This is the core package offering a portal to the many packages universe. It includes functions to help researchers access, work across, and maintain ensembles of datasets on global governance called datacubes.

Implementation of Multiple Comparison Procedures with Modeling (MCP-Mod) procedure with bias-corrected estimators and second-order covariance matrices as described in Diniz, Gallardo and Magalhaes (2023) <doi:10.1002/pst.2303>.

Age-specific mortality rates are estimated and projected using the Kannisto, Lee-Carter and related methods as described in Sevcikova et al. (2016) <doi:10.1007/978-3-319-26603-9_15>.

This package provides functions to calculate and plot event and pointer years as well as resilience indices. Designed for dendroecological applications, but also suitable to analyze patterns in other ecological time series.

Likelihood based population viability analysis in the presence of observation error and missing data. The package can be used to fit, compare, predict, and forecast various growth model types using data cloning.

This package implements the primePCA algorithm, developed and analysed in Zhu, Z., Wang, T. and Samworth, R. J. (2019) High-dimensional principal component analysis with heterogeneous missingness. <arXiv:1906.12125>.

This version of the permutational algorithm generates a dataset in which event and censoring times are conditional on an user-specified list of covariates, some or all of which are time-dependent.

Can be used to carry out permutation based gene expression pathway analysis. This work was supported by a National Institute of Allergy and Infectious Disease/National Institutes of Health contract (No. HHSN272200900059C).

This package provides functions and data sets for reproducing selected results from the book "Quantitative Risk Management: Concepts, Techniques and Tools". Furthermore, new developments and auxiliary functions for Quantitative Risk Management practice.

This package creates a contextual menu that can be triggered with keyboard shortcuts or programmatically. This can replace traditional sidebars or navigation bars, thereby enhancing the user experience with lighter user interfaces.

Implementation of the SAM prior and generation of its operating characteristics for dynamically borrowing information from historical data. For details, please refer to Yang et al. (2023) <doi:10.1111/biom.13927>.

Interactively gate points on a scatter plot. Interactively drawn gates are recorded and can be applied programmatically to reproduce results exactly. Programmatic gating is based on the package gatepoints by Wajid Jawaid.

Generates a game of 2048 that can be played in the console. Supports grids of arbitrary sizes, undoing the last move, and resuming a game that was exited during the current session.

Conducts single coefficient tests and multiple-contrast hypothesis tests of meta-regression models using cluster wild bootstrapping, based on methods examined in Joshi, Pustejovsky, and Beretvas (2022) <DOI:10.1002/jrsm.1554>.

Converts pathways from WikiPathways GPML format or KEGG KGML format into igraph objects. Includes tools to find all cycles in the resulting graphs and determine which ones involve negative feedback (inhibition).

This package provides a header-only C++ library is provided with support for dates, time zones, ISO weeks, Julian dates, and Islamic dates. date offers extensive date and time functionality for the C++11, C++14 and C++17 standards. A slightly modified version has been accepted (along with tz.h) as part of C++20. This package regroups all header files from the upstream repository so that other R packages can use them in their C++ code.

RETROFIT is a Bayesian non-negative matrix factorization framework to decompose cell type mixtures in ST data without using external single-cell expression references. RETROFIT outperforms existing reference-based methods in estimating cell type proportions and reconstructing gene expressions in simulations with varying spot size and sample heterogeneity, irrespective of the quality or availability of the single-cell reference. RETROFIT recapitulates known cell-type localization patterns in a Slide-seq dataset of mouse cerebellum without using any single-cell data.

This package implements the Clustering-Informed Shared-Structure Variational Autoencoder ('CISS-VAE'), a deep learning framework for missing data imputation introduced in Khadem Charvadeh et al. (2025) <doi:10.1002/sim.70335>. The model accommodates all three types of missing data mechanisms: Missing Completely At Random (MCAR), Missing At Random (MAR), and Missing Not At Random (MNAR). While it is particularly well-suited to MNAR scenarios, where missingness patterns carry informative signals, CISS-VAE also functions effectively under MAR assumptions.

The basic algorithm to perform the folding test of unimodality. Given a dataset X (d dimensional, n samples), the test checks whether the distribution of the data are rather unimodal or rather multimodal. This package stems from the following research publication: Siffer Alban, Pierre-Alain Fouque, Alexandre Termier, and Christine Largouët. "Are your data gathered?" In Proceedings of the 24th ACM SIGKDD International Conference on Knowledge Discovery Data Mining, pp. 2210-2218. ACM, 2018. <doi:10.1145/3219819.3219994>.

The SPRITE algorithm creates possible distributions of discrete responses based on reported sample parameters, such as mean, standard deviation and range (Heathers et al., 2018, <doi:10.7287/peerj.preprints.26968v1>). This package implements it, drawing heavily on the code for Nick Brown's rSPRITE Shiny app <https://shiny.ieis.tue.nl/sprite/>. In addition, it supports the modeling of distributions based on multi-item (Likert-type) scales and the use of restrictions on the frequency of particular responses.

F-informed MDS is a new multidimensional scaling-based ordination method that configures data distribution based on the F-statistic (i.e., the ratio of dispersion between groups with shared or differing labels).

This package provides tools to analyze alternative splicing sites, interpret outcomes based on sequence information, select and design primers for site validiation and give visual representation of the event to guide downstream experiments.

This package contains a set of functions to perform large-scale analysis of toxicogenomic data, providing a standardized data structure to hold information relevant to annotation, visualization and statistical analysis of toxicogenomic data.

The package allows users to readily import spatial data obtained from the 10X Xenium Analyzer pipeline. Supported formats include parquet', h5', and mtx files. The package mainly represents data as SpatialExperiment objects.