Perform mediation analysis in the presence of high-dimensional mediators based on the potential outcome framework. Bayesian Mediation Analysis (BAMA), developed by Song et al (2019) <doi:10.1111/biom.13189> and Song et al (2020) <doi:10.48550/arXiv.2009.11409>, relies on two Bayesian sparse linear mixed models to simultaneously analyze a relatively large number of mediators for a continuous exposure and outcome assuming a small number of mediators are truly active. This sparsity assumption also allows the extension of univariate mediator analysis by casting the identification of active mediators as a variable selection problem and applying Bayesian methods with continuous shrinkage priors on the effects.

Bayesian estimation of dynamic conditional correlation GARCH model for multivariate time series volatility (Fioruci, J.A., Ehlers, R.S. and Andrade-Filho, M.G., (2014). <doi:10.1080/02664763.2013.839635>.

Defines operating characteristics of Bayesian Adaptive Trials considering a generalised linear model response via Monte Carlo simulations of Bayesian GLM fitted via integrated Laplace approximations (INLA).

Analysis of gene expression RNA-seq data using Bartlett-Adjusted Likelihood-based LInear model (BALLI). Based on likelihood ratio test, it provides comparisons for effect of one or more variables. See Kyungtaek Park (2018) <doi:10.1101/344929> for more information.

Functional gradient descent algorithm for a variety of convex and non-convex loss functions, for both classical and robust regression and classification problems. See Wang (2011) <doi:10.2202/1557-4679.1304>, Wang (2012) <doi:10.3414/ME11-02-0020>, Wang (2018) <doi:10.1080/10618600.2018.1424635>, Wang (2018) <doi:10.1214/18-EJS1404>.

This package provides a comprehensive framework for batch effect diagnostics, harmonization, and post-harmonization downstream analysis. Features include interactive visualization tools, robust statistical tests, and a range of harmonization techniques. Additionally, ComBatFamQC enables the creation of life-span age trend plots with estimated age-adjusted centiles and facilitates the generation of covariate-corrected residuals for analytical purposes. Methods for harmonization are based on approaches described in Johnson et al., (2007) <doi:10.1093/biostatistics/kxj037>, Beer et al., (2020) <doi:10.1016/j.neuroimage.2020.117129>, Pomponio et al., (2020) <doi:10.1016/j.neuroimage.2019.116450>, and Chen et al., (2021) <doi:10.1002/hbm.25688>.

Coalescent simulators can rapidly simulate biological sequences evolving according to a given model of evolution. You can use this package to specify such models, to conduct the simulations and to calculate additional statistics from the results (Staab, Metzler, 2016 <doi:10.1093/bioinformatics/btw098>). It relies on existing simulators for doing the simulation, and currently supports the programs ms', msms and scrm'. It also supports finite-sites mutation models by combining the simulators with the program seq-gen'. Coala provides functions for calculating certain summary statistics, which can also be applied to actual biological data. One possibility to import data is through the PopGenome package (<https://github.com/pievos101/PopGenome>).

Analyze and compare conversations using various similarity measures including topic, lexical, semantic, structural, stylistic, sentiment, participant, and timing similarities. Supports both pairwise conversation comparisons and analysis of multiple dyads. Methods are based on established research: Topic modeling: Blei et al. (2003) <doi:10.1162/jmlr.2003.3.4-5.993>; Landauer et al. (1998) <doi:10.1080/01638539809545028>; Lexical similarity: Jaccard (1912) <doi:10.1111/j.1469-8137.1912.tb05611.x>; Semantic similarity: Salton & Buckley (1988) <doi:10.1016/0306-4573(88)90021-0>; Mikolov et al. (2013) <doi:10.48550/arXiv.1301.3781>; Pennington et al. (2014) <doi:10.3115/v1/D14-1162>; Structural and stylistic analysis: Graesser et al. (2004) <doi:10.1075/target.21131.ryu>; Sentiment analysis: Rinker (2019) <https://github.com/trinker/sentimentr>.

The Large Language Model (LLM) represents a groundbreaking advancement in data science and programming, and also allows us to extend the world of R. A seamless interface for integrating the OpenAI Web APIs into R is provided in this package. This package leverages LLM-based AI techniques, enabling efficient knowledge discovery and data analysis. The previous functions such as seamless translation and image generation have been moved to other packages deepRstudio and stableDiffusion4R'.

This package provides a method for determining groups in multiple curves with an automatic selection of their number based on k-means or k-medians algorithms. The selection of the optimal number is provided by bootstrap methods or other approaches with lower computational cost. The methodology can be applied both in regression and survival framework. Implemented methods are: Grouping multiple survival curves described by Villanueva et al. (2018) <doi:10.1002/sim.8016>.

Convex Partition is a black-box optimisation algorithm for single objective real-parameters functions. The basic principle is to progressively estimate and exploit a regression tree similar to a CART (Classification and Regression Tree) of the objective function. For more details see de Paz (2024) <doi:10.1007/978-3-031-62836-8_3> and Loh (2011) <doi:10.1002/widm.8> .

Jointly model the accuracy of cognitive responses and item choices within a Bayesian hierarchical framework as described by Culpepper and Balamuta (2015) <doi:10.1007/s11336-015-9484-7>. In addition, the package contains the datasets used within the analysis of the paper.

Tool for performing computational testing for conditional independence between variables in a dataset. CCI implements permutation in combination with Monte Carlo Cross-Validation in generating null distributions and test statistics. For more details see Computational Test for Conditional Independence (2024) <doi:10.3390/a17080323>.

Integrated, convenient, and uniform access to Canadian Census data and geography retrieved using the CensusMapper API. This package produces analysis-ready tidy data frames and spatial data in multiple formats, as well as convenience functions for working with Census variables, variable hierarchies, and region selection. API keys are freely available with free registration at <https://censusmapper.ca/api>. Census data and boundary geometries are reproduced and distributed on an "as is" basis with the permission of Statistics Canada (Statistics Canada 1996; 2001; 2006; 2011; 2016; 2021).

Downloads wrangled Colombian socioeconomic, geospatial,population and climate data from DANE <https://www.dane.gov.co/> (National Administrative Department of Statistics) and IDEAM (Institute of Hydrology, Meteorology and Environmental Studies). It solves the problem of Colombian data being issued in different web pages and sources by using functions that allow the user to select the desired database and download it without having to do the exhausting acquisition process.

Facilitates local polynomial regression for state dependent covariates in state-space models. The functionality can also be used from C++ based model builder tools such as Rcpp'/'inline', TMB', or JAGS'.

This package contains the R functions needed to perform Cluster-Of-Clusters Analysis (COCA) and Consensus Clustering (CC). For further details please see Cabassi and Kirk (2020) <doi:10.1093/bioinformatics/btaa593>.

Enumerate orientation-consistent directed networks from an undirected or partially directed skeleton, detect feedback loops, summarize topology, and simulate node dynamics via stochastic differential equations.

Count transformation models featuring parameters interpretable as discrete hazard ratios, odds ratios, reverse-time discrete hazard ratios, or transformed expectations. An appropriate data transformation for a count outcome and regression coefficients are simultaneously estimated by maximising the exact discrete log-likelihood using the computational framework provided in package mlt', technical details are given in Siegfried & Hothorn (2020) <DOI:10.1111/2041-210X.13383>. The package also contains an experimental implementation of multivariate count transformation models with an application to multi-species distribution models <DOI:10.48550/arXiv.2201.13095>.

This package provides methods to deal with under sampling in ecological bipartite networks from Terry and Lewis (2020) Ecology <doi:10.1002/ecy.3047> Includes tools to fit a variety of statistical network models and sample coverage estimators to highlight most likely missing links. Also includes simple functions to resample from observed networks to generate confidence intervals for common ecological network metrics.

We aim to deal with the average treatment effect (ATE), where the data are subject to high-dimensionality and measurement error. This package primarily contains two functions, which are used to generate artificial data and estimate ATE with high-dimensional and error-prone data accommodated.

This package provides tools for the fitting and cross validation of exact conditional logistic regression models with lasso and elastic net penalties. Uses cyclic coordinate descent and warm starts to compute the entire path efficiently.

Builds the coincident profile proposed by Martinez, W and Nieto, Fabio H and Poncela, P (2016) <doi:10.1016/j.spl.2015.11.008>. This methodology studies the relationship between a couple of time series based on the the set of turning points of each time series. The coincident profile establishes if two time series are coincident, or one of them leads the second.

This package provides a framework for specifying and running flexible linear-time reachability-based algorithms for graphical causal inference. Rule tables are used to encode and customize the reachability algorithm to typical causal and probabilistic reasoning tasks such as finding d-connected nodes or more advanced applications. For more information, see Wienöbst, Weichwald and Henckel (2025) <doi:10.48550/arXiv.2506.15758>.