This package implements the navigated weighting (NAWT) proposed by Katsumata (2020) <arXiv:2005.10998>, which improves the inverse probability weighting by utilizing estimating equations suitable for a specific pre-specified parameter of interest (e.g., the average treatment effects or the average treatment effects on the treated) in propensity score estimation. It includes the covariate balancing propensity score proposed by Imai and Ratkovic (2014) <doi:10.1111/rssb.12027>, which uses covariate balancing conditions in propensity score estimation. The point estimate of the parameter of interest as well as coefficients for propensity score estimation and their uncertainty are produced using the M-estimation. The same functions can be used to estimate average outcomes in missing outcome cases.

In the spirit of Anscombe's quartet, this package includes datasets that demonstrate the importance of visualizing your data, the importance of not relying on statistical summary measures alone, and why additional assumptions about the data generating mechanism are needed when estimating causal effects. The package includes "Anscombe's Quartet" (Anscombe 1973) <doi:10.1080/00031305.1973.10478966>, D'Agostino McGowan & Barrett (2023) "Causal Quartet" <doi:10.48550/arXiv.2304.02683>, "Datasaurus Dozen" (Matejka & Fitzmaurice 2017), "Interaction Triptych" (Rohrer & Arslan 2021) <doi:10.1177/25152459211007368>, "Rashomon Quartet" (Biecek et al. 2023) <doi:10.48550/arXiv.2302.13356>, and Gelman "Variation and Heterogeneity Causal Quartets" (Gelman et al. 2023) <doi:10.48550/arXiv.2302.12878>.

In epigenome-wide association studies, the measured signals for each sample are a mixture of methylation profiles from different cell types. The current approaches to the association detection only claim whether a cytosine-phosphate-guanine (CpG) site is associated with the phenotype or not, but they cannot determine the cell type in which the risk-CpG site is affected by the phenotype. We propose a solid statistical method, HIgh REsolution (HIRE), which not only substantially improves the power of association detection at the aggregated level as compared to the existing methods but also enables the detection of risk-CpG sites for individual cell types. The "HIREewas" R package is to implement HIRE model in R.

OMICsPCA is an analysis pipeline designed to integrate multi OMICs experiments done on various subjects (e.g. Cell lines, individuals), treatments (e.g. disease/control) or time points and to analyse such integrated data from various various angles and perspectives. In it's core OMICsPCA uses Principal Component Analysis (PCA) to integrate multiomics experiments from various sources and thus has ability to over data insufficiency issues by using the ingegrated data as representatives. OMICsPCA can be used in various application including analysis of overall distribution of OMICs assays across various samples /individuals /time points; grouping assays by user-defined conditions; identification of source of variation, similarity/dissimilarity between assays, variables or individuals.

The fossil record is a joint expression of ecological, taphonomic, evolutionary, and stratigraphic processes (Holland and Patzkowsky, 2012, ISBN:978-0226649382). This package allowing to simulate biological processes in the time domain (e.g., trait evolution, fossil abundance), and examine how their expression in the rock record (stratigraphic domain) is influenced based on age-depth models, ecological niche models, and taphonomic effects. Functions simulating common processes used in modeling trait evolution or event type data such as first/last occurrences are provided and can be used standalone or as part of a pipeline. The package comes with example data sets and tutorials in several vignettes, which can be used as a template to set up one's own simulation.

Analyze telemetry datasets generalized to allow any technology. The filtering steps check for false positives caused by reflected transmissions from surfaces and false pings from other noise generating equipment. The filters are based on JSATS filtering algorithms found in package filteRjsats <https://CRAN.R-project.org/package=filteRjsats> but have been generalized to allow the user to define many of the filtering variables. Additionally, this package contains scripts used to help identify an optimal maximum blanking period as defined in Capello et al (2015) <doi:10.1371/journal.pone.0134002>. The functions were written according to their manuscript description, but have not been reviewed by the authors for accuracy. It is included here as is, without warranty.

Implementation of Johansen's general formulation of Welch-James's statistic with Approximate Degrees of Freedom, which makes it suitable for testing any linear hypothesis concerning cell means in univariate and multivariate mixed model designs when the data pose non-normality and non-homogeneous variance. Some improvements, namely trimmed means and Winsorized variances, and bootstrapping for calculating an empirical critical value, have been added to the classical formulation. The code departs from a previous SAS implementation by L.M. Lix and H.J. Keselman, available at <http://supp.apa.org/psycarticles/supplemental/met_13_2_110/SAS_Program.pdf> and published in Keselman, H.J., Wilcox, R.R., and Lix, L.M. (2003) <DOI:10.1111/1469-8986.00060>.

This is a package for graphical and statistical analyses of environmental data, with a focus on analyzing chemical concentrations and physical parameters, usually in the context of mandated environmental monitoring. It provides major environmental statistical methods found in the literature and regulatory guidance documents, with extensive help that explains what these methods do, how to use them, and where to find them in the literature. It comes with numerous built-in data sets from regulatory guidance documents and environmental statistics literature. It includes scripts reproducing analyses presented in the book "EnvStats: An R Package for Environmental Statistics" (Millard, 2013, Springer, ISBN 978-1-4614-8455-4, https://link.springer.com/book/10.1007/978-1-4614-8456-1).

Original ctsem (continuous time structural equation modelling) functionality, based on the OpenMx software, as described in Driver, Oud, Voelkle (2017) <doi:10.18637/jss.v077.i05>, with updated details in vignette. Combines stochastic differential equations representing latent processes with structural equation measurement models. These functions were split off from the main package of ctsem', as the main package uses the rstan package as a backend now -- offering estimation options from max likelihood to Bayesian. There are nevertheless use cases for the wide format SEM style approach as offered here, particularly when there are no individual differences in observation timing and the number of individuals is large. For the main ctsem package, see <https://cran.r-project.org/package=ctsem>.

Constructing niche models and analyzing patterns of niche evolution. Acts as an interface for many popular modeling algorithms, and allows users to conduct Monte Carlo tests to address basic questions in evolutionary ecology and biogeography. Warren, D.L., R.E. Glor, and M. Turelli (2008) <doi:10.1111/j.1558-5646.2008.00482.x> Glor, R.E., and D.L. Warren (2011) <doi:10.1111/j.1558-5646.2010.01177.x> Warren, D.L., R.E. Glor, and M. Turelli (2010) <doi:10.1111/j.1600-0587.2009.06142.x> Cardillo, M., and D.L. Warren (2016) <doi:10.1111/geb.12455> D.L. Warren, L.J. Beaumont, R. Dinnage, and J.B. Baumgartner (2019) <doi:10.1111/ecog.03900>.

The lipid scrambling activity of protein extracts and purified scramblases is often determined using a fluorescence-based assay involving many manual steps. flippant offers an integrated solution for the analysis and publication-grade graphical presentation of dithionite scramblase assays, as well as a platform for review, dissemination and extension of the strategies it employs. The package's name derives from a play on the fact that lipid scrambling is also sometimes referred to as flipping'. The package is originally published as Cotton, R.J., Ploier, B., Goren, M.A., Menon, A.K., and Graumann, J. (2017). "flippantâ An R package for the automated analysis of fluorescence-based scramblase assays." BMC Bioinformatics 18, 146. <DOI:10.1186/s12859-017-1542-y>.

Handles univariate non-parametric density estimation with parametric starts and asymmetric kernels in a simple and flexible way. Kernel density estimation with parametric starts involves fitting a parametric density to the data before making a correction with kernel density estimation, see Hjort & Glad (1995) <doi:10.1214/aos/1176324627>. Asymmetric kernels make kernel density estimation more efficient on bounded intervals such as (0, 1) and the positive half-line. Supported asymmetric kernels are the gamma kernel of Chen (2000) <doi:10.1023/A:1004165218295>, the beta kernel of Chen (1999) <doi:10.1016/S0167-9473(99)00010-9>, and the copula kernel of Jones & Henderson (2007) <doi:10.1093/biomet/asm068>. User-supplied kernels, parametric starts, and bandwidths are supported.

This package provides a utility library to facilitate the generalization of statistical methods built on a regression framework. Package developers can use modelObj methods to initiate a regression analysis without concern for the details of the regression model and the method to be used to obtain parameter estimates. The specifics of the regression step are left to the user to define when calling the function. The user of a function developed within the modelObj framework creates as input a modelObj that contains the model and the R methods to be used to obtain parameter estimates and to obtain predictions. In this way, a user can easily go from linear to non-linear models within the same package.

PAM (Partitioning Around Medoids) algorithm application to samples of single cell sequencing techniques with a high number of cells (as many as the computer memory allows). The package uses a binary format to store matrices (either full, sparse or symmetric) in files written in the disk that can contain any data type (not just double) which allows its manipulation when memory is sufficient to load them as int or float, but not as double. The PAM implementation is done in parallel, using several/all the cores of the machine, if it has them. This package shares a great part of its code with packages jmatrix and parallelpam but their functionality is included here so there is no need to install them.

This package implements the algorithm described in Barron, M., Zhang, S. and Li, J. 2017, "A sparse differential clustering algorithm for tracing cell type changes via single-cell RNA-sequencing data", Nucleic Acids Research, gkx1113, <doi:10.1093/nar/gkx1113>. This algorithm clusters samples from two different populations, links the clusters across the conditions and identifies marker genes for these changes. The package was designed for scRNA-Seq data but is also applicable to many other data types, just replace cells with samples and genes with variables. The package also contains functions for estimating the parameters for SparseDC as outlined in the paper. We recommend that users further select their marker genes using the magnitude of the cluster centers.

This is a collection of functions optimized for working with with various kinds of text matrices. Focusing on the text matrix as the primary object - represented either as a base R dense matrix or a Matrix package sparse matrix - allows for a consistent and intuitive interface that stays close to the underlying mathematical foundation of computational text analysis. In particular, the package includes functions for working with word embeddings, text networks, and document-term matrices. Methods developed in Stoltz and Taylor (2019) <doi:10.1007/s42001-019-00048-6>, Taylor and Stoltz (2020) <doi:10.1007/s42001-020-00075-8>, Taylor and Stoltz (2020) <doi:10.15195/v7.a23>, and Stoltz and Taylor (2021) <doi:10.1016/j.poetic.2021.101567>.

Recent advances in single cell/nucleus transcriptomic technology has enabled collection of cohort-scale datasets to study cell type specific gene expression differences associated disease state, stimulus, and genetic regulation. The scale of these data, complex study designs, and low read count per cell mean that characterizing cell type specific molecular mechanisms requires a user-frieldly, purpose-build analytical framework. We have developed the dreamlet package that applies a pseudobulk approach and fits a regression model for each gene and cell cluster to test differential expression across individuals associated with a trait of interest. Use of precision-weighted linear mixed models enables accounting for repeated measures study designs, high dimensional batch effects, and varying sequencing depth or observed cells per biosample.

This package provides a Bayesian Nonparametric model for the study of time-evolving frequencies, which has become renowned in the study of population genetics. The model consists of a Hidden Markov Model (HMM) in which the latent signal is a distribution-valued stochastic process that takes the form of a finite mixture of Dirichlet Processes, indexed by vectors that count how many times each value is observed in the population. The package implements methodologies presented in Ascolani, Lijoi and Ruggiero (2021) <doi:10.1214/20-BA1206> and Ascolani, Lijoi and Ruggiero (2023) <doi:10.3150/22-BEJ1504> that make it possible to study the process at the time of data collection or to predict its evolution in future or in the past.

Allows the user to generate a list of features (gene, pseudo, RNA, CDS, and/or UTR) directly from NCBI database for any species with a current build available. Option to save downloaded and formatted files is available, and the user can prioritize the feature list based on type and assembly builds present in the current build used. The user can then use the list of features generated or provide a list to map a set of markers (designed for SNP markers with a single base pair position available) to the closest feature based on the map build. This function does require map positions of the markers to be provided and the positions should be based on the build being queried through NCBI.

Construct a principal surface that are two-dimensional surfaces that pass through the middle of a p-dimensional data set. They minimise the distance from the data points, and provide a nonlinear summary of data. The surfaces are nonparametric and their shape is suggested by the data. The formation of a surface is found using an iterative procedure which starts with a linear summary, typically with a principal component plane. Each successive iteration is a local average of the p-dimensional points, where an average is based on a projection of a point onto the nonlinear surface of the previous iteration. For more information on principal surfaces, see Ganey, R. (2019, "https://open.uct.ac.za/items/4e655d7d-d10c-481b-9ccc-801903aebfc8").

This package provides some tools for developing and validating prediction models, estimate expected survival of patients and visualize them graphically. Most of the implemented methods are based on penalized regressions such as: the lasso (Tibshirani R (1996)), the elastic net (Zou H et al. (2005) <doi:10.1111/j.1467-9868.2005.00503.x>), the adaptive lasso (Zou H (2006) <doi:10.1198/016214506000000735>), the stability selection (Meinshausen N et al. (2010) <doi:10.1111/j.1467-9868.2010.00740.x>), some extensions of the lasso (Ternes et al. (2016) <doi:10.1002/sim.6927>), some methods for the interaction setting (Ternes N et al. (2016) <doi:10.1002/bimj.201500234>), or others. A function generating simulated survival data set is also provided.

This package provides methods for estimation and hypothesis testing of proportions in group testing designs: methods for estimating a proportion in a single population (assuming sensitivity and specificity equal to 1 in designs with equal group sizes), as well as hypothesis tests and functions for experimental design for this situation. For estimating one proportion or the difference of proportions, a number of confidence interval methods are included, which can deal with various different pool sizes. Further, regression methods are implemented for simple pooling and matrix pooling designs. Methods for identification of positive items in group testing designs: Optimal testing configurations can be found for hierarchical and array-based algorithms. Operating characteristics can be calculated for testing configurations across a wide variety of situations.

Given a likelihood provided by the user, this package applies it to a given matrix dataset in order to find change points in the data that maximize the sum of the likelihoods of all the segments. This package provides a handful of algorithms with different time complexities and assumption compromises so the user is able to choose the best one for the problem at hand. The implementation of the segmentation algorithms in this package are based on the paper by Bruno M. de Castro, Florencia Leonardi (2018) <arXiv:1501.01756>. The Berlin weather sample dataset was provided by Deutscher Wetterdienst <https://dwd.de/>. You can find all the references in the Acknowledgments section of this package's repository via the URL below.

Allow user to run the Adaptive Correlated Spike and Slab (ACSS) algorithm, corresponding INdependent Spike and Slab (INSS) algorithm, and Giannone, Lenza and Primiceri (GLP) algorithm with adaptive burn-in. All of the three algorithms are used to fit high dimensional data set with either sparse structure, or dense structure with smaller contributions from all predictors. The state-of-the-art GLP algorithm is in Giannone, D., Lenza, M., & Primiceri, G. E. (2021, ISBN:978-92-899-4542-4) "Economic predictions with big data: The illusion of sparsity". The two new algorithms, ACSS algorithm and INSS algorithm, and the discussion on their performance can be seen in Yang, Z., Khare, K., & Michailidis, G. (2024, preprint) "Bayesian methodology for adaptive sparsity and shrinkage in regression".