This package provides a cross-platform framework for dynamic binding of C libraries using a flexible Foreign Function Interface (FFI). The FFI supports almost all fundamental C types, multiple calling conventions, symbolic access to foreign C struct/union data types and wrapping of R functions as C callback function pointers. Dynamic bindings to shared C libraries are data-driven by cross-platform binding specifications using a compact plain text format; the package includes a DynPort binding specification for SDL3 generated from current headers with porter'. The package includes a variety of technology demos and OS-specific notes for installation of shared libraries. For the underlying methods and bundled DynCall libraries, see Adler (2012) <doi:10.32614/RJ-2012-004> and Adler and Philipp (2008) <https://dyncall.org>.

This package provides a complete seven-step workflow for copy number variation (CNV) analysis applicable to any disease or condition where samples with genomic copy number data is available. Supports built-in grading and risk stratification presets for seven major cancers (viz. prostate, breast, colorectal, lung, cervical, lymphoma, melanoma) based on clinically validated systems including ISUP Grade Groups, Nottingham Grading System, Dukes staging, IASLC TNM, FIGO, Ann Arbor/Lugano classification, and Breslow depth. Generalizable to other disease types. An automatic mode derives a normalised Risk Score from the data using min-max normalisation and adaptive binning. Custom user-defined thresholds are supported for any other disease type. Downstream functions for CNV aberration detection, recurrence analysis, gene annotation, CNV matrix generation, and CNV-RNA expression correlation are disease-type agnostic.

Defines storage standard for Read, process, and analyze intracranial electroencephalography and deep-brain stimulation in RAVE', a reproducible framework for analysis and visualization of iEEG by Magnotti, Wang, and Beauchamp, (2020, <doi:10.1016/j.neuroimage.2020.117341>). Supports brain imaging data structure (BIDS) <https://bids.neuroimaging.io> and native file structure to ingest signals from Matlab data files, hierarchical data format 5 (HDF5), European data format (EDF), BrainVision core data format (BVCDF), or BlackRock Microsystem (NEV/NSx); process images in Neuroimaging informatics technology initiative (NIfTI) and FreeSurfer formats, providing brain imaging normalization to template brain, facilitating threeBrain package for comprehensive electrode localization via YAEL (your advanced electrode localizer) by Wang, Magnotti, Zhang, and Beauchamp (2023, <doi:10.1523/ENEURO.0328-23.2023>).

DoRothEA is a gene regulatory network containing signed transcription factor (TF) - target gene interactions. DoRothEA regulons, the collection of a TF and its transcriptional targets, were curated and collected from different types of evidence for both human and mouse. A confidence level was assigned to each TF-target interaction based on the number of supporting evidence.

Visualization functions for spatial transcriptomics data. Includes functions to generate several types of plots, including spot plots, feature (molecule) plots, reduced dimension plots, spot-level quality control (QC) plots, and feature-level QC plots, for datasets from the 10x Genomics Visium and other technological platforms. Datasets are assumed to be in either SpatialExperiment or SingleCellExperiment format.

GEOfastq is used to download fastq files from the European Nucleotide Archive (ENA) starting with an accession from the Gene Expression Omnibus (GEO). To do this, sample metadata is retrieved from GEO and the Sequence Read Archive (SRA). SRA run accessions are then used to construct FTP and aspera download links for fastq files generated by the ENA.

Named after the Irish name for weather, this package contains tidied data from the Irish Meteorological Service's hourly observations for 2017. In all, the data sets include observations from 25 weather stations, and also latitude and longitude coordinates for each weather station. Now includes energy generation data for Ireland and Northern Ireland (2017), including Wind Generation data.

Computation and visualization of Bayesian Regions of Evidence to systematically evaluate the sensitivity of a superiority or non-inferiority claim against any prior assumption of its assessors. Methodological details are elaborated by Hoefler and Miller (<https://osf.io/jxnsv>). Besides generic functions, the package also provides an intuitive Shiny application, that can be run in local R environments.

Doubly robust methods for evaluating surrogate markers as outlined in: Agniel D, Hejblum BP, Thiebaut R & Parast L (2022). "Doubly robust evaluation of high-dimensional surrogate markers", Biostatistics <doi:10.1093/biostatistics/kxac020>. You can use these methods to determine how much of the overall treatment effect is explained by a (possibly high-dimensional) set of surrogate markers.

This package provides a set of fast tools for converting a textual corpus into a set of normalized tables. Users may make use of the udpipe back end with no external dependencies, or a Python back ends with spaCy <https://spacy.io>. Exposed annotation tasks include tokenization, part of speech tagging, named entity recognition, and dependency parsing.

This package provides function to create, read, write, and work with iCalendar files (which typically have .ics or .ical extensions), and the scheduling data, calendars and timelines of people, organisations and other entities that they represent. iCalendar is an open standard for exchanging calendar and scheduling information between users and computers, described at <https://icalendar.org/>.

Calculate a set of corrected test statistics for cases when samples are not independent, such as when classification accuracy values are obtained over resamples or through k-fold cross-validation, as proposed by Nadeau and Bengio (2003) <doi:10.1023/A:1024068626366> and presented in Bouckaert and Frank (2004) <doi:10.1007/978-3-540-24775-3_3>.

This package provides tools for simulating from continuous-time individual level models of disease transmission, and carrying out infectious disease data analyses with the same models. The epidemic models considered are distance-based and/or contact network-based models within Susceptible-Infectious-Removed (SIR) or Susceptible-Infectious-Notified-Removed (SINR) compartmental frameworks. <doi:10.18637/jss.v098.i10>.

Experiences studies are an integral component of the actuarial control cycle. Regardless of the decrement or policyholder behavior of interest, the analyses conducted is often the same. Ultimately, this package aims to reduce time spent writing the same code used for different experience studies, therefore increasing the time for to uncover new insights inherit within the relevant experience.

This package provides tools for exploratory analysis of tabular data using colour highlighting. Highlighting is displayed in any console supporting ANSI colours, and can be converted to HTML', typst', latex and SVG'. quarto and rmarkdown rendering are directly supported. It is also possible to add colour to regular expression matches and highlight differences between two arbitrary R objects.

Statistical tool set for population genetics. The package provides following functions: 1) estimators of genetic differentiation (FST), 2) regression analysis of environmental effects on genetic differentiation using generalized least squares (GLS) method, 3) interfaces to read and manipulate GENEPOP format data files). For more information, see Kitada, Nakamichi and Kishino (2020) <doi:10.1101/2020.01.30.927186>.

Implementation of Fair Interpolated Transport (FIT), an algorithm-agnostic preprocessing framework for group-fair clustering. Group-conditional empirical distributions are moved along Wasserstein-2 geodesics toward a shared barycenter at a tunable transport intensity, and the smallest intensity meeting a soft-fairness tolerance is selected. Three soft clustering families are provided, centroid based, graph based, and model based.

An easy way to conduct flexible scan. Monte-Carlo method is used to test the spatial clusters given the cases, population, and shapefile. A table with formal style and a map with clusters are included in the result report. The method can be referenced at: Toshiro Tango and Kunihiko Takahashi (2005) <doi:10.1186/1476-072X-4-11>.

Penalized methods are useful for fitting over-parameterized models. This package includes functions for restructuring an ordinal response dataset for fitting continuation ratio models for datasets where the number of covariates exceeds the sample size or when there is collinearity among the covariates. The glmnet fitting algorithm is used to fit the continuation ratio model after data restructuring.

Inference, goodness-of-fit tests, and predictions for continuous and discrete univariate Hidden Markov Models (HMM), including zero-inflated distributions. The goodness-of-fit test is based on a Cramer-von Mises statistic and uses parametric bootstrap to estimate the p-value. The description of the methodology is taken from Nasri et al (2020) <doi:10.1029/2019WR025122>.

This package provides basic distribution functions for a generalized logistic distribution proposed by Rathie and Swamee (2006) <https://www.rroij.com/open-access/on-new-generalized-logistic-distributions-and-applicationsbarreto-fhs-mota-jma-and-rathie-pn-.pdf>. It also has an interactive RStudio plot for better guessing dynamically of initial values for ease of included optimization and simulating.

This network estimation procedure eLasso, which is based on the Ising model, combines l1-regularized logistic regression with model selection based on the Extended Bayesian Information Criterion (EBIC). EBIC is a fit measure that identifies relevant relationships between variables. The resulting network consists of variables as nodes and relevant relationships as edges. Can deal with binary data.

Deriving density-independent and density-dependent niche breadth indices from abundance data of two or more habitats, including both the pairwise and n-dimensional methods to calculate isodar-adjusted inequality. Methods are described in Granot, Dubiner & Belmaker (in revision), "Why abundance-based indices of niche breadth are biased, and what can be done to improve them", Ecology Letters.

This package provides an R interface to the JBrowse 2 genome browser. Enables embedding a JB2 genome browser in a Shiny app or R Markdown document. The browser can also be launched from an interactive R console. The browser can be loaded with a variety of common genomics data types, and can be used with a custom theme.