowledge-weighted estimate" -- inputs a) judges estimates of a continuous outcome (E) and b) predictions of others average estimate of this outcome (P). In this R-package, the function knowledge_weighted_estimate(E,P) implements the knowledge-weighted estimate. Its use is illustrated with a simple stylized example and on real-world experimental data.

Exploits dynamical seasonal forecasts in order to provide information relevant to stakeholders at the seasonal timescale. The package contains process-based methods for forecast calibration, bias correction, statistical and stochastic downscaling, optimal forecast combination and multivariate verification, as well as basic and advanced tools to obtain tailored products. This package was developed in the context of the ERA4CS project MEDSCOPE and the H2020 S2S4E project and includes contributions from ArticXchange project founded by EU-PolarNet 2. Implements methods described in Pérez-Zanón et al. (2022) <doi:10.5194/gmd-15-6115-2022>, Doblas-Reyes et al. (2005) <doi:10.1111/j.1600-0870.2005.00104.x>, Mishra et al. (2018) <doi:10.1007/s00382-018-4404-z>, Sanchez-Garcia et al. (2019) <doi:10.5194/asr-16-165-2019>, Straus et al. (2007) <doi:10.1175/JCLI4070.1>, Terzago et al. (2018) <doi:10.5194/nhess-18-2825-2018>, Torralba et al. (2017) <doi:10.1175/JAMC-D-16-0204.1>, D'Onofrio et al. (2014) <doi:10.1175/JHM-D-13-096.1>, Verfaillie et al. (2017) <doi:10.5194/gmd-10-4257-2017>, Van Schaeybroeck et al. (2019) <doi:10.1016/B978-0-12-812372-0.00010-8>, Yiou et al. (2013) <doi:10.1007/s00382-012-1626-3>.

Phylogenetic comparative methods represent models of continuous trait data associated with the tips of a phylogenetic tree. Examples of such models are Gaussian continuous time branching stochastic processes such as Brownian motion (BM) and Ornstein-Uhlenbeck (OU) processes, which regard the data at the tips of the tree as an observed (final) state of a Markov process starting from an initial state at the root and evolving along the branches of the tree. The PCMBase R package provides a general framework for manipulating such models. This framework consists of an application programming interface for specifying data and model parameters, and efficient algorithms for simulating trait evolution under a model and calculating the likelihood of model parameters for an assumed model and trait data. The package implements a growing collection of models, which currently includes BM, OU, BM/OU with jumps, two-speed OU as well as mixed Gaussian models, in which different types of the above models can be associated with different branches of the tree. The PCMBase package is limited to trait-simulation and likelihood calculation of (mixed) Gaussian phylogenetic models. The PCMFit package provides functionality for inference of these models to tree and trait data. The package web-site <https://venelin.github.io/PCMBase/> provides access to the documentation and other resources.

Generalized meta-analysis is a technique for estimating parameters associated with a multiple regression model through meta-analysis of studies which may have information only on partial sets of the regressors. It estimates the effects of each variable while fully adjusting for all other variables that are measured in at least one of the studies. Using algebraic relationships between regression parameters in different dimensions, a set of moment equations is specified for estimating the parameters of a maximal model through information available on sets of parameter estimates from a series of reduced models available from the different studies. The specification of the equations requires a reference dataset to estimate the joint distribution of the covariates. These equations are solved using the generalized method of moments approach, with the optimal weighting of the equations taking into account uncertainty associated with estimates of the parameters of the reduced models. The proposed framework is implemented using iterated reweighted least squares algorithm for fitting generalized linear regression models. For more details about the method, please see pre-print version of the manuscript on generalized meta-analysis by Prosenjit Kundu, Runlong Tang and Nilanjan Chatterjee (2018) <doi:10.1093/biomet/asz030>.The current version (0.2.0) is updated to address some of the stability issues in the previous version (0.1).

Estimation of the most-left informative set of gross returns (i.e., the informative set). The procedure to compute the informative set adjusts the method proposed by Mariani et al. (2022a) <doi:10.1007/s11205-020-02440-6> and Mariani et al. (2022b) <doi:10.1007/s10287-022-00422-2> to gross returns of financial assets. This is accomplished through an adaptive algorithm that identifies sub-groups of gross returns in each iteration by approximating their distribution with a sequence of two-component log-normal mixtures. These sub-groups emerge when a significant change in the distribution occurs below the median of the financial returns, with their boundary termed as the â change point" of the mixture. The process concludes when no further change points are detected. The outcome encompasses parameters of the leftmost mixture distributions and change points of the analyzed financial time series. The functionalities of the INFOSET package include: (i) modelling asset distribution detecting the parameters which describe left tail behaviour (infoset function), (ii) clustering, (iii) labeling of the financial series for predictive and classification purposes through a Left Risk measure based on the first change point (LR_cp function) (iv) portfolio construction (ptf_construction function). The package also provide a specific function to construct rolling windows of different length size and overlapping time.

This package implements a four-stage pipeline for probabilistic seismic performance analysis of slopes and embankments. The package takes a uniform-hazard spectrum at multiple return periods as input (any source) and produces: (1) synthetic soil profile generation and fundamental period estimation from USCS classification via Ishihara's small-strain shear-modulus model and the inhomogeneous truncated shear-beam theory of Gazetas and Dakoulas; (2) nonlinear site amplification using the NGA-East ergodic site-response models (Stewart et al. (2020) <doi:10.1177/8755293019878185> and Hashash et al. (2020) <doi:10.1177/8755293019878193>, with the 2017 PEER-report generation retained as an option), with inter-period correlation via Baker & Jayaram (2008) <doi:10.1193/1.2857544>; (3) Monte Carlo ensemble of six empirical Newmark sliding-block displacement models (Ambraseys & Menu (1988) <doi:10.1002/eqe.4290160704>, Jibson (2007) <doi:10.1016/j.enggeo.2007.01.013>, Saygili & Rathje (2008) <doi:10.1061/(ASCE)1090-0241(2008)134:6(790)>, Bray & Travasarou (2007) <doi:10.1061/(ASCE)1090-0241(2007)133:4(381)>, Bray & Macedo (2017) <doi:10.1016/j.soildyn.2017.05.024>, and the Bray and Macedo shallow-crustal update) with coherent correlated draws; (4) log-log inversion to the performance-based seismic coefficient kmax at user-specified displacement targets. All outputs are data.table objects.

Extracts features from biological sequences. It contains most features which are presented in related work and also includes features which have never been introduced before. It extracts numerous features from nucleotide and peptide sequences. Each feature converts the input sequences to discrete numbers in order to use them as predictors in machine learning models. There are many features and information which are hidden inside a sequence. Utilizing the package, users can convert biological sequences to discrete models based on chosen properties. References: iLearn Z. Chen et al. (2019) <DOI:10.1093/bib/bbz041>. iFeature Z. Chen et al. (2018) <DOI:10.1093/bioinformatics/bty140>. <https://CRAN.R-project.org/package=rDNAse>. PseKRAAC Y. Zuo et al. PseKRAAC: a flexible web server for generating pseudo K-tuple reduced amino acids composition (2017) <DOI:10.1093/bioinformatics/btw564>. iDNA6mA-PseKNC P. Feng et al. iDNA6mA-PseKNC: Identifying DNA N6-methyladenosine sites by incorporating nucleotide physicochemical properties into PseKNC (2019) <DOI:10.1016/j.ygeno.2018.01.005>. I. Dubchak et al. Prediction of protein folding class using global description of amino acid sequence (1995) <DOI:10.1073/pnas.92.19.8700>. W. Chen et al. Identification and analysis of the N6-methyladenosine in the Saccharomyces cerevisiae transcriptome (2015) <DOI:10.1038/srep13859>.

This package provides functions to access and download data from the Open Case Studies <https://www.opencasestudies.org/> repositories on GitHub <https://github.com/opencasestudies>. Different functions enable users to grab the data they need at different sections in the case study, as well as download the whole case study repository. All the user needs to do is input the name of the case study being worked on. The package relies on the httr::GET() function to access files through the GitHub API. The functions usethis::use_zip() and usethis::create_from_github() are used to clone and/or download the case study repositories. To cite an individual case study, please see the respective README file at <https://github.com/opencasestudies/>. <https://github.com/opencasestudies/ocs-bp-rural-and-urban-obesity> <https://github.com/opencasestudies/ocs-bp-air-pollution> <https://github.com/opencasestudies/ocs-bp-vaping-case-study> <https://github.com/opencasestudies/ocs-bp-opioid-rural-urban> <https://github.com/opencasestudies/ocs-bp-RTC-wrangling> <https://github.com/opencasestudies/ocs-bp-RTC-analysis> <https://github.com/opencasestudies/ocs-bp-youth-disconnection> <https://github.com/opencasestudies/ocs-bp-youth-mental-health> <https://github.com/opencasestudies/ocs-bp-school-shootings-dashboard> <https://github.com/opencasestudies/ocs-bp-co2-emissions> <https://github.com/opencasestudies/ocs-bp-diet>.

Identification, model fitting and estimation for time series with periodic structure. Additionally, procedures for simulation of periodic processes and real data sets are included. Hurd, H. L., Miamee, A. G. (2007) <doi:10.1002/9780470182833> Box, G. E. P., Jenkins, G. M., Reinsel, G. (1994) <doi:10.1111/jtsa.12194> Brockwell, P. J., Davis, R. A. (1991, ISBN:978-1-4419-0319-8) Bretz, F., Hothorn, T., Westfall, P. (2010, ISBN: 9780429139543) Westfall, P. H., Young, S. S. (1993, ISBN:978-0-471-55761-6) Bloomfield, P., Hurd, H. L.,Lund, R. (1994) <doi:10.1111/j.1467-9892.1994.tb00181.x> Dehay, D., Hurd, H. L. (1994, ISBN:0-7803-1023-3) Vecchia, A. (1985) <doi:10.1080/00401706.1985.10488076> Vecchia, A. (1985) <doi:10.1111/j.1752-1688.1985.tb00167.x> Jones, R., Brelsford, W. (1967) <doi:10.1093/biomet/54.3-4.403> Makagon, A. (1999) <https://www.math.uni.wroc.pl/~pms/files/19.2/Article/19.2.5.pdf> Sakai, H. (1989) <doi:10.1111/j.1467-9892.1991.tb00069.x> Gladyshev, E. G. (1961) <https://www.mathnet.ru/php/archive.phtml?wshow=paper&jrnid=dan&paperid=24851> Ansley (1979) <doi:10.1093/biomet/66.1.59> Hurd, H. L., Gerr, N. L. (1991) <doi:10.1111/j.1467-9892.1991.tb00088.x>.

This package provides a tidy toolkit for text that is written in Chinese, Japanese or Korean. Most text tooling in R assumes that words are separated by whitespace, which CJK writing does not use, so ordinary summaries of a text column either treat a sentence as one undifferentiated blob or split it into isolated characters. Word segmentation is therefore a pluggable engine that the caller names explicitly rather than a bundled dictionary, because where a word ends is a fact about a language and not about Unicode. tidycjk classifies characters by Unicode block, reports which script and which language a text is written in, measures how much of a text is CJK, and turns those measurements into tibbles that slot straight into a tidyverse workflow. It also measures display width in terminal columns, pads and truncates to a width rather than to a character count, and normalises fullwidth and halfwidth forms surgically -- including composing halfwidth katakana voiced marks into single code points -- without the collateral damage of a full NFKC pass. Language detection deliberately returns NA rather than guessing when a text is written in Han characters only, because Japanese written without kana cannot be distinguished from Chinese by script alone. Everything is derived from the Unicode specification; the package makes no network requests and needs no compiled code of its own.