Estimates correlation coefficients with associated confidence limits for bivariate, partially censored survival times. Uses the iterative multiple imputation approach proposed by Schemper, Kaider, Wakounig and Heinze (2013) <doi:10.1002/sim.5874>. Provides a scatterplot function to visualize the bivariate distribution, either on the original time scale or as copula.

This package provides functions to access the database of 217 data-frames with aggregate study-level characteristics (that may act as effect modifiers) extracted from published systematic reviews with network meta-analysis. The database shall only be used for developing and appraising the methodology to assess the transitivity assumption quantitatively.

Download daily interest rates from the US Treasury XML feed. Leveraging <https://home.treasury.gov/treasury-daily-interest-rate-xml-feed>, this package serves as a wrapper, facilitating the retrieval of daily treasury rates across various categories, including par yield curves, treasury bills, long-term rates, and real yield curves.

Add publication-quality custom legends with vertical brackets. Designed for displaying statistical comparisons between groups, commonly used in scientific publications for showing significance levels. Features include adaptive positioning, automatic bracket spacing for overlapping comparisons, font family inheritance, and support for asterisks, p-values, or custom labels. Compatible with ggplot2 graphics.

Make working with ZIP codes in R painless with an integrated dataset of U.S. ZIP codes and functions for working with them. Search ZIP codes by multiple geographies, including state, county, city & across time zones. Also included are functions for relating ZIP codes to Census data, geocoding & distance calculations.

This package implements a grid search algorithm with an adaptive zooming strategy for global optimisation problems with multiple local optima. The method recursively refines the search region around promising grid points, providing reliable initial values for subsequent optimisation procedures. The algorithm is computationally efficient in moderate- to high-dimensional settings.

Fit the reduced-rank multinomial logistic regression model for Markov chains developed by Wang, Abner, Fardo, Schmitt, Jicha, Eldik and Kryscio (2021)<doi:10.1002/sim.8923> in R. It combines the ideas of multinomial logistic regression in Markov chains and reduced-rank. It is very useful in a study where multi-states model is assumed and each transition among the states is controlled by a series of covariates. The key advantage is to reduce the number of parameters to be estimated. The final coefficients for all the covariates and the p-values for the interested covariates will be reported. The p-values for the whole coefficient matrix can be calculated by two bootstrap methods.

Fits a multivariate value-added model (VAM), see Broatch, Green, and Karl (2018) <doi:10.32614/RJ-2018-033> and Broatch and Lohr (2012) <doi:10.3102/1076998610396900>, with normally distributed test scores and a binary outcome indicator. A pseudo-likelihood approach, Wolfinger (1993) <doi:10.1080/00949659308811554>, is used for the estimation of this joint generalized linear mixed model. The inner loop of the pseudo-likelihood routine (estimation of a linear mixed model) occurs in the framework of the EM algorithm presented by Karl, Yang, and Lohr (2013) <DOI:10.1016/j.csda.2012.10.004>. This material is based upon work supported by the National Science Foundation under grants DRL-1336027 and DRL-1336265.

Implementation of JQuery <https://jquery.com> and CSS styles to allow easy incorporation of various social media elements on a page. The elements include addition of share buttons or connect with us buttons or hyperlink buttons to Shiny applications or dashboards and Rmarkdown documents.Sharing capability on social media platforms including Facebook <https://www.facebook.com>, Linkedin <https://www.linkedin.com>, X/Twitter <https://x.com>, Tumblr <https://www.tumblr.com>, Pinterest <https://www.pinterest.com>, Whatsapp <https://www.whatsapp.com>, Reddit <https://www.reddit.com>, Baidu <https://www.baidu.com>, Blogger <https://www.blogger.com>, Weibo <https://www.weibo.com>, Instagram <https://www.instagram.com>, Telegram <https://www.telegram.me>, Youtube <https://www.youtube.com>.

The AffiXcan package imputes a genetically regulated expression (GReX) for a set of genes in a sample of individuals, using a method based on the total binding affinity (TBA). Statistical models to impute GReX can be trained with a training dataset where the real total expression values are known.

The package performs alignment of the amplicon reads, normalizes gathered data, calculates multiple statistics (e.g. cut rates, frameshifts) and presents the results in the form of aggregated reports. Data and statistics can be broken down by experiments, barcodes, user defined groups, guides and amplicons allowing for quick identification of potential problems.

This package provides a non-linear model, termed ACME, that reflects a parsimonious biological model for allelic contributions of cis-acting eQTLs. With non-linear least-squares algorithm the maximum likelihood parameters can be estimated. The ACME model provides interpretable effect size estimates and p-values with well controlled Type-I error.

This is a package for stubbing and setting expectations on HTTP requests. It includes tools for stubbing HTTP requests, including expected request conditions and response conditions. You can match on HTTP method, query parameters, request body, headers and more. It can be used for unit tests or outside of a testing context.

This package provides functions for fitting the Autoregressive and Moving Average Symmetric Model for univariate time series introduced by Maior and Cysneiros (2018), <doi:10.1007/s00362-016-0753-z>. Fitting method: conditional maximum likelihood estimation. For details see: Wei (2006), Time Series Analysis: Univariate and Multivariate Methods, Section 7.2.

This package provides fast and memory-friendly tools for text vectorization, topic modeling (LDA, LSA), word embeddings (GloVe), similarities. It provides a source-agnostic streaming API, which allows researchers to perform analysis of collections of documents which are larger than available RAM. All core functions are parallelized to benefit from multicore machines.

The package allows users to readily import spatial data obtained from either the 10X website or from the Space Ranger pipeline. Supported formats include tar.gz, h5, and mtx files. Multiple files can be imported at once with *List type of functions. The package represents data mainly as SpatialExperiment objects.

BEAST2 (<https://www.beast2.org>) is a widely used Bayesian phylogenetic tool, that uses DNA/RNA/protein data and many model priors to create a posterior of jointly estimated phylogenies and parameters. BEAST2 is a command-line tool. This package provides a way to call BEAST2 from an R function call.

Extend lasso and elastic-net model fitting for large data sets that cannot be loaded into memory. Designed to be more memory- and computation-efficient than existing lasso-fitting packages like glmnet and ncvreg', thus allowing the user to analyze big data with limited RAM <doi:10.32614/RJ-2021-001>.

Facilitates the importation of the Boston Blue Bike trip data since 2015. Functions include the computation of trip distances of given trip data. It can also map the location of stations within a given radius and calculate the distance to nearby stations. Data is from <https://www.bluebikes.com/system-data>.

The reliability of clusters is estimated using random projections. A set of stability measures is provided to assess the reliability of the clusters discovered by a generic clustering algorithm. The stability measures are taylored to high dimensional data (e.g. DNA microarray data) (Valentini, G (2005), <doi:10.1093/bioinformatics/bti817>.

Engines for survival models from the parsnip package. These include parametric models (e.g., Jackson (2016) <doi:10.18637/jss.v070.i08>), semi-parametric (e.g., Simon et al (2011) <doi:10.18637/jss.v039.i05>), and tree-based models (e.g., Buehlmann and Hothorn (2007) <doi:10.1214/07-STS242>).

Direction analysis is a set of tools designed to identify combinatorial effects of multiple treatments/conditions on pathways and kinases profiled by microarray, RNA-seq, proteomics, or phosphoproteomics data. See Yang P et al (2014) <doi:10.1093/bioinformatics/btt616>; and Yang P et al. (2016) <doi:10.1002/pmic.201600068>.

Uses the delta-method to estimate the Potential Impact Fraction (PIF) and the Population Attributable Fraction (PAF) from summary data. It creates point-estimates, confidence intervals, and estimates of the variance. Provides an extension to the aggregated data method in Chan, Zepeda-Tello et al (2025) <doi:10.1002/sim.70214>.

Discretely-sampled function is first smoothed. Features of the smoothed function are then extracted. Some of the key features include mean value, first and second derivatives, critical points (i.e. local maxima and minima), curvature of cunction at critical points, wiggliness of the function, noise in data, and outliers in data.