Mechanistically models/predicts the phenology (macro-phases) of 10 crop plants (trained on a big dataset over 80 years derived from the German weather service (DWD) <https://opendata.dwd.de/>). Can be applied for remote sensing purposes, dynamically check the best subset of available covariates for the given dataset and crop.

This package creates full factorial experimental designs and designs based on orthogonal arrays for (industrial) experiments. Provides diverse quality criteria. Provides utility functions for the class design, which is also used by other packages for designed experiments.

Manage your source code dependencies by decorating your existing R code with special, roxygen'-style comments.

Computes dynamical correlation estimates and percentile bootstrap confidence intervals for pairs of longitudinal responses, including consideration of lags and derivatives.

Developed to Solve the Multi-Criteria Decision Making Problems with Decision Making Trial and Evaluation Laboratory Technique in R.

This package provides functions for inferring longitudinal dominance hierarchies, which describe dominance relationships and their dynamics in a single latent hierarchy over time. Strauss & Holekamp (in press).

The implemented methods are: Standard Bass model, Generalized Bass model (with rectangular shock, exponential shock, and mixed shock. You can choose to add from 1 to 3 shocks), Guseo-Guidolin model and Variable Potential Market model, and UCRCD model. The Bass model consists of a simple differential equation that describes the process of how new products get adopted in a population, the Generalized Bass model is a generalization of the Bass model in which there is a "carrier" function x(t) that allows to change the speed of time sliding. In some real processes the reachable potential of the resource available in a temporal instant may appear to be not constant over time, because of this we use Variable Potential Market model, in which the Guseo-Guidolin has a particular specification for the market function. The UCRCD model (Unbalanced Competition and Regime Change Diachronic) is a diffusion model used to capture the dynamics of the competitive or collaborative transition.

The DoseFinding package provides functions for the design and analysis of dose-finding experiments (with focus on pharmaceutical Phase II clinical trials). It provides functions for: multiple contrast tests, fitting non-linear dose-response models (using Bayesian and non-Bayesian estimation), calculating optimal designs and an implementation of the MCPMod methodology (Pinheiro et al. (2014) <doi:10.1002/sim.6052>).

Phase I/II adaptive dose-finding design for combination studies where toxicity rates are supposed to increase with both agents.

Density ratio estimation. The estimated density ratio function can be used in many applications such as anomaly detection, change-point detection, covariate shift adaptation. The implemented methods are uLSIF (Hido et al. (2011) <doi:10.1007/s10115-010-0283-2>), RuLSIF (Yamada et al. (2011) <doi:10.1162/NECO_a_00442>), and KLIEP (Sugiyama et al. (2007) <doi:10.1007/s10463-008-0197-x>).

This package performs the drifting Markov models (DMM) which are non-homogeneous Markov models designed for modeling the heterogeneities of sequences in a more flexible way than homogeneous Markov chains or even hidden Markov models. In this context, we developed an R package dedicated to the estimation, simulation and the exact computation of associated reliability of drifting Markov models. The implemented methods are described in Vergne, N. (2008), <doi:10.2202/1544-6115.1326> and Barbu, V.S., Vergne, N. (2019) <doi:10.1007/s11009-018-9682-8> .

Constructs confidence regions without the need to know the sampling distribution of bivariate data. The method was proposed by Zhiqiu Hu & Rong-cai Yang (2013) <doi:10.1371/journal.pone.0081179.g001>.

Ingredient specific diagnostics for drug exposure records in the Observational Medical Outcomes Partnership (OMOP) common data model.

This package provides a Bayesian framework for parameter inference in differential equations. This approach offers a rigorous methodology for parameter inference as well as modeling the link between unobservable model states and parameters, and observable quantities. Provides templates for the DE model, the observation model and data likelihood, and the model parameters and their prior distributions. A Markov chain Monte Carlo (MCMC) procedure processes these inputs to estimate the posterior distributions of the parameters and any derived quantities, including the model trajectories. Further functionality is provided to facilitate MCMC diagnostics and the visualisation of the posterior distributions of model parameters and trajectories.

The debar sequence processing pipeline is designed for denoising high throughput sequencing data for the animal DNA barcode marker cytochrome c oxidase I (COI). The package is designed to detect and correct insertion and deletion errors within sequencer outputs. This is accomplished through comparison of input sequences against a profile hidden Markov model (PHMM) using the Viterbi algorithm (for algorithm details see Durbin et al. 1998, ISBN: 9780521629713). Inserted base pairs are removed and deleted base pairs are accounted for through the introduction of a placeholder character. Since the PHMM is a probabilistic representation of the COI barcode, corrections are not always perfect. For this reason debar censors base pairs adjacent to reported indel sites, turning them into placeholder characters (default is 7 base pairs in either direction, this feature can be disabled). Testing has shown that this censorship results in the correct sequence length being restored, and erroneous base pairs being masked the vast majority of the time (>95%).

You can load a schema from a DTR (data type registry) as an R object. Use this schema to write your data in JSON-LD (JavaScript Object Notation for Linked Data) format to make it machine readable.

Integrated differential expression (DE) and differential co-expression (DC) analysis on gene expression data based on DECODE (DifferEntial CO-expression and Differential Expression) algorithm.

Design, conduct and analyze DCEs from a virtual interface in shiny. Reference: Perez-Troncoso, D. (2022) <https://github.com/danielpereztr/DCEtool>.

Several statistical methods for analyzing survival data under various forms of dependent censoring are implemented in the package. In addition to accounting for dependent censoring, it offers tools to adjust for unmeasured confounding factors. The implemented approaches allow users to estimate the dependency between survival time and dependent censoring time, based solely on observed survival data. For more details on the methods, refer to Deresa and Van Keilegom (2021) <doi:10.1093/biomet/asaa095>, Czado and Van Keilegom (2023) <doi:10.1093/biomet/asac067>, Crommen et al. (2024) <doi:10.1007/s11749-023-00903-9>, Deresa and Van Keilegom (2024) <doi:10.1080/01621459.2022.2161387>, Willems et al. (2025) <doi:10.48550/arXiv.2403.11860>, Ding and Van Keilegom (2025) and D'Haen et al. (2025) <doi:10.1007/s10985-025-09647-0>.

An implementation of deliberative reasoning index (DRI) and related tools for analysis of deliberation survey data. Calculation of DRI, plot of intersubjective correlations (IC), generation of large-language model (LLM) survey data, and permutation tests are supported. Example datasets and a graphical user interface (GUI) are also available to support analysis. For more information, see Niemeyer and Veri (2022) <doi:10.1093/oso/9780192848925.003.0007>.

Test for no adverse shift in two-sample comparison when we have a training set, the reference distribution, and a test set. The approach is flexible and relies on a robust and powerful test statistic, the weighted AUC. Technical details are in Kamulete, V. M. (2021) <arXiv:1908.04000>. Modern notions of outlyingness such as trust scores and prediction uncertainty can be used as the underlying scores for example.

Access data sets for demonstrating or testing diagnostic classification models. Simulated data sets can be used to compare estimated model output to true data-generating values. Real data sets can be used to demonstrate real-world applications of diagnostic models.

Computes the double bootstrap as discussed in McKnight, McKean, and Huitema (2000) <doi:10.1037/1082-989X.5.1.87>. The double bootstrap method provides a better fit for a linear model with autoregressive errors than ARIMA when the sample size is small.

Differential Item Functioning (DIF) Analysis with shiny application interfaces. You can run the functions in this package without any arguments and perform your DIF analysis using user-friendly interfaces.