Allows biomechanical pressure data from a range of systems to be imported and processed in a reproducible manner. Automatic and manual tools are included to let the user define regions (masks) to be analyzed. Also includes functions for visualizing and animating pressure data. Example methods are described in Shi et al., (2022) <doi:10.1038/s41598-022-19814-0>, Lee et al., (2014) <doi:10.1186/1757-1146-7-18>, van der Zward et al., (2014) <doi:10.1186/1757-1146-7-20>, Najafi et al., (2010) <doi:10.1016/j.gaitpost.2009.09.003>, Cavanagh and Rodgers (1987) <doi:10.1016/0021-9290(87)90255-7>.

Generate common data forms for complex data suitable for conversions and transmission by decomposition as paths or primitives. Paths are sequentially-linked records, primitives are basic atomic elements and both can model many forms and be grouped into hierarchical structures. The universal models SC0 (structural) and SC (labelled, relational) are composed of edges and can represent any hierarchical form. Specialist models PATH', ARC and TRI provide the most common intermediate forms used for converting from one form to another. The methods are inspired by the simplicial complex <https://en.wikipedia.org/wiki/Simplicial_complex> and provide intermediate forms that relate spatial data structures to this mathematical construct.

This package provides a suite of methods for powerful and robust microbiome data analysis, including data normalization, data simulation, community-level association testing and differential abundance analysis. It implements generalized UniFrac distances, Geometric Mean of Pairwise Ratios (GMPR) normalization, semiparametric data simulator, distance-based statistical methods, and feature- based statistical methods. The distance-based statistical methods include three extensions of PERMANOVA:

• PERMANOVA using the Freedman-Lane permutation scheme,

• PERMANOVA omnibus test using multiple matrices, and

• analytical approach to approximating PERMANOVA p-value.

Feature-based statistical methods include linear model-based methods for differential abundance analysis of zero-inflated high-dimensional compositional data.

This package provides a lightweight, dependency-free toolbox for pre-processing XY data from experimental methods (i.e. any signal that can be measured along a continuous variable). This package provides methods for baseline estimation and correction, smoothing, normalization, integration and peaks detection. Baseline correction methods includes polynomial fitting as described in Lieber and Mahadevan-Jansen (2003) <doi:10.1366/000370203322554518>, Rolling Ball algorithm after Kneen and Annegarn (1996) <doi:10.1016/0168-583X(95)00908-6>, SNIP algorithm after Ryan et al. (1988) <doi:10.1016/0168-583X(88)90063-8>, 4S Peak Filling after Liland (2015) <doi:10.1016/j.mex.2015.02.009> and more.

Bayesian methods for predicting the calendar time at which a target number of events is reached in clinical trials. The methodology applies to both blinded and unblinded settings and jointly models enrollment, event-time, and censoring processes. The package provides tools for trial data simulation, model fitting using Stan via the rstan interface, and event time prediction under a wide range of trial designs, including varying sample sizes, enrollment patterns, treatment effects, and event or censoring time distributions. The package is intended to support interim monitoring, operational planning, and decision-making in clinical trial development. Methods are described in Fu et al. (2025) <doi:10.1002/sim.70310>.

Automates delta log-normal boosted regression tree abundance prediction. Loops through parameters provided (LR (learning rate), TC (tree complexity), BF (bag fraction)), chooses best, simplifies, & generates line, dot & bar plots, & outputs these & predictions & a report, makes predicted abundance maps, and Unrepresentativeness surfaces. Package core built around gbm (gradient boosting machine) functions in dismo (Hijmans, Phillips, Leathwick & Jane Elith, 2020 & ongoing), itself built around gbm (Greenwell, Boehmke, Cunningham & Metcalfe, 2020 & ongoing, originally by Ridgeway). Indebted to Elith/Leathwick/Hastie 2008 Working Guide <doi:10.1111/j.1365-2656.2008.01390.x>; workflow follows Appendix S3. See <https://www.simondedman.com/> for published guides and papers using this package.

This package provides a shiny application, which allows you to perform single- and multi-omics analyses using your own omics datasets. After the upload of the omics datasets and a metadata file, single-omics is performed for feature selection and dataset reduction. These datasets are used for pairwise- and multi-omics analyses, where automatic tuning is done to identify correlations between the datasets - the end goal of the recommended Holomics workflow. Methods used in the package were implemented in the package mixomics by Florian Rohart,Benoît Gautier,Amrit Singh,Kim-Anh Lê Cao (2017) <doi:10.1371/journal.pcbi.1005752> and are described there in further detail.

This package provides a simulation modeling framework which significantly extends capabilities from the MGDrivE simulation package via a new mathematical and computational framework based on stochastic Petri nets. For more information about MGDrivE', see our publication: Sánchez et al. (2019) <doi:10.1111/2041-210X.13318> Some of the notable capabilities of MGDrivE2 include: incorporation of human populations, epidemiological dynamics, time-varying parameters, and a continuous-time simulation framework with various sampling algorithms for both deterministic and stochastic interpretations. MGDrivE2 relies on the genetic inheritance structures provided in package MGDrivE', so we suggest installing that package initially.

This package provides a collection of functions for converting and visualization the free induction decay of mono dimensional nuclear magnetic resonance (NMR) spectra into an audio file. It facilitates the conversion of Bruker datasets in files WAV. The sound of NMR signals could provide an alternative to the current representation of the individual metabolic fingerprint and supply equally significant information. The package includes also NMR spectra of the urine samples provided by four healthy donors. Based on Cacciatore S, Saccenti E, Piccioli M. Hypothesis: the sound of the individual metabolic phenotype? Acoustic detection of NMR experiments. OMICS. 2015;19(3):147-56. <doi:10.1089/omi.2014.0131>.

Time series prediction is a critical task in data analysis, requiring not only the selection of appropriate models, but also suitable data preprocessing and tuning strategies. TSPredIT (Time Series Prediction with Integrated Tuning) is a framework that provides a seamless integration of data preprocessing, decomposition, model training, hyperparameter optimization, and evaluation. Unlike other frameworks, TSPredIT emphasizes the co-optimization of both preprocessing and modeling steps, improving predictive performance. It supports a variety of statistical and machine learning models, filtering techniques, outlier detection, data augmentation, and ensemble strategies. More information is available in Salles et al. <doi:10.1007/978-3-662-68014-8_2>.

Bayesian power/type I error calculation and model fitting using the power prior and the normalized power prior for generalized linear models. Detailed examples of applying the package are available at <doi:10.32614/RJ-2023-016>. Models for time-to-event outcomes are implemented in the R package BayesPPDSurv'. The Bayesian clinical trial design methodology is described in Chen et al. (2011) <doi:10.1111/j.1541-0420.2011.01561.x>, and Psioda and Ibrahim (2019) <doi:10.1093/biostatistics/kxy009>. The normalized power prior is described in Duan et al. (2006) <doi:10.1002/env.752> and Ibrahim et al. (2015) <doi:10.1002/sim.6728>.

This package provides tools for fitting Bayesian single index models with flexible choices of priors for both the index and the link function. The package implements model estimation and posterior inference using efficient MCMC algorithms built on the nimble framework, allowing users to specify, extend, and simulate models in a unified and reproducible manner. The following methods are implemented in the package: Antoniadis et al. (2004) <https://www.jstor.org/stable/24307224>, Wang (2009) <doi:10.1016/j.csda.2008.12.010>, Choi et al. (2011) <doi:10.1080/10485251003768019>, Dhara et al. (2019) <doi:10.1214/19-BA1170>, McGee et al. (2023) <doi:10.1111/biom.13569>.

This package provides a set of functions for counterfactual decomposition (cfdecomp). The functions available in this package decompose differences in an outcome attributable to a mediating variable (or sets of mediating variables) between groups based on counterfactual (causal inference) theory. By using Monte Carlo (MC) integration (simulations based on empirical estimates from multivariable models) we provide added flexibility compared to existing (analytical) approaches, at the cost of computational power or time. The added flexibility means that we can decompose difference between groups in any outcome or and with any mediator (any variable type and distribution). See Sudharsanan & Bijlsma (2019) <doi:10.4054/MPIDR-WP-2019-004> for more information.

This package performs the identification of differential risk hotspots (Briz-Redon et al. 2019) <doi:10.1016/j.aap.2019.105278> along a linear network. Given a marked point pattern lying on the linear network, the method implemented uses a network-constrained version of kernel density estimation (McSwiggan et al. 2017) <doi:10.1111/sjos.12255> to approximate the probability of occurrence across space for the type of event specified by the user through the marks of the pattern (Kelsall and Diggle 1995) <doi:10.2307/3318678>. The goal is to detect microzones of the linear network where the type of event indicated by the user is overrepresented.

With this package, it is possible to compute nonparametric simultaneous confidence intervals for relative contrast effects in the unbalanced one way layout. Moreover, it computes simultaneous p-values. The simultaneous confidence intervals can be computed using multivariate normal distribution, multivariate t-distribution with a Satterthwaite Approximation of the degree of freedom or using multivariate range preserving transformations with Logit or Probit as transformation function. 2 sample comparisons can be performed with the same methods described above. There is no assumption on the underlying distribution function, only that the data have to be at least ordinal numbers. See Konietschke et al. (2015) <doi:10.18637/jss.v064.i09> for details.

Contemporary software commonly used to design stated preference experiments are expensive and the code is closed source. This is a free software package with an easy to use interface to make flexible stated preference experimental designs using state-of-the-art methods. For an overview of stated choice experimental design theory, see e.g., Rose, J. M. & Bliemer, M. C. J. (2014) in Hess S. & Daly. A. <doi:10.4337/9781781003152>. The package website can be accessed at <https://spdesign.edsandorf.me>. We acknowledge funding from the European Unionâ s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant INSPiRE (Grant agreement ID: 793163).

MetaPhOR was developed to enable users to assess metabolic dysregulation using transcriptomic-level data (RNA-sequencing and Microarray data) and produce publication-quality figures. A list of differentially expressed genes (DEGs), which includes fold change and p value, from DESeq2 or limma, can be used as input, with sample size for MetaPhOR, and will produce a data frame of scores for each KEGG pathway. These scores represent the magnitude and direction of transcriptional change within the pathway, along with estimated p-values.MetaPhOR then uses these scores to visualize metabolic profiles within and between samples through a variety of mechanisms, including: bubble plots, heatmaps, and pathway models.

This package provides a common misconception is that the Hochberg procedure comes up with adequate overall type I error control when test statistics are positively correlated. However, unless the test statistics follow some standard distributions, the Hochberg procedure requires a more stringent positive dependence assumption, beyond mere positive correlation, to ensure valid overall type I error control. To fill this gap, we formulate statistical tests grounded in rank correlation coefficients to validate fulfillment of the positive dependence through stochastic ordering (PDS) condition. See Gou, J., Wu, K. and Chen, O. Y. (2024). Rank correlation coefficient based tests on positive dependence through stochastic ordering with application in cancer studies, Technical Report.

This package provides wrapper of various machine learning models. In applied machine learning, there is a strong belief that we need to strike a balance between interpretability and accuracy. However, in field of the interpretable machine learning, there are more and more new ideas for explaining black-box models, that are implemented in R'. DALEXtra creates DALEX Biecek (2018) <doi:10.48550/arXiv.1806.08915> explainer for many type of models including those created using python scikit-learn and keras libraries, and java h2o library. Important part of the package is Champion-Challenger analysis and innovative approach to model performance across subsets of test data presented in Funnel Plot.

Enables the automation of actions across the pipeline, including initial steps of transforming binocular data and gap repair to event-based processing such as fixations, saccades, and entry/duration in Areas of Interest (AOIs). It also offers visualisation of eye movement and AOI entries. These tools take relatively raw (trial, time, x, and y form) data and can be used to return fixations, saccades, and AOI entries and time spent in AOIs. As the tools rely on this basic data format, the functions can work with data from any eye tracking device. Implements fixation and saccade detection using methods proposed by Salvucci and Goldberg (2000) <doi:10.1145/355017.355028>.

Provides an interactive toolkit for educational and psychological measurement implemented using the shiny framework. The package supports content validity analysis, dimensionality assessment, and Classical Test Theory using the CTT package (Willse, 2018) <doi:10.32614/CRAN.package.CTT>.Item Response Theory (IRT) analyses are conducted via mirt (Chalmers, 2012) <doi:10.18637/jss.v048.i06>. Exploratory Factor Analysis is performed using psych (Revelle, 2025), while Confirmatory Factor Analysis and Structural Equation Modeling are based on the lavaan framework (Rosseel, 2012) <doi:10.18637/jss.v048.i02>. The application allows users to upload data, evaluate statistical models, visualize results, and export outputs through an intuitive graphical interface without requiring programming experience.

This package provides interactive plotting for mathematical models of infectious disease spread. Users can choose from a variety of common built-in ordinary differential equation (ODE) models (such as the SIR, SIRS, and SIS models), or create their own. This latter flexibility allows shinySIR to be applied to simple ODEs from any discipline. The package is a useful teaching tool as students can visualize how changing different parameters can impact model dynamics, with minimal knowledge of coding in R. The built-in models are inspired by those featured in Keeling and Rohani (2008) <doi:10.2307/j.ctvcm4gk0> and Bjornstad (2018) <doi:10.1007/978-3-319-97487-3>.

An English language syllable counter, plus readability score measure-er. For readability, we support Flesch Reading Ease and Flesch-Kincaid Grade Level ('Kincaid et al'. 1975) <https://stars.library.ucf.edu/cgi/viewcontent.cgi?article=1055&context=istlibrary>, Automated Readability Index ('Senter and Smith 1967) <https://apps.dtic.mil/sti/citations/AD0667273>, Simple Measure of Gobbledygook (McLaughlin 1969), and Coleman-Liau (Coleman and Liau 1975) <doi:10.1037/h0076540>. The package has been carefully optimized and should be very efficient, both in terms of run time performance and memory consumption. The main methods are vectorized by document, and scores for multiple documents are computed in parallel via OpenMP'.

The main objective of cooperative Transferable-Utility games (TU-games) is to allocate a good among the agents involved. The package implements major solution concepts including the Shapley value, Banzhaf value, and egalitarian rules, alongside their extensions for structured games: the Owen value and Banzhaf-Owen value for games with a priori unions, and the Myerson value for communication games on networks. To address the inherent exponential computational complexity of exact evaluation, the package offers both exact algorithms and linear approximation methods based on sampling, enabling the analysis of large-scale games. Additionally, it supports core set-based solutions, allowing computation of the vertices and the centroid of the core.