The Core Microbiome refers to the group of microorganisms that are consistently present in a particular environment, habitat, or host species. These microorganisms play a crucial role in the functioning and stability of that ecosystem. Identifying these microorganisms can contribute to the emerging field of personalized medicine. The CoreMicrobiomeR is designed to facilitate the identification, statistical testing, and visualization of this group of microorganisms.This package offers three key functions to analyze and visualize microbial community data. This package has been developed based on the research papers published by Pereira et al.(2018) <doi:10.1186/s12864-018-4637-6> and Beule L, Karlovsky P. (2020) <doi:10.7717/peerj.9593>.

Method for identifying the instar of Curculionid larvae from the observed distribution of the headcapsule size of mature larvae.

This package provides a comprehensive framework for time series omics analysis, integrating changepoint detection, smooth and shape-constrained trends, and uncertainty quantification. It supports gene- and transcript-level inferences, p-value aggregation for improved power, and both case-only and case-control designs. It includes an interactive shiny interface. The methods are described in Yates et al. (2024) <doi:10.1101/2024.12.22.630003>.

Interact with Condor from R via SSH connection. Files are first uploaded from user machine to submitter machine, and the job is then submitted from the submitter machine to Condor'. Functions are provided to submit, list, and download Condor jobs from R. Condor is an open source high-throughput computing software framework for distributed parallelization of computationally intensive tasks.

Modeling periodic mortality (or other time-to event) processes from right-censored data. Given observations of a process with a known period (e.g. 365 days, 24 hours), functions determine the number, intensity, timing, and duration of peaks of periods of elevated hazard within a period. The underlying model is a mixed wrapped Cauchy function fitted using maximum likelihoods (details in Gurarie et al. (2020) <doi:10.1111/2041-210X.13305>). The development of these tools was motivated by the strongly seasonal mortality patterns observed in many wild animal populations. Thus, the respective periods of higher mortality can be identified as "mortality seasons".

This package provides a graphical user interface for simulating the effects of mergers, tariffs, and quotas under an assortment of different economic models. The interface is powered by the Shiny web application framework from RStudio'.

This package provides tools to process CBASS-derived PAM data efficiently. Minimal requirements are PAM-based photosynthetic efficiency data (or data from any other continuous variable that changes with temperature, e.g. relative bleaching scores) from 4 coral samples (nubbins) subjected to 4 temperature profiles of at least 2 colonies from 1 coral species from 1 site. Please refer to the following CBASS (Coral Bleaching Automated Stress System) papers for in-depth information regarding CBASS acute thermal stress assays, experimental design considerations, and ED5/ED50/ED95 thermal parameters: Nicolas R. Evensen et al. (2023) <doi:10.1002/lom3.10555> Christian R. Voolstra et al. (2020) <doi:10.1111/gcb.15148> Christian R. Voolstra et al. (2025) <doi:10.1146/annurev-marine-032223-024511>.

Computes conditional multivariate t probabilities, random deviates, and densities. It can also be used to create missing values at random in a dataset, resulting in a missing at random (MAR) mechanism. Inbuilt in the package are the Expectation-Maximization (EM), Monte Carlo EM, and Stochastic EM algorithms for imputation of missing values in datasets assuming the multivariate t distribution. See Kinyanjui, Tamba, Orawo, and Okenye (2020)<doi:10.3233/mas-200493>, and Kinyanjui, Tamba, and Okenye(2021)<http://www.ceser.in/ceserp/index.php/ijamas/article/view/6726/0> for more details.

In computationally demanding analysis projects, statisticians and data scientists asynchronously deploy long-running tasks to distributed systems, ranging from traditional clusters to cloud services. The crew.cluster package extends the mirai'-powered crew package with worker launcher plugins for traditional high-performance computing systems. Inspiration also comes from packages mirai by Gao (2023) <https://github.com/r-lib/mirai>, future by Bengtsson (2021) <doi:10.32614/RJ-2021-048>, rrq by FitzJohn and Ashton (2023) <https://github.com/mrc-ide/rrq>, clustermq by Schubert (2019) <doi:10.1093/bioinformatics/btz284>), and batchtools by Lang, Bischl, and Surmann (2017). <doi:10.21105/joss.00135>.

This package provides methods and functions to implement a Recommendation System based on Collaborative Filtering Methodology. See Aggarwal (2016) <doi:10.1007/978-3-319-29659-3> for an overview.

Contrast trees represent a new approach for assessing the accuracy of many types of machine learning estimates that are not amenable to standard (cross) validation methods; see "Contrast trees and distribution boosting", Jerome H. Friedman (2020) <doi:10.1073/pnas.1921562117>. In situations where inaccuracies are detected, boosted contrast trees can often improve performance. Functions are provided to to build such trees in addition to a special case, distribution boosting, an assumption free method for estimating the full probability distribution of an outcome variable given any set of joint input predictor variable values.

Convex Clustering methods, including K-means algorithm, On-line Update algorithm (Hard Competitive Learning) and Neural Gas algorithm (Soft Competitive Learning), and calculation of several indexes for finding the number of clusters in a data set.

Simulation of the stochastic 3D structure model for the nanoporous binder-conductive additive phase in battery cathodes introduced in P. Gräfensteiner, M. Osenberg, A. Hilger, N. Bohn, J. R. Binder, I. Manke, V. Schmidt, M. Neumann (2024) <doi:10.48550/arXiv.2409.11080>. The model is developed for a binder-conductive additive phase of consisting of carbon black, polyvinylidene difluoride binder and graphite particles. For its stochastic 3D modeling, a three-step procedure based on methods from stochastic geometry is used. First, the graphite particles are described by a Boolean model with ellipsoidal grains. Second, the mixture of carbon black and binder is modeled by an excursion set of a Gaussian random field in the complement of the graphite particles. Third, large pore regions within the mixture of carbon black and binder are described by a Boolean model with spherical grains.

Facilitate Pharmacokinetic (PK) and Pharmacodynamic (PD) modeling and simulation with powerful tools for Nonlinear Mixed-Effects (NLME) modeling. The package provides access to the same advanced Maximum Likelihood algorithms used by the NLME-Engine in the Phoenix platform. These tools support a range of analyses, from parametric methods to individual and pooled data, and support integrated use within the Pirana pharmacometric workbench <doi:10.1002/psp4.70067>. Execution is supported both locally or on remote machines.

Robust regression methods for compositional data. The distribution of the estimates can be approximated with various bootstrap methods. These bootstrap methods are available for the compositional as well as for standard robust regression estimates. This allows for direct comparison between them.

Sample and cell filtering as well as visualisation of output metrics from Cell Ranger by Grace X.Y. Zheng et al. (2017) <doi:10.1038/ncomms14049>. CRMetrics allows for easy plotting of output metrics across multiple samples as well as comparative plots including statistical assessments of these. CRMetrics allows for easy removal of ambient RNA using SoupX by Matthew D Young and Sam Behjati (2020) <doi:10.1093/gigascience/giaa151> or CellBender by Stephen J Fleming et al. (2022) <doi:10.1101/791699>. Furthermore, it is possible to preprocess data using Pagoda2 by Nikolas Barkas et al. (2021) <https://github.com/kharchenkolab/pagoda2> or Seurat by Yuhan Hao et al. (2021) <doi:10.1016/j.cell.2021.04.048> followed by embedding of cells using Conos by Nikolas Barkas et al. (2019) <doi:10.1038/s41592-019-0466-z>. Finally, doublets can be detected using scrublet by Samuel L. Wolock et al. (2019) <doi:10.1016/j.cels.2018.11.005> or DoubletDetection by Gayoso et al. (2020) <doi:10.5281/zenodo.2678041>. In the end, cells are filtered based on user input for use in downstream applications.

Interactive shiny application for running classical test theory (item analysis).

This package provides a generic, easy-to-use and intuitive pharmacokinetic/pharmacodynamic (PK/PD) simulation platform based on the R packages rxode2 and mrgsolve'. Campsis provides an abstraction layer over the underlying processes of defining a PK/PD model, assembling a custom dataset and running a simulation. The package has a strong dependency on the R package campsismod', which allows models to be read from and written to files, including through a JSON-based interface, and to be adapted further on the fly in the R environment. In addition, campsis allows users to assemble datasets in an intuitive manner, including via a JSON-based interface to import Campsis datasets defined using formal JSON schemas distributed with the package. Once the dataset is ready, the package prepares the simulation, calls rxode2 or mrgsolve (at the user's choice), and returns the results for the given model, dataset and desired simulation settings. The package itself is licensed under the GPL (>= 3); the JSON schema files shipped in inst/extdata are licensed separately under the Creative Commons Attribution 4.0 International (CC BY 4.0).

This package performs a Correspondence Analysis (CA) on a contingency table and creates a scatterplot of the row and column points on the selected dimensions. Optionally, the function can add segments to the plot to visualize significant associations between row and column categories on the basis of positive (unadjusted) standardized residuals larger than a given threshold.

Estimation of quantile regression models for survival data.

Reads chromatograms from binary formats into R objects. Currently supports conversion of Agilent ChemStation', Agilent MassHunter', Shimadzu LabSolutions', ThermoRaw', and Varian Workstation files as well as various text-based formats. In addition to its internal parsers, chromConverter contains bindings to parsers in external libraries, such as Aston <https://github.com/bovee/aston>, Entab <https://github.com/bovee/entab>, rainbow <https://rainbow-api.readthedocs.io/>, and ThermoRawFileParser <https://github.com/compomics/ThermoRawFileParser>.

Pull raw and pre-cleaned versions of national and state-level COVID-19 time-series data from covid19india.org <https://www.covid19india.org>. Easily obtain and merge case count data, testing data, and vaccine data. Also assists in calculating the time-varying effective reproduction number with sensible parameters for COVID-19.

This package provides tools to interface with Cytobank's API via R, organized by endpoints that represent various areas of Cytobank functionality. Learn more about Cytobank at <https://www.beckman.com/flow-cytometry/software>.

Immune related gene sets provided along with the cinaR package.