It provides versatile tools for analysis of birth and death based Markovian Queueing Models and Single and Multiclass Product-Form Queueing Networks. It implements M/M/1, M/M/c, M/M/Infinite, M/M/1/K, M/M/c/K, M/M/c/c, M/M/1/K/K, M/M/c/K/K, M/M/c/K/m, M/M/Infinite/K/K, Multiple Channel Open Jackson Networks, Multiple Channel Closed Jackson Networks, Single Channel Multiple Class Open Networks, Single Channel Multiple Class Closed Networks and Single Channel Multiple Class Mixed Networks. Also it provides a B-Erlang, C-Erlang and Engset calculators. This work is dedicated to the memory of D. Sixto Rios Insua.

The purpose of this package is to manipulate SVG files that are templates of charts the user wants to produce. In vector graphics one copes with x-/y-coordinates of elements (e.g. lines, rectangles, text). Their scale is often dependent on the program that is used to produce the graphics. In applied statistics one usually has numeric values on a fixed scale (e.g. percentage values between 0 and 100) to show in a chart. Basically, svgtools transforms the statistical values into coordinates and widths/heights of the vector graphics. This is done by stackedBar() for bar charts, by linesSymbols() for charts with lines and/or symbols (dot markers) and scatterSymbols() for scatterplots.

Estimates the authors or speakers of texts. Methods developed in Huang, Perry, and Spirling (2020) <doi:10.1017/pan.2019.49>. The model is built on a Bayesian framework in which the distinctiveness of each speaker is defined by how different, on average, the speaker's terms are to everyone else in the corpus of texts. An optional cross-validation method is implemented to select the subset of terms that generate the most accurate speaker predictions. Once a set of terms is selected, the model can be estimated. Speaker distinctiveness and term influence can be recovered from parameters in the model using package functions. Once fitted, the model can be used to predict authorship of new texts.

SqueezeMeta is a versatile pipeline for the automated analysis of metagenomics/metatranscriptomics data (<https://github.com/jtamames/SqueezeMeta>). This package provides functions loading SqueezeMeta results into R, filtering them based on different criteria, and visualizing the results using basic plots. The SqueezeMeta project (and any subsets of it generated by the different filtering functions) is parsed into a single object, whose different components (e.g. tables with the taxonomic or functional composition across samples, contig/gene abundance profiles) can be easily analyzed using other R packages such as vegan or DESeq2'. The methods in this package are further described in Puente-Sánchez et al., (2020) <doi:10.1186/s12859-020-03703-2>.

Allows users to quickly load multiple patients electrocardiographic (ECG) data at once and conduct relevant time analysis of heart rate variability (HRV) without manual edits from a physician or data cleaning specialist. The package provides the unique ability to iteratively filter, plot, and store time analysis results in a data frame while writing plots to a predefined folder. This streamlines the workflow for HRV analysis across multiple datasets. Methods are based on Rodrà guez-Liñares et al. (2011) <doi:10.1016/j.cmpb.2010.05.012>. Examples of applications using this package include Kwon et al. (2022) <doi:10.1007/s10286-022-00865-2> and Lawrence et al. (2023) <doi:10.1016/j.autneu.2022.103056>.

This is a package for graphical and statistical analyses of environmental data, with a focus on analyzing chemical concentrations and physical parameters, usually in the context of mandated environmental monitoring. It provides major environmental statistical methods found in the literature and regulatory guidance documents, with extensive help that explains what these methods do, how to use them, and where to find them in the literature. It comes with numerous built-in data sets from regulatory guidance documents and environmental statistics literature. It includes scripts reproducing analyses presented in the book "EnvStats: An R Package for Environmental Statistics" (Millard, 2013, Springer, ISBN 978-1-4614-8455-4, https://link.springer.com/book/10.1007/978-1-4614-8456-1).

In epigenome-wide association studies, the measured signals for each sample are a mixture of methylation profiles from different cell types. The current approaches to the association detection only claim whether a cytosine-phosphate-guanine (CpG) site is associated with the phenotype or not, but they cannot determine the cell type in which the risk-CpG site is affected by the phenotype. We propose a solid statistical method, HIgh REsolution (HIRE), which not only substantially improves the power of association detection at the aggregated level as compared to the existing methods but also enables the detection of risk-CpG sites for individual cell types. The "HIREewas" R package is to implement HIRE model in R.

OMICsPCA is an analysis pipeline designed to integrate multi OMICs experiments done on various subjects (e.g. Cell lines, individuals), treatments (e.g. disease/control) or time points and to analyse such integrated data from various various angles and perspectives. In it's core OMICsPCA uses Principal Component Analysis (PCA) to integrate multiomics experiments from various sources and thus has ability to over data insufficiency issues by using the ingegrated data as representatives. OMICsPCA can be used in various application including analysis of overall distribution of OMICs assays across various samples /individuals /time points; grouping assays by user-defined conditions; identification of source of variation, similarity/dissimilarity between assays, variables or individuals.

Description: Provides comprehensive tools for analysing and characterizing mixed-level factorial designs arranged in blocks. Includes construction and validation of incidence structures, computation of C-matrices, evaluation of A-, D-, E-, and MV-efficiencies, checking of orthogonal factorial structure (OFS), diagnostics based on Hamming distance, discrepancy measures, B-criterion, Es^2 statistics, J2-distance and J2-efficiency, Phi-p optimality, and symmetry conditions for universal optimality. The methodological framework follows foundational work on factorial and mixed-level design assessment by Xu and Wu (2001) <doi:10.1214/aos/1013699993>, and Gupta (1983) <doi:10.1111/j.2517-6161.1983.tb01253.x>. These methods assist in selecting, comparing, and studying factorial block designs across a range of experimental situations.

Uses ggplot2 to visualise either (a) a single DNA/RNA sequence split across multiple lines, (b) multiple DNA/RNA sequences, each occupying a whole line, or (c) base modifications such as DNA methylation called by modified bases models in Dorado or Guppy. Functions starting with visualise_<>() are the main plotting functions, and functions starting with extract_and_sort_<>() are key helper functions for reading files and reformatting data. Source code is available at <https://github.com/ejade42/ggDNAvis>, a full non-expert user guide is available at <https://ejade42.github.io/ggDNAvis/>, and an interactive web-app version of the software is available at <https://ejade42.github.io/ggDNAvis/articles/interactive_app.html>.

This package provides tools for longitudinal meta-analysis where studies contribute effect sizes at multiple follow-up time points. Implements robust variance estimation (RVE) with Tipton small-sample corrections following Hedges, Tipton, and Johnson (2010) <doi:10.1002/jrsm.5> and Tipton (2015) <doi:10.1037/met0000011>, time-varying sensitivity analysis via the Impact Threshold for a Confounding Variable (ITCV) following Frank (2000) <doi:10.1177/0049124100029002003>, benchmark calibration of the ITCV threshold against observed study-level covariates, spline-based nonlinear time-trend modeling with a nonlinearity test, and leave-k-out fragility analysis across the follow-up trajectory. Designed for researchers synthesising evidence from studies with repeated outcome measurement in education, psychology, health, and the social sciences.

This package implements the navigated weighting (NAWT) proposed by Katsumata (2020) <arXiv:2005.10998>, which improves the inverse probability weighting by utilizing estimating equations suitable for a specific pre-specified parameter of interest (e.g., the average treatment effects or the average treatment effects on the treated) in propensity score estimation. It includes the covariate balancing propensity score proposed by Imai and Ratkovic (2014) <doi:10.1111/rssb.12027>, which uses covariate balancing conditions in propensity score estimation. The point estimate of the parameter of interest as well as coefficients for propensity score estimation and their uncertainty are produced using the M-estimation. The same functions can be used to estimate average outcomes in missing outcome cases.

In the spirit of Anscombe's quartet, this package includes datasets that demonstrate the importance of visualizing your data, the importance of not relying on statistical summary measures alone, and why additional assumptions about the data generating mechanism are needed when estimating causal effects. The package includes "Anscombe's Quartet" (Anscombe 1973) <doi:10.1080/00031305.1973.10478966>, D'Agostino McGowan & Barrett (2023) "Causal Quartet" <doi:10.48550/arXiv.2304.02683>, "Datasaurus Dozen" (Matejka & Fitzmaurice 2017), "Interaction Triptych" (Rohrer & Arslan 2021) <doi:10.1177/25152459211007368>, "Rashomon Quartet" (Biecek et al. 2023) <doi:10.48550/arXiv.2302.13356>, and Gelman "Variation and Heterogeneity Causal Quartets" (Gelman et al. 2023) <doi:10.48550/arXiv.2302.12878>.

This package implements a faster and more expressive version of Bayesian Additive Regression Trees that, at a high level, approximates unknown functions as a weighted sum of binary regression tree ensembles. Supports fitting (generalized) linear varying coefficient models that posits a linear relationship between the inverse link and some covariates but allows that relationship to change as a function of other covariates. Additionally supports fitting heteroscedastic BART models, in which both the mean and log-variance are approximated with separate regression tree ensembles. A formula interface allows for different splitting variables to be used in each ensemble. For more details see Deshpande (2025) <doi:10.1080/10618600.2024.2431072> and Deshpande et al. (2024) <doi:10.1214/24-BA1470>.

Analyze telemetry datasets generalized to allow any technology. The filtering steps check for false positives caused by reflected transmissions from surfaces and false pings from other noise generating equipment. The filters are based on JSATS filtering algorithms found in package filteRjsats <https://CRAN.R-project.org/package=filteRjsats> but have been generalized to allow the user to define many of the filtering variables. Additionally, this package contains scripts used to help identify an optimal maximum blanking period as defined in Capello et al (2015) <doi:10.1371/journal.pone.0134002>. The functions were written according to their manuscript description, but have not been reviewed by the authors for accuracy. It is included here as is, without warranty.

Implementation of Johansen's general formulation of Welch-James's statistic with Approximate Degrees of Freedom, which makes it suitable for testing any linear hypothesis concerning cell means in univariate and multivariate mixed model designs when the data pose non-normality and non-homogeneous variance. Some improvements, namely trimmed means and Winsorized variances, and bootstrapping for calculating an empirical critical value, have been added to the classical formulation. The code departs from a previous SAS implementation by L.M. Lix and H.J. Keselman, available at <http://supp.apa.org/psycarticles/supplemental/met_13_2_110/SAS_Program.pdf> and published in Keselman, H.J., Wilcox, R.R., and Lix, L.M. (2003) <DOI:10.1111/1469-8986.00060>.

This package provides methods for testing the equality between groups of estimated density functions. The package implements FDET (Fourier-based Density Equality Testing) and MDET (Moment-based Density Equality Testing), two new approaches introduced by the author. Both methods extend an earlier testing approach by Delicado (2007), "Functional k-sample problem when data are density functions" <doi:10.1007/s00180-007-0047-y>, which is referred to as DET (Density Equality Testing) in this package for clarity. FDET compares groups of densities based on their global shape using Fourier transforms, while MDET tests for differences in distributional moments. All methods are described in Anarat, Krutmann and Schwender (2025), "Testing for Differences in Extrinsic Skin Aging Based on Density Functions" (Submitted).

Constructing niche models and analyzing patterns of niche evolution. Acts as an interface for many popular modeling algorithms, and allows users to conduct Monte Carlo tests to address basic questions in evolutionary ecology and biogeography. Warren, D.L., R.E. Glor, and M. Turelli (2008) <doi:10.1111/j.1558-5646.2008.00482.x> Glor, R.E., and D.L. Warren (2011) <doi:10.1111/j.1558-5646.2010.01177.x> Warren, D.L., R.E. Glor, and M. Turelli (2010) <doi:10.1111/j.1600-0587.2009.06142.x> Cardillo, M., and D.L. Warren (2016) <doi:10.1111/geb.12455> D.L. Warren, L.J. Beaumont, R. Dinnage, and J.B. Baumgartner (2019) <doi:10.1111/ecog.03900>.

The lipid scrambling activity of protein extracts and purified scramblases is often determined using a fluorescence-based assay involving many manual steps. flippant offers an integrated solution for the analysis and publication-grade graphical presentation of dithionite scramblase assays, as well as a platform for review, dissemination and extension of the strategies it employs. The package's name derives from a play on the fact that lipid scrambling is also sometimes referred to as flipping'. The package is originally published as Cotton, R.J., Ploier, B., Goren, M.A., Menon, A.K., and Graumann, J. (2017). "flippantâ An R package for the automated analysis of fluorescence-based scramblase assays." BMC Bioinformatics 18, 146. <DOI:10.1186/s12859-017-1542-y>.

Handles univariate non-parametric density estimation with parametric starts and asymmetric kernels in a simple and flexible way. Kernel density estimation with parametric starts involves fitting a parametric density to the data before making a correction with kernel density estimation, see Hjort & Glad (1995) <doi:10.1214/aos/1176324627>. Asymmetric kernels make kernel density estimation more efficient on bounded intervals such as (0, 1) and the positive half-line. Supported asymmetric kernels are the gamma kernel of Chen (2000) <doi:10.1023/A:1004165218295>, the beta kernel of Chen (1999) <doi:10.1016/S0167-9473(99)00010-9>, and the copula kernel of Jones & Henderson (2007) <doi:10.1093/biomet/asm068>. User-supplied kernels, parametric starts, and bandwidths are supported.

This package provides a utility library to facilitate the generalization of statistical methods built on a regression framework. Package developers can use modelObj methods to initiate a regression analysis without concern for the details of the regression model and the method to be used to obtain parameter estimates. The specifics of the regression step are left to the user to define when calling the function. The user of a function developed within the modelObj framework creates as input a modelObj that contains the model and the R methods to be used to obtain parameter estimates and to obtain predictions. In this way, a user can easily go from linear to non-linear models within the same package.

Recent advances in single cell/nucleus transcriptomic technology has enabled collection of cohort-scale datasets to study cell type specific gene expression differences associated disease state, stimulus, and genetic regulation. The scale of these data, complex study designs, and low read count per cell mean that characterizing cell type specific molecular mechanisms requires a user-frieldly, purpose-build analytical framework. We have developed the dreamlet package that applies a pseudobulk approach and fits a regression model for each gene and cell cluster to test differential expression across individuals associated with a trait of interest. Use of precision-weighted linear mixed models enables accounting for repeated measures study designs, high dimensional batch effects, and varying sequencing depth or observed cells per biosample.

PAM (Partitioning Around Medoids) algorithm application to samples of single cell sequencing techniques with a high number of cells (as many as the computer memory allows). The package uses a binary format to store matrices (either full, sparse or symmetric) in files written in the disk that can contain any data type (not just double) which allows its manipulation when memory is sufficient to load them as int or float, but not as double. The PAM implementation is done in parallel, using several/all the cores of the machine, if it has them. This package shares a great part of its code with packages jmatrix and parallelpam but their functionality is included here so there is no need to install them.

This package implements the algorithm described in Barron, M., Zhang, S. and Li, J. 2017, "A sparse differential clustering algorithm for tracing cell type changes via single-cell RNA-sequencing data", Nucleic Acids Research, gkx1113, <doi:10.1093/nar/gkx1113>. This algorithm clusters samples from two different populations, links the clusters across the conditions and identifies marker genes for these changes. The package was designed for scRNA-Seq data but is also applicable to many other data types, just replace cells with samples and genes with variables. The package also contains functions for estimating the parameters for SparseDC as outlined in the paper. We recommend that users further select their marker genes using the magnitude of the cluster centers.