Enrich your ggplots with group-wise comparisons. This package provides an easy way to indicate if two groups are significantly different. Commonly this is shown by a bracket on top connecting the groups of interest which itself is annotated with the level of significance. The package provides a single layer that takes the groups for comparison and the test as arguments and adds the annotation to the plot.

This library lets you write interactive programs without callbacks or side-effects. Functional Reactive Programming (FRP) uses composable events and time-varying values to describe interactive systems as pure functions. Just like other pure functional code, functional reactive code is easier to get right on the first try, maintain, and reuse. Reflex is a fully-deterministic, higher-order FRP interface and an engine that efficiently implements that interface.

Calculates risk differences (or prevalence differences for cross-sectional data) using generalized linear models with automatic link function selection. Provides robust model fitting with fallback methods, support for stratification and adjustment variables, inverse probability of treatment weighting (IPTW) for causal inference, and publication-ready output formatting. Handles model convergence issues gracefully and provides confidence intervals using multiple approaches. Methods are based on approaches described in Mark W. Donoghoe and Ian C. Marschner (2018) "logbin: An R Package for Relative Risk Regression Using the Log-Binomial Model" <doi:10.18637/jss.v086.i09> for robust GLM fitting, Peter C. Austin (2011) "An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies" <doi:10.1080/00273171.2011.568786> for IPTW methods, and standard epidemiological methods for risk difference estimation as described in Kenneth J. Rothman, Sander Greenland and Timothy L. Lash (2008, ISBN:9780781755641) "Modern Epidemiology".

An R wrapper for agena.ai <https://www.agena.ai> which provides users capabilities to work with agena.ai using the R environment. Users can create Bayesian network models from scratch or import existing models in R and export to agena.ai cloud or local API for calculations. Note: running calculations requires a valid agena.ai API license (past the initial trial period of the local API).

It calculates the Air Pollution Tolerance Index (APTI) of plant species using biochemical parameters such as chlorophyll content, leaf extract pH, relative water content, and ascorbic acid content. It helps in identifying tolerant species for greenbelt development and pollution mitigation studies. It includes a shiny app for interactive APTI calculation and visualisation. For method details see, Sahu et al. (2020).<DOI:10.1007/s42452-020-3120-6>.

An iterative implementation of a recursive binary partitioning algorithm to measure pairwise dependence with a modular design that allows user specification of the splitting logic and stop criteria. Helper functions provide suggested versions of both and support visualization and the computation of summary statistics on final binnings. For a complete description of the functionality and algorithm, see Salahub and Oldford (2023) <doi:10.48550/arXiv.2311.08561>.

The Bayesian Adjustment for Confounding (BAC) algorithm (Wang et al., 2012) can be used to estimate the causal effect of a continuous exposure on a continuous outcome. This package provides an approximate sensitivity analysis of BAC with regards to the hyperparameter omega. BACprior also provides functions to guide the user in their choice of an appropriate omega value. The method is based on Lefebvre, Atherton and Talbot (2014).

Selection of informative features like genes, transcripts, RNA seq, etc. using Bootstrap Maximum Relevance and Minimum Redundancy technique from a given high dimensional genomic dataset. Informative gene selection involves identification of relevant genes and removal of redundant genes as much as possible from a large gene space. Main applications in high-dimensional expression data analysis (e.g. microarray data, NGS expression data and other genomics and proteomics applications).

Calculates and visualises cumulative percent decay curves, which are typically calculated from metagenomic taxonomic profiles. These can be used to estimate the level of expected endogenous taxa at different abundance levels retrieved from metagenomic samples, when comparing to samples of known sampling site or source. Method described in Fellows Yates, J. A. et. al. (2021) Proceedings of the National Academy of Sciences USA <doi:10.1073/pnas.2021655118>.

One way to choose the number of principal components is via the reconstruction error. This package is designed mainly for this purpose. Graphical representation is also supported, plus some other principal component analysis related functions. References include: Jolliffe I.T. (2002). Principal Component Analysis. <doi:10.1007/b98835> and Mardia K.V., Kent J.T. and Bibby J.M. (1979). Multivariate Analysis. ISBN: 978-0124712522. London: Academic Press.

Conducts conditional random sampling on observed values in sparse matrices. Useful for training and test set splitting sparse matrices prior to model fitting in cross-validation procedures and estimating the predictive accuracy of data imputation methods, such as matrix factorization or singular value decomposition (SVD). Although designed for applications with sparse matrices, CRASSMAT can also be applied to complete matrices, as well as to those containing missing values.

Estimate prior variable weights for Bayesian Additive Regression Trees (BART). These weights correspond to the probabilities of the variables being selected in the splitting rules of the sum-of-trees. Weights are estimated using empirical Bayes and external information on the explanatory variables (co-data). BART models are fitted using the dbarts R package. See Goedhart and others (2023) <doi:10.48550/arXiv.2311.09997> for details.

This package provides a multi-layered untargeted pipeline for high-throughput LC/HRMS data processing to extract signals of organic small molecules. The package performs ion pairing, peak detection, peak table alignment, retention time correction, aligned peak table gap filling, peak annotation and visualization of extracted ion chromatograms (EICs) and total ion chromatograms (TICs). The IDSL.IPA package was introduced in <doi:10.1021/acs.jproteome.2c00120> .

Fit parametric models for time-to-event data that show an initial incubation period', i.e., a variable delay phase where the hazard is zero. The delayed Weibull distribution serves as foundational data model. The specific method of MPSE (maximum product of spacings estimation) and MLE-based methods are used for parameter estimation. Bootstrap confidence intervals for parameters and significance tests in a two group setting are provided.

This package provides methods to extract information on pathways, genes and various single-nucleotid polymorphisms (SNPs) from online databases. It provides functions for data preparation and evaluation of genetic influence on a binary outcome using the logistic kernel machine test (LKMT). Three different kernel functions are offered to analyze genotype information in this variance component test: A linear kernel, a size-adjusted kernel and a network-based kernel).

Nonparametric kernel distribution function estimation is performed. Three bandwidth selectors are implemented: the plug-in selectors of Altman and Leger and of Polansky and Baker, and the cross-validation selector of Bowman, Hall and Prvan. The exceedance function, the mean return period and the return level are also computed. For details, see Quintela-del-Rà o and Estévez-Pérez (2012) <doi:10.18637/jss.v050.i08>.

This package performs meta-analysis and meta-regression using standard and robust methods with confidence intervals based on the profile likelihood. Robust methods are based on alternative distributions for the random effect, either the t-distribution (Lee and Thompson, 2008 <doi:10.1002/sim.2897> or Baker and Jackson, 2008 <doi:10.1007/s10729-007-9041-8>) or mixtures of normals (Beath, 2014 <doi:10.1002/jrsm.1114>).

Function pip3d() tests whether a point in 3D space is within, exactly on, or outside an enclosed surface defined by a triangular mesh. Function pip2d() tests whether a point in 2D space is within, exactly on, or outside a polygon. For a reference, see: Liu et al., A new point containment test algorithm based on preprocessing and determining triangles, Computer-Aided Design 42(12):1143-1150.

This package performs parametric synthesis of sounds with harmonic and noise components such as animal vocalizations or human voice. Also offers tools for audio manipulation and acoustic analysis, including pitch tracking, spectral analysis, audio segmentation, pitch and formant shifting, etc. Includes four interactive web apps for synthesizing and annotating audio, manually correcting pitch contours, and measuring formant frequencies. Reference: Anikin (2019) <doi:10.3758/s13428-018-1095-7>.

Species sensitivity distributions are cumulative probability distributions which are fitted to toxicity concentrations for different species as described by Posthuma et al.(2001) <isbn:9781566705783>. The ssdtools package uses Maximum Likelihood to fit distributions such as the gamma, log-logistic, log-normal and log-normal log-normal mixture. Multiple distributions can be averaged using Akaike Information Criteria. Confidence intervals on hazard concentrations and proportions are produced by bootstrapping.

This package provides functions to estimate a strategic selection estimator. A strategic selection estimator is an agent error model in which the two random components are not assumed to be orthogonal. In addition this package provides generic functions to print and plot objects of its class as well as the necessary functions to create tables for LaTeX. There is also a function to create dyadic data sets.

The goal of safejoin is to guarantee that when performing joins extra rows are not added to your data. safejoin provides a wrapper around dplyr::left_join that will raise an error when extra rows are unexpectedly added to your data. This can be useful when working with data where you expect there to be a many to one relationship but you are not certain the relationship holds.

This package provides a novel feature-wise normalization method based on a zero-inflated negative binomial model. This method assumes that the effects of sequencing depth vary for each taxon on their mean and also incorporates a rational link of zero probability and taxon dispersion as a function of sequencing depth. Ziyue Wang, Dillon Lloyd, Shanshan Zhao, Alison Motsinger-Reif (2023) <doi:10.1101/2023.10.31.563648>.

This package performs maximum likelihood based estimation and inference on time to event data, possibly subject to non-informative right censoring. FitParaSurv() provides maximum likelihood estimates of model parameters and distributional characteristics, including the mean, median, variance, and restricted mean. CompParaSurv() compares the mean, median, and restricted mean survival experiences of two treatment groups. Candidate distributions include the exponential, gamma, generalized gamma, log-normal, and Weibull.