MsImpute is a package for imputation of peptide intensity in proteomics experiments. It additionally contains tools for MAR/MNAR diagnosis and assessment of distortions to the probability distribution of the data post imputation. The missing values are imputed by low-rank approximation of the underlying data matrix if they are MAR (method = "v2"), by Barycenter approach if missingness is MNAR ("v2-mnar"), or by Peptide Identity Propagation (PIP).

This package provides next-generation sequencing (NGS) and mass spectrometry (MS) sample data, code snippets and replication material used for developing NestLink. The NestLink approach is a protein binder selection and identification technology able to biophysically characterize thousands of library members at once without handling individual clones at any stage of the process. Data were acquired on NGS and MS platforms at the Functional Genomics Center Zurich.

srnadiff is a package that finds differently expressed regions from RNA-seq data at base-resolution level without relying on existing annotation. To do so, the package implements the identify-then-annotate methodology that builds on the idea of combining two pipelines approachs differential expressed regions detection and differential expression quantification. It reads BAM files as input, and outputs a list differentially regions, together with the adjusted p-values.

This package offers functions to process multiple ChIP-seq BAM files and detect allele-specific events. It computes allele counts at individual variants (SNPs/SNVs), implements extensive QC (quality control) steps to remove problematic variants, and utilizes a Bayesian framework to identify statistically significant allele-specific events. BaalChIP is able to account for copy number differences between the two alleles, a known phenotypical feature of cancer samples.

Phylogenetic clustering (phyloclustering) is an evolutionary continuous time Markov Chain model-based approach to identify population structure from molecular data without assuming linkage equilibrium. The package phyclust provides a convenient implementation of phyloclustering for DNA and SNP data, capable of clustering individuals into subpopulations and identifying molecular sequences representative of those subpopulations. It is designed in C for performance and interfaced with R for visualization.

The first day of any MMWR week is Sunday. MMWR week numbering is sequential beginning with 1 and incrementing with each week to a maximum of 52 or 53. MMWR week #1 of an MMWR year is the first week of the year that has at least four days in the calendar year. This package provides functionality to convert dates to MMWR day, week, and year and the reverse.

Models time-to-event data from interval-censored screening studies. It accounts for latent prevalence at baseline and incorporates misclassification due to imperfect test sensitivity. For usage details, see the package vignette ("BayesPIM_intro"). Further details can be found in T. Klausch, B. I. Lissenberg-Witte, and V. M. Coupe (2024), "A Bayesian prevalence-incidence mixture model for screening outcomes with misclassification", <doi:10.48550/arXiv.2412.16065>.

This package provides tools to facilitate the access and processing of data from the Central Bank of Brazil API. The package allows users to retrieve economic and financial data, transforming them into usable tabular formats for further analysis. The data is obtained from the Central Bank of Brazil API: <https://api.bcb.gov.br/dados/serie/bcdata.sgs.series_code/dados?formato=json&dataInicial=start_date&dataFinal=end_date>.

Finds the largest possible regression model that will still converge for various types of regression analyses (including mixed models and generalized additive models) and then optionally performs stepwise elimination similar to the forward and backward effect-selection methods in SAS, based on the change in log-likelihood or its significance, Akaike's Information Criterion, the Bayesian Information Criterion, the explained deviance, or the F-test of the change in R².

An R interface to Cheetah Grid', a high-performance JavaScript table widget. cheetahR allows users to render millions of rows in just a few milliseconds, making it an excellent alternative to other R table widgets. The package wraps the Cheetah Grid JavaScript functions and makes them readily available for R users. The underlying grid implementation is based on Cheetah Grid <https://github.com/future-architect/cheetah-grid>.

The nonparametric trend and its derivatives in equidistant time series (TS) with long-memory errors can be estimated. The estimation is conducted via local polynomial regression using an automatically selected bandwidth obtained by a built-in iterative plug-in algorithm or a bandwidth fixed by the user. The smoothing methods of the package are described in Letmathe, S., Beran, J. and Feng, Y., (2023) <doi:10.1080/03610926.2023.2276049>.

The goal of this package is to provide an improved version of WA-PLS (Weighted Averaging Partial Least Squares) by including the tolerances of taxa and the frequency of the sampled climate variable. This package also provides a way of leave-out cross-validation that removes both the test site and sites that are both geographically close and climatically close for each cycle, to avoid the risk of pseudo-replication.

This package provides functions for converting decimals to a matrix of numerators and denominators or a character vector of fractions. Supports mixed or improper fractions, finding common denominators for vectors of fractions, limiting denominators to powers of ten, and limiting denominators to a maximum value. Also includes helper functions for finding the least common multiple and greatest common divisor for a vector of integers. Implemented using C++ for maximum speed.

Hedgehog will eat all your bugs. Hedgehog is a property-based testing package in the spirit of QuickCheck'. With Hedgehog', one can test properties of their programs against randomly generated input, providing far superior test coverage compared to unit testing. One of the key benefits of Hedgehog is integrated shrinking of counterexamples, which allows one to quickly find the cause of bugs, given salient examples when incorrect behaviour occurs.

This package provides common components (classes, methods, documentation) for packages that conduct meta-analytic corrections and sensitivity analyses for within-study and/or across-study biases in meta-analysis. See the packages PublicationBias', phacking', and multibiasmeta'. These package implement methods described in, respectively: Mathur & VanderWeele (2020) <doi:10.31219/osf.io/s9dp6>; Mathur (2022) <doi:10.31219/osf.io/ezjsx>; Mathur (2022) <doi:10.31219/osf.io/u7vcb>.

Supports the generation of parallelogram, equilateral triangle, regular hexagon, isosceles trapezoid, Koch snowflake, hexaflake', Sierpinski triangle, Sierpinski carpet and Sierpinski trapezoid mazes via TurtleGraphics'. Mazes are generated by the recursive method: the domain is divided into sub-domains in which mazes are generated, then dividing lines with holes are drawn between them, see J. Buck, Recursive Division, <http://weblog.jamisbuck.org/2011/1/12/maze-generation-recursive-division-algorithm>.

To test whether the missing data mechanism, in a set of incompletely observed data, is one of missing completely at random (MCAR). For detailed description see Jamshidian, M. Jalal, S., and Jansen, C. (2014). "MissMech: An R Package for Testing Homoscedasticity, Multivariate Normality, and Missing Completely at Random (MCAR)", Journal of Statistical Software, 56(6), 1-31. <https://www.jstatsoft.org/v56/i06/> <doi:10.18637/jss.v056.i06>.

It aggregates protein panel data and metadata for protein quantitative trait locus (pQTL) analysis using pQTLtools (<https://jinghuazhao.github.io/pQTLtools/>). The package includes data from affinity-based panels such as Olink (<https://olink.com/>) and SomaScan (<https://somalogic.com/>), as well as mass spectrometry-based panels from CellCarta (<https://cellcarta.com/>) and Seer (<https://seer.bio/>). The metadata encompasses updated annotations and publication details.

Create phantom variables, which are variables that were not observed, for the purpose of sensitivity analyses for structural equation models. The package makes it easier for a user to test different combinations of covariances between the phantom variable(s) and observed variables. The package may be used to assess a model's or effect's sensitivity to temporal bias (e.g., if cross-sectional data were collected) or confounding bias.

This package provides an interface to PDFMiner <https://github.com/pdfminer/pdfminer.six> a Python package for extracting information from PDF'-files. PDFMiner has the goal to get all information available in a PDF'-file, position of the characters, font type, font size and informations about lines. Which makes it the perfect starting point for extracting tables from PDF'-files. More information can be found in the package README'-file.

This package provides a collection of utilities and ggplot2 extensions to assist with visualisations in genomic epidemiology. This includes the phylepic chart, a visual combination of a phylogenetic tree and a matched epidemic curve. The included ggplot2 extensions such as date axes binned by week are relevant for other applications in epidemiology and beyond. The approach is described in Suster et al. (2024) <doi:10.1101/2024.04.02.24305229>.

This is an implementation of model-based trees with global model parameters (PALM trees). The PALM tree algorithm is an extension to the MOB algorithm (implemented in the partykit package), where some parameters are fixed across all groups. Details about the method can be found in Seibold, Hothorn, Zeileis (2016) <arXiv:1612.07498>. The package offers coef(), logLik(), plot(), and predict() functions for PALM trees.

These functions use data augmentation and Bayesian techniques for the assessment of single-member and incomplete ensembles of climate projections. It provides unbiased estimates of climate change responses of all simulation chains and of all uncertainty variables. It additionally propagates uncertainty due to missing information in the estimates. - Evin, G., B. Hingray, J. Blanchet, N. Eckert, S. Morin, and D. Verfaillie. (2019) <doi:10.1175/JCLI-D-18-0606.1>.

This package provides a set of functions of increasing complexity allows users to (1) convert QuadKey-identified datasets, based on Microsoft's Bing Maps Tile System', into Simple Features data frames, (2) transform Simple Features data frames into rasters, and (3) process multiple Meta ('Facebook') QuadKey-identified human mobility files directly into raster files. For more details, see Dâ Andrea et al. (2024) <doi:10.21105/joss.06500>.