The AffiXcan package imputes a genetically regulated expression (GReX) for a set of genes in a sample of individuals, using a method based on the total binding affinity (TBA). Statistical models to impute GReX can be trained with a training dataset where the real total expression values are known.

The package performs alignment of the amplicon reads, normalizes gathered data, calculates multiple statistics (e.g. cut rates, frameshifts) and presents the results in the form of aggregated reports. Data and statistics can be broken down by experiments, barcodes, user defined groups, guides and amplicons allowing for quick identification of potential problems.

This is a package for stubbing and setting expectations on HTTP requests. It includes tools for stubbing HTTP requests, including expected request conditions and response conditions. You can match on HTTP method, query parameters, request body, headers and more. It can be used for unit tests or outside of a testing context.

This package provides fast and memory-friendly tools for text vectorization, topic modeling (LDA, LSA), word embeddings (GloVe), similarities. It provides a source-agnostic streaming API, which allows researchers to perform analysis of collections of documents which are larger than available RAM. All core functions are parallelized to benefit from multicore machines.

This package provides a non-linear model, termed ACME, that reflects a parsimonious biological model for allelic contributions of cis-acting eQTLs. With non-linear least-squares algorithm the maximum likelihood parameters can be estimated. The ACME model provides interpretable effect size estimates and p-values with well controlled Type-I error.

This package provides functions for fitting the Autoregressive and Moving Average Symmetric Model for univariate time series introduced by Maior and Cysneiros (2018), <doi:10.1007/s00362-016-0753-z>. Fitting method: conditional maximum likelihood estimation. For details see: Wei (2006), Time Series Analysis: Univariate and Multivariate Methods, Section 7.2.

The package uses exogenous enzyme imprinted information to map protein-DNA binding on individual sequenced DNA molecules. For example, GpC methyltransferase, CpG methyltransferase, and Adenine methyltransferases. Public datasets from such assays are compiled into tracks, and hosted at public servers like Galaxy for their seamless access by this package.

The package allows users to readily import spatial data obtained from either the 10X website or from the Space Ranger pipeline. Supported formats include tar.gz, h5, and mtx files. Multiple files can be imported at once with *List type of functions. The package represents data mainly as SpatialExperiment objects.

This package provides baseline functions for reading actigraphy and activity data, relying on baseline functions from actibase'. Reads data from Axivity CWA <https://axivity.com/> , ActiGraph GT3X <https://ametris.com/actigraph-wgt3x-bt>, SensorLog <https://sensorlog.berndthomas.net/>, and SensorLogger <https://www.tszheichoi.com/sensorlogger> zipped CSV files.

Automatic testing of R packages by tracing function calls made in examples and tests, then systematically varying the inputs to check that functions respond sensibly. The package is a development aid for authors submitting to the rOpenSci statistical software review project ('rOpenSci authors, 2021; <doi:10.5281/zenodo.5556756>).

Facilitates the importation of the Boston Blue Bike trip data since 2015. Functions include the computation of trip distances of given trip data. It can also map the location of stations within a given radius and calculate the distance to nearby stations. Data is from <https://www.bluebikes.com/system-data>.

Extend lasso and elastic-net model fitting for large data sets that cannot be loaded into memory. Designed to be more memory- and computation-efficient than existing lasso-fitting packages like glmnet and ncvreg', thus allowing the user to analyze big data with limited RAM <doi:10.32614/RJ-2021-001>.

BEAST2 (<https://www.beast2.org>) is a widely used Bayesian phylogenetic tool, that uses DNA/RNA/protein data and many model priors to create a posterior of jointly estimated phylogenies and parameters. BEAST2 is a command-line tool. This package provides a way to call BEAST2 from an R function call.

Engines for survival models from the parsnip package. These include parametric models (e.g., Jackson (2016) <doi:10.18637/jss.v070.i08>), semi-parametric (e.g., Simon et al (2011) <doi:10.18637/jss.v039.i05>), and tree-based models (e.g., Buehlmann and Hothorn (2007) <doi:10.1214/07-STS242>).

This package provides tools for the combination of individual study results in meta-analyses using p-value functions. Implements various combination methods including those by Fisher, Stouffer, Tippett, Edgington along with weighted generalizations. Contains functionality for the visualization and calculation of confidence curves and drapery plots to summarize evidence across studies.

The reliability of clusters is estimated using random projections. A set of stability measures is provided to assess the reliability of the clusters discovered by a generic clustering algorithm. The stability measures are taylored to high dimensional data (e.g. DNA microarray data) (Valentini, G (2005), <doi:10.1093/bioinformatics/bti817>.

Uses the delta-method to estimate the Potential Impact Fraction (PIF) and the Population Attributable Fraction (PAF) from summary data. It creates point-estimates, confidence intervals, and estimates of the variance. Provides an extension to the aggregated data method in Chan, Zepeda-Tello et al (2025) <doi:10.1002/sim.70214>.

Direction analysis is a set of tools designed to identify combinatorial effects of multiple treatments/conditions on pathways and kinases profiled by microarray, RNA-seq, proteomics, or phosphoproteomics data. See Yang P et al (2014) <doi:10.1093/bioinformatics/btt616>; and Yang P et al. (2016) <doi:10.1002/pmic.201600068>.

Discretely-sampled function is first smoothed. Features of the smoothed function are then extracted. Some of the key features include mean value, first and second derivatives, critical points (i.e. local maxima and minima), curvature of cunction at critical points, wiggliness of the function, noise in data, and outliers in data.

This package performs the Fairlie decomposition for nonlinear models (logit models). This function breaks down the difference in average outcomes between two groups into the part explained by group differences in observable characteristics and the unexplained part (Fairlie 1999 <doi:10.1086/209914>; Fairlie 2005 <doi:10.3233/JEM-2005-0259>).

The ggplot2 package provides a powerful set of tools for visualising and investigating data. The ggsoccer package provides a set of functions for elegantly displaying and exploring soccer event data with ggplot2'. Providing extensible layers and themes, it is designed to work smoothly with a variety of popular sports data providers.

This package contains techniques for mining large and high-dimensional data sets by using the concept of Intrinsic Dimension (ID). Here the ID is not necessarily an integer. It is extended to fractal dimensions. And the Morisita estimator is used for the ID estimation, but other tools are included as well.

This package performs Invariant Coordinate Selection (ICS) (Tyler, Critchley, Duembgen and Oja (2009) <doi:10.1111/j.1467-9868.2009.00706.x>) and especially ICS for multivariate outlier detection with application to quality control (Archimbaud, Nordhausen, Ruiz-Gazen (2018) <doi:10.1016/j.csda.2018.06.011>) using a shiny app.

This package implements a partitioned Empirical Bayes Expectation Conditional Maximization (ECM) algorithm for sparse high-dimensional linear mixed modeling as described in Zgodic, Bai, Zhang, and McLain (2025) <doi:10.1007/s11222-025-10649-z>. The package provides efficient estimation and inference for mixed models with high-dimensional fixed effects.