Computation of key characteristics and plots for blinded sample size recalculation. Continuous as well as binary endpoints are supported in superiority and non-inferiority trials. See Baumann, Pilz, Kieser (2022) <doi:10.32614/RJ-2022-001> for a detailed description. The implemented methods include the approaches by Lu, K. (2016) <doi:10.1002/pst.1737>, Kieser, M. and Friede, T. (2000) <doi:10.1002/(SICI)1097-0258(20000415)19:7%3C901::AID-SIM405%3E3.0.CO;2-L>, Friede, T. and Kieser, M. (2004) <doi:10.1002/pst.140>, Friede, T., Mitchell, C., Mueller-Veltern, G. (2007) <doi:10.1002/bimj.200610373>, and Friede, T. and Kieser, M. (2011) <doi:10.3414/ME09-01-0063>.

Fully Bayesian Classification with a subset of high-dimensional features, such as expression levels of genes. The data are modeled with a hierarchical Bayesian models using heavy-tailed t distributions as priors. When a large number of features are available, one may like to select only a subset of features to use, typically those features strongly correlated with the response in training cases. Such a feature selection procedure is however invalid since the relationship between the response and the features has be exaggerated by feature selection. This package provides a way to avoid this bias and yield better-calibrated predictions for future cases when one uses F-statistic to select features.

Combine diverse evidence across multiple studies to test a high level scientific theory. The methods can also be used as an alternative to a standard meta-analysis.

The function \codebarcode() produces a histogram-like plot of a distribution that shows granularity in the data.

Models discrete sequential data using Bayesian Context Trees. Context trees, also known as Variable Length Markov Chains (VLMCs), are parsimonious Markov models where the order of dependence can vary with the observed past. Provides a generic R6 class structure that exposes the full tree for building custom algorithms, exact Bayesian inference via a bottom-up recursive algorithm (closed-form marginal likelihood, Maximum A Posteriori (MAP) tree, exact posterior probabilities, and exact sampling from the posterior), a frequentist estimator via the context algorithm with likelihood-ratio pruning, simulation utilities, and a Metropolis-Hastings sampler. See Paulichen and Freguglia (2026) <doi:10.48550/arXiv.2603.25806>.

This R package offers block Gibbs samplers for the Bayesian (adaptive) graphical lasso, ridge, and naive elastic net priors. These samplers facilitate the simulation of the posterior distribution of precision matrices for Gaussian distributed data and were originally proposed by: Wang (2012) <doi:10.1214/12-BA729>; Smith et al. (2022) <doi:10.48550/arXiv.2210.16290> and Smith et al. (2023) <doi:10.48550/arXiv.2306.14199>, respectively.

Application of genome prediction for a continuous variable, focused on genotype by environment (GE) genomic selection models (GS). It consists a group of functions that help to create regression kernels for some GE genomic models proposed by Jarquà n et al. (2014) <doi:10.1007/s00122-013-2243-1> and Lopez-Cruz et al. (2015) <doi:10.1534/g3.114.016097>. Also, it computes genomic predictions based on Bayesian approaches. The prediction function uses an orthogonal transformation of the data and specific priors present by Cuevas et al. (2014) <doi:10.1534/g3.114.013094>.

Bootstraps and imputes incomplete datasets. Then performs inference on estimates obtained from analysing the imputed datasets as proposed by von Hippel and Bartlett (2021) <doi:10.1214/20-STS793>.

It is designed to calculate connection between (among) brain regions and plot connection lines. Also, the summary function is included to summarize group-level connectivity network. Kang, Jian (2016) <doi:10.1016/j.neuroimage.2016.06.042>.

This package provides Partial least squares Regression and various regular, sparse or kernel, techniques for fitting Cox models for big data. Provides a Partial Least Squares (PLS) algorithm adapted to Cox proportional hazards models that works with bigmemory matrices without loading the entire dataset in memory. Also implements a gradient-descent based solver for Cox proportional hazards models that works directly on bigmemory matrices. Bertrand and Maumy (2023) <https://hal.science/hal-05352069>, and <https://hal.science/hal-05352061> highlighted fitting and cross-validating PLS-based Cox models to censored big data.

Assume that a temporal process is composed of contiguous segments with differing slopes and replicated noise-corrupted time series measurements are observed. The unknown mean of the data generating process is modelled as a piecewise linear function of time with an unknown number of change-points. The package infers the joint posterior distribution of the number and position of change-points as well as the unknown mean parameters per time-series by MCMC sampling. A-priori, the proposed model uses an overfitting number of mean parameters but, conditionally on a set of change-points, only a subset of them influences the likelihood. An exponentially decreasing prior distribution on the number of change-points gives rise to a posterior distribution concentrating on sparse representations of the underlying sequence, but also available is the Poisson distribution. See Papastamoulis et al (2019) <doi:10.1515/ijb-2018-0052> for a detailed presentation of the method.

Client for the Binance <https://www.binance.com/> Spot, Futures, and Options REST APIs. Provides helper functions for signed and unsigned requests, market data retrieval, account access, and order management with data.table output by default.

Various layers of B.C., including administrative boundaries, natural resource management boundaries, census boundaries etc. All layers are available in BC Albers (<https://spatialreference.org/ref/epsg/3005/>) equal-area projection, which is the B.C. government standard. The layers are sourced from the British Columbia and Canadian government under open licenses, including B.C. Data Catalogue (<https://data.gov.bc.ca>), the Government of Canada Open Data Portal (<https://open.canada.ca/en/using-open-data>), and Statistics Canada (<https://www.statcan.gc.ca/en/terms-conditions/open-licence>).

This package provides methods for piecewise smooth regression. A piecewise smooth signal is estimated by applying a bootstrapped test recursively (binary segmentation approach). Each bootstrapped test decides whether the underlying signal is smooth on the currently considered subsegment or contains at least one further change-point.

Implementation of an efficient BLAST-like sequence comparison algorithm, written in C++11 and using native R datatypes. Blaster is based on nsearch - Schmid et al (2018) <doi:10.1101/399782>.

Full implementation of the 28 distributions introduced as benchmarks for nonparametric density estimation by Berlinet and Devroye (1994) <https://hal.science/hal-03659919>. Includes densities, cdfs, quantile functions and generators for samples as well as additional information on features of the densities. Also contains the 4 histogram densities used in Rozenholc/Mildenberger/Gather (2010) <doi:10.1016/j.csda.2010.04.021>.

Provide early termination phase II trial designs with a decreasingly informative prior (DIP) or a regular Bayesian prior chosen by the user. The program can determine the minimum planned sample size necessary to achieve the user-specified admissible designs. The program can also perform power and expected sample size calculations for the tests in early termination Phase II trials. See Wang C and Sabo RT (2022) <doi:10.18203/2349-3259.ijct20221110>; Sabo RT (2014) <doi:10.1080/10543406.2014.888441>.

The Bootstrap framework lets you add some JavaScript functionality to your web site by adding attributes to your HTML tags - Bootstrap takes care of the JavaScript <https://getbootstrap.com/docs/3.3/javascript/>. If you are using R Markdown or Shiny, you can use these functions to create collapsible sections, accordion panels, modals, tooltips, popovers, and an accordion sidebar framework (not described at Bootstrap site). Please note this package was designed for Bootstrap 3.3.

An R interface to the Base dos Dados API <https://basedosdados.org/docs/api_reference_python/>). Authenticate your project, query our tables, save data to disk and memory, all from R.

This package provides a computational toolbox designed for handling missing values in large datasets with the Multiple Imputation by Chained Equations (MICE) by using Apache Spark'. The methodology is described in Morvan et al. (2026) <doi:10.48550/arXiv.2601.21613>.

This package provides simplified access to selected Brazilian macroeconomic and financial time series from official sources, primarily the Central Bank of Brazil through the SGS (Sistema Gerenciador de Séries Temporais) API. The package enables users to quickly retrieve and visualize indicators such as the unemployment rate and the Selic interest rate using a standardized data structure. It is designed for data access and visualization purposes, without performing forecasts or statistical modeling. For more information, see the official API: <https://dadosabertos.bcb.gov.br/dataset/>.

We provide a framework for testing the probability of ruin in the classical (compound Poisson) risk process. It also includes some procedures for assessing and comparing the performance between the bootstrap test and the test using asymptotic normality.

Subgroup analyses are routinely performed in clinical trial analyses. From a methodological perspective, two key issues of subgroup analyses are multiplicity (even if only predefined subgroups are investigated) and the low sample sizes of subgroups which lead to highly variable estimates, see e.g. Yusuf et al (1991) <doi:10.1001/jama.1991.03470010097038>. This package implements subgroup estimates based on Bayesian shrinkage priors, see Carvalho et al (2019) <https://proceedings.mlr.press/v5/carvalho09a.html>. In addition, estimates based on penalized likelihood inference are available, based on Simon et al (2011) <doi:10.18637/jss.v039.i05>. The corresponding shrinkage based forest plots address the aforementioned issues and can complement standard forest plots in practical clinical trial analyses.

This is a sub national population projection model for calculating population development. The model uses a cohort component method. Further reading: Stanley K. Smith: A Practitioner's Guide to State and Local Population Projections. 2013. <doi:10.1007/978-94-007-7551-0>.