This package performs linear regression with respect to a data-driven convex loss function that is chosen to minimize the asymptotic covariance of the resulting M-estimator. The convex loss function is estimated in 5 steps: (1) form an initial OLS (ordinary least squares) or LAD (least absolute deviation) estimate of the regression coefficients; (2) use the resulting residuals to obtain a kernel estimator of the error density; (3) estimate the score function of the errors by differentiating the logarithm of the kernel density estimate; (4) compute the L2 projection of the estimated score function onto the set of decreasing functions; (5) take a negative antiderivative of the projected score function estimate. Newton's method (with Hessian modification) is then used to minimize the convex empirical risk function. Further details of the method are given in Feng et al. (2024) <doi:10.48550/arXiv.2403.16688>.

This package provides a likelihood-based hypothesis testing approach is implemented for assessing causal mediation. Described in Millstein, Chen, and Breton (2016), <DOI:10.1093/bioinformatics/btw135>, it could be used to test for mediation of a known causal association between a DNA variant, the instrumental variable', and a clinical outcome or phenotype by gene expression or DNA methylation, the potential mediator. Another example would be testing mediation of the effect of a drug on a clinical outcome by the molecular target. The hypothesis test generates a p-value or permutation-based FDR value with confidence intervals to quantify uncertainty in the causal inference. The outcome can be represented by either a continuous or binary variable, the potential mediator is continuous, and the instrumental variable can be continuous or binary and is not limited to a single variable but may be a design matrix representing multiple variables.

Collective matrix factorization (CMF) finds joint low-rank representations for a collection of matrices with shared row or column entities. This code learns a variational Bayesian approximation for CMF, supporting multiple likelihood potentials and missing data, while identifying both factors shared by multiple matrices and factors private for each matrix. For further details on the method see Klami et al. (2014) <arXiv:1312.5921>. The package can also be used to learn Bayesian canonical correlation analysis (CCA) and group factor analysis (GFA) models, both of which are special cases of CMF. This is likely to be useful for people looking for CCA and GFA solutions supporting missing data and non-Gaussian likelihoods. See Klami et al. (2013) <https://research.cs.aalto.fi/pml/online-papers/klami13a.pdf> and Virtanen et al. (2012) <http://proceedings.mlr.press/v22/virtanen12.html> for details on Bayesian CCA and GFA, respectively.

General P-splines are non-uniform B-splines penalized by a general difference penalty, proposed by Li and Cao (2022) <arXiv:2201.06808>. Constructible on arbitrary knots, they extend the standard P-splines of Eilers and Marx (1996) <doi:10.1214/ss/1038425655>. They are also related to the O-splines of O'Sullivan (1986) <doi:10.1214/ss/1177013525> via a sandwich formula that links a general difference penalty to a derivative penalty. The package includes routines for setting up and handling difference and derivative penalties. It also fits P-splines and O-splines to (x, y) data (optionally weighted) for a grid of smoothing parameter values in the automatic search intervals of Li and Cao (2023) <doi:10.1007/s11222-022-10178-z>. It aims to facilitate other packages to implement P-splines or O-splines as a smoothing tool in their model estimation framework.

This package implements the doubly robust distribution balancing weighting proposed by Katsumata (2024) <doi:10.1017/psrm.2024.23>, which improves the augmented inverse probability weighting (AIPW) by estimating propensity scores with estimating equations suitable for the pre-specified parameter of interest (e.g., the average treatment effects or the average treatment effects on the treated) and estimating outcome models with the estimated inverse probability weights. It also implements the covariate balancing propensity score proposed by Imai and Ratkovic (2014) <doi:10.1111/rssb.12027> and the entropy balancing weighting proposed by Hainmueller (2012) <doi:10.1093/pan/mpr025>, both of which use covariate balancing conditions in propensity score estimation. The point estimate of the parameter of interest and its uncertainty as well as coefficients for propensity score estimation and outcome regression are produced using the M-estimation. The same functions can be used to estimate average outcomes in missing outcome cases.

Index of Multiple Deprivation for UK nations at various geographical levels. In England, deprivation data is for Lower Layer Super Output Areas, Middle Layer Super Output Areas, Wards, and Local Authorities based on data from <https://www.gov.uk/government/statistics/english-indices-of-deprivation-2019>. In Wales, deprivation data is for Lower Layer Super Output Areas, Middle Layer Super Output Areas, Wards, and Local Authorities based on data from <https://gov.wales/welsh-index-multiple-deprivation-full-index-update-ranks-2019>. In Scotland, deprivation data is for Data Zones, Intermediate Zones, and Council Areas based on data from <https://simd.scot>. In Northern Ireland, deprivation data is for Super Output Areas and Local Government Districts based on data from <https://www.nisra.gov.uk/statistics/deprivation/northern-ireland-multiple-deprivation-measure-2017-nimdm2017>. The IMD package also provides the composite UK index developed by <https://github.com/mysociety/composite_uk_imd>.

Accumulated Local Effects (ALE) were initially developed as a model-agnostic approach for global explanations of the results of black-box machine learning algorithms. ALE has a key advantage over other approaches like partial dependency plots (PDP) and SHapley Additive exPlanations (SHAP): its values represent a clean functional decomposition of the model. As such, ALE values are not affected by the presence or absence of interactions among variables in a mode. Moreover, its computation is relatively rapid. This package reimplements the algorithms for calculating ALE data and develops highly interpretable visualizations for plotting these ALE values. It also extends the original ALE concept to add bootstrap-based confidence intervals and ALE-based statistics that can be used for statistical inference. For more details, see Okoli, Chitu. 2023. â Statistical Inference Using Machine Learning and Classical Techniques Based on Accumulated Local Effects (ALE).â arXiv. <doi:10.48550/arXiv.2310.09877>.

There is no ophthalmic researcher who has not had headaches from the handling of visual acuity entries. Different notations, untidy entries. This shall now be a matter of the past. Eye makes it as easy as pie to work with VA data - easy cleaning, easy conversion between Snellen, logMAR, ETDRS letters, and qualitative visual acuity shall never pester you again. The eye package automates the pesky task to count number of patients and eyes, and can help to clean data with easy re-coding for right and left eyes. It also contains functions to help reshaping eye side specific variables between wide and long format. Visual acuity conversion is based on Schulze-Bonsel et al. (2006) <doi:10.1167/iovs.05-0981>, Gregori et al. (2010) <doi:10.1097/iae.0b013e3181d87e04>, Beck et al. (2003) <doi:10.1016/s0002-9394(02)01825-1> and Bach (2007) <https://michaelbach.de/sci/acuity.html>.

Create and learn Chain Event Graph (CEG) models using a Bayesian framework. It provides us with a Hierarchical Agglomerative algorithm to search the CEG model space. The package also includes several facilities for visualisations of the objects associated with a CEG. The CEG class can represent a range of relational data types, and supports arbitrary vertex, edge and graph attributes. A Chain Event Graph is a tree-based graphical model that provides a powerful graphical interface through which domain experts can easily translate a process into sequences of observed events using plain language. CEGs have been a useful class of graphical model especially to capture context-specific conditional independences. References: Collazo R, Gorgen C, Smith J. Chain Event Graph. CRC Press, ISBN 9781498729604, 2018 (forthcoming); and Barday LM, Collazo RA, Smith JQ, Thwaites PA, Nicholson AE. The Dynamic Chain Event Graph. Electronic Journal of Statistics, 9 (2) 2130-2169 <doi:10.1214/15-EJS1068>.

This package provides statistical methods for auditing as implemented in JASP for Audit (Derks et al., 2021 <doi:10.21105/joss.02733>). First, the package makes it easy for an auditor to plan a statistical sample, select the sample from the population, and evaluate the misstatement in the sample compliant with international auditing standards. Second, the package provides statistical methods for auditing data, including tests of digit distributions and repeated values. Finally, the package includes methods for auditing algorithms on the aspect of fairness and bias. Next to classical statistical methodology, the package implements Bayesian equivalents of these methods whose statistical underpinnings are described in Derks et al. (2021) <doi:10.1111/ijau.12240>, Derks et al. (2024) <doi:10.2308/AJPT-2021-086>, Derks et al. (2022) <doi:10.31234/osf.io/8nf3e> Derks et al. (2024) <doi:10.31234/osf.io/tgq5z>, and Derks et al. (2025) <doi:10.31234/osf.io/b8tu2>.

Univariate and multivariate SQC tools that completes and increases the SQC techniques available in R. Apart from integrating different R packages devoted to SQC ('qcc','MSQC'), provides nonparametric tools that are highly useful when Gaussian assumption is not met. This package computes standard univariate control charts for individual measurements, X-bar', S', R', p', np', c', u', EWMA and CUSUM'. In addition, it includes functions to perform multivariate control charts such as Hotelling T2', MEWMA and MCUSUM'. As representative feature, multivariate nonparametric alternatives based on data depth are implemented in this package: r', Q and S control charts. In addition, Phase I and II control charts for functional data are included. This package also allows the estimation of the most complete set of capability indices from first to fourth generation, covering the nonparametric alternatives, and performing the corresponding capability analysis graphical outputs, including the process capability plots. See Flores et al. (2021) <doi:10.32614/RJ-2021-034>.

The standard Difference-in-Differences (DID) setup involves two periods and two groups -- a treated group and untreated group. Many applications of DID methods involve more than two periods and have individuals that are treated at different points in time. This package contains tools for computing average treatment effect parameters in Difference in Differences setups with more than two periods and with variation in treatment timing using the methods developed in Callaway and Sant'Anna (2021) <doi:10.1016/j.jeconom.2020.12.001>. The main parameters are group-time average treatment effects which are the average treatment effect for a particular group at a a particular time. These can be aggregated into a fewer number of treatment effect parameters, and the package deals with the cases where there is selective treatment timing, dynamic treatment effects, calendar time effects, or combinations of these. There are also functions for testing the Difference in Differences assumption, and plotting group-time average treatment effects.

Introduction to some novel accurate hybrid methods of geostatistical and machine learning methods for spatial predictive modelling. It contains two commonly used geostatistical methods, two machine learning methods, four hybrid methods and two averaging methods. For each method, two functions are provided. One function is for assessing the predictive errors and accuracy of the method based on cross-validation. The other one is for generating spatial predictions using the method. For details please see: Li, J., Potter, A., Huang, Z., Daniell, J. J. and Heap, A. (2010) <https://ecat.ga.gov.au/geonetwork/srv/eng/catalog.search#/metadata/71407> Li, J., Heap, A. D., Potter, A., Huang, Z. and Daniell, J. (2011) <doi:10.1016/j.csr.2011.05.015> Li, J., Heap, A. D., Potter, A. and Daniell, J. (2011) <doi:10.1016/j.envsoft.2011.07.004> Li, J., Potter, A., Huang, Z. and Heap, A. (2012) <https://ecat.ga.gov.au/geonetwork/srv/eng/catalog.search#/metadata/74030>.

We provide tools to estimate the individualized interval-valued dose rule (I2DR) that maximizes the expected beneficial clinical outcome for each individual and returns an optimal interval-valued dose, by using the jump Q-learning (JQL) method. The jump Q-learning method directly models the conditional mean of the response given the dose level and the baseline covariates via jump penalized least squares regression under the framework of Q learning. We develop a searching algorithm by dynamic programming in order to find the optimal I2DR with the time complexity O(n2) and spatial complexity O(n). To alleviate the effects of misspecification of the Q-function, a residual jump Q-learning is further proposed to estimate the optimal I2DR. The outcome of interest includes the best partition of the entire dosage of interest, the regression coefficients of each partition, and the value function under the estimated I2DR as well as the Wald-type confidence interval of value function constructed through the Bootstrap.

This package provides methods and tools for (pre-)processing of metabolomics datasets (i.e. peak matrices), including filtering, normalisation, missing value imputation, scaling, and signal drift and batch effect correction methods. Filtering methods are based on: the fraction of missing values (across samples or features); Relative Standard Deviation (RSD) calculated from the Quality Control (QC) samples; the blank samples. Normalisation methods include Probabilistic Quotient Normalisation (PQN) and normalisation to total signal intensity. A unified user interface for several commonly used missing value imputation algorithms is also provided. Supported methods are: k-nearest neighbours (knn), random forests (rf), Bayesian PCA missing value estimator (bpca), mean or median value of the given feature and a constant small value. The generalised logarithm (glog) transformation algorithm is available to stabilise the variance across low and high intensity mass spectral features. Finally, this package provides an implementation of the Quality Control-Robust Spline Correction (QCRSC) algorithm for signal drift and batch effect correction of mass spectrometry-based datasets.

The main goal of this package is drawing the membership function of the fuzzy p-value which is defined as a fuzzy set on the unit interval for three following problems: (1) testing crisp hypotheses based on fuzzy data, see Filzmoser and Viertl (2004) <doi:10.1007/s001840300269>, (2) testing fuzzy hypotheses based on crisp data, see Parchami et al. (2010) <doi:10.1007/s00362-008-0133-4>, and (3) testing fuzzy hypotheses based on fuzzy data, see Parchami et al. (2012) <doi:10.1007/s00362-010-0353-2>. In all cases, the fuzziness of data or / and the fuzziness of the boundary of null fuzzy hypothesis transported via the p-value function and causes to produce the fuzzy p-value. If the p-value is fuzzy, it is more appropriate to consider a fuzzy significance level for the problem. Therefore, the comparison of the fuzzy p-value and the fuzzy significance level is evaluated by a fuzzy ranking method in this package.

Conducts analyses for healthcare program evaluations or intervention studies. Calculates regression analyses for standard ordinary least squares (OLS or linear) or logistic models. Performs regression models used for causal modeling such as differences-in-differences (DID) and interrupted time series (ITS) models. Provides limited interpretations of model results and a ranking of variable importance in models. Performs propensity score models, top-coding of model outcome variables, and can return new data with the newly formed variables. Also performs Cronbach's alpha for various scale items (e.g., survey questions). See Github URL for examples in the README file. For more details on the statistical methods, see Allen & Yen (1979, ISBN:0-8185-0283-5), Angrist & Pischke (2009, ISBN:9780691120355), Harrell (2016, ISBN:978-3-319-19424-0), Kline (1999, ISBN:9780415211581), Linden (2015) <doi:10.1177/1536867X1501500208>, Merlo (2006) <doi:10.1136/jech.2004.029454> Muthen & Satorra (1995) <doi:10.2307/271070>, and Rabe-Hesketh & Skrondal (2008, ISBN:978-1-59718-040-5).

Incorporating node-level covariates for community detection has gained increasing attention these years. This package provides the function for implementing the novel community detection algorithm known as Network-Adjusted Covariates for Community Detection (NAC), which is designed to detect latent community structure in graphs with node-level information, i.e., covariates. This algorithm can handle models such as the degree-corrected stochastic block model (DCSBM) with covariates. NAC specifically addresses the discrepancy between the community structure inferred from the adjacency information and the community structure inferred from the covariates information. For more detailed information, please refer to the reference paper: Yaofang Hu and Wanjie Wang (2023) <arXiv:2306.15616>. In addition to NAC, this package includes several other existing community detection algorithms that are compared to NAC in the reference paper. These algorithms are Spectral Clustering On Ratios-of Eigenvectors (SCORE), network-based regularized spectral clustering (Net-based), covariate-based spectral clustering (Cov-based), covariate-assisted spectral clustering (CAclustering) and semidefinite programming (SDP).

Mortality rates are typically provided in an abridged format, i.e., by age groups 0, [1, 5], [5, 10]', [10, 15]', and so on. Some applications necessitate a detailed (single) age description. Despite the large number of proposed approaches in the literature, only a few methods ensure great performance at both younger and higher ages. For example, the 6-term Lagrange interpolation function is well suited to mortality interpolation at younger ages (with irregular intervals), but not at older ages. The Karup-King method, on the other hand, performs well at older ages but is not suitable for younger ones. Interested readers can find a full discussion of the two stated methods in the book Shryock, Siegel, and Associates (1993).The Q2q package combines the two methods to allow for the interpolation of mortality rates across all age groups. It begins by implementing each method independently, and then the resulting curves are linked using a 5-age averaged error between the two partial curves.

Implementations of the kernel measure of multi-sample dissimilarity (KMD) between several samples using K-nearest neighbor graphs and minimum spanning trees. The KMD measures the dissimilarity between multiple samples, based on the observations from them. It converges to the population quantity (depending on the kernel) which is between 0 and 1. A small value indicates the multiple samples are from the same distribution, and a large value indicates the corresponding distributions are different. The population quantity is 0 if and only if all distributions are the same, and 1 if and only if all distributions are mutually singular. The package also implements the tests based on KMD for H0: the M distributions are equal against H1: not all the distributions are equal. Both permutation test and asymptotic test are available. These tests are consistent against all alternatives where at least two samples have different distributions. For more details on KMD and the associated tests, see Huang, Z. and B. Sen (2022) <arXiv:2210.00634>.

The kernelSmoothing() function allows you to square and smooth geolocated data. It calculates a classical kernel smoothing (conservative) or a geographically weighted median. There are four major call modes of the function. The first call mode is kernelSmoothing(obs, epsg, cellsize, bandwidth) for a classical kernel smoothing and automatic grid. The second call mode is kernelSmoothing(obs, epsg, cellsize, bandwidth, quantiles) for a geographically weighted median and automatic grid. The third call mode is kernelSmoothing(obs, epsg, cellsize, bandwidth, centroids) for a classical kernel smoothing and user grid. The fourth call mode is kernelSmoothing(obs, epsg, cellsize, bandwidth, quantiles, centroids) for a geographically weighted median and user grid. Geographically weighted summary statistics : a framework for localised exploratory data analysis, C.Brunsdon & al., in Computers, Environment and Urban Systems C.Brunsdon & al. (2002) <doi:10.1016/S0198-9715(01)00009-6>, Statistical Analysis of Spatial and Spatio-Temporal Point Patterns, Third Edition, Diggle, pp. 83-86, (2003) <doi:10.1080/13658816.2014.937718>.

Developed for computing the probability density function, computing the cumulative distribution function, computing the quantile function, random generation, drawing q-q plot, and estimating the parameters of 24 G-family of statistical distributions via the maximum product spacing approach introduced in <https://www.jstor.org/stable/2345411>. The set of families contains: beta G distribution, beta exponential G distribution, beta extended G distribution, exponentiated G distribution, exponentiated exponential Poisson G distribution, exponentiated generalized G distribution, exponentiated Kumaraswamy G distribution, gamma type I G distribution, gamma type II G distribution, gamma uniform G distribution, gamma-X generated of log-logistic family of G distribution, gamma-X family of modified beta exponential G distribution, geometric exponential Poisson G distribution, generalized beta G distribution, generalized transmuted G distribution, Kumaraswamy G distribution, log gamma type I G distribution, log gamma type II G distribution, Marshall Olkin G distribution, Marshall Olkin Kumaraswamy G distribution, modified beta G distribution, odd log-logistic G distribution, truncated-exponential skew-symmetric G distribution, and Weibull G distribution.

Calculate magnetic field at a given location and time according to the World Magnetic Model (WMM). Both the main field and secular variation components are returned. This functionality is useful for physicists and geophysicists who need orthogonal components from WMM. Currently, this package supports annualized time inputs between 2000 and 2025. If desired, users can specify which WMM version to use, e.g., the original WMM2015 release or the recent out-of-cycle WMM2015 release. Methods used to implement WMM, including the Gauss coefficients for each release, are described in the following publications: Chulliat et al (2020) <doi:10.25923/ytk1-yx35>, Chulliat et al (2019) <doi:10.25921/xhr3-0t19>, Chulliat et al (2015) <doi:10.7289/V5TB14V7>, Maus et al (2010) <https://www.ngdc.noaa.gov/geomag/WMM/data/WMMReports/WMM2010_Report.pdf>, McLean et al (2004) <https://www.ngdc.noaa.gov/geomag/WMM/data/WMMReports/TRWMM_2005.pdf>, and Macmillian et al (2000) <https://www.ngdc.noaa.gov/geomag/WMM/data/WMMReports/wmm2000.pdf>.

This package provides a toolbox to derive flexible cutoffs for fit indices in Covariance-based Structural Equation Modeling based on the paper by Niemand & Mai (2018) <doi:10.1007/s11747-018-0602-9>. Flexible cutoffs are an alternative to fixed cutoffs - rules-of-thumb - regarding an appropriate cutoff for fit indices such as CFI or SRMR'. It has been demonstrated that these flexible cutoffs perform better than fixed cutoffs in grey areas where misspecification is not easy to detect. The package provides an alternative to the tool at <https://flexiblecutoffs.org> as it allows to tailor flexible cutoffs to a given dataset and model, which is so far not available in the tool. The package simulates fit indices based on a given dataset and model and then estimates the flexible cutoffs. Some useful functions, e.g., to determine the GoF- or BoF-nature of a fit index, are provided. So far, additional options for a relative use (is a model better than another?) are provided in an exploratory manner.