This package provides a collection of useful helper routines developed by students of the Center for Mathematical Research, Stankin, Moscow.

P-values and no/lowest observed (adverse) effect concentration values derived from the closure principle computational approach test (Lehmann, R. et al. (2015) <doi:10.1007/s00477-015-1079-4>) are provided. The package contains functions to generate intersection hypotheses according to the closure principle (Bretz, F., Hothorn, T., Westfall, P. (2010) <doi:10.1201/9781420010909>), an implementation of the computational approach test (Ching-Hui, C., Nabendu, P., Jyh-Jiuan, L. (2010) <doi:10.1080/03610918.2010.508860>) and the combination of both, that is, the closure principle computational approach test.

Collects several different methods for analyzing and working with connectivity data in R. Though primarily oriented towards marine larval dispersal, many of the methods are general and useful for terrestrial systems as well.

Given a patient-sharing network, calculate either the classic care density as proposed by Pollack et al. (2013) <doi:10.1007/s11606-012-2104-7> or the fragmented care density as proposed by Engels et al. (2024) <doi:10.1186/s12874-023-02106-0>. By utilizing the igraph and data.table packages, the provided functions scale well for very large graphs.

Classification method described in Dancik et al (2011) <doi:10.1158/0008-5472.CAN-11-2427> that classifies a sample according to the class with the maximum mean (or any other function of) correlation between the test and training samples with known classes.

This package implements the Bayesian calibration model described in Pratola and Chkrebtii (2018) <DOI:10.5705/ss.202016.0403> for stochastic and deterministic simulators. Additive and multiplicative discrepancy models are currently supported. See <http://www.matthewpratola.com/software> for more information and examples.

Provide the CrossClustering algorithm (Tellaroli et al. (2016) <doi:10.1371/journal.pone.0152333>), which is a partial clustering algorithm that combines the Ward's minimum variance and Complete Linkage algorithms, providing automatic estimation of a suitable number of clusters and identification of outlier elements.

Combines taxonomic classifications of high-throughput 16S rRNA gene sequences with reference proteomes of archaeal and bacterial taxa to generate amino acid compositions of community reference proteomes. Calculates chemical metrics including carbon oxidation state ('Zc'), stoichiometric oxidation and hydration state ('nO2 and nH2O'), H/C, N/C, O/C, and S/C ratios, grand average of hydropathicity ('GRAVY'), isoelectric point ('pI'), protein length, and average molecular weight of amino acid residues. Uses precomputed reference proteomes for archaea and bacteria derived from the Genome Taxonomy Database ('GTDB'). Also includes reference proteomes derived from the NCBI Reference Sequence ('RefSeq') database and manual mapping from the RDP Classifier training set to RefSeq taxonomy as described by Dick and Tan (2023) <doi:10.1007/s00248-022-01988-9>. Processes taxonomic classifications in RDP Classifier format or OTU tables in phyloseq-class objects from the Bioconductor package phyloseq'.

Generates tree plots with precise branch lengths, gene annotations, and cellular prevalence. The package handles complex tree structures (angles, lengths, etc.) and can be further refined as needed by the user.

Sequential and batch change detection for univariate data streams, using the change point model framework. Functions are provided to allow nonparametric distribution-free change detection in the mean, variance, or general distribution of a given sequence of observations. Parametric change detection methods are also provided for Gaussian, Bernoulli and Exponential sequences. Both the batch (Phase I) and sequential (Phase II) settings are supported, and the sequences may contain either a single or multiple change points. A full description of this package is available in Ross, G.J (2015) - "Parametric and nonparametric sequential change detection in R" available at <https://www.jstatsoft.org/article/view/v066i03>.

The CloudOS client library for R makes it easy to interact with CloudOS in the R environment for analysis.

This package provides functions to access data from public RESTful APIs including FINDIC API', REST Countries API', World Bank API', and Nager.Date', retrieving real-time or historical data related to Chile such as financial indicators, holidays, international demographic and geopolitical indicators, and more. Additionally, the package includes curated datasets related to Chile, covering topics such as human rights violations during the Pinochet regime, electoral data, census samples, health surveys, seismic events, territorial codes, and environmental measurements. The package supports research and analysis focused on Chile by integrating open APIs with high-quality datasets from multiple domains. For more information on the APIs, see: FINDIC <https://findic.cl/>, REST Countries <https://restcountries.com/>, World Bank API <https://datahelpdesk.worldbank.org/knowledgebase/articles/889392>, and Nager.Date <https://date.nager.at/Api>.

The ConNEcT approach investigates the pairwise association strength of binary time series by calculating contingency measures and depicts the results in a network. The package includes features to explore and visualize the data. To calculate the pairwise concurrent or temporal sequenced relationship between the variables, the package provides seven contingency measures (proportion of agreement, classical & corrected Jaccard, Cohen's kappa, phi correlation coefficient, odds ratio, and log odds ratio), however, others can easily be implemented. The package also includes non-parametric significance tests, that can be applied to test whether the contingency value quantifying the relationship between the variables is significantly higher than chance level. Most importantly this test accounts for auto-dependence and relative frequency.See Bodner et al.(2021) <doi: 10.1111/bmsp.12222>.Finally, a network can be drawn. Variables depicted the nodes of the network, with the node size adapted to the prevalence. The association strength between the variables defines the undirected (concurrent) or directed (temporal sequenced) links between the nodes. The results of the non-parametric significance test can be included by depicting either all links or only the significant ones. Tutorial see Bodner et al.(2021) <doi:10.3758/s13428-021-01760-w>.

Create simplex plots to visualize the similarity between single-cells and selected clusters in a 1-/2-/3-simplex space. Velocity information can be added as an additional layer. See Liu J, Wang Y et al (2023) <doi:10.1093/bioinformatics/btaf119> for more details.

Modeling associations between covariates and power spectra of replicated time series using a cepstral-based semiparametric framework. Implements a fast two-stage estimation procedure via Whittle likelihood and multivariate regression.The methodology is based on Li and Dong (2025) <doi:10.1080/10618600.2025.2473936>.

This package provides tools for measuring the compositionality of signalling systems (in particular the information-theoretic measure due to Spike (2016) <http://hdl.handle.net/1842/25930> and the Mantel test for distance matrix correlation (after Dietz 1983) <doi:10.1093/sysbio/32.1.21>), functions for computing string and meaning distance matrices as well as an implementation of the Page test for monotonicity of ranks (Page 1963) <doi:10.1080/01621459.1963.10500843> with exact p-values up to k = 22.

Method for visualizing proportions between objects of different sizes. The proportions are drawn as circles with different diameters, which makes them ideal for visualizing proportions between planets.

This package provides tools that allow developers to write functions for cross-validation with minimal programming effort and assist users with model selection.

Processes survey data and displays estimation results along with the relative standard error in a table, including the number of samples and also uses a t-distribution approach to compute confidence intervals, similar to SPSS (Statistical Package for the Social Sciences) software.

Computation of Multiscale Codependence Analysis and spatial eigenvector maps.

Various tools for inferring causal models from observational data. The package includes an implementation of the temporal Peter-Clark (TPC) algorithm. Petersen, Osler and Ekstrøm (2021) <doi:10.1093/aje/kwab087>. It also includes general tools for evaluating differences in adjacency matrices, which can be used for evaluating performance of causal discovery procedures.

Circumplex models, which organize constructs in a circle around two underlying dimensions, are popular for studying interpersonal functioning, mood/affect, and vocational preferences/environments. This package provides tools for analyzing and visualizing circular data, including scoring functions for relevant instruments and a generalization of the bootstrapped structural summary method from Zimmermann & Wright (2017) <doi:10.1177/1073191115621795> and functions for creating publication-ready tables and figures from the results.

Biotechnology in spatial omics has advanced rapidly over the past few years, enhancing both throughput and resolution. However, existing annotation pipelines in spatial omics predominantly rely on clustering methods, lacking the flexibility to integrate extensive annotated information from single-cell RNA sequencing (scRNA-seq) due to discrepancies in spatial resolutions, species, or modalities. Here we introduce the CAESAR suite, an open-source software package that provides image-based spatial co-embedding of locations and genomic features. It uniquely transfers labels from scRNA-seq reference, enabling the annotation of spatial omics datasets across different technologies, resolutions, species, and modalities, based on the conserved relationship between signature genes and cells/locations at an appropriate level of granularity. Notably, CAESAR enriches location-level pathways, allowing for the detection of gradual biological pathway activation within spatially defined domain types. More details on the methods related to our paper currently under submission. A full reference to the paper will be provided in future versions once the paper is published.

Implementation of the d/p/q/r family of functions for a continuous analog to the standard discrete beta-binomial with continuous size parameter and continuous support with x in [0, size + 1].