Penalized methods are useful for fitting over-parameterized models. This package includes functions for restructuring an ordinal response dataset for fitting continuation ratio models for datasets where the number of covariates exceeds the sample size or when there is collinearity among the covariates. The glmnet fitting algorithm is used to fit the continuation ratio model after data restructuring.

This network estimation procedure eLasso, which is based on the Ising model, combines l1-regularized logistic regression with model selection based on the Extended Bayesian Information Criterion (EBIC). EBIC is a fit measure that identifies relevant relationships between variables. The resulting network consists of variables as nodes and relevant relationships as edges. Can deal with binary data.

This package provides an R interface to the JBrowse 2 genome browser. Enables embedding a JB2 genome browser in a Shiny app or R Markdown document. The browser can also be launched from an interactive R console. The browser can be loaded with a variety of common genomics data types, and can be used with a custom theme.

Conducting linear and nonlinear dose-response meta-regression using study-level summary data. It supports both continuous and binary outcomes and allows modeling of dose-effect relationships using linear trends or nonlinear restricted cubic splines. The package is designed to facilitate transparent, flexible, and reproducible dose-response meta-analyses, with built-in visualization of fitted dose-response curves.

Mixed, low-rank, and sparse multivariate regression ('mixedLSR') provides tools for performing mixture regression when the coefficient matrix is low-rank and sparse. mixedLSR allows subgroup identification by alternating optimization with simulated annealing to encourage global optimum convergence. This method is data-adaptive, automatically performing parameter selection to identify low-rank substructures in the coefficient matrix.

This package provides an interface to MetaPost (Hobby, 1998) <http://www.tug.org/docs/metapost/mpman.pdf>. There are functions to generate an R description of a MetaPost curve, functions to generate MetaPost code from an R description, functions to process MetaPost code, and functions to read solved MetaPost paths back into R.

This package provides Partial least squares Regression for (weighted) beta regression models (Bertrand 2013, <https://ojs-test.apps.ocp.math.cnrs.fr/index.php/J-SFdS/article/view/215>) and k-fold cross-validation of such models using various criteria. It allows for missing data in the explanatory variables. Bootstrap confidence intervals constructions are also available.

Generalized Least Squares (GLS) estimation of Seemingly Unrelated Regression (SUR) systems on unbalanced panel in the one/two-way cases also taking into account the possibility of cross equation restrictions. Methodological details can be found in Biørn (2004) <doi:10.1016/j.jeconom.2003.10.023> and Platoni, Sckokai, Moro (2012) <doi:10.1080/07474938.2011.607098>.

Develop spatial interaction models (SIMs). SIMs predict the amount of interaction, for example number of trips per day, between geographic entities representing trip origins and destinations. Contains functions for creating origin-destination datasets from geographic input datasets and calculating movement between origin-destination pairs with constrained, production-constrained, and attraction-constrained models (Wilson 1979) <doi:10.1068/a030001>.

This package provides a port of the Scarabee toolkit originally written as a Matlab-based application. scaRabee provides a framework for simulation and optimization of pharmacokinetic-pharmacodynamic models at the individual and population level. It is built on top of the neldermead package, which provides the direct search algorithm proposed by Nelder and Mead for model optimization.

Uses parametric and nonparametric methods to quantify the proportion of the estimated selection bias (SB) explained by each observed confounder when estimating propensity score weighted treatment effects. Parast, L and Griffin, BA (2020). "Quantifying the Bias due to Observed Individual Confounders in Causal Treatment Effect Estimates". Statistics in Medicine, 39(18): 2447- 2476 <doi: 10.1002/sim.8549>.

Takes one or more fitted Cox proportional hazards models and writes a shiny application to a directory specified by the user. The shiny application displays predicted survival curves based on user input, and contains none of the original data used to create the Cox model or models. The goal is towards visualization and presentation of predicted survival curves.

This package provides functions for validating the structure and properties of data frames. Answers essential questions about a data set after initial import or modification. What are the unique or missing values? What columns form a primary key? What are the properties of the numeric or categorical columns? What kind of overlap or mapping exists between 2 columns?

Assess Water Quality Trends for Long-Term Monitoring Data in Estuaries using Generalized Additive Models following Wood (2017) <doi:10.1201/9781315370279> and Error Propagation with Mixed-Effects Meta-Analysis following Sera et al. (2019) <doi:10.1002/sim.8362>. Methods are available for model fitting, assessment of fit, annual and seasonal trend tests, and visualization of results.

Automatic coding of open-ended responses to the Cognitive Reflection Test (CRT), a widely used class of tests in cognitive science and psychology that assess the tendency to override an initial intuitive (but incorrect) answer and engage in reflection to reach a correct solution. The package standardizes CRT response coding across datasets in cognitive psychology, decision-making, and related fields. Automated coding reduces manual effort and improves reproducibility by limiting variability from subjective interpretation of open-ended responses. The package supports automatic coding and machine scoring for the original English-language CRT (Frederick, 2005) <doi:10.1257/089533005775196732>, CRT4 and CRT7 (Toplak et al., 2014) <doi:10.1080/13546783.2013.844729>, CRT-long (Primi et al., 2016) <doi:10.1002/bdm.1883>, and CRT-2 (Thomson & Oppenheimer, 2016) <doi:10.1017/s1930297500007622>.

RaySession is a session manager for audio programs such as Ardour, Carla, QTractor, Guitarix, Patroneo, Jack Mixer, etc. The principle is to load together audio programs, then be able to save or close all documents together. Its main purpose is to manage NSM compatible programs, but it also helps for other programs. It offers a patchbay for visualizing and editing connections.

The sparse nature of single cell epigenomics data can be overruled using probabilistic modelling methods such as Latent Dirichlet Allocation (LDA). This package allows the probabilistic modelling of cis-regulatory topics (cisTopics) from single cell epigenomics data, and includes functionalities to identify cell states based on the contribution of cisTopics and explore the nature and regulatory proteins driving them.

This package provides a differential evolution (DE) stochastic algorithms for global optimization of problems with and without constraints. The aim is to curate a collection of its state-of-the-art variants that

1. do not sacrifice simplicity of design,

2. are essentially tuning-free, and

3. can be efficiently implemented directly in the R language.

Magrittr provides a mechanism for chaining commands with a new forward-pipe operator, %>%. This operator will forward a value, or the result of an expression, into the next function call/expression. There is flexible support for the type of right-hand side expressions. For more information, see package vignette. To quote Rene Magritte, "Ceci n'est pas un pipe."

This package is a usability wrapper around snow for easier development of parallel R programs. This package offers e.g. extended error checks, and additional functions. All functions work in sequential mode, too, if no cluster is present or wished. The package is also designed as connector to the cluster management tool sfCluster, but can also used without it.

This package provides a toolkit for all URL-handling needs, including encoding and decoding, parsing, parameter extraction and modification. All functions are designed to be both fast and entirely vectorized. It is intended to be useful for people dealing with web-related datasets, such as server-side logs, although may be useful for other situations involving large sets of URLs.

This package conveniently wraps all functions needed to reproduce the figures in the IHW paper (https://www.nature.com/articles/nmeth.3885) and the data analysis in https://rss.onlinelibrary.wiley.com/doi/10.1111/rssb.12411, cf. the arXiv preprint (http://arxiv.org/abs/1701.05179). Thus it is a companion package to the Bioconductor IHW package.

mitology allows to study the mitochondrial activity throught high-throughput RNA-seq data. It is based on a collection of genes whose proteins localize in to the mitochondria. From these, mitology provides a reorganization of the pathways related to mitochondria activity from Reactome and Gene Ontology. Further a ready-to-use implementation of MitoCarta3.0 pathways is included.

The package facilitates implementation of workflows requiring miRNA predictions, it allows to integrate ranked miRNA target predictions from multiple sources available online and aggregate them with various methods which improves quality of predictions above any of the single sources. Currently predictions are available for Homo sapiens, Mus musculus and Rattus norvegicus (the last one through homology translation).