Principal component analysis (PCA) is one of the most widely used data analysis techniques. This package provides a series of vignettes explaining PCA starting from basic concepts. The primary purpose is to serve as a self-study resource for anyone wishing to understand PCA better. A few convenience functions are provided as well.

This package provides functions for multivariate and propensity score matching and for finding optimal balance based on a genetic search algorithm. A variety of univariate and multivariate metrics to determine if balance has been obtained are also provided. For details, see the paper by Jasjeet Sekhon (2007, <doi:10.18637/jss.v042.i07>).

This package provides functions for calculating the point and interval estimates of the natural indirect effect (NIE), total effect (TE), and mediation proportion (MP), based on the product approach. We perform the methods considered in Cheng, Spiegelman, and Li (2021) Estimating the natural indirect effect and the mediation proportion via the product method.

Quantitative trait loci (QTL) analysis and exploration of meiotic patterns in autopolyploid bi-parental F1 populations. For all ploidy levels, identity-by-descent (IBD) probabilities can be estimated. Significance thresholds, exploring QTL allele effects and visualising results are provided. For more background and to reference the package see <doi:10.1093/bioinformatics/btab574>.

Implementation of small area estimation using Hierarchical Bayesian (HB) Method when auxiliary variable measured with error. The rjags package is employed to obtain parameter estimates. For the references, see Rao and Molina (2015) <doi:10.1002/9781118735855>, Ybarra and Lohr (2008) <doi:10.1093/biomet/asn048>, and Ntzoufras (2009, ISBN-10: 1118210352).

Renders plots to a temporary image using the ragg graphics device and returns knitr::include_graphics() output. Optionally saves the image to a specified path. This helps ensure consistent appearance across interactive sessions, saved files, and knitted documents. For more details see Pedersen and Shemanarev (2025) <doi: 10.32614/CRAN.package.ragg>.

This package provides a comprehensive suite of functions designed for constructing and managing ShinyItemAnalysis modules, supplemented with detailed guides, ready-to-use templates, linters, and tests. This package allows developers to seamlessly create and integrate one or more modules into their existing packages or to start a new module project from scratch.

This package provides flexible hazard ratio curves allowing non-linear relationships between continuous predictors and survival. To better understand the effects that each continuous covariate has on the outcome, results are expressed in terms of hazard ratio curves, taking a specific covariate value as reference. Confidence bands for these curves are also derived.

This package provides a set of functions to: (1) perform fuzzy clustering of vegetation data (De Caceres et al, 2010) <doi:10.1111/j.1654-1103.2010.01211.x>; (2) to assess ecological community similarity on the basis of structure and composition (De Caceres et al, 2013) <doi:10.1111/2041-210X.12116>.

DoRothEA is a gene regulatory network containing signed transcription factor. DoRothEA regulons, the collection of a TF and its transcriptional targets, were curated and collected from different types of evidence for both human and mouse. A confidence level was assigned to each TF-target interaction based on the number of supporting evidence.

The STRINGdb package provides an R interface to the STRING protein-protein interactions database. STRING is a database of known and predicted protein-protein interactions. The interactions include direct (physical) and indirect (functional) associations. Each interaction is associated with a combined confidence score that integrates the various evidences.

Package for the analysis of pooled genetic screens (e.g. CRISPR-KO). The analysis of such screens is based on the comparison of gRNA abundances before and after a cell proliferation phase. The gscreend packages takes gRNA counts as input and allows detection of genes whose knockout decreases or increases cell proliferation.

Single sample estimation of exposure to mutational signatures. Exposures to known mutational signatures are estimated for single samples, based on quadratic programming algorithms. Bootstrapping the input mutational catalogues provides estimations on the stability of these exposures. The effect of the sequence composition of mutational context can be taken into account by normalising the catalogues.

Implementation of the augmented Simulation-Extrapolation (SIMEX) algorithm proposed by Yi et al. (2015) <doi:10.1080/01621459.2014.922777> for analyzing the data with mixed measurement error and misclassification. The main function provides a similar summary output as that of glm() function. Both parametric and empirical SIMEX are considered in the package.

Testing, Implementation, and Forecasting of the ARIMA-ANN hybrid model. The ARIMA-ANN hybrid model combines the distinct strengths of the Auto-Regressive Integrated Moving Average (ARIMA) model and the Artificial Neural Network (ANN) model for time series forecasting.For method details see Zhang, GP (2003) <doi:10.1016/S0925-2312(01)00702-0>.

Modern software often poorly support older file formats. This package intends to handle many file formats that were native to the antiquated Commodore Amiga machine. This package focuses on file types from the older Amiga operating systems (<= 3.0). It will read and write specific file formats and coerces them into more contemporary data.

Hansen's (1995) Covariate-Augmented Dickey-Fuller (CADF) test. The only required argument is y, the Tx1 time series to be tested. If no stationary covariate X is passed to the procedure, then an ordinary ADF test is performed. The p-values of the test are computed using the procedure illustrated in Lupi (2009).

Estimates a lasso penalized precision matrix via the blockwise coordinate descent (BCD). This package is a simple wrapper around the popular glasso package that extends and enhances its capabilities. These enhancements include built-in cross validation and visualizations. See Friedman et al (2008) <doi:10.1093/biostatistics/kxm045> for details regarding the estimation method.

An efficient cross-validated approach for covariance matrix estimation, particularly useful in high-dimensional settings. This method relies upon the theory of high-dimensional loss-based covariance matrix estimator selection developed by Boileau et al. (2022) <doi:10.1080/10618600.2022.2110883> to identify the optimal estimator from among a prespecified set of candidates.

Basic sensitivity analysis of the observed relative risks adjusting for unmeasured confounding and misclassification of the exposure/outcome, or both. It follows the bias analysis methods and examples from the book by Fox M.P., MacLehose R.F., and Lash T.L. "Applying Quantitative Bias Analysis to Epidemiologic Data, second ed.", ('Springer', 2021).

Implementation of uniformly most powerful invariant equivalence tests for one- and two-sample problems (paired and unpaired) as described in Wellek (2010, ISBN:978-1-4398-0818-4). Also one-sided alternatives (non-inferiority and non-superiority tests) are supported. Basically a variant of a t-test with (relaxed) null and alternative hypotheses exchanged.

This package provides a fast, flexible tool for generating disease surveillance reports from data exported from EpiTrax', a central repository for epidemiological data used by public health officials. It provides functions to manipulate EpiTrax datasets, tailor reports to internal or public use, and export reports in CSV, Excel xlsx', or PDF formats.

This package provides functions to estimate model parameters and forecast future volatilities using the Unified GARCH-Ito [Kim and Wang (2016) <doi:10.1016/j.jeconom.2016.05.003>] and Realized GARCH-Ito [Song et. al. (2020) <doi:10.1016/j.jeconom.2020.07.007>] models. Optimization is done using augmented Lagrange multiplier method.

Computes the solution path for generalized lasso problems. Important use cases are the fused lasso over an arbitrary graph, and trend fitting of any given polynomial order. Specialized implementations for the latter two subproblems are given to improve stability and speed. See Taylor Arnold and Ryan Tibshirani (2016) <doi:10.1080/10618600.2015.1008638>.