Analyze data from next-generation sequencing experiments on genomic samples. CLONETv2 offers a set of functions to compute allele specific copy number and clonality from segmented data and SNPs position pileup. The package has also calculated the clonality of single nucleotide variants given read counts at mutated positions. The package has been developed at the laboratory of Computational and Functional Oncology, Department of CIBIO, University of Trento (Italy), under the supervision of prof Francesca Demichelis. References: Prandi et al. (2014) <doi:10.1186/s13059-014-0439-6>; Carreira et al. (2014) <doi:10.1126/scitranslmed.3009448>; Romanel et al. (2015) <doi:10.1126/scitranslmed.aac9511>.

This package provides a method for determining groups in multiple curves with an automatic selection of their number based on k-means or k-medians algorithms. The selection of the optimal number is provided by bootstrap methods or other approaches with lower computational cost. The methodology can be applied both in regression and survival framework. Implemented methods are: Grouping multiple survival curves described by Villanueva et al. (2018) <doi:10.1002/sim.8016>.

One of the strengths of R is its vast package ecosystem. Indeed, R packages extend from visualization to Bayesian inference and from spatial analyses to pharmacokinetics (<https://cran.r-project.org/web/views/>). There is probably not an area of quantitative research that isn't represented by at least one R package. At the time of this writing, there are more than 10,000 active CRAN packages. Because of this massive ecosystem, it is important to have tools to search and learn about packages related to your personal R needs. For this reason, we developed an RStudio addin capable of searching available CRAN packages directly within RStudio.

It is devoted to Cramer-von Mises goodness-of-fit tests. It implements three statistical methods based on Cramer-von Mises statistics to estimate and test a regression model.

Computation of decision intervals (H) and average run lengths (ARL) for CUSUM charts. Details of the method are seen in Hawkins and Olwell (2012): Cumulative sum charts and charting for quality improvement, Springer Science & Business Media.

Compute expected shortfall (ES) and Value at Risk (VaR) from a quantile function, distribution function, random number generator, probability density function, or data. ES is also known as Conditional Value at Risk (CVaR). Virtually any continuous distribution can be specified. The functions are vectorized over the arguments. The computations are done directly from the definitions, see e.g. Acerbi and Tasche (2002) <doi:10.1111/1468-0300.00091>. Some support for GARCH models is provided, as well.

Converts numbers to continued fractions and back again. A solver for Pell's Equation is provided. The method for calculating roots in continued fraction form is provided without published attribution in such places as Professor Emeritus Jonathan Lubin, <http://www.math.brown.edu/jlubin/> and his post to StackOverflow, <https://math.stackexchange.com/questions/2215918> , or Professor Ron Knott, e.g., <https://r-knott.surrey.ac.uk/Fibonacci/cfINTRO.html> .

Cluster analysis with compositional data using the alpha--transformation. Relevant papers include: Tsagris M. and Kontemeniotis N. (2025), <doi:10.48550/arXiv.2509.05945>. Tsagris M.T., Preston S. and Wood A.T.A. (2011), <doi:10.48550/arXiv.1106.1451>. Garcia-Escudero Luis A., Gordaliza Alfonso, Matran Carlos, Mayo-Iscar Agustin. (2008), <doi:10.1214/07-AOS515>.

Find multiple solutions of a nonlinear least squares problem. Cluster Gauss-Newton method does not assume uniqueness of the solution of the nonlinear least squares problem and compute multiple minimizers. Please cite the following paper when this software is used in your research: Aoki et al. (2020) <doi:10.1007/s11081-020-09571-2>. Cluster Gaussâ Newton method. Optimization and Engineering, 1-31. Please cite the following paper when profile likelihood plot is drawn with this software and used in your research: Aoki and Sugiyama (2024) <doi:10.1002/psp4.13055>. Cluster Gauss-Newton method for a quick approximation of profile likelihood: With application to physiologically-based pharmacokinetic models. CPT Pharmacometrics Syst Pharmacol.13(1):54-67. GPT based helper bot available at <https://chatgpt.com/g/g-684936db9e748191a2796debb00cd755-cluster-gauss-newton-method-helper-bot> .

Compute covariate-adjusted specificity at controlled sensitivity level, or covariate-adjusted sensitivity at controlled specificity level, or covariate-adjust receiver operating characteristic curve, or covariate-adjusted thresholds at controlled sensitivity/specificity level. All statistics could also be computed for specific sub-populations given their covariate values. Methods are described in Ziyi Li, Yijian Huang, Datta Patil, Martin G. Sanda (2021+) "Covariate adjustment in continuous biomarker assessment".

Utilities to make your clinical collaborations easier if not fun. It contains functions for designing studies such as Simon 2-stage and group sequential designs and for data analysis such as Jonckheere-Terpstra test and estimating survival quantiles.

It computes full conformal, split conformal and multi-split conformal prediction regions when the response variable is multivariate (i.e. dimension is greater than one). Moreover, the package also contains plot functions to visualize the output of the full and split conformal functions. To guarantee consistency, the package structure mimics the univariate package conformalInference by Ryan Tibshirani. See Lei, Gâ sell, Rinaldo, Tibshirani, & Wasserman (2018) <doi:10.1080/01621459.2017.1307116> for full and split conformal prediction in regression, and Barber, Candès, Ramdas, & Tibshirani (2023) <doi:10.1214/23-AOS2276> for extensions beyond exchangeability.

Quick and easy access to datasets that let you replicate the empirical examples in Cameron and Trivedi (2005) "Microeconometrics: Methods and Applications" (ISBN: 9780521848053).The data are available as soon as you install and load the package (lazy-loading) as data frames. The documentation includes reference to chapter sections and page numbers where the datasets are used.

This package provides functions to create contour-enhanced forest plots for meta-analysis, supporting binary outcomes (e.g., odds ratios, risk ratios), continuous outcomes (e.g., correlations), and prevalence estimates. Includes options for prediction intervals, customized colors, study labeling, and contour shading to highlight regions of statistical significance. Based on metafor and ggplot2'.

It fits finite mixture models for censored or/and missing data using several multivariate distributions. Point estimation and asymptotic inference (via empirical information matrix) are offered as well as censored data generation. Pairwise scatter and contour plots can be generated. Possible multivariate distributions are the well-known normal, Student-t and skew-normal distributions. This package is an complement of Lachos, V. H., Moreno, E. J. L., Chen, K. & Cabral, C. R. B. (2017) <doi:10.1016/j.jmva.2017.05.005> for the multivariate skew-normal case.

This package provides a convenient set of wrapper functions to install pharmacometric packages and Shiny applications developed by Certara PMX and Integrated Drug Development (iDD). The functions ensure the successful installation of packages from non-standard repositories.

Offers a diverse collection of datasets focused on cardiovascular and heart disease research, including heart failure, myocardial infarction, aortic dissection, transplant outcomes, cardiovascular risk factors, drug efficacy, and mortality trends. Designed for researchers, clinicians, epidemiologists, and data scientists, the package features clinical, epidemiological, and simulated datasets covering a wide range of conditions and treatments such as statins, anticoagulants, and beta blockers. It supports analyses related to disease progression, treatment effects, rehospitalization, and public health outcomes across various cardiovascular patient populations.

This package provides tools for extracting occurrences, assessing potential driving factors, predicting occurrences, and quantifying impacts of compound events in hydrology and climatology. Please see Hao Zengchao et al. (2019) <doi:10.1088/1748-9326/ab4df5>.

Users can declare causal models over binary nodes, update beliefs about causal types given data, and calculate arbitrary queries. Updating is implemented in stan'. See Humphreys and Jacobs, 2023, Integrated Inferences (<DOI: 10.1017/9781316718636>) and Pearl, 2009 Causality (<DOI:10.1017/CBO9780511803161>).

Ceteris Paribus Profiles (What-If Plots) are designed to present model responses around selected points in a feature space. For example around a single prediction for an interesting observation. Plots are designed to work in a model-agnostic fashion, they are working for any predictive Machine Learning model and allow for model comparisons. Ceteris Paribus Plots supplement the Break Down Plots from breakDown package.

Cohort plAtform Trial Simulation whereby every cohort consists of two arms, control and experimental treatment. Endpoints are co-primary binary endpoints and decisions are made using either Bayesian or frequentist decision rules. Realistic trial trajectories are simulated and the operating characteristics of the designs are calculated.

Systematically Run R checks against multiple packages. Checks are run in parallel with strategies to minimize dependency installation. Provides out of the box interface for running reverse dependency check.

Computes a range of scatterplot diagnostics (scagnostics) on pairs of numerical variables in a data set. A range of scagnostics, including graph and association-based scagnostics described by Leland Wilkinson and Graham Wills (2008) <doi:10.1198/106186008X320465> and association-based scagnostics described by Katrin Grimm (2016,ISBN:978-3-8439-3092-5) can be computed. Summary and plotting functions are provided.

Conditioned Latin hypercube sampling, as published by Minasny and McBratney (2006) <DOI:10.1016/j.cageo.2005.12.009>. This method proposes to stratify sampling in presence of ancillary data. An extension of this method, which propose to associate a cost to each individual and take it into account during the optimisation process, is also proposed (Roudier et al., 2012, <DOI:10.1201/b12728>).