Generates tree plots with precise branch lengths, gene annotations, and cellular prevalence. The package handles complex tree structures (angles, lengths, etc.) and can be further refined as needed by the user.

This package provides adaptive trend estimation, cycle detection, Fourier harmonic selection, bootstrap confidence intervals, change-point detection, and rolling-origin forecasting. Supports LOESS (Locally Estimated Scatterplot Smoothing), GAM (Generalized Additive Model), and GAMM (Generalized Additive Mixed Model), and automatically handles irregular sampling using the Lomb-Scargle periodogram. Methods implemented in this package are described in Cleveland et al. (1990) <doi:10.2307/2289548>, Wood (2017) <doi:10.1201/9781315370279>, and Scargle (1982) <doi:10.1086/160554>.

Provide functions for reading and writing CSVW - i.e. CSV tables and JSON metadata. The metadata helps interpret CSV by setting the types and variable names.

Fit a CoxSEI (Cox type Self-Exciting Intensity) model to right-censored counting process data.

Implementing seven Covariate-Adaptive Randomization to assign patients to two treatments. Three of these procedures can also accommodate quantitative and mixed covariates. Given a set of covariates, the user can generate a single sequence of allocations or replicate the design multiple times by simulating the patients covariate profiles. At the end, an extensive assessment of the performance of the randomization procedures is provided, calculating several imbalance measures. See Baldi Antognini A, Frieri R, Zagoraiou M and Novelli M (2022) <doi:10.1007/s00362-022-01381-1> for details.

Tool for performing computational testing for conditional independence between variables in a dataset. CCI implements permutation in combination with Monte Carlo Cross-Validation in generating null distributions and test statistics. For more details see Computational Test for Conditional Independence (2024) <doi:10.3390/a17080323>.

Procedures for making continuous cartogram. Procedures available are: flow based cartogram (Gastner & Newman (2004) <doi:10.1073/pnas.0400280101>), fast flow based cartogram (Gastner, Seguy & More (2018) <doi:10.1073/pnas.1712674115>), rubber band based cartogram (Dougenik et al. (1985) <doi:10.1111/j.0033-0124.1985.00075.x>).

This package provides a set of functions for conducting cognitive diagnostic computerized adaptive testing applications (Chen, 2009) <DOI:10.1007/s11336-009-9123-2>). It includes different item selection rules such us the global discrimination index (Kaplan, de la Torre, and Barrada (2015) <DOI:10.1177/0146621614554650>) and the nonparametric selection method (Chang, Chiu, and Tsai (2019) <DOI:10.1177/0146621618813113>), as well as several stopping rules. Functions for generating item banks and responses are also provided. To guide item bank calibration, model comparison at the item level can be conducted using the two-step likelihood ratio test statistic by Sorrel, de la Torre, Abad and Olea (2017) <DOI:10.1027/1614-2241/a000131>.

This package provides a class of methods that combine dimension reduction and clustering of continuous, categorical or mixed-type data (Markos, Iodice D'Enza and van de Velden 2019; <DOI:10.18637/jss.v091.i10>). For continuous data, the package contains implementations of factorial K-means (Vichi and Kiers 2001; <DOI:10.1016/S0167-9473(00)00064-5>) and reduced K-means (De Soete and Carroll 1994; <DOI:10.1007/978-3-642-51175-2_24>); both methods that combine principal component analysis with K-means clustering. For categorical data, the package provides MCA K-means (Hwang, Dillon and Takane 2006; <DOI:10.1007/s11336-004-1173-x>), i-FCB (Iodice D'Enza and Palumbo 2013, <DOI:10.1007/s00180-012-0329-x>) and Cluster Correspondence Analysis (van de Velden, Iodice D'Enza and Palumbo 2017; <DOI:10.1007/s11336-016-9514-0>), which combine multiple correspondence analysis with K-means. For mixed-type data, it provides mixed Reduced K-means and mixed Factorial K-means (van de Velden, Iodice D'Enza and Markos 2019; <DOI:10.1002/wics.1456>), which combine PCA for mixed-type data with K-means.

Connect to WFP's Moda platform to R, download data, and obtain the list of individuals with access to the project along with their access level.

This package provides functions and a workflow to easily and powerfully calculating specificity, sensitivity and ROC curves of biomarkers combinations. Allows to rank and select multi-markers signatures as well as to find the best performing sub-signatures, now also from single-cell RNA-seq datasets. The method used was first published as a Shiny app and described in Mazzara et al. (2017) <doi:10.1038/srep45477> and further described in Bombaci & Rossi (2019) <doi:10.1007/978-1-4939-9164-8_16>, and widely expanded as a package as presented in the bioRxiv pre print Ferrari et al. <doi:10.1101/2022.01.17.476603>.

Use optimal equal-HR method to determine two optimal cutpoints of a continuous predictor that has a U-shaped relationship with survival outcomes based on Cox regression model. The optimal equal-HR method estimates two optimal cut-points that have approximately the same log hazard value based on Cox regression model and divides individuals into different groups according to their HR values.

This package provides a simple, fast algorithm to find the neighbors and similarities of users in user-based filtering systems, to break free from the complex computation of existing similarity formulas and the ability to solve big data.

Fit multiclass Classification version of Bayesian Adaptive Smoothing Splines (CBASS) to data using reversible jump MCMC. The multiclass classification problem consists of a response variable that takes on unordered categorical values with at least three levels, and a set of inputs for each response variable. The CBASS model consists of a latent multivariate probit formulation, and the means of the latent Gaussian random variables are specified using adaptive regression splines. The MCMC alternates updates of the latent Gaussian variables and the spline parameters. All the spline parameters (variables, signs, knots, number of interactions), including the number of basis functions used to model each latent mean, are inferred. Functions are provided to process inputs, initialize the chain, run the chain, and make predictions. Predictions are made on a probabilistic basis, where, for a given input, the probabilities of each categorical value are produced. See Marrs and Francom (2023) "Multiclass classification using Bayesian multivariate adaptive regression splines" Under review.

The implementation of bias-corrected sandwich variance estimators for the analysis of cluster randomized trials with time-to-event outcomes using the marginal Cox model, proposed by Wang et al. (under review).

We propose a method to estimate the probability of an undetected case of COVID-19 in a defined setting, when a given number of people have been exposed, with a given pretest probability of having COVID-19 as a result of that exposure. Since we are interested in undetected COVID-19, we assume no person has developed symptoms (which would warrant further investigation) and that everyone was tested on a given day, and all tested negative.

Stacking rings are tools used to stack pottery in a Kiln. A relatively large group of stacking rings was found in the area of the sanctuary of Dionysos in Miletus in the 1970s. Measurements and additional info is gathered in this package and made available for use by other researchers. The data along with its archaeological context and analysis has been published in "Archäologischer Anzeiger" (2020/1, <doi:10.34780/aa.v0i1.1014>).

This package implements cluster-polarization coefficient for measuring distributional polarization in single or multiple dimensions, as well as associated functions. Contains support for hierarchical clustering, k-means, partitioning around medoids, density-based spatial clustering with noise, and manually imposed cluster membership. Mehlhaff (2024) <doi:10.1017/S0003055423001041>.

This package provides functions for cost-sensitive multi-criteria ensemble selection (CSMES) (as described in De bock et al. (2020) <doi:10.1016/j.ejor.2020.01.052>) for cost-sensitive learning under unknown cost conditions.

This package performs survival analysis using general non-linear models. Risk models can be the sum or product of terms. Each term is the product of exponential/linear functions of covariates. Additionally sub-terms can be defined as a sum of exponential, linear threshold, and step functions. Cox Proportional hazards <https://en.wikipedia.org/wiki/Proportional_hazards_model>, Poisson <https://en.wikipedia.org/wiki/Poisson_regression>, and Fine-Gray competing risks <https://www.publichealth.columbia.edu/research/population-health-methods/competing-risk-analysis> regression are supported. This work was sponsored by NASA Grants 80NSSC19M0161 and 80NSSC23M0129 through a subcontract from the National Council on Radiation Protection and Measurements (NCRP). The computing for this project was performed on the Beocat Research Cluster at Kansas State University, which is funded in part by NSF grants CNS-1006860, EPS-1006860, EPS-0919443, ACI-1440548, CHE-1726332, and NIH P20GM113109.

We provide a computationally efficient and robust implementation of the recently proposed C-JAMP (Copula-based Joint Analysis of Multiple Phenotypes) method (Konigorski et al., 2019, submitted). C-JAMP allows estimating and testing the association of one or multiple predictors on multiple outcomes in a joint model, and is implemented here with a focus on large-scale genome-wide association studies with two phenotypes. The use of copula functions allows modeling a wide range of multivariate dependencies between the phenotypes, and previous results are supporting that C-JAMP can increase the power of association studies to identify associated genetic variants in comparison to existing methods (Konigorski, Yilmaz, Pischon, 2016, <DOI:10.1186/s12919-016-0045-6>; Konigorski, Yilmaz, Bull, 2014, <DOI:10.1186/1753-6561-8-S1-S72>). In addition to the C-JAMP functions, functions are available to generate genetic and phenotypic data, to compute the minor allele frequency (MAF) of genetic markers, and to estimate the phenotypic variance explained by genetic markers.

This package provides a simple interface for multivariate correlation analysis that unifies various classical statistical procedures including t-tests, tests in univariate and multivariate linear models, parametric and nonparametric tests for correlation, Kruskal-Wallis tests, common approximate versions of Wilcoxon rank-sum and signed rank tests, chi-squared tests of independence, score tests of particular hypotheses in generalized linear models, canonical correlation analysis and linear discriminant analysis.

An interface to the cycle routing/data services provided by CycleStreets', a not-for-profit social enterprise and advocacy organisation. The application programming interfaces (APIs) provided by CycleStreets are documented at (<https://www.cyclestreets.net/api/>). The focus of this package is the journey planning API, which aims to emulate the routes taken by a knowledgeable cyclist. An innovative feature of the routing service of its provision of fastest, quietest and balanced profiles. These represent routes taken to minimise time, avoid traffic and compromise between the two, respectively.

This package provides functions and data files to help CE Public-Use Microdata (PUMD) users calculate annual estimated expenditure means, standard errors, and quantiles according to the methods used by the CE with PUMD. For more information on the CE please visit <https://www.bls.gov/cex>. For further reading on CE estimate calculations please see the CE Calculation section of the U.S. Bureau of Labor Statistics (BLS) Handbook of Methods at <https://www.bls.gov/opub/hom/cex/calculation.htm>. For further information about CE PUMD please visit <https://www.bls.gov/cex/pumd.htm>.