Package for CShapes 2.0, a GIS dataset of country borders (1886-today). Includes functions for data extraction and the computation of distance matrices and -lists.

This package implements the iterated RMCD method of Cerioli (2010) for multivariate outlier detection via robust Mahalanobis distances. Also provides the finite-sample RMCD method discussed in the paper, as well as the methods provided in Hardin and Rocke (2005) <doi:10.1198/106186005X77685> and Green and Martin (2017) <https://christopherggreen.github.io/papers/hr05_extension.pdf>. See also Chapter 2 of Green (2017) <https://digital.lib.washington.edu/researchworks/handle/1773/40304>.

Different tools for describing and analysing paired comparison data are presented. Main methods are estimation of products scores according Bradley Terry Luce model. A segmentation of the individual could be conducted on the basis of a mixture distribution approach. The number of classes can be tested by the use of Monte Carlo simulations. This package deals also with multi-criteria paired comparison data.

Utility functions that provides wrapper to descriptive base functions like cor, mean and table. It makes use of the formula interface to pass variables to functions. It also provides operators to concatenate (%+%), to repeat (%n%) and manage character vectors for nice display.

Causal Distillation Tree (CDT) is a novel machine learning method for estimating interpretable subgroups with heterogeneous treatment effects. CDT allows researchers to fit any machine learning model (or metalearner) to estimate heterogeneous treatment effects for each individual, and then "distills" these predicted heterogeneous treatment effects into interpretable subgroups by fitting an ordinary decision tree to predict the previously-estimated heterogeneous treatment effects. This package provides tools to estimate causal distillation trees (CDT), as detailed in Huang, Tang, and Kenney (2025) <doi:10.48550/arXiv.2502.07275>.

This package provides a convenient set of wrapper functions to install pharmacometric packages and Shiny applications developed by Certara PMX and Integrated Drug Development (iDD). The functions ensure the successful installation of packages from non-standard repositories.

This package provides several functions to identify and analyse miRNA sponge, including popular methods for identifying miRNA sponge interactions, two types of global ceRNA regulation prediction methods and four types of context-specific prediction methods( Li Y et al.(2017) <doi:10.1093/bib/bbx137>), which are based on miRNA-messenger RNA regulation alone, or by integrating heterogeneous data, respectively. In addition, For predictive ceRNA relationship pairs, this package provides several downstream analysis algorithms, including regulatory network analysis and functional annotation analysis, as well as survival prognosis analysis based on expression of ceRNA ternary pair.

Users can declare causal models over binary nodes, update beliefs about causal types given data, and calculate arbitrary queries. Updating is implemented in stan'. See Humphreys and Jacobs, 2023, Integrated Inferences (<DOI: 10.1017/9781316718636>) and Pearl, 2009 Causality (<DOI:10.1017/CBO9780511803161>).

Utilize the shiny interface to generate Goodness of Fit (GOF) plots and tables for Non-Linear Mixed Effects (NLME / NONMEM) pharmacometric models. From the interface, users can customize model diagnostics and generate the underlying R code to reproduce the diagnostic plots and tables outside of the shiny session. Model diagnostics can be included in a rmarkdown document and rendered to desired output format.

This package provides a tool for analyzing conjoint experiments using Bayesian Additive Regression Trees ('BART'), a machine learning method developed by Chipman, George and McCulloch (2010) <doi:10.1214/09-AOAS285>. This tool focuses specifically on estimating, identifying, and visualizing the heterogeneity within marginal component effects, at the observation- and individual-level. It uses a variable importance measure ('VIMP') with delete-d jackknife variance estimation, following Ishwaran and Lu (2019) <doi:10.1002/sim.7803>, to obtain bias-corrected estimates of which variables drive heterogeneity in the predicted individual-level effects.

Cluster Evolution Analytics allows us to use exploratory what if questions in the sense that the present information of an object is plugged-in a dataset in a previous time frame so that we can explore its evolution (and of its neighbors) to the present. See the URL for the papers associated with this package, as for instance, Morales-Oñate and Morales-Oñate (2024) <doi:10.1016/j.softx.2024.101921>.

It helps in development of a principal component analysis based composite index by assigning weights to variables and combining the weighted variables. For method details see Sendhil, R., Jha, A., Kumar, A. and Singh, S. (2018). <doi:10.1016/j.ecolind.2018.02.053>, and Wu, T. (2021). <doi:10.1016/j.ecolind.2021.108006>.

Sample and cell filtering as well as visualisation of output metrics from Cell Ranger by Grace X.Y. Zheng et al. (2017) <doi:10.1038/ncomms14049>. CRMetrics allows for easy plotting of output metrics across multiple samples as well as comparative plots including statistical assessments of these. CRMetrics allows for easy removal of ambient RNA using SoupX by Matthew D Young and Sam Behjati (2020) <doi:10.1093/gigascience/giaa151> or CellBender by Stephen J Fleming et al. (2022) <doi:10.1101/791699>. Furthermore, it is possible to preprocess data using Pagoda2 by Nikolas Barkas et al. (2021) <https://github.com/kharchenkolab/pagoda2> or Seurat by Yuhan Hao et al. (2021) <doi:10.1016/j.cell.2021.04.048> followed by embedding of cells using Conos by Nikolas Barkas et al. (2019) <doi:10.1038/s41592-019-0466-z>. Finally, doublets can be detected using scrublet by Samuel L. Wolock et al. (2019) <doi:10.1016/j.cels.2018.11.005> or DoubletDetection by Gayoso et al. (2020) <doi:10.5281/zenodo.2678041>. In the end, cells are filtered based on user input for use in downstream applications.

Automated and robust framework for analyzing R-R interval (RRi) signals using advanced nonlinear modeling and preprocessing techniques. The package implements a dual-logistic model to capture the rapid drop and subsequent recovery of RRi during exercise, as described by Castillo-Aguilar et al. (2025) <doi:10.1038/s41598-025-93654-6>. In addition, CardioCurveR includes tools for filtering RRi signals using zero-phase Butterworth low-pass filtering and for cleaning ectopic beats via adaptive outlier replacement using local regression and robust statistics. These integrated methods preserve the dynamic features of RRi signals and facilitate accurate cardiovascular monitoring and clinical research.

Calculate date of birth, age, and gender, and generate anonymous sequence numbers from CPR numbers. <https://en.wikipedia.org/wiki/Personal_identification_number_(Denmark)>.

Generate project files and directories following a pre-made template. You can specify variables to customize file names and content, and flexibly adapt the template to your needs. cookiecutter for R implements a subset of the excellent cookiecutter package for the Python programming language (<https://github.com/cookiecutter/>), and aims to be largely compatible with the original cookiecutter template format.

Estimate one or two cutpoints of a metric or ordinal-scaled variable in the multivariable context of survival data or time-to-event data. Visualise the cutpoint estimation process using contour plots, index plots, and spline plots. It is also possible to estimate cutpoints based on the assumption of a U-shaped or inverted U-shaped relationship between the predictor and the hazard ratio. Govindarajulu, U., and Tarpey, T. (2022) <doi:10.1080/02664763.2020.1846690>.

Encode and decode c-squares, from and to simple feature (sf) or spatiotemporal arrays (stars) objects. Use c-squares codes to quickly join or query spatial data.

These functions implement collocation-inference for continuous-time and discrete-time stochastic processes. They provide model-based smoothing, gradient-matching, generalized profiling and forwards prediction error methods.

Developing general equilibrium models, computing general equilibrium and simulating economic dynamics with structural dynamic models in LI (2019, ISBN: 9787521804225) "General Equilibrium and Structural Dynamics: Perspectives of New Structural Economics. Beijing: Economic Science Press". When developing complex general equilibrium models, GE package should be used in addition to this package.

The biases introduced in association measures, particularly mutual information, are influenced by factors such as tumor purity, mutation burden, and hypermethylation. This package provides the estimation of conditional mutual information (CMI) and its statistical significance with a focus on its application to multi-omics data. Utilizing B-spline functions (inspired by Daub et al. (2004) <doi:10.1186/1471-2105-5-118>), the package offers tools to estimate the association between heterogeneous multi- omics data, while removing the effects of confounding factors. This helps to unravel complex biological interactions. In addition, it includes methods to evaluate the statistical significance of these associations, providing a robust framework for multi-omics data integration and analysis. This package is ideal for researchers in computational biology, bioinformatics, and systems biology seeking a comprehensive tool for understanding interdependencies in omics data.

CEU (CEU San Pablo University) Mass Mediator is an on-line tool for aiding researchers in performing metabolite annotation. cmmr (CEU Mass Mediator RESTful API) allows for programmatic access in R: batch search, batch advanced search, MS/MS (tandem mass spectrometry) search, etc. For more information about the API Endpoint please go to <https://github.com/YaoxiangLi/cmmr>.

This package provides recent kernel density estimation methods for circular data, including adaptive and higher-order techniques. The implementation is based on recent advances in bandwidth selection and circular smoothing. Key methods include adaptive bandwidth selection methods by ZámeÄ nà k et al. (2024) <doi:10.1007/s00180-023-01401-0>, complete cross-validation by Hasilová et al. (2024) <doi:10.59170/stattrans-2024-024>, Fourier-based plug-in rules by Tenreiro (2022) <doi:10.1080/10485252.2022.2057974>, and higher-order kernels by Tsuruta & Sagae (2017) <doi:10.1016/j.spl.2017.08.003>.

The number of bird or bat fatalities from collisions with buildings, towers or wind energy turbines can be estimated based on carcass searches and experimentally assessed carcass persistence times and searcher efficiency. Functions for estimating the probability that a bird or bat that died is found by a searcher are provided. Further functions calculate the posterior distribution of the number of fatalities based on the number of carcasses found and the estimated detection probability.