Calculates risk differences (or prevalence differences for cross-sectional data) and Number Needed to Treat (NNT) using generalized linear models with automatic link function selection. Provides robust model fitting with fallback methods, support for stratification and adjustment variables, inverse probability of treatment weighting (IPTW) for causal inference with NNT calculations, and publication-ready output formatting. Handles model convergence issues gracefully and provides confidence intervals using multiple approaches. Methods are based on approaches described in Mark W. Donoghoe and Ian C. Marschner (2018) "logbin: An R Package for Relative Risk Regression Using the Log-Binomial Model" <doi:10.18637/jss.v086.i09> for robust GLM fitting, Peter C. Austin (2011) "An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies" <doi:10.1080/00273171.2011.568786> for IPTW methods, and standard epidemiological methods for risk difference estimation as described in Kenneth J. Rothman, Sander Greenland and Timothy L. Lash (2008, ISBN:9780781755641) "Modern Epidemiology".

This package produces tables with the level of replication (number of replicates) and the experimental uncoded values of the quantitative factors to be used for rotatable Central Composite Design (CCD) experimentation and a 2-D contour plot of the corresponding variance of the predicted response according to Mead et al. (2012) <doi:10.1017/CBO9781139020879> design_ccd(), and analyzes CCD data with response surface methodology ccd_analysis(). A rotatable CCD provides values of the variance of the predicted response that are concentrically distributed around the average treatment combination used in the experimentation, which with uniform precision (implied by the use of several replicates at the average treatment combination) improves greatly the search and finding of an optimum response. These properties of a rotatable CCD represent undeniable advantages over the classical factorial design, as discussed by Panneton et al. (1999) <doi:10.13031/2013.13267> and Mead et al. (2012) <doi:10.1017/CBO9781139020879.018> among others.

Monocle 3 performs clustering, differential expression and trajectory analysis for single-cell expression experiments. It orders individual cells according to progress through a biological process, without knowing ahead of time which genes define progress through that process. Monocle 3 also performs differential expression analysis, clustering, visualization, and other useful tasks on single-cell expression data. It is designed to work with RNA-Seq data, but could be used with other types as well.

Tree based algorithms can be improved by introducing boosting frameworks. LightGBM is one such framework, based on Ke, Guolin et al. (2017). This package offers an R interface to work with it. It is designed to be distributed and efficient with the following goals:

1. Faster training speed and higher efficiency;

2. lower memory usage;

3. better accuracy;

4. parallel learning supported; and

5. capable of handling large-scale data.

This package aims to make it easy to use various types of fonts (TrueType, OpenType, Type 1, web fonts, etc.) in R graphs, and supports most output formats of R graphics including PNG, PDF and SVG. Text glyphs will be converted into polygons or raster images, hence after the plot has been created, it no longer relies on the font files. No external software such as Ghostscript is needed to use this package.

This package is a collection of baseline correction algorithms. Beside those it provides a framework and a Tcl/Tk enabled GUI for optimizing baseline algorithm parameters. Typical use is the removal of the background effects from spectra, which are originating from various types of spectroscopy and spectrometry. Also, there is a possibility of optimizing this with regard to regression or classification results. Correction methods include polynomial fitting, weighted local smoothers and many more.

cfDNA fragments carry important features for building cancer sample classification ML models, such as fragment size, and fragment end motif etc. Analyzing and visualizing fragment size metrics, as well as other biological features in a curated, standardized, scalable, well-documented, and reproducible way might be time intensive. This package intends to resolve these problems and simplify the process. It offers two sets of functions for cfDNA feature characterization and visualization.

These tools facilitate batch effects analysis and correction in high-throughput experiments. It was developed primarily for mass-spectrometry proteomics (DIA/SWATH), but could also be applicable to most omic data with minor adaptations. The package contains functions for diagnostics (proteome/genome-wide and feature-level), correction (normalization and batch effects correction) and quality control. Non-linear fitting based approaches were also included to deal with complex, mass spectrometry-specific signal drifts.

An idiomatic R interface to the age file encryption format (<https://age-encryption.org/v1>), backed by a vendored copy of the agec C implementation (<https://git.sr.ht/~min/agec>). Encrypt and decrypt raw vectors, files, and strings for one or more X25519 recipients or with a passphrase, with optional ASCII armor. Cryptography is vendored and randomness is drawn from the operating system, so the package has no external library dependencies.

This package provides a backward-pipe operator for magrittr (%<%) or pipeR (%<<%) that allows for a performing operations from right-to-left. This allows writing more legible code where right-to-left ordering is natural. This is common with hierarchies and nested structures such as trees, directories or markup languages (e.g. HTML and XML). The package also includes a R-Studio add-in that can be bound to a keyboard shortcut.

This package provides a method for identifying pattern changes between 2 experimental conditions in correlation networks (e.g., gene co-expression networks), which builds on a commonly used association measure, such as Pearson's correlation coefficient. This package includes functions to calculate correlation matrices for high-dimensional dataset and to test differential correlation, which means the changes in the correlation relationship among variables (e.g., genes and metabolites) between 2 experimental conditions.

This package provides tools to analyse human and mosquito behavioral interactions and to compute exposure to mosquito bites estimates. Using behavioral data for human individuals and biting patterns for mosquitoes, you will be able to compute hourly exposure for bed net users and non-users, and summarize (e.g. proportion indoors and outdoors, proportion per time periods, and proportion prevented by bed nets) or visualize these dynamics across a 24-hour cycle.

This package provides access to EIDOS <https://iepnb.gob.es/areas-tematicas/especies-silvestres/eidos>, the taxonomic information service from the Spanish Inventory of Natural Patrimony and Biodiversity. This package includes a suite of functions that help retrieve species taxonomic and conservation information from EIDOS and match taxa names against the checklists available in the database. More information can be found at Miranda Cebrián, H. (2025) <doi:10.7818/ECOS.3134>.

This package provides tools for flexible non-linear least squares model fitting using general-purpose optimization techniques. The package supports a variety of optimization algorithms, including those provided by the optimx package, making it suitable for handling complex non-linear models. Features include parallel processing support via the future and foreach packages, comprehensive model diagnostics, and visualization capabilities. Implements methods described in Nash and Varadhan (2011, <doi:10.18637/jss.v043.i09>).

Graphical approach provides a useful framework for multiplicity adjustment in clinical trials with multiple endpoints. This package includes statistical methods to optimize sample size over initial weight and transition probability in a graphical approach under a common setting, which is to use marginal power for each endpoint in a trial design. See Zhang, F. and Gou, J. (2023). Sample size optimization for clinical trials using graphical approaches for multiplicity adjustment, Technical Report.

Scientific journal numeric formatting policies implemented in code. Emphasis on formatting mean/upper/lower sets of values to pasteable text for journal submission. For example c(2e6, 1e6, 3e6) becomes "2.00 million (1.00--3.00)". Lancet and Nature have built-in styles for rounding and punctuation marks. Users may extend journal styles arbitrarily. Four metrics are supported; proportions, percentage points, counts and rates. Magnitudes for all metrics are discovered automatically.

Changes of landscape diversity and structure can be detected soon if relying on landscape class combinations and analysing patterns at multiple scales. LandComp provides such an opportunity, based on Juhász-Nagy's functions (Juhász-Nagy P, Podani J 1983 <doi:10.1007/BF00129432>). Functions can handle multilayered data. Requirements of the input: binary data contained by a regular square or hexagonal grid, and the grid should have projected coordinates.

Estimates group transmission assortativity coefficients from transmission trees. Group transmission assortativity coefficients measure the tendency for individuals to transmit within their own group (e.g. age group, vaccination status, or location) compared to other groups. The package requires information on who infected whom, group membership for all individuals, and the relative sizes of each group in the population. For more details see Geismar et al. (2024) <doi:10.1371/journal.pone.0313037>.

Predicts gene dependency relationships (GDRs) from functional genomics data. Regularised Gaussian mixture modelling may be applied for unsupervised clustering in addition to other data partitioning strategies. GDR analysis tools include discovery of synthetic lethal relationships and predicting population coverage for candidate drug targets from cancer patient mutational profiles. Functionality for visualisation is also available. MultiSEp is applicable to data from a variety of sources including clinical cohorts, organoids and cell lines.

Estimate the causal effect of sustained treatment strategies on overall survival in clinical trials with possible treatment crossover and switch to subsequent therapy. Simulate faithful longitudinal clinical trials data with survival endpoints and multi-way treatment switches allowing for time-dependent prognostic factors. For more on methodological background, please see: Keogh and colleagues (2021) <doi:10.1002/bimj.202000040> and Suarez and colleagues (2008) <doi:10.1016/j.jclinepi.2007.11.007>.

This package provides a toolkit containing statistical analysis models motivated by multivariate forms of the Conway-Maxwell-Poisson (COM-Poisson) distribution for flexible modeling of multivariate count data, especially in the presence of data dispersion. Currently the package only supports bivariate data, via the bivariate COM-Poisson distribution described in Sellers et al. (2016) <doi:10.1016/j.jmva.2016.04.007>. Future development will extend the package to higher-dimensional data.

This package provides an end-to-end workflow for estimating average treatment effects in clustered (multilevel) observational data. Core functionality includes cluster-aware propensity score estimation using fixed effects and Mundlak-style specifications, inverse probability weighting, within-cluster nearest-neighbor matching, covariate balance diagnostics at both individual and cluster-mean levels, outcome regression with cluster-robust standard errors, propensity score overlap visualization, and tipping-point sensitivity analysis for omitted cluster-level confounding.

Fits regularised multi-task learning models where relationships between tasks are controlled via orthogonality or disjoint-support constraints. Supports regression, binary classification, and censored survival data. In survival mode, time-to-event outcomes are converted into binary labels at user-defined thresholds, enabling the discovery of features with time-varying effects that standard proportional-hazards models cannot detect. Implements the penalty described in Vervier et al. (2014) <https://hal.science/hal-00985654>.

This package provides functions are provided for internal use by the spatial capture-recapture package secr (from version 5.4.0). The idea is to speed up the installation of secr', and possibly reduce its size. Initially the functions are those for area and transect search that use numerical integration code from RcppNumerical and RcppEigen'. The functions are not intended to be user-friendly and require considerable preprocessing of data.