This package generates interactive visualisations for analysis of RNA-sequencing data using output from limma, edgeR or DESeq2 packages in an HTML page. The interactions are built on top of the popular static representations of analysis results in order to provide additional information.

This package implements the Python leidenalg module to be called in R. It enables clustering using the Leiden algorithm for partitioning a graph into communities. See also Traag et al (2018) "From Louvain to Leiden: guaranteeing well-connected communities." <arXiv:1810.08473>.

This package provides miscellaneous functions for SciViews or general use, including tools to manage a temporary environment attached to the search path for temporary variables you do not want to save() or load(); test the current platform; showing progress bars, etc.

This package provides a set of Shiny apps for effective communication and understanding in statistics. The current version includes properties of normal distribution, properties of sampling distribution, one-sample z and t tests, two samples independent (unpaired) t test and analysis of variance.

This package provides bindings to libsodium: a library for encryption, decryption, signatures, password hashing and more. Sodium uses curve25519, a Diffie-Hellman function by Daniel Bernstein, which has become very popular after it was discovered that the NSA had backdoored Dual EC DRBG.

Quality Ensured Demonstrations (QED) is a test framework for Test Driven Development (TDD) and Behaviour Driven Development (BDD) utilizing Literate Programming techniques. QED sits somewhere between lower-level testing tools like Test::Unit and requirement specifications systems like Cucumber.

simPIC is a package for simulating single-cell ATAC-seq count data. It provides a user-friendly, well documented interface for data simulation. Functions are provided for parameter estimation, realistic scATAC-seq data simulation, and comparing real and simulated datasets.

This package provides functions to analyze methylation data can be found here. Some functions are relevant for single cell methylation data but most other functions can be used for any methylation data. Highlight of this workflow is the comprehensive quality control report.

High-throughput single-cell measurements of DNA methylation allows studying inter-cellular epigenetic heterogeneity, but this task faces the challenges of sparsity and noise. We present vmrseq, a statistical method that overcomes these challenges and identifies variably methylated regions accurately and robustly.

The package ASGSCA (Association Study using Generalized Structured Component Analysis) provides tools to model and test the association between multiple genotypes and multiple traits, taking into account the prior biological knowledge. Genes, and clinical pathways are incorporated in the model as latent variables.

This package provides an implementation of Adaptive Base Error Model in Ultra-deep Sequencing data (ABEMUS), which combines platform-specific genetic knowledge and empirical signal to readily detect and quantify somatic single nucleotide variants (SNVs) in circulating cell free DNA (cfDNA).

This package provides a collection of high-performance utilities. It can be used to compute distances, correlations, autocorrelations, clustering, and other tasks. It also contains a graph clustering algorithm described in MetaCell analysis of single-cell RNA-seq data using K-nn graph partitions.

This package implements tools for weighted network visualization and analysis, as well as Gaussian graphical model computation. It contains graph plotting methods, and tools for psychometric data visualization and graphical model estimation. See Epskamp et al. (2012) doi:10.18637/jss.v048.i04.

The x-resize command detects physical display resolution changes via udev and invokes the xrandr command to reconfigure the active display resolution accordingly. It can be used to implement dynamic resize support for desktop environments that lack native support such as Xfce.

The package implements MBASED algorithm for detecting allele-specific gene expression from RNA count data, where allele counts at individual loci (SNVs) are integrated into a gene-specific measure of ASE, and utilizes simulations to appropriately assess the statistical significance of observed ASE.

The Shaman package implements functions for resampling Hi-C matrices in order to generate expected contact distributions given constraints on marginal coverage and contact-distance probability distributions. The package also provides support for visualizing normalized matrices and statistical analysis of contact distributions around selected landmarks.

This package provides an implementation of both the exact and approximation methods for computing the cumulative distribution function (CDF) of the Poisson binomial distribution. It also provides the probability mass function (PMF), quantile function, and random number generation for the Poisson binomial distribution.

The glmnet package provides efficient procedures for fitting the entire lasso or elastic-net regularization path for linear and Poisson regression, as well as logistic, multinomial, Cox, multiple-response Gaussian and grouped multinomial models. The algorithm uses cyclical coordinate descent in a path-wise fashion.

This package provides tools for the analysis of high-dimensional data developed/implemented at the group "Statistical Complexity Reduction In Molecular Epidemiology" (SCRIME). The main focus is on SNP data, but most of the functions can also be applied to other types of categorical data.

The httpuv package provides low-level socket and protocol support for handling HTTP and WebSocket requests directly from within R. It is primarily intended as a building block for other packages, rather than making it particularly easy to create complete web applications using httpuv alone.

An unsupervised cross-validation method to select the optimal number of mutational signatures. A data set of mutational counts is split into training and validation data.Signatures are estimated in the training data and then used to predict the mutations in the validation data.

There are increasing demands on designing virus mutants with specific dinucleotide or codon composition. This tool can take both dinucleotide preference and/or codon usage bias into account while designing mutants. It is a powerful tool for in silico designs of DNA sequence mutants.

Range-v3 is an extension of the Standard Template Library that makes its iterators and algorithms more powerful by making them composable. Unlike other range-like solutions which, seek to do away with iterators, in range-v3 ranges are an abstraction layer on top of iterators.

This package provides tools to create dynamic, submission-ready manuscripts, which conform to American Psychological Association manuscript guidelines. It provides R Markdown document formats for manuscripts (PDF and Word) and revision letters (PDF). Helper functions facilitate reporting statistical analyses or create publication-ready tables and plots.