This package contains functions performing Bayesian inference for meta-analytic and network meta-analytic models through Markov chain Monte Carlo algorithm. Currently, the package implements Hui Yao, Sungduk Kim, Ming-Hui Chen, Joseph G. Ibrahim, Arvind K. Shah, and Jianxin Lin (2015) <doi:10.1080/01621459.2015.1006065> and Hao Li, Daeyoung Lim, Ming-Hui Chen, Joseph G. Ibrahim, Sungduk Kim, Arvind K. Shah, Jianxin Lin (2021) <doi:10.1002/sim.8983>. For maximal computational efficiency, the Markov chain Monte Carlo samplers for each model, written in C++, are fine-tuned. This software has been developed under the auspices of the National Institutes of Health and Merck & Co., Inc., Kenilworth, NJ, USA.

Designed for performing impact analysis of opinions in a digital text document (DTD). The package allows a user to assess the extent to which a theme or subject within a document impacts the overall opinion expressed in the document. The package can be applied to a wide range of opinion-based DTD, including commentaries on social media platforms (such as Facebook', Twitter and Youtube'), online products reviews, and so on. The utility of opitools was originally demonstrated in Adepeju and Jimoh (2021) <doi:10.31235/osf.io/c32qh> in the assessment of COVID-19 impacts on neighbourhood policing using Twitter data. Further examples can be found in the vignette of the package.

This package provides high-level API and a wide range of options to create stunning, publication-quality plots effortlessly. It is built upon ggplot2 and other plotting packages, and is designed to be easy to use and to work seamlessly with ggplot2 objects. It is particularly useful for creating complex plots with multiple layers, facets, and annotations. It also provides a set of functions to create plots for specific types of data, such as Venn diagrams, alluvial diagrams, and phylogenetic trees. The package is designed to be flexible and customizable, and to work well with the ggplot2 ecosystem. The API can be found at <https://pwwang.github.io/plotthis/reference/index.html>.

Implementation of the SIC epsilon-telescope method, either using single or distributional (multiparameter) regression. Includes classical regression with normally distributed errors and robust regression, where the errors are from the Laplace distribution. The "smooth generalized normal distribution" is used, where the estimation of an additional shape parameter allows the user to move smoothly between both types of regression. See O'Neill and Burke (2022) "Robust Distributional Regression with Automatic Variable Selection" for more details. <doi:10.48550/arXiv.2212.07317>. This package also contains the data analyses from O'Neill and Burke (2023). "Variable selection using a smooth information criterion for distributional regression models". <doi:10.1007/s11222-023-10204-8>.

This package provides tools to import, clean, validate, and analyze freshwater quality data in Brazil. Implements water quality indices including the Water Quality Index (WQI/IQA), the Trophic State Index (TSI/IET) after Carlson (1977) <doi:10.4319/lo.1977.22.2.0361> and Lamparelli (2004) <https://www.teses.usp.br/teses/disponiveis/41/41134/tde-20032006-075813/publico/TeseLamparelli2004.pdf>, and the National Sanitation Foundation Water Quality Index (NSF WQI) <doi:10.1007/s11157-023-09650-7>. The package also checks compliance with Brazilian standard CONAMA Resolution 357/2005 <https://conama.mma.gov.br/?id=450&option=com_sisconama&task=arquivo.download> and generates reproducible reports for routine monitoring workflows.

An implementation of tidy speaker vowel normalization. This includes generic functions for defining new normalization methods for points, formant tracks, and Discrete Cosine Transform coefficients, as well as convenience functions implementing established normalization methods. References for the implemented methods are: Johnson, Keith (2020) <doi:10.5334/labphon.196> Lobanov, Boris (1971) <doi:10.1121/1.1912396> Nearey, Terrance M. (1978) <https://sites.ualberta.ca/~tnearey/Nearey1978_compressed.pdf> Syrdal, Ann K., and Gopal, H. S. (1986) <doi:10.1121/1.393381> Watt, Dominic, and Fabricius, Anne (2002) <https://www.latl.leeds.ac.uk/article/evaluation-of-a-technique-for-improving-the-mapping-of-multiple-speakers-vowel-spaces-in-the-f1-f2-plane/>.

GARFIELD is a non-parametric functional enrichment analysis approach described in the paper GARFIELD: GWAS analysis of regulatory or functional information enrichment with LD correction. Briefly, it is a method that leverages GWAS findings with regulatory or functional annotations (primarily from ENCODE and Roadmap epigenomics data) to find features relevant to a phenotype of interest. It performs greedy pruning of GWAS SNPs (LD r2 > 0.1) and then annotates them based on functional information overlap. Next, it quantifies Fold Enrichment (FE) at various GWAS significance cutoffs and assesses them by permutation testing, while matching for minor allele frequency, distance to nearest transcription start site and number of LD proxies (r2 > 0.8).

ProteoMM is a statistical method to perform model-based peptide-level differential expression analysis of single or multiple datasets. For multiple datasets ProteoMM produces a single fold change and p-value for each protein across multiple datasets. ProteoMM provides functionality for normalization, missing value imputation and differential expression. Model-based peptide-level imputation and differential expression analysis component of package follows the analysis described in “A statistical framework for protein quantitation in bottom-up MS based proteomics" (Karpievitch et al. Bioinformatics 2009). EigenMS normalisation is implemented as described in "Normalization of peak intensities in bottom-up MS-based proteomics using singular value decomposition." (Karpievitch et al. Bioinformatics 2009).

The functions proposed in this package allows to evaluate the process of measurement of the chemical components of water numerically or graphically. TSSS(), ICHS and datacheck() functions are useful to control the quality of measurements of chemical components of a sample of water. If one or more measurements include an error, the generated graph will indicate it with a position of the point that represents the sample outside the confidence interval. The function CI() allows to evaluate the possibility of contamination of a water sample after being obtained. Validation() is a function that allows to calculate the quality parameters of a technique for the measurement of a chemical component.

Designed to support the visualization, numerical computation, qualitative analysis, model-data fusion, and stochastic simulation for autonomous systems of differential equations. Euler and Runge-Kutta methods are implemented, along with tools to visualize the two-dimensional phaseplane. Likelihood surfaces and a simple Markov Chain Monte Carlo parameter estimator can be used for model-data fusion of differential equations and empirical models. The Euler-Maruyama method is provided for simulation of stochastic differential equations. The package was originally written for internal use to support teaching by Zobitz, and refined to support the text "Exploring modeling with data and differential equations using R" by John Zobitz (2021) <https://jmzobitz.github.io/ModelingWithR/index.html>.

This package provides a collection of fast and flexible functions for analyzing omics data in observational studies. Multiple different approaches for integrating multiple environmental/genetic factors, omics data, and/or phenotype data are implemented. This includes functions for performing omics wide association studies with one or more variables of interest as the exposure or outcome; a function for performing a meet in the middle analysis for linking exposures, omics, and outcomes (as described by Chadeau-Hyam et al., (2010) <doi:10.3109/1354750X.2010.533285>); and a function for performing a mixtures analysis across all omics features using quantile-based g-Computation (as described by Keil et al., (2019) <doi:10.1289/EHP5838>).

IsoSpec is a fine structure calculator used for obtaining the most probable masses of a chemical compound given the frequencies of the composing isotopes and their masses. It finds the smallest set of isotopologues with a given probability. The probability is assumed to be that of the product of multinomial distributions, each corresponding to one particular element and parametrized by the frequencies of finding these elements in nature. These numbers are supplied by IUPAC - the International Union of Pure and Applied Chemistry. See: Lacki, Valkenborg, Startek (2020) <DOI:10.1021/acs.analchem.0c00959> and Lacki, Startek, Valkenborg, Gambin (2017) <DOI:10.1021/acs.analchem.6b01459> for the description of the algorithms used.

This package provides a stochastic, spatially-explicit, demo-genetic model simulating the spread and evolution of a plant pathogen in a heterogeneous landscape to assess resistance deployment strategies. It is based on a spatial geometry for describing the landscape and allocation of different cultivars, a dispersal kernel for the dissemination of the pathogen, and a SEIR ('Susceptible-Exposed-Infectious-Removedâ ) structure with a discrete time step. It provides a useful tool to assess the performance of a wide range of deployment options with respect to their epidemiological, evolutionary and economic outcomes. Loup Rimbaud, Julien Papaïx, Jean-François Rey, Luke G Barrett, Peter H Thrall (2018) <doi:10.1371/journal.pcbi.1006067>.

The aim is to develop an R package, which is the new.dist package, for the probability (density) function, the distribution function, the quantile function and the associated random number generation function for discrete and continuous distributions, which have recently been proposed in the literature. This package implements the following distributions: The Power Muth Distribution, a Bimodal Weibull Distribution, the Discrete Lindley Distribution, The Gamma-Lomax Distribution, Weighted Geometric Distribution, a Power Log-Dagum Distribution, Kumaraswamy Distribution, Lindley Distribution, the Unit-Inverse Gaussian Distribution, EP Distribution, Akash Distribution, Ishita Distribution, Maxwell Distribution, the Standard Omega Distribution, Slashed Generalized Rayleigh Distribution, Two-Parameter Rayleigh Distribution, Muth Distribution, Uniform-Geometric Distribution, Discrete Weibull Distribution.

Classify Open Street Map (OSM) features into meaningful functional or analytical categories. Designed for OSM PBF files, e.g. from <https://download.geofabrik.de/> imported as spatial data frames. A classification consists of a list of categories that are related to certain OSM tags and values. Given a layer from an OSM PBF file and a classification, the main osm_classify() function returns a classification data table giving, for each feature, the primary and alternative categories (if there is overlap) assigned, and the tag(s) and value(s) matched on. The package also contains a classification of OSM features by economic function/significance, following Krantz (2023) <https://www.ssrn.com/abstract=4537867>.

Diagnostics for fixed effects linear and general linear regression models fitted with survey data. Extensions of standard diagnostics to complex survey data are included: standardized residuals, leverages, Cook's D, dfbetas, dffits, condition indexes, and variance inflation factors as found in Li and Valliant (Surv. Meth., 2009, 35(1), pp. 15-24; Jnl. of Off. Stat., 2011, 27(1), pp. 99-119; Jnl. of Off. Stat., 2015, 31(1), pp. 61-75); Liao and Valliant (Surv. Meth., 2012, 38(1), pp. 53-62; Surv. Meth., 2012, 38(2), pp. 189-202). Variance inflation factors and condition indexes are also computed for some general linear models as described in Liao (U. Maryland thesis, 2010).

Powerful graphical displays and statistical tools for structured problem solving and diagnosis. The functions of the sherlock package are especially useful for applying the process of elimination as a problem diagnosis technique. The sherlock package was designed to seamlessly work with the tidyverse set of packages and provides a collection of graphical displays built on top of the ggplot and plotly packages, such as different kinds of small multiple plots as well as helper functions such as adding reference lines, normalizing observations, reading in data or saving analysis results in an Excel file. References: David Hartshorne (2019, ISBN: 978-1-5272-5139-7). Stefan H. Steiner, R. Jock MacKay (2005, ISBN: 0873896467).

An Electronic Data Capture system (EDC) and Data Standard agnostic solution that enables the pharmaceutical programming community to develop Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM) datasets in R. The reusable algorithms concept in sdtm.oak provides a framework for modular programming and can potentially automate the conversion of raw clinical data to SDTM through standardized SDTM specifications. SDTM is one of the required standards for data submission to the Food and Drug Administration (FDA) in the United States and Pharmaceuticals and Medical Devices Agency (PMDA) in Japan. SDTM standards are implemented following the SDTM Implementation Guide as defined by CDISC <https://www.cdisc.org/standards/foundational/sdtmig>.

This package provides functions to generate K-fold cross validation (CV) folds and CV test error estimates that take into account how a survey dataset's sampling design was constructed (SRS, clustering, stratification, and/or unequal sampling weights). You can input linear and logistic regression models, along with data and a type of survey design in order to get an output that can help you determine which model best fits the data using K-fold cross validation. Our paper on "K-Fold Cross-Validation for Complex Sample Surveys" by Wieczorek, Guerin, and McMahon (2022) <doi:10.1002/sta4.454> explains why differing how we take folds based on survey design is useful.

To facilitate the analysis of positron emission tomography (PET) time activity curve (TAC) data, and to encourage open science and replicability, this package supports data loading and analysis of multiple TAC file formats. Functions are available to analyze loaded TAC data for individual participants or in batches. Major functionality includes weighted TAC merging by region of interest (ROI), calculating models including standardized uptake value ratio (SUVR) and distribution volume ratio (DVR, Logan et al. 1996 <doi:10.1097/00004647-199609000-00008>), basic plotting functions and calculation of cut-off values (Aizenstein et al. 2008 <doi:10.1001/archneur.65.11.1509>). Please see the walkthrough vignette for a detailed overview of tacmagic functions.

This package provides functions to access data from public RESTful APIs including World Bank API', and REST Countries API', retrieving real-time or historical data related to India, such as economic indicators, and international demographic and geopolitical indicators. Additionally, the package includes one of the largest curated collections of open datasets focused on India, covering topics such as population, economy, weather, politics, health, biodiversity, sports, agriculture, cybercrime, infrastructure, and more. The package supports reproducible research and teaching by integrating reliable international APIs and structured datasets from public, academic, and government sources. For more information on the APIs, see: World Bank API <https://datahelpdesk.worldbank.org/knowledgebase/articles/889392>, REST Countries API <https://restcountries.com/>.

Clustering via parsimonious Gaussian Mixtures of Experts using the MoEClust models introduced by Murphy and Murphy (2020) <doi:10.1007/s11634-019-00373-8>. This package fits finite Gaussian mixture models with a formula interface for supplying gating and/or expert network covariates using a range of parsimonious covariance parameterisations from the GPCM family via the EM/CEM algorithm. Visualisation of the results of such models using generalised pairs plots and the inclusion of an additional noise component is also facilitated. A greedy forward stepwise search algorithm is provided for identifying the optimal model in terms of the number of components, the GPCM covariance parameterisation, and the subsets of gating/expert network covariates.

This package provides functions for comparing survival curves using the max-combo test at a single timepoint or repeatedly at successive respective timepoints while controlling type I error (i.e., the group sequential setting), as published by Prior (2020) <doi:10.1177/0962280220931560>. The max-combo test is a generalization of the weighted log-rank test, which itself is a generalization of the log-rank test, which is a commonly used statistical test for comparing survival curves, e.g., during or after a clinical trial as part of an effort to determine if a new drug or therapy is more effective at delaying undesirable outcomes than an established drug or therapy or a placebo.

This package provides methods for detecting structural breaks, determining the number of breaks, and estimating break locations in linear quantile regression, using one or multiple quantiles, based on Qu (2008) and Oka and Qu (2011). Applicable to both time series and repeated cross-sectional data. The main function is rq.break(). . References for detailed theoretical and empirical explanations: . (1) Qu, Z. (2008). "Testing for Structural Change in Regression Quantiles." Journal of Econometrics, 146(1), 170-184 <doi:10.1016/j.jeconom.2008.08.006> . (2) Oka, T., and Qu, Z. (2011). "Estimating Structural Changes in Regression Quantiles." Journal of Econometrics, 162(2), 248-267 <doi:10.1016/j.jeconom.2011.01.005>.