Supports propensity score weighting analysis of observational studies and randomized trials. Enables the estimation and inference of average causal effects with binary and multiple treatments using overlap weights (ATO), inverse probability of treatment weights (ATE), average treatment effect among the treated weights (ATT), matching weights (ATM) and entropy weights (ATEN), with and without propensity score trimming. These weights are members of the family of balancing weights introduced in Li, Morgan and Zaslavsky (2018) <doi:10.1080/01621459.2016.1260466> and Li and Li (2019) <doi:10.1214/19-AOAS1282>.
Applies phylogenetic comparative methods (PCM) and phylogenetic trait imputation using structural equation models (SEM), extending methods from Thorson et al. (2023) <doi:10.1111/2041-210X.14076>. This implementation includes a minimal set of features, to allow users to easily read all of the documentation and source code. PCM using SEM includes phylogenetic linear models and structural equation models as nested submodels, but also allows imputation of missing values. Features and comparison with other packages are described in Thorson and van der Bijl (2023) <doi:10.1111/jeb.14234>.
This package contains three simulation functions for implementing the entire Phase 123 trial and the separate Eff-Tox and Phase 3 portions of the trial, which may be beneficial for use on clusters. The functions AssignEffTox() and RandomizeEffTox() assign doses to patient cohorts during phase 12 and Reoptimize() determines the optimal dose to continue with during Phase 3. The functions ReturnMeansAgent() and ReturnMeanControl() gives the true mean survival for the agent doses and control and ReturnOCS() gives the operating characteristics of the design.
This package provides tools for an automated identification of diagnostic molecular characters, i.e. such columns in a given nucleotide or amino acid alignment that allow to distinguish taxa from each other. These characters can then be used to complement the formal descriptions of the taxa, which are often based on morphological and anatomical features. Especially for morphologically cryptic species, this will be helpful. QUIDDICH distinguishes between four different types of diagnostic characters. For more information, see "Kuehn, A.L., Haase, M. 2019. QUIDDICH: QUick IDentification of DIagnostic CHaracters.".
This package provides user friendly methods for the identification of sequence patterns that are statistically significantly associated with a property of the sequence. For instance, SeqFeatR allows to identify viral immune escape mutations for hosts of given HLA types. The underlying statistical method is Fisher's exact test, with appropriate corrections for multiple testing, or Bayes. Patterns may be point mutations or n-tuple of mutations. SeqFeatR offers several ways to visualize the results of the statistical analyses, see Budeus (2016) <doi:10.1371/journal.pone.0146409>.
Treatment and visualization of membrane (selective) transport data. Transport profiles involving up to three species are produced as publication-ready plots and several membrane performance parameters (e.g. separation factors as defined in Koros et al. (1996) <doi:10.1351/pac199668071479> and non-linear regression parameters for the equations described in Rodriguez de San Miguel et al. (2014) <doi:10.1016/j.jhazmat.2014.03.052>) can be obtained. Many widely used experimental setups (e.g. membrane physical aging) can be easily studied through the package's graphical representations.
Mainly data sets to accompany the VGAM package and the book "Vector Generalized Linear and Additive Models: With an Implementation in R" (Yee, 2015) <DOI:10.1007/978-1-4939-2818-7>. These are used to illustrate vector generalized linear and additive models (VGLMs/VGAMs), and associated models (Reduced-Rank VGLMs, Quadratic RR-VGLMs, Row-Column Interaction Models, and constrained and unconstrained ordination models in ecology). This package now contains some old VGAM family functions which have been replaced by newer ones (often because they are now special cases).
Retro is a modern, pragmatic set of Forths drawing influence from many sources. It clean, elegant, tiny, easy to grasp, and adaptable to many tasks.
It's not a traditional Forth. Drawing influence from colorForth, it uses prefixes to guide the compiler. From Joy and Factor, it uses quotations (anonymous, nestable functions) and combinators (functions that operate on functions) for much of the stack and flow control. It also adds vocabularies for working with strings, arrays, and other data types. Source files are written in Unu, allowing for simple, literate sources.
This package provides R bindings for NNG (Nanomsg Next Gen), a successor to ZeroMQ. NNG is a socket library for reliable, high-performance messaging over in-process, IPC, TCP, WebSocket and secure TLS transports. It implements Scalability Protocols, a standard for common communications patterns including publish/subscribe, request/reply and service discovery. As its own threaded concurrency framework, it provides a toolkit for asynchronous programming and distributed computing. Intuitive aio objects resolve automatically when asynchronous operations complete, and synchronisation primitives allow R to wait upon events signalled by concurrent threads.
RubyMoney provides a library for dealing with money and currency conversion. Its features are:
Provides a Money class which encapsulates all information about a certain amount of money, such as its value and its currency.
Provides a Money::Currency class which encapsulates all information about a monetary unit.
Represents monetary values as integers, in cents; so avoids floating point rounding errors.
Represents currency as Money::Currency instances providing a high level of flexibility.
Provides APIs for exchanging money from one currency to another.
The easylift package provides a convenient tool for genomic liftover operations between different genome assemblies. It seamlessly works with Bioconductor's GRanges objects and chain files from the UCSC Genome Browser, allowing for straightforward handling of genomic ranges across various genome versions. One noteworthy feature of easylift is its integration with the BiocFileCache package. This integration automates the management and caching of chain files necessary for liftover operations. Users no longer need to manually specify chain file paths in their function calls, reducing the complexity of the liftover process.
This package provides a simple framework to facilitate the comparison of pipelines involving various steps and parameters. The `pipelineDefinition` class represents pipelines as, minimally, a set of functions consecutively executed on the output of the previous one, and optionally accompanied by step-wise evaluation and aggregation functions. Given such an object, a set of alternative parameters/methods, and benchmark datasets, the `runPipeline` function then proceeds through all combinations arguments, avoiding recomputing the same step twice and compiling evaluations on the fly to avoid storing potentially large intermediate data.
The use of structured elicitation to inform decision making has grown dramatically in recent decades, however, judgements from multiple experts must be aggregated into a single estimate. Empirical evidence suggests that mathematical aggregation provides more reliable estimates than enforcing behavioural consensus on group estimates. aggreCAT provides state-of-the-art mathematical aggregation methods for elicitation data including those defined in Hanea, A. et al. (2021) <doi:10.1371/journal.pone.0256919>. The package also provides functions to visualise and evaluate the performance of your aggregated estimates on validation data.
In practical applications, the assumptions underlying generalized linear models frequently face violations, including incorrect specifications of the outcome variable's distribution or omitted predictors. These deviations can render the results of standard generalized linear models unreliable. As the sample size increases, what might initially appear as minor issues can escalate to critical concerns. To address these challenges, we adopt a permutation-based inference method tailored for generalized linear models. This approach offers robust estimations that effectively counteract the mentioned problems, and its effectiveness remains consistent regardless of the sample size.
This package provides functions to calculate the out-of-bag learning curve for random forests for any measure that is available in the mlr package. Supported random forest packages are randomForest and ranger and trained models of these packages with the train function of mlr'. The main function is OOBCurve() that calculates the out-of-bag curve depending on the number of trees. With the OOBCurvePars() function out-of-bag curves can also be calculated for mtry', sample.fraction and min.node.size for the ranger package.
This package implements a sequential imputation framework using Bayesian Mixed-Effects Trees ('SBMTrees') for handling missing data in longitudinal studies. The package supports a variety of models, including non-linear relationships and non-normal random effects and residuals, leveraging Dirichlet Process priors for increased flexibility. Key features include handling Missing at Random (MAR) longitudinal data, imputation of both covariates and outcomes, and generating posterior predictive samples for further analysis. The methodology is designed for applications in epidemiology, biostatistics, and other fields requiring robust handling of missing data in longitudinal settings.
In the past decade, genome-scale metabolic reconstructions have widely been used to comprehend the systems biology of metabolic pathways within an organism. Different GSMs are constructed using various techniques that require distinct steps, but the input data, information conversion and software tools are neither concisely defined nor mathematically or programmatically formulated in a context-specific manner.The tool that quantitatively and qualitatively specifies each reconstruction steps and can generate a template list of reconstruction steps dynamically selected from a reconstruction step reservoir, constructed based on all available published papers.
Stock-and-flow models are a computational method from the field of system dynamics. They represent how systems change over time and are mathematically equivalent to ordinary differential equations. sdbuildR (system dynamics builder) provides an intuitive interface for constructing stock-and-flow models without requiring extensive domain knowledge. Models can quickly be simulated and revised, supporting iterative development. sdbuildR simulates models in R and Julia', where Julia offers unit support and large-scale ensemble simulations. Additionally, sdbuildR can import models created in Insight Maker (<https://insightmaker.com/>).
The United Nations Sustainable Development Goals (SDGs) have become an important guideline for organisations to monitor and plan their contributions to social, economic, and environmental transformations. The text2sdg package is an open-source analysis package that identifies SDGs in text using scientifically developed query systems, opening up the opportunity to monitor any type of text-based data, such as scientific output or corporate publications. For more information see Meier, Mata & Wulff (2025) <doi:10.32614/RJ-2024-005> and Wulff, Meier & Mata (2024) <doi:10.1007/s11625-024-01516-3>.
TensorFlow SIG Addons <https://www.tensorflow.org/addons> is a repository of community contributions that conform to well-established API patterns, but implement new functionality not available in core TensorFlow'. TensorFlow natively supports a large number of operators, layers, metrics, losses, optimizers, and more. However, in a fast moving field like Machine Learning, there are many interesting new developments that cannot be integrated into core TensorFlow (because their broad applicability is not yet clear, or it is mostly used by a smaller subset of the community).
The purpose of this package is to identify traits in a dataset that can separate groups. This is done on two levels. First, clustering is performed, using an implementation of sparse K-means. Secondly, the generated clusters are used to predict outcomes of groups of individuals based on their distribution of observations in the different clusters. As certain clusters with separating information will be identified, and these clusters are defined by a sparse number of variables, this method can reduce the complexity of data, to only emphasize the data that actually matters.
Circular layout is an efficient way to visualise huge amounts of information. This package provides an implementation of circular layout generation in R as well as an enhancement of available software. Its flexibility is based on the usage of low-level graphics functions such that self-defined high-level graphics can be easily implemented by users for specific purposes. Together with the seamless connection between the powerful computational and visual environment in R, it gives users more convenience and freedom to design figures for better understanding complex patterns behind multi-dimensional data.
Estimation and inference methods for bounding average treatment effects (on the treated) that are valid under an unconfoundedness assumption. The bounds are designed to be robust in challenging situations, for example, when the conditioning variables take on a large number of different values in the observed sample, or when the overlap condition is violated. This robustness is achieved by only using limited "pooling" of information across observations. For more details, see the paper by Lee and Weidner (2021), "Bounding Treatment Effects by Pooling Limited Information across Observations," <arXiv:2111.05243>.
Analysis of agreement for nominal data between two raters using the Delta model. This model is proposed as an alternative to the widespread measure Cohen kappa coefficient, which performs poorly when the marginal distributions are very asymmetric (Martin-Andres and Femia-Marzo (2004), <doi:10.1348/000711004849268>; Martin-Andres and Femia-Marzo (2008) <doi:10.1080/03610920701669884>). The package also contains a function to perform a massive analysis of multiple raters against a gold standard. A shiny app is also provided to obtain the measures of nominal agreement between two raters.