This package implements a tree-based method specifically designed for personalized medicine applications. By using genomic and mutational data, ODT efficiently identifies optimal drug recommendations tailored to individual patient profiles. The ODT algorithm constructs decision trees that bifurcate at each node, selecting the most relevant markers (discrete or continuous) and corresponding treatments, thus ensuring that recommendations are both personalized and statistically robust. This iterative approach enhances therapeutic decision-making by refining treatment suggestions until a predefined group size is achieved. Moreover, the simplicity and interpretability of the resulting trees make the method accessible to healthcare professionals. Includes functions for training the decision tree, making predictions on new samples or patients, and visualizing the resulting tree. For detailed insights into the methodology, please refer to Gimeno et al. (2023) <doi:10.1093/bib/bbad200>.

This package provides functions are provided that implement the use of the Fieller's formula methodology, for calculating a confidence interval for a ratio of (commonly, correlated) means. See Fieller (1954) <doi:10.1111/j.2517-6161.1954.tb00159.x>. Here, the application of primary interest is to studies of insect mortality response to increasing doses of a fumigant, or, e.g., to time in coolstorage. The formula is used to calculate a confidence interval for the dose or time required to achieve a specified mortality proportion, commonly 0.5 or 0.99. Vignettes demonstrate link functions that may be considered, checks on fitted models, and alternative choices of error family. Note in particular the betabinomial error family. See also Maindonald, Waddell, and Petry (2001) <doi:10.1016/S0925-5214(01)00082-5>.

Biterm Topic Models find topics in collections of short texts. It is a word co-occurrence based topic model that learns topics by modeling word-word co-occurrences patterns which are called biterms. This in contrast to traditional topic models like Latent Dirichlet Allocation and Probabilistic Latent Semantic Analysis which are word-document co-occurrence topic models. A biterm consists of two words co-occurring in the same short text window. This context window can for example be a twitter message, a short answer on a survey, a sentence of a text or a document identifier. The techniques are explained in detail in the paper 'A Biterm Topic Model For Short Text' by Xiaohui Yan, Jiafeng Guo, Yanyan Lan, Xueqi Cheng (2013) https://github.com/xiaohuiyan/xiaohuiyan.github.io/blob/master/paper/BTM-WWW13.pdf.

This package implements the Interpolate, Truncate, Project (ITP) root-finding algorithm developed by Oliveira and Takahashi (2021) <doi:10.1145/3423597>. The user provides the function, from the real numbers to the real numbers, and an interval with the property that the values of the function at its endpoints have different signs. If the function is continuous over this interval then the ITP method estimates the value at which the function is equal to zero. If the function is discontinuous then a point of discontinuity at which the function changes sign may be found. The function can be supplied using either an R function or an external pointer to a C++ function. Tuning parameters of the ITP algorithm can be set by the user. Default values are set based on arguments in Oliveira and Takahashi (2021).

Conducts Bayesian Hypothesis tests of a point null hypothesis against a two-sided alternative using Non-local Alternative Prior (NAP) for one- and two-sample z- and t-tests (Pramanik and Johnson, 2022). Under the alternative, the NAP is assumed on the standardized effects size in one-sample tests and on their differences in two-sample tests. The package considers two types of NAP densities: (1) the normal moment prior, and (2) the composite alternative. In fixed design tests, the functions calculate the Bayes factors and the expected weight of evidence for varied effect size and sample size. The package also provides a sequential testing framework using the Sequential Bayes Factor (SBF) design. The functions calculate the operating characteristics (OC) and the average sample number (ASN), and also conducts sequential tests for a sequentially observed data.

This package provides a single, phenome-wide permutation of large-scale biobank data. When a large number of phenotypes are analyzed in parallel, a single permutation across all phenotypes followed by genetic association analyses of the permuted data enables estimation of false discovery rates (FDRs) across the phenome. These FDR estimates provide a significance criterion for interpreting genetic associations in a biobank context. For the basic permutation of unrelated samples, this package takes a sample-by-variable file with ID, genotypic covariates, phenotypic covariates, and phenotypes as input. For data with related samples, it also takes a file with sample pair-wise identity-by-descent information. The function outputs a permuted sample-by-variable file ready for genome-wide association analysis. See Annis et al. (2021) <doi:10.21203/rs.3.rs-873449/v1> for details.

It performs interlaboratory studies (ILS) to detect those laboratories that provide non-consistent results when comparing to others. It permits to work simultaneously with various testing materials, from standard univariate, and functional data analysis (FDA) perspectives. The univariate approach based on ASTM E691-08 consist of estimating the Mandel's h and k statistics to identify those laboratories that provide more significant different results, testing also the presence of outliers by Cochran and Grubbs tests, Analysis of variance (ANOVA) techniques are provided (F and Tuckey tests) to test differences in means corresponding to different laboratories per each material. Taking into account the functional nature of data retrieved in analytical chemistry, applied physics and engineering (spectra, thermograms, etc.). ILS package provides a FDA approach for finding the Mandel's k and h statistics distribution by smoothing bootstrap resampling.

This package provides a single analysis path that includes distance-based ordination, global tests of any effect of the microbiome, and tests of the effects of individual taxa with false-discovery-rate (FDR) control. It accommodates both continuous and discrete covariates as well as interaction terms to be tested either singly or in combination, allows for adjustment of confounding covariates, and uses permutation-based p-values that can control for sample correlations. It can be applied to transformed data, and an omnibus test can combine results from analyses conducted on different transformation scales. It can also be used for testing presence-absence associations based on infinite number of rarefaction replicates, testing mediation effects of the microbiome, analyzing censored time-to-event outcomes, and for compositional analysis by fitting linear models to centered-log-ratio taxa count data.

This package provides functions for creating ensembles of optimal trees for regression, classification (Khan, Z., Gul, A., Perperoglou, A., Miftahuddin, M., Mahmoud, O., Adler, W., & Lausen, B. (2019). (2019) <doi:10.1007/s11634-019-00364-9>) and class membership probability estimation (Khan, Z, Gul, A, Mahmoud, O, Miftahuddin, M, Perperoglou, A, Adler, W & Lausen, B (2016) <doi:10.1007/978-3-319-25226-1_34>) are given. A few trees are selected from an initial set of trees grown by random forest for the ensemble on the basis of their individual and collective performance. Three different methods of tree selection for the case of classification are given. The prediction functions return estimates of the test responses and their class membership probabilities. Unexplained variations, error rates, confusion matrix, Brier scores, etc. are also returned for the test data.

It brings together several aspects of biodiversity data-cleaning in one place. bdc is organized in thematic modules related to different biodiversity dimensions, including 1) Merge datasets: standardization and integration of different datasets; 2) pre-filter: flagging and removal of invalid or non-interpretable information, followed by data amendments; 3) taxonomy: cleaning, parsing, and harmonization of scientific names from several taxonomic groups against taxonomic databases locally stored through the application of exact and partial matching algorithms; 4) space: flagging of erroneous, suspect, and low-precision geographic coordinates; and 5) time: flagging and, whenever possible, correction of inconsistent collection date. In addition, it contains features to visualize, document, and report data quality â which is essential for making data quality assessment transparent and reproducible. The reference for the methodology is Ribeiro and colleagues (2022) <doi:10.1111/2041-210X.13868>.

Quantile-frequency analysis (QFA) of time series based on trigonometric quantile regression. Spline quantile regression (SQR) for regression coefficient estimation. References: [1] Li, T.-H. (2012) "Quantile periodograms," Journal of the American Statistical Association, 107, 765â 776, <doi:10.1080/01621459.2012.682815>. [2] Li, T.-H. (2014) Time Series with Mixed Spectra, CRC Press, <doi:10.1201/b15154> [3] Li, T.-H. (2022) "Quantile Fourier transform, quantile series, and nonparametric estimation of quantile spectra," <doi:10.48550/arXiv.2211.05844>. [4] Li, T.-H. (2024) "Quantile crossing spectrum and spline autoregression estimation," <doi:10.48550/arXiv.2412.02513>. [5] Li, T.-H. (2024) "Spline autoregression method for estimation of quantile spectrum," <doi:10.48550/arXiv.2412.17163>. [6] Li, T.-H., and Megiddo, N. (2025) "Spline quantile regression," <doi:10.48550/arXiv.2501.03883>.

Support for fuzzy spatial objects, their operations, and fuzzy spatial inference models based on Spatial Plateau Algebra. It employs fuzzy set theory and fuzzy logic as foundation to deal with spatial fuzziness. It mainly implements underlying concepts defined in the following research papers: (i) "Spatial Plateau Algebra: An Executable Type System for Fuzzy Spatial Data Types" <doi:10.1109/FUZZ-IEEE.2018.8491565>; (ii) "A Systematic Approach to Creating Fuzzy Region Objects from Real Spatial Data Sets" <doi:10.1109/FUZZ-IEEE.2019.8858878>; (iii) "Spatial Data Types for Heterogeneously Structured Fuzzy Spatial Collections and Compositions" <doi:10.1109/FUZZ48607.2020.9177620>; (iv) "Fuzzy Inference on Fuzzy Spatial Objects (FIFUS) for Spatial Decision Support Systems" <doi:10.1109/FUZZ-IEEE.2017.8015707>; (v) "Evaluating Region Inference Methods by Using Fuzzy Spatial Inference Models" <doi:10.1109/FUZZ-IEEE55066.2022.9882658>.

Graph signals residing on the vertices of a graph have recently gained prominence in research in various fields. Many methodologies have been proposed to analyze graph signals by adapting classical signal processing tools. Recently, several notable graph signal decomposition methods have been proposed, which include graph Fourier decomposition based on graph Fourier transform, graph empirical mode decomposition, and statistical graph empirical mode decomposition. This package efficiently implements multiscale analysis applicable to various fields, and offers an effective tool for visualizing and decomposing graph signals. For the detailed methodology, see Ortega et al. (2018) <doi:10.1109/JPROC.2018.2820126>, Shuman et al. (2013) <doi:10.1109/MSP.2012.2235192>, Tremblay et al. (2014) <https://www.eurasip.org/Proceedings/Eusipco/Eusipco2014/HTML/papers/1569922141.pdf>, and Cho et al. (2024) "Statistical graph empirical mode decomposition by graph denoising and boundary treatment".

Tensor Composition Analysis (TCA) allows the deconvolution of two-dimensional data (features by observations) coming from a mixture of heterogeneous sources into a three-dimensional matrix of signals (features by observations by sources). The TCA framework further allows to test the features in the data for different statistical relations with an outcome of interest while modeling source-specific effects; particularly, it allows to look for statistical relations between source-specific signals and an outcome. For example, TCA can deconvolve bulk tissue-level DNA methylation data (methylation sites by individuals) into a three-dimensional tensor of cell-type-specific methylation levels for each individual (i.e. methylation sites by individuals by cell types) and it allows to detect cell-type-specific statistical relations (associations) with phenotypes. For more details see Rahmani et al. (2019) <DOI:10.1038/s41467-019-11052-9>.

This package provides a set of estimators for models and (robust) covariance matrices, and tests for panel data econometrics, including within/fixed effects, random effects, between, first-difference, nested random effects as well as instrumental-variable (IV) and Hausman-Taylor-style models, panel generalized method of moments (GMM) and general FGLS models, mean groups (MG), demeaned MG, and common correlated effects (CCEMG) and pooled (CCEP) estimators with common factors, variable coefficients and limited dependent variables models. Test functions include model specification, serial correlation, cross-sectional dependence, panel unit root and panel Granger (non-)causality. Typical references are general econometrics text books such as Baltagi (2021), Econometric Analysis of Panel Data (<doi:10.1007/978-3-030-53953-5>), Hsiao (2014), Analysis of Panel Data (<doi:10.1017/CBO9781139839327>), and Croissant and Millo (2018), Panel Data Econometrics with R (<doi:10.1002/9781119504641>).

Applies Beta Control Charts to defined values. The Beta Chart presents control limits based on the Beta probability distribution, making it suitable for monitoring fraction data from a Binomial distribution as a replacement for p-Charts. The Beta Chart has been applied in three real studies and compared with control limits from three different schemes. The comparative analysis showed that: (i) the Beta approximation to the Binomial distribution is more appropriate for values confined within the [0, 1] interval; and (ii) the proposed charts are more sensitive to the average run length (ARL) in both in-control and out-of-control process monitoring. Overall, the Beta Charts outperform the Shewhart control charts in monitoring fraction data. For more details, see à ngelo Márcio Oliveira Santâ Anna and Carla Schwengber ten Caten (2012) <doi:10.1016/j.eswa.2012.02.146>.

ANOVA and REML estimation of linear mixed models is implemented, once following Searle et al. (1991, ANOVA for unbalanced data), once making use of the lme4 package. The primary objective of this package is to perform a variance component analysis (VCA) according to CLSI EP05-A3 guideline "Evaluation of Precision of Quantitative Measurement Procedures" (2014). There are plotting methods for visualization of an experimental design, plotting random effects and residuals. For ANOVA type estimation two methods for computing ANOVA mean squares are implemented (SWEEP and quadratic forms). The covariance matrix of variance components can be derived, which is used in estimating confidence intervals. Linear hypotheses of fixed effects and LS means can be computed. LS means can be computed at specific values of covariables and with custom weighting schemes for factor variables. See ?VCA for a more comprehensive description of the features.

Implementation of the Dual Feature Reduction (DFR) approach for the Sparse Group Lasso (SGL) and the Adaptive Sparse Group Lasso (aSGL) (Feser and Evangelou (2024) <doi:10.48550/arXiv.2405.17094>). The DFR approach is a feature reduction approach that applies strong screening to reduce the feature space before optimisation, leading to speed-up improvements for fitting SGL (Simon et al. (2013) <doi:10.1080/10618600.2012.681250>) and aSGL (Mendez-Civieta et al. (2020) <doi:10.1007/s11634-020-00413-8> and Poignard (2020) <doi:10.1007/s10463-018-0692-7>) models. DFR is implemented using the Adaptive Three Operator Splitting (ATOS) (Pedregosa and Gidel (2018) <doi:10.48550/arXiv.1804.02339>) algorithm, with linear and logistic SGL models supported, both of which can be fit using k-fold cross-validation. Dense and sparse input matrices are supported.

This package provides a comprehensive set of tools for working with order statistics, including functions for simulating order statistics, censored samples (Type I and Type II), and record values from various continuous distributions. Additionally, it offers functions to compute moments (mean, variance, skewness, kurtosis) of order statistics for several continuous distributions. These tools assist researchers and statisticians in understanding and analyzing the properties of order statistics and related data. The methods and algorithms implemented in this package are based on several published works, including Ahsanullah et al (2013, ISBN:9789491216831), Arnold and Balakrishnan (2012, ISBN:1461236444), Harter and Balakrishnan (1996, ISBN:9780849394522), Balakrishnan and Sandhu (1995) <doi:10.1080/00031305.1995.10476150>, Genç (2012) <doi:10.1007/s00362-010-0320-y>, Makouei et al (2021) <doi:10.1016/j.cam.2021.113386> and Nagaraja (2013) <doi:10.1016/j.spl.2013.06.028>.

Network meta-analysis tools based on contrast-based approach using the multivariate meta-analysis and meta-regression models (Noma et al. (2025) <doi:10.1101/2025.09.15.25335823>). Comprehensive analysis tools for network meta-analysis and meta-regression (e.g., synthesis analysis, ranking analysis, and creating league table) are available through simple commands. For inconsistency assessment, the local and global inconsistency tests based on the Higgins design-by-treatment interaction model are available. In addition, the side-splitting methods and Jackson's random inconsistency model can be applied. Standard graphical tools for network meta-analysis, including network plots, ranked forest plots, and transitivity analyses, are also provided. For the synthesis analyses, the Noma-Hamura's improved REML (restricted maximum likelihood)-based methods (Noma et al. (2023) <doi:10.1002/jrsm.1652> <doi:10.1002/jrsm.1651>) are adopted as the default methods.

Computing package for Multidimensional Poverty Index (MPI) using Alkire-Foster method. Given N individuals, each person has D indicators of deprivation, the package compute MPI value to represent the degree of poverty in a population. The inputs are 1) an N by D matrix, which has the element (i,j) represents whether an individual i is deprived in an indicator j (1 is deprived and 0 is not deprived), and 2) the deprivation threshold. The main output is the MPI value, which has the range between zero and one. MPI value is approaching one if almost all people are deprived in all indicators, and it is approaching zero if almost no people are deprived in any indicator. Please see Alkire S., Chatterjee, M., Conconi, A., Seth, S. and Ana Vaz (2014) <doi:10.35648/20.500.12413/11781/ii039> for The Alkire-Foster methodology.

This package performs parametric and non-parametric estimation and simulation for multi-state discrete-time semi-Markov processes. For the parametric estimation, several discrete distributions are considered for the sojourn times: Uniform, Geometric, Poisson, Discrete Weibull and Negative Binomial. The non-parametric estimation concerns the sojourn time distributions, where no assumptions are done on the shape of distributions. Moreover, the estimation can be done on the basis of one or several sample paths, with or without censoring at the beginning or/and at the end of the sample paths. The implemented methods are described in Barbu, V.S., Limnios, N. (2008) <doi:10.1007/978-0-387-73173-5>, Barbu, V.S., Limnios, N. (2008) <doi:10.1080/10485250701261913> and Trevezas, S., Limnios, N. (2011) <doi:10.1080/10485252.2011.555543>. Estimation and simulation of discrete-time k-th order Markov chains are also considered.

This package provides an integrated analysis workflow for robust and reproducible analysis of mass spectrometry proteomics data for differential protein expression or differential enrichment. It requires tabular input (e.g. txt files) as generated by quantitative analysis softwares of raw mass spectrometry data, such as MaxQuant or IsobarQuant. Functions are provided for data preparation, filtering, variance normalization and imputation of missing values, as well as statistical testing of differentially enriched / expressed proteins. It also includes tools to check intermediate steps in the workflow, such as normalization and missing values imputation. Finally, visualization tools are provided to explore the results, including heatmap, volcano plot and barplot representations. For scientists with limited experience in R, the package also contains wrapper functions that entail the complete analysis workflow and generate a report. Even easier to use are the interactive Shiny apps that are provided by the package.

Paired mass distance (PMD) analysis proposed in Yu, Olkowicz and Pawliszyn (2018) <doi:10.1016/j.aca.2018.10.062> and PMD based reactomics analysis proposed in Yu and Petrick (2020) <doi:10.1038/s42004-020-00403-z> for gas/liquid chromatographyâ mass spectrometry (GC/LC-MS) based non-targeted analysis. PMD analysis including GlobalStd algorithm and structure/reaction directed analysis. GlobalStd algorithm could found independent peaks in m/z-retention time profiles based on retention time hierarchical cluster analysis and frequency analysis of paired mass distances within retention time groups. Structure directed analysis could be used to find potential relationship among those independent peaks in different retention time groups based on frequency of paired mass distances. Reactomics analysis could also be performed to build PMD network, assign sources and make biomarker reaction discovery. GUIs for PMD analysis is also included as shiny applications.