Identification of Latent Patient Phenotype from Electronic Health Records (EHR) Data using Variational Bayes Gaussian Mixture Model for Latent Class Analysis and Variational Bayes regression for Biomarker level shifts, both implemented by Coordinate Ascent Variational Inference algorithms. Variational methods are used to enable Bayesian analysis of very large Electronic Health Records data. For VB GMM details see Bishop (2006,ISBN:9780-387-31073-2). For Logistic VB see Jaakkola and Jordan (2000) <doi:10.1023/A:1008932416310>. Please see preprint of JSS-submitted paper <doi:10.48550/arXiv.2512.14272>.

This package provides a flexible method for fitting regression models that can be used to find genes that are differentially expressed along one or multiple lineages in a trajectory. Based on the fitted models, it uses a variety of tests suited to answer different questions of interest, e.g. the discovery of genes for which expression is associated with pseudotime, or which are differentially expressed (in a specific region) along the trajectory. It fits a negative binomial generalized additive model (GAM) for each gene, and performs inference on the parameters of the GAM.

Dropout events make the lowly expressed genes indistinguishable from true zero expression and different than the low expression present in cells of the same type. This issue makes any subsequent downstream analysis difficult. ccImpute is an imputation algorithm that uses cell similarity established by consensus clustering to impute the most probable dropout events in the scRNA-seq datasets. ccImpute demonstrated performance which exceeds the performance of existing imputation approaches while introducing the least amount of new noise as measured by clustering performance characteristics on datasets with known cell identities.

Automates the process of containerizing R projects. The core function of containr is generate_dockerfile()', which analyzes an R project's environment and dependencies via an renv lock file and generates a ready-to-use Dockerfile that encapsulates the computational setup. The package helps researchers build portable and consistent workflows so that analyses can be reliably shared, archived, and rerun across systems. See R Core Team (2025) <https://www.R-project.org/>, Ushey et al. (2025) <https://CRAN.R-project.org/package=renv>, and Docker Inc. (2025) <https://www.docker.com/>.

Fast and easy computation of Euclidean Minimum Spanning Trees (EMST) from data, relying on the R API for mlpack - the C++ Machine Learning Library (Curtin et. al., 2013). emstreeR uses the Dual-Tree Boruvka (March, Ram, Gray, 2010, <doi:10.1145/1835804.1835882>), which is theoretically and empirically the fastest algorithm for computing an EMST. This package also provides functions and an S3 method for readily visualizing Minimum Spanning Trees (MST) using either the style of the base', scatterplot3d', or ggplot2 libraries; and functions to export the MST output to shapefiles.

This package provides a user friendly, easy to understand way of doing event history regression for marginal estimands of interest, including the cumulative incidence and the restricted mean survival, using the pseudo observation framework for estimation. For a review of the methodology, see Andersen and Pohar Perme (2010) <doi:10.1177/0962280209105020> or Sachs and Gabriel (2022) <doi:10.18637/jss.v102.i09>. The interface uses the well known formulation of a generalized linear model and allows for features including plotting of residuals, the use of sampling weights, and corrected variance estimation.

This package implements a Fellegi-Sunter probabilistic record linkage model that allows for missing data and the inclusion of auxiliary information. This includes functionalities to conduct a merge of two datasets under the Fellegi-Sunter model using the Expectation-Maximization algorithm. In addition, tools for preparing, adjusting, and summarizing data merges are included. The package implements methods described in Enamorado, Fifield, and Imai (2019) Using a Probabilistic Model to Assist Merging of Large-scale Administrative Records <doi:10.1017/S0003055418000783> and is available at <https://imai.fas.harvard.edu/research/linkage.html>.

An interval-valued extension of ordinary and simple kriging. Optimization of the function is based on a generalized interval distance. This creates a non-differentiable cost function that requires a differentiable approximation to the absolute value function. This differentiable approximation is optimized using a Newton-Raphson algorithm with a penalty function to impose the constraints. Analyses in the package are driven by the intsp and intgrd classes, which are interval-valued extensions of SpatialPointsDataFrame and SpatialPixelsDataFrame respectively. The package includes several wrappers to functions in the gstat and sp packages.

This package provides functions to standardize and whiten data, and to perform Principal Component Analysis (PCA). The main advantage of this package over alternatives like prcomp() is, that jvcoords makes it easy to convert (additional) data between the original and the transformed coordinates. The package also provides a class coords, which can represent affine coordinate transformations. This class forms the basis of the transformations provided by the package, but can also be used independently. The implementation has been optimized to be of comparable speed (and sometimes even faster) than existing alternatives.

Implementation of a theoretically supported alternative to k-nearest neighbors for functional data to solve problems of estimating unobserved segments of a partially observed functional data sample, functional classification and outlier detection. The approximating neighbor curves are piecewise functions built from a functional sample. Instead of a distance on a function space we use a locally defined distance function that satisfies stabilization criteria. The package allows the implementation of the methodology and the replication of the results in Elà as, A., Jiménez, R. and Yukich, J. (2020) <arXiv:2007.16059>.

Comprehensive analytical tools are provided to characterize infectious disease superspreading from contact tracing surveillance data. The underlying theoretical frameworks of this toolkit include branching process with transmission heterogeneity (Lloyd-Smith et al. (2005) <doi:10.1038/nature04153>), case cluster size distribution (Nishiura et al. (2012) <doi:10.1016/j.jtbi.2011.10.039>, Blumberg et al. (2014) <doi:10.1371/journal.ppat.1004452>, and Kucharski and Althaus (2015) <doi:10.2807/1560-7917.ES2015.20.25.21167>), and decomposition of reproduction number (Zhao et al. (2022) <doi:10.1371/journal.pcbi.1010281>).

Pupillometric data collected using SR Research Eyelink eye trackers requires significant preprocessing. This package contains functions for preparing pupil dilation data for visualization and statistical analysis. Specifically, it provides a pipeline of functions which aid in data validation, the removal of blinks/artifacts, downsampling, and baselining, among others. Additionally, plotting functions for creating grand average and conditional average plots are provided. See the vignette for samples of the functionality. The package is designed for handling data collected with SR Research Eyelink eye trackers using Sample Reports created in SR Research Data Viewer.

This package provides functions for conducting power analysis in ANOVA designs, including between-, within-, and mixed-factor designs, with full support for both main effects and interactions. The package allows calculation of statistical power, required total sample size, significance level, and minimal detectable effect sizes expressed as partial eta squared or Cohen's f for ANOVA terms and planned contrasts. In addition, complementary functions are included for common related tests such as t-tests and correlation tests, making the package a convenient toolkit for power analysis in experimental psychology and related fields.

Traditional model evaluation metrics fail to capture model performance under less than ideal conditions. This package employs techniques to evaluate models "under-stress". This includes testing models extrapolation ability, or testing accuracy on specific sub-samples of the overall model space. Details describing stress-testing methods in this package are provided in Haycock (2023) <doi:10.26076/2am5-9f67>. The other primary contribution of this package is provided to R users access to the Python library PyCaret <https://pycaret.org/> for quick and easy access to auto-tuned machine learning models.

This package provides a latent, quasi-independent truncation time is assumed to be linked with the observed dependent truncation time, the event time, and an unknown transformation parameter via a structural transformation model. The transformation parameter is chosen to minimize the conditional Kendall's tau (Martin and Betensky, 2005) <doi:10.1198/016214504000001538> or the regression coefficient estimates (Jones and Crowley, 1992) <doi:10.2307/2336782>. The marginal distribution for the truncation time and the event time are completely left unspecified. The methodology is applied to survival curve estimation and regression analysis.

Create adjacency matrices of vocalisation graphs from dataframes containing sequences of speech and silence intervals, transforming these matrices into Markov diagrams, and generating datasets for classification of these diagrams by flattening them and adding global properties (functionals) etc. Vocalisation diagrams date back to early work in psychiatry (Jaffe and Feldstein, 1970) and social psychology (Dabbs and Ruback, 1987) but have only recently been employed as a data representation method for machine learning tasks including meeting segmentation (Luz, 2012) <doi:10.1145/2328967.2328970> and classification (Luz, 2013) <doi:10.1145/2522848.2533788>.

This package provides a graphical R package designed to visualize behavioral observations over time. Based on raw time data extracted from video recorded sessions of experimental observations, ViSiElse grants a global overview of a process by combining the visualization of multiple actions timestamps for all participants in a single graph. Individuals and/or group behavior can easily be assessed. Supplementary features allow users to further inspect their data by adding summary statistics (mean, standard deviation, quantile or statistical test) and/or time constraints to assess the accuracy of the realized actions.

Quickly install Java Development Kit (JDK) without administrative privileges and set environment variables in current R session or project to solve common issues with Java environment management in R'. Recommended to users of Java'/'rJava'-dependent R packages such as r5r', opentripplanner', xlsx', openNLP', rWeka', RJDBC', tabulapdf', and many more. rJavaEnv prevents common problems like Java not found, Java version conflicts, missing Java installations, and the inability to install Java due to lack of administrative privileges. rJavaEnv automates the download, installation, and setup of the Java on a per-project basis by setting the relevant JAVA_HOME in the current R session or the current working directory (via .Rprofile', with the user's consent). Similar to what renv does for R packages, rJavaEnv allows different Java versions to be used across different projects, but can also be configured to allow multiple versions within the same project (e.g. with the help of targets package). Note: there are a few extra steps for Linux users, who don't have any Java previously installed in their system, and who prefer package installation from source, rather then installing binaries from Posit Package Manager'. See documentation for details.

This package provides a fast and accurate analysis toolkit for single cell ATAC-seq (Assay for transposase-accessible chromatin using sequencing). Single cell ATAC-seq can resolve the heterogeneity of a complex tissue and reveal cell-type specific regulatory landscapes. However, the exceeding data sparsity has posed unique challenges for the data analysis. This package r-snapatac is an end-to-end bioinformatics pipeline for analyzing large- scale single cell ATAC-seq data which includes quality control, normalization, clustering analysis, differential analysis, motif inference and exploration of single cell ATAC-seq sequencing data.

This package provides utilities for computation and analysis of correlation/covariation in multiple sequence alignments and in side chain motions during molecular dynamics simulations. Features include the computation of correlation/covariation scores using a variety of scoring functions between either sequence positions in alignments or side chain dihedral angles in molecular dynamics simulations and utilities to analyze the correlation/covariation matrix through a variety of tools including network representation and principal components analysis. In addition, several utility functions are based on the R graphical environment to provide friendly tools for help in data interpretation.

This package provides a self-tuning spectral clustering method for single or multi-view data. Spectrum uses a new type of adaptive density aware kernel that strengthens connections in the graph based on common nearest neighbours. It uses a tensor product graph data integration and diffusion procedure to integrate different data sources and reduce noise. Spectrum uses either the eigengap or multimodality gap heuristics to determine the number of clusters. The method is sufficiently flexible so that a wide range of Gaussian and non-Gaussian structures can be clustered with automatic selection of K.

This package provides tools for raster georeferencing, grid affine transforms, and general raster logic. These functions provide converters between raster specifications, world vector, geotransform, RasterIO window, and RasterIO window in sf package list format. There are functions to offset a matrix by padding any of four corners (useful for vectorizing neighbourhood operations), and helper functions to harvesting user clicks on a graphics device to use for simple georeferencing of images. Methods used are available from <https://en.wikipedia.org/wiki/World_file> and <https://gdal.org/user/raster_data_model.html>.

This package provides JAR to perform Markov chain Monte Carlo (MCMC) inference using the popular Bayesian Evolutionary Analysis by Sampling Trees BEAST X software library of Baele et al (2025) <doi:10.1038/s41592-025-02751-x>. BEAST X supports auto-tuning Metropolis-Hastings, slice, Hamiltonian Monte Carlo and Sequential Monte Carlo sampling for a large variety of composable standard and phylogenetic statistical models using high performance computing. By placing the BEAST X JAR in this package, we offer an efficient distribution system for BEAST X use by other R packages using CRAN.

This package provides a client for the Environmental Data Initiative repository REST API. The EDI data repository <https://portal.edirepository.org/nis/home.jsp> is for publication and reuse of ecological data with emphasis on metadata accuracy and completeness. It is built upon the PASTA+ software stack <https://pastaplus-core.readthedocs.io/en/latest/index.html#> and was developed in collaboration with the US LTER Network <https://lternet.edu/>. EDIutils includes functions to search and access existing data, evaluate and upload new data, and assist other data management tasks common to repository users.