To make the semiparametric transformation models easier to apply in real studies, we introduce this R package, in which the MLE in transformation models via an EM algorithm proposed by Zeng D, Lin DY(2007) <doi:10.1111/j.1369-7412.2007.00606.x> and adaptive lasso method in transformation models proposed by Liu XX, Zeng D(2013) <doi:10.1093/biomet/ast029> are implemented. C++ functions are used to compute complex loops. The coefficient vector and cumulative baseline hazard function can be estimated, along with the corresponding standard errors and P values.

Simulate genotypes for case-parent triads, case-control, and quantitative trait samples with realistic linkage diequilibrium structure and allele frequency distribution. For studies of epistasis one can simulate models that involve specific SNPs at specific sets of loci, which we will refer to as "pathways". TriadSim generates genotype data by resampling triad genotypes from existing data. The details of the method is described in the manuscript under preparation "Simulating Autosomal Genotypes with Realistic Linkage Disequilibrium and a Spiked in Genetic Effect" Shi, M., Umbach, D.M., Wise A.S., Weinberg, C.R.

This package provides a flexible method for fitting regression models that can be used to find genes that are differentially expressed along one or multiple lineages in a trajectory. Based on the fitted models, it uses a variety of tests suited to answer different questions of interest, e.g. the discovery of genes for which expression is associated with pseudotime, or which are differentially expressed (in a specific region) along the trajectory. It fits a negative binomial generalized additive model (GAM) for each gene, and performs inference on the parameters of the GAM.

Quickly install Java Development Kit (JDK) without administrative privileges and set environment variables in current R session or project to solve common issues with Java environment management in R'. Recommended to users of Java'/'rJava'-dependent R packages such as r5r', opentripplanner', xlsx', openNLP', rWeka', RJDBC', tabulapdf', and many more. rJavaEnv prevents common problems like Java not found, Java version conflicts, missing Java installations, and the inability to install Java due to lack of administrative privileges. rJavaEnv automates the download, installation, and setup of the Java on a per-project basis by setting the relevant JAVA_HOME in the current R session or the current working directory (via .Rprofile', with the user's consent). Similar to what renv does for R packages, rJavaEnv allows different Java versions to be used across different projects, but can also be configured to allow multiple versions within the same project (e.g. with the help of targets package). Note: there are a few extra steps for Linux users, who don't have any Java previously installed in their system, and who prefer package installation from source, rather then installing binaries from Posit Package Manager'. See documentation for details.

Quickly run experiments to compare the run time and output of code blocks. The function mbc() can make fast comparisons of code, and will calculate statistics comparing the resulting outputs. It can be used to compare model fits to the same data or see which function runs faster. The R6 class ffexp$new() runs a function using all possible combinations of selected inputs. This is useful for comparing the effect of different parameter values. It can also run in parallel and automatically save intermediate results, which is very useful for long computations.

Intelligently assign samples to batches in order to reduce batch effects. Batch effects can have a significant impact on data analysis, especially when the assignment of samples to batches coincides with the contrast groups being studied. By defining a batch container and a scoring function that reflects the contrasts, this package allows users to assign samples in a way that minimizes the potential impact of batch effects on the comparison of interest. Among other functionality, we provide an implementation for OSAT score by Yan et al. (2012, <doi:10.1186/1471-2164-13-689>).

The dfmirroR package allows users to input a data frame, simulate some number of observations based on specified columns of that data frame, and then outputs a string that contains the code to re-create the simulation. The goal is to both provide workable test data sets and provide users with the information they need to set up reproducible examples with team members. This package was created out of a need to share examples in cases where data are private and where a full data frame is not needed for testing or coordinating.

This package provides a ggplot2 based implementation of biplots, giving a representation of a dataset in a two dimensional space accounting for the greatest variance, together with variable vectors showing how the data variables relate to this space. It provides a replacement for stats::biplot(), but with many enhancements to control the analysis and graphical display. It implements biplot and scree plot methods which can be used with the results of prcomp(), princomp(), FactoMineR::PCA(), ade4::dudi.pca() or MASS::lda() and can be customized using ggplot2 techniques.

This package contains datasets and several smaller functions suitable for analysis of interval-censored data. The package complements the book Bogaerts, Komárek and Lesaffre (2017, ISBN: 978-1-4200-7747-6) "Survival Analysis with Interval-Censored Data: A Practical Approach" <https://www.routledge.com/Survival-Analysis-with-Interval-Censored-Data-A-Practical-Approach-with/Bogaerts-Komarek-Lesaffre/p/book/9781420077476>. Full R code related to the examples presented in the book can be found at <https://ibiostat.be/online-resources/icbook/supplemental>. Packages mentioned in the "Suggests" section are used in those examples.

The unique function of this package allows representing in a single graph the relative occurrence and co-occurrence of events measured in a sample. As examples, the package was applied to describe the occurrence and co-occurrence of different species of bacterial or viral symbionts infecting arthropods at the individual level. The graphics allows determining the prevalence of each symbiont and the patterns of multiple infections (i.e. how different symbionts share or not the same individual hosts). We named the package after the famous painter as the graphical output recalls Mondrianâ s paintings.

It computes arbitrary products moments (mean vector and variance-covariance matrix), for some double truncated (and folded) multivariate distributions. These distributions belong to the family of selection elliptical distributions, which includes well known skewed distributions as the unified skew-t distribution (SUT) and its particular cases as the extended skew-t (EST), skew-t (ST) and the symmetric student-t (T) distribution. Analogous normal cases unified skew-normal (SUN), extended skew-normal (ESN), skew-normal (SN), and symmetric normal (N) are also included. Density, probabilities and random deviates are also offered for these members.

Indices, heuristics and strategies to help determine the number of factors/components to retain: 1. Acceleration factor (af with or without Parallel Analysis); 2. Optimal Coordinates (noc with or without Parallel Analysis); 3. Parallel analysis (components, factors and bootstrap); 4. lambda > mean(lambda) (Kaiser, CFA and related); 5. Cattell-Nelson-Gorsuch (CNG); 6. Zoski and Jurs multiple regression (b, t and p); 7. Zoski and Jurs standard error of the regression coeffcient (sescree); 8. Nelson R2; 9. Bartlett khi-2; 10. Anderson khi-2; 11. Lawley khi-2 and 12. Bentler-Yuan khi-2.

The CytoGLMM R package implements two multiple regression strategies: A bootstrapped generalized linear model (GLM) and a generalized linear mixed model (GLMM). Most current data analysis tools compare expressions across many computationally discovered cell types. CytoGLMM focuses on just one cell type. Our narrower field of application allows us to define a more specific statistical model with easier to control statistical guarantees. As a result, CytoGLMM finds differential proteins in flow and mass cytometry data while reducing biases arising from marker correlations and safeguarding against false discoveries induced by patient heterogeneity.

This package provides a fast and accurate analysis toolkit for single cell ATAC-seq (Assay for transposase-accessible chromatin using sequencing). Single cell ATAC-seq can resolve the heterogeneity of a complex tissue and reveal cell-type specific regulatory landscapes. However, the exceeding data sparsity has posed unique challenges for the data analysis. This package r-snapatac is an end-to-end bioinformatics pipeline for analyzing large- scale single cell ATAC-seq data which includes quality control, normalization, clustering analysis, differential analysis, motif inference and exploration of single cell ATAC-seq sequencing data.

This package provides a self-tuning spectral clustering method for single or multi-view data. Spectrum uses a new type of adaptive density aware kernel that strengthens connections in the graph based on common nearest neighbours. It uses a tensor product graph data integration and diffusion procedure to integrate different data sources and reduce noise. Spectrum uses either the eigengap or multimodality gap heuristics to determine the number of clusters. The method is sufficiently flexible so that a wide range of Gaussian and non-Gaussian structures can be clustered with automatic selection of K.

This package provides utilities for computation and analysis of correlation/covariation in multiple sequence alignments and in side chain motions during molecular dynamics simulations. Features include the computation of correlation/covariation scores using a variety of scoring functions between either sequence positions in alignments or side chain dihedral angles in molecular dynamics simulations and utilities to analyze the correlation/covariation matrix through a variety of tools including network representation and principal components analysis. In addition, several utility functions are based on the R graphical environment to provide friendly tools for help in data interpretation.

Outliers virtually exist in any datasets of any application field. To avoid the impact of outliers, we need to use robust estimators. Classical estimators of multivariate mean and covariance matrix are the sample mean and the sample covariance matrix. Outliers will affect the sample mean and the sample covariance matrix, and thus they will affect the classical factor analysis which depends on the classical estimators (Pison, G., Rousseeuw, P.J., Filzmoser, P. and Croux, C. (2003) <doi:10.1016/S0047-259X(02)00007-6>). So it is necessary to use the robust estimators of the sample mean and the sample covariance matrix. There are several robust estimators in the literature: Minimum Covariance Determinant estimator, Orthogonalized Gnanadesikan-Kettenring, Minimum Volume Ellipsoid, M, S, and Stahel-Donoho. The most direct way to make multivariate analysis more robust is to replace the sample mean and the sample covariance matrix of the classical estimators to robust estimators (Maronna, R.A., Martin, D. and Yohai, V. (2006) <doi:10.1002/0470010940>) (Todorov, V. and Filzmoser, P. (2009) <doi:10.18637/jss.v032.i03>), which is our choice of robust factor analysis. We created an object oriented solution for robust factor analysis based on new S4 classes.

This package provides tools designed to perform and evaluate cluster analysis (including Tocher's algorithm), discriminant analysis and path analysis (standard and under collinearity), as well as some useful miscellaneous tools for dealing with sample size and optimum plot size calculations. A test for seed sample heterogeneity is now available. Mantel's permutation test can be found in this package. A new approach for calculating its power is implemented. biotools also contains tests for genetic covariance components. Heuristic approaches for performing non-parametric spatial predictions of generic response variables and spatial gene diversity are implemented.

General optimisation and specific tools for the parameter estimation (i.e. calibration) of complex models, including stochastic ones. It implements generic functions that can be used for fitting any type of models, especially those with non-differentiable objective functions, with the same syntax as base::optim. It supports multiple phases estimation (sequential parameter masking), constrained optimization (bounding box restrictions) and automatic parallel computation of numerical gradients. Some common maximum likelihood estimation methods and automated construction of the objective function from simulated model outputs is provided. See <https://roliveros-ramos.github.io/calibrar/> for more details.

Statistical methods for retrospectively detecting changes in location and/or dispersion of univariate and multivariate variables. Data values are assumed to be independent, can be individual (one observation at each instant of time) or subgrouped (more than one observation at each instant of time). Control limits are computed, often using a permutation approach, so that a prescribed false alarm probability is guaranteed without making any parametric assumptions on the stable (in-control) distribution. See G. Capizzi and G. Masarotto (2018) <doi:10.1007/978-3-319-75295-2_1> for an introduction to the package.

The EM algorithm is a powerful tool for computing maximum likelihood estimates with incomplete data. This package will help to applying EM algorithm based on triangular and trapezoidal fuzzy numbers (as two kinds of incomplete data). A method is proposed for estimating the unknown parameter in a parametric statistical model when the observations are triangular or trapezoidal fuzzy numbers. This method is based on maximizing the observed-data likelihood defined as the conditional probability of the fuzzy data; for more details and formulas see Denoeux (2011) <doi:10.1016/j.fss.2011.05.022>.

Bayesian (and some likelihoodist) functions as alternatives to hypothesis-testing functions in R base using a user interface patterned after those of R's hypothesis testing functions. See McElreath (2016, ISBN: 978-1-4822-5344-3), Gelman and Hill (2007, ISBN: 0-521-68689-X) (new edition in preparation) and Albert (2009, ISBN: 978-0-387-71384-7) for good introductions to Bayesian analysis and Pawitan (2002, ISBN: 0-19-850765-8) for the Likelihood approach. The functions in the package also make extensive use of graphical displays for data exploration and model comparison.

This package provides tools for simulating mathematical models of infectious disease dynamics. Epidemic model classes include deterministic compartmental models, stochastic individual-contact models, and stochastic network models. Network models use the robust statistical methods of exponential-family random graph models (ERGMs) from the Statnet suite of software packages in R. Standard templates for epidemic modeling include SI, SIR, and SIS disease types. EpiModel features an API for extending these templates to address novel scientific research aims. Full methods for EpiModel are detailed in Jenness et al. (2018, <doi:10.18637/jss.v084.i08>).

This package provides a shiny-based front end (the ExPanD app) and a set of functions for exploratory data analysis. Run as a web-based app, ExPanD enables users to assess the robustness of empirical evidence without providing them access to the underlying data. You can export a notebook containing the analysis of ExPanD and/or use the functions of the package to support your exploratory data analysis workflow. Refer to the vignettes of the package for more information on how to use ExPanD and/or the functions of this package.