This package provides a reproducible and modular workflow for absolute microbial quantification using spike-in controls. Supports both single spike-in taxa and synthetic microbial communities with user-defined spike-in volumes and genome copy numbers. Compatible with phyloseq and TreeSummarizedExperiment (TSE) data structures. The package implements methods for spike-in validation, preprocessing, scaling factor estimation, absolute abundance conversion, bias correction, and normalization. Facilitates downstream statistical analyses with DESeq2', edgeR', and other Bioconductor-compatible methods. Visualization tools are provided via ggplot2', ggtree', and related packages. Includes detailed vignettes, case studies, and function-level documentation to guide users through experimental design, quantification, and interpretation.

This package implements optimal matching with near-fine balance in large observational studies with the use of optimal calipers to get a sparse network. The caliper is optimal in the sense that it is as small as possible such that a matching exists. The main functions in the bigmatch package are optcal() to find the optimal caliper, optconstant() to find the optimal number of nearest neighbors, and nfmatch() to find a near-fine balance match with a caliper and a restriction on the number of nearest neighbors. Yu, R., Silber, J. H., and Rosenbaum, P. R. (2020). <DOI:10.1214/19-sts699>.

Analyze data from next-generation sequencing experiments on genomic samples. CLONETv2 offers a set of functions to compute allele specific copy number and clonality from segmented data and SNPs position pileup. The package has also calculated the clonality of single nucleotide variants given read counts at mutated positions. The package has been developed at the laboratory of Computational and Functional Oncology, Department of CIBIO, University of Trento (Italy), under the supervision of prof Francesca Demichelis. References: Prandi et al. (2014) <doi:10.1186/s13059-014-0439-6>; Carreira et al. (2014) <doi:10.1126/scitranslmed.3009448>; Romanel et al. (2015) <doi:10.1126/scitranslmed.aac9511>.

This package implements choice models based on economic theory, including estimation using Markov chain Monte Carlo (MCMC), prediction, and more. Its usability is inspired by ideas from tidyverse'. Models include versions of the Hierarchical Multinomial Logit and Multiple Discrete-Continous (Volumetric) models with and without screening. The foundations of these models are described in Allenby, Hardt and Rossi (2019) <doi:10.1016/bs.hem.2019.04.002>. Models with conjunctive screening are described in Kim, Hardt, Kim and Allenby (2022) <doi:10.1016/j.ijresmar.2022.04.001>. Models with set-size variation are described in Hardt and Kurz (2020) <doi:10.2139/ssrn.3418383>.

This package provides a toolkit for the analysis and management of data for genes in the so-called "Human Leukocyte Antigen" (HLA) region. Functions extract reference data from the Anthony Nolan HLA Informatics Group/ImmunoGeneTics HLA GitHub repository (ANHIG/IMGTHLA) <https://github.com/ANHIG/IMGTHLA>, validate Genotype List (GL) Strings, convert between UNIFORMAT and GL String Code (GLSC) formats, translate HLA alleles and GLSCs across ImmunoPolymorphism Database (IPD) IMGT/HLA Database release versions, identify differences between pairs of alleles at a locus, generate customized, multi-position sequence alignments, trim and convert allele-names across nomenclature epochs, and extend existing data-analysis methods.

This package provides functionality for working with raster-like quadtrees (also called â region quadtreesâ ), which allow for variable-sized cells. The package allows for flexibility in the quadtree creation process. Several functions defining how to split and aggregate cells are provided, and custom functions can be written for both of these processes. In addition, quadtrees can be created using other quadtrees as â templatesâ , so that the new quadtree's structure is identical to the template quadtree. The package also includes functionality for modifying quadtrees, querying values, saving quadtrees to a file, and calculating least-cost paths using the quadtree as a resistance surface.

RcppArmadillo implementation for the Matlab code of the Variational Mode Decomposition and Two-Dimensional Variational Mode Decomposition'. For more information, see (i) Variational Mode Decomposition by K. Dragomiretskiy and D. Zosso in IEEE Transactions on Signal Processing, vol. 62, no. 3, pp. 531-544, Feb.1, 2014, <doi:10.1109/TSP.2013.2288675>; (ii) Two-Dimensional Variational Mode Decomposition by Dragomiretskiy, K., Zosso, D. (2015), In: Tai, XC., Bae, E., Chan, T.F., Lysaker, M. (eds) Energy Minimization Methods in Computer Vision and Pattern Recognition. EMMCVPR 2015. Lecture Notes in Computer Science, vol 8932. Springer, <doi:10.1007/978-3-319-14612-6_15>.

DEsingle is an R package for differential expression (DE) analysis of single-cell RNA-seq (scRNA-seq) data. It defines and detects 3 types of differentially expressed genes between two groups of single cells, with regard to different expression status (DEs), differential expression abundance (DEa), and general differential expression (DEg). DEsingle employs Zero-Inflated Negative Binomial model to estimate the proportion of real and dropout zeros and to define and detect the 3 types of DE genes. Results showed that DEsingle outperforms existing methods for scRNA-seq DE analysis, and can reveal different types of DE genes that are enriched in different biological functions.

Allows access to selected services that are part of the Google Adwords API <https://developers.google.com/adwords/api/docs/guides/start>. Google Adwords is an online advertising service by Google', that delivers Ads to users. This package offers a authentication process using OAUTH2'. Currently, there are two methods of data of accessing the API, depending on the type of request. One method uses SOAP requests which require building an XML structure and then sent to the API. These are used for the ManagedCustomerService and the TargetingIdeaService'. The second method is by building AWQL queries for the reporting side of the Google Adwords API.

Simplify bivariate and regression analyses by automating result generation, including summary tables, statistical tests, and customizable graphs. It supports tests for continuous and dichotomous data, as well as stepwise regression for linear, logistic, and Firth penalized logistic models. While not a substitute for tailored analysis, BiVariAn accelerates workflows and is expanding features like multilingual interpretations of results.The methods for selecting significant statistical tests, as well as the predictor selection in prediction functions, can be referenced in the works of Marc Kery (2003) <doi:10.1890/0012-9623(2003)84[92:NORDIG]2.0.CO;2> and Rainer Puhr (2017) <doi:10.1002/sim.7273>.

Implementation of the double/debiased machine learning framework of Chernozhukov et al. (2018) <doi:10.1111/ectj.12097> for partially linear regression models, partially linear instrumental variable regression models, interactive regression models and interactive instrumental variable regression models. DoubleML allows estimation of the nuisance parts in these models by machine learning methods and computation of the Neyman orthogonal score functions. DoubleML is built on top of mlr3 and the mlr3 ecosystem. The object-oriented implementation of DoubleML based on the R6 package is very flexible. More information available in the publication in the Journal of Statistical Software: <doi:10.18637/jss.v108.i03>.

There are many different formats dates are commonly represented with: the order of day, month, or year can differ, different separators ("-", "/", or whitespace) can be used, months can be numerical, names, or abbreviations and year given as two digits or four. datefixR takes dates in all these different formats and converts them to R's built-in date class. If datefixR cannot standardize a date, such as because it is too malformed, then the user is told which date cannot be standardized and the corresponding ID for the row. datefixR also allows the imputation of missing days and months with user-controlled behavior.

This package provides a flexible container to transport and manipulate complex sets of data. These data may consist of multiple data files and associated meta data and ancillary files. Individual data objects have associated system level meta data, and data files are linked together using the OAI-ORE standard resource map which describes the relationships between the files. The OAI- ORE standard is described at <https://www.openarchives.org/ore/>. Data packages can be serialized and transported as structured files that have been created following the BagIt specification. The BagIt specification is described at <https://datatracker.ietf.org/doc/html/draft-kunze-bagit-08>.

We implement various classical tests for the composite hypothesis of testing the fit to the family of gamma distributions as the Kolmogorov-Smirnov test, the Cramer-von Mises test, the Anderson Darling test and the Watson test. For each test a parametric bootstrap procedure is implemented, as considered in Henze, Meintanis & Ebner (2012) <doi:10.1080/03610926.2010.542851>. The recent procedures presented in Henze, Meintanis & Ebner (2012) <doi:10.1080/03610926.2010.542851> and Betsch & Ebner (2019) <doi:10.1007/s00184-019-00708-7> are implemented. Estimation of parameters of the gamma law are implemented using the method of Bhattacharya (2001) <doi:10.1080/00949650108812100>.

Converts table-like objects to stand-alone PDF or PNG. Can be used to embed tables and arbitrary content in PDF or Word documents. Provides a low-level R interface for creating LaTeX code, e.g. command() and a high-level interface for creating PDF documents, e.g. as.pdf.data.frame(). Extensive customization is available via mid-level functions, e.g. as.tabular(). See also package?latexpdf'. Support for PNG is experimental; see as.png.data.frame'. Adapted from metrumrg <https://r-forge.r-project.org/R/?group_id=1215>. Requires a compatible installation of pdflatex', e.g. <https://miktex.org/>.

This function obtains a Random Number Generator (RNG) or collection of RNGs that replicate the required parameter(s) of a distribution for a time series of data. Consider the case of reproducing a time series data set of size 20 that uses an autoregressive (AR) model with phi = 0.8 and standard deviation equal to 1. When one checks the arima.sin() function's estimated parameters, it's possible that after a single trial or a few more, one won't find the precise parameters. This enables one to look for the ideal RNG setting for a simulation that will accurately duplicate the desired parameters.

The epistack package main objective is the visualizations of stacks of genomic tracks (such as, but not restricted to, ChIP-seq, ATAC-seq, DNA methyation or genomic conservation data) centered at genomic regions of interest. epistack needs three different inputs: 1) a genomic score objects, such as ChIP-seq coverage or DNA methylation values, provided as a `GRanges` (easily obtained from `bigwig` or `bam` files). 2) a list of feature of interest, such as peaks or transcription start sites, provided as a `GRanges` (easily obtained from `gtf` or `bed` files). 3) a score to sort the features, such as peak height or gene expression value.

Intended to analyse recordings from multiple microphones (e.g., backpack microphones in captive setting). It allows users to align recordings even if there is non-linear drift of several minutes between them. A call detection and assignment pipeline can be used to find vocalisations and assign them to the vocalising individuals (even if the vocalisation is picked up on multiple microphones). The tracing and measurement functions allow for detailed analysis of the vocalisations and filtering of noise. Finally, the package includes a function to run spectrographic cross correlation, which can be used to compare vocalisations. It also includes multiple other functions related to analysis of vocal behaviour.

This package provides functions and a workflow to easily and powerfully calculating specificity, sensitivity and ROC curves of biomarkers combinations. Allows to rank and select multi-markers signatures as well as to find the best performing sub-signatures, now also from single-cell RNA-seq datasets. The method used was first published as a Shiny app and described in Mazzara et al. (2017) <doi:10.1038/srep45477> and further described in Bombaci & Rossi (2019) <doi:10.1007/978-1-4939-9164-8_16>, and widely expanded as a package as presented in the bioRxiv pre print Ferrari et al. <doi:10.1101/2022.01.17.476603>.

This package provides a comprehensive visualization toolkit built with coders of all skill levels and color-vision impaired audiences in mind. It allows creation of finely-tuned, publication-quality figures from single function calls. Visualizations include scatter plots, compositional bar plots, violin, box, and ridge plots, and more. Customization ranges from size and title adjustments to discrete-group circling and labeling, hidden data overlay upon cursor hovering via ggplotly() conversion, and many more, all with simple, discrete inputs. Color blindness friendliness is powered by legend adjustments (enlarged keys), and by allowing the use of shapes or letter-overlay in addition to the carefully selected dittoColors().

Implementation of Das Gupta's standardisation and decomposition of population rates, as set out "Standardization and decomposition of rates: A userâ s manual", Das Gupta (1993) <https://www2.census.gov/library/publications/1993/demographics/p23-186.pdf>. The goal of these methods is to calculate adjusted rates based on compositional factors and quantify the contribution of each factor to the difference in crude rates between populations. The package offers functionality to handle various scenarios for any number of factors and populations, where said factors can be comprised of vectors across sub-populations (including cross-classified population breakdowns), and with the option to specify user-defined rate functions.

This package provides a toolbox for estimating vector fields from intensive longitudinal data, and construct potential landscapes thereafter. The vector fields can be estimated with two nonparametric methods: the Multivariate Vector Field Kernel Estimator (MVKE) by Bandi & Moloche (2018) <doi:10.1017/S0266466617000305> and the Sparse Vector Field Consensus (SparseVFC) algorithm by Ma et al. (2013) <doi:10.1016/j.patcog.2013.05.017>. The potential landscapes can be constructed with a simulation-based approach with the simlandr package (Cui et al., 2021) <doi:10.31234/osf.io/pzva3>, or the Bhattacharya et al. (2011) method for path integration <doi:10.1186/1752-0509-5-85>.

We consider studies in which information from error-prone diagnostic tests or self-reports are gathered sequentially to determine the occurrence of a silent event. Using a likelihood-based approach incorporating the proportional hazards assumption, we provide functions to estimate the survival distribution and covariate effects. We also provide functions for power and sample size calculations for this setting. Please refer to Xiangdong Gu, Yunsheng Ma, and Raji Balasubramanian (2015) <doi: 10.1214/15-AOAS810>, Xiangdong Gu and Raji Balasubramanian (2016) <doi: 10.1002/sim.6962>, Xiangdong Gu, Mahlet G Tadesse, Andrea S Foulkes, Yunsheng Ma, and Raji Balasubramanian (2020) <doi: 10.1186/s12911-020-01223-w>.

Generates Weibull-parameterized estimates of phenology for any percentile of a distribution using the framework established in Cooke (1979) <doi:10.1093/biomet/66.2.367>. Extensive testing against other estimators suggest the weib_percentile() function is especially useful in generating more accurate and less biased estimates of onset and offset (Belitz et al. 2020) <doi:10.1111/2041-210X.13448>. Non-parametric bootstrapping can be used to generate confidence intervals around those estimates, although this is computationally expensive. Additionally, this package offers an easy way to perform non-parametric bootstrapping to generate confidence intervals for quantile estimates, mean estimates, or any statistical function of interest.