CHAP-GWAS (Chromosomal Haplotype-Integrated Genome-Wide Association Study) provides a dynamically adaptive framework for genome-wide association studies (GWAS) that integrates chromosome-scale haplotypes with single nucleotide polymorphism (SNP) analysis. The method identifies and extends haplotype variants based on their phenotypic associations rather than predefined linkage blocks, enabling high-resolution detection of quantitative trait loci (QTL). By leveraging long-range phased haplotype information, CHAP-GWAS improves statistical power and offers a more comprehensive view of the genetic architecture underlying complex traits.

This package provides tools for assessing data quality, performing exploratory analysis, and semi-automatic preprocessing of messy data with change tracking for integral dataset cleaning.

The Chinese ID number contains a lot of information, this package helps you get the region, date of birth, age, age based on year, gender, zodiac, constellation information from the Chinese ID number.

Analyze and compare conversations using various similarity measures including topic, lexical, semantic, structural, stylistic, sentiment, participant, and timing similarities. Supports both pairwise conversation comparisons and analysis of multiple dyads. Methods are based on established research: Topic modeling: Blei et al. (2003) <doi:10.1162/jmlr.2003.3.4-5.993>; Landauer et al. (1998) <doi:10.1080/01638539809545028>; Lexical similarity: Jaccard (1912) <doi:10.1111/j.1469-8137.1912.tb05611.x>; Semantic similarity: Salton & Buckley (1988) <doi:10.1016/0306-4573(88)90021-0>; Mikolov et al. (2013) <doi:10.48550/arXiv.1301.3781>; Pennington et al. (2014) <doi:10.3115/v1/D14-1162>; Structural and stylistic analysis: Graesser et al. (2004) <doi:10.1075/target.21131.ryu>; Sentiment analysis: Rinker (2019) <https://github.com/trinker/sentimentr>.

This package provides a matrix of agreement patterns and counts for record pairs is the input for the procedure. An EM algorithm is used to impute plausible values for missing record pairs. A second EM algorithm, incorporating possible correlations between per-field agreement, is used to estimate posterior probabilities that each pair is a true match - i.e. constitutes the same individual.

This package implements the cross-validation methodology from Pein and Shah (2021) <arXiv:2112.03220>. Can be customised by providing different cross-validation criteria, estimators for the change-point locations and local parameters, and freely chosen folds. Pre-implemented estimators and criteria are available. It also includes our own implementation of the COPPS procedure <doi:10.1214/19-AOS1814>.

Significance tests are provided for canonical correlation analysis, including asymptotic tests and a Monte Carlo method.

This package provides tools to interface with Cytobank's API via R, organized by endpoints that represent various areas of Cytobank functionality. Learn more about Cytobank at <https://www.beckman.com/flow-cytometry/software>.

We unify various nonparametric hypothesis testing problems in a framework of permutation testing, enabling hypothesis testing on multi-sample, multidimensional data and contingency tables. Most of the functions available in the R environment to implement permutation tests are single functions constructed for specific test problems; to facilitate the use of the package, the package encapsulates similar tests in a categorized manner, greatly improving ease of use. We will all provide functions for self-selected permutation scoring methods and self-selected p-value calculation methods (asymptotic, exact, and sampling). For two-sample tests, we will provide mean tests and estimate drift sizes; we will provide tests on variance; we will provide paired-sample tests; we will provide correlation coefficient tests under three measures. For multi-sample problems, we will provide both ordinary and ordered alternative test problems. For multidimensional data, we will implement multivariate means (including ordered alternatives) and multivariate pairwise tests based on four statistics; the components with significant differences are also calculated. For contingency tables, we will perform permutation chi-square test or ordered alternative.

Composite Kernel Machine Regression based on Likelihood Ratio Test (CKLRT): in this package, we develop a kernel machine regression framework to model the overall genetic effect of a SNP-set, considering the possible GE interaction. Specifically, we use a composite kernel to specify the overall genetic effect via a nonparametric function and we model additional covariates parametrically within the regression framework. The composite kernel is constructed as a weighted average of two kernels, one corresponding to the genetic main effect and one corresponding to the GE interaction effect. We propose a likelihood ratio test (LRT) and a restricted likelihood ratio test (RLRT) for statistical significance. We derive a Monte Carlo approach for the finite sample distributions of LRT and RLRT statistics. (N. Zhao, H. Zhang, J. Clark, A. Maity, M. Wu. Composite Kernel Machine Regression based on Likelihood Ratio Test with Application for Combined Genetic and Gene-environment Interaction Effect (Submitted).).

This package implements the iterated RMCD method of Cerioli (2010) for multivariate outlier detection via robust Mahalanobis distances. Also provides the finite-sample RMCD method discussed in the paper, as well as the methods provided in Hardin and Rocke (2005) <doi:10.1198/106186005X77685> and Green and Martin (2017) <https://christopherggreen.github.io/papers/hr05_extension.pdf>. See also Chapter 2 of Green (2017) <https://digital.lib.washington.edu/researchworks/handle/1773/40304>.

In metabolic flux experiments tracer molecules (often glucose containing labelled carbon) are incorporated in compounds measured using mass spectrometry. The mass isotopologue distributions of these compounds needs to be corrected for natural abundance of labelled carbon and other effects, which are specific on the compound and ionization technique applied. This package provides functions to correct such effects in gas chromatography atmospheric pressure chemical ionization mass spectrometry analyses.

An integrated set of tools for thermodynamic calculations in aqueous geochemistry and geobiochemistry. Functions are provided for writing balanced reactions to form species from user-selected basis species and for calculating the standard molal properties of species and reactions, including the standard Gibbs energy and equilibrium constant. Calculations of the non-equilibrium chemical affinity and equilibrium chemical activity of species can be portrayed on diagrams as a function of temperature, pressure, or activity of basis species; in two dimensions, this gives a maximum affinity or predominance diagram. The diagrams have formatted chemical formulas and axis labels, and water stability limits can be added to Eh-pH, oxygen fugacity- temperature, and other diagrams with a redox variable. The package has been developed to handle common calculations in aqueous geochemistry, such as solubility due to complexation of metal ions, mineral buffers of redox or pH, and changing the basis species across a diagram ("mosaic diagrams"). CHNOSZ also implements a group additivity algorithm for the standard thermodynamic properties of proteins.

Various cladogenesis-related calculations that are slow in pure R are implemented in C++ with Rcpp. These include the calculation of the probability of various scenarios for the inheritance of geographic range at the divergence events on a phylogenetic tree, and other calculations necessary for models which are not continuous-time markov chains (CTMC), but where change instead occurs instantaneously at speciation events. Typically these models must assess the probability of every possible combination of (ancestor state, left descendent state, right descendent state). This means that there are up to (# of states)^3 combinations to investigate, and in biogeographical models, there can easily be hundreds of states, so calculation time becomes an issue. C++ implementation plus clever tricks (many combinations can be eliminated a priori) can greatly speed the computation time over naive R implementations. CITATION INFO: This package is the result of my Ph.D. research, please cite the package if you use it! Type: citation(package="cladoRcpp") to get the citation information.

Cox model inference for relative hazard and covariate-specific pure risk estimated from stratified and unstratified case-cohort data as described in Etievant, L., Gail, M.H. (Lifetime Data Analysis, 2024) <doi:10.1007/s10985-024-09621-2>.

This package implements functions for comparing strings, sequences and numeric vectors for clustering and record linkage applications. Supported comparison functions include: generalized edit distances for comparing sequences/strings, Monge-Elkan similarity for fuzzy comparison of token sets, and L-p distances for comparing numeric vectors. Where possible, comparison functions are implemented in C/C++ to ensure good performance.

This package provides a framework is provided to develop R packages using Rust <https://www.rust-lang.org/> with minimal overhead, and more wrappers are easily added. Help is provided to use Cargo <https://doc.rust-lang.org/cargo/> in a manner consistent with CRAN policies. Rust code can also be embedded directly in an R script. The package is not official, affiliated with, nor endorsed by the Rust project.

This package provides a tidy, pipe-friendly toolkit for reproducible web crawling and structured data collection, inspired by the architecture of the Crawlee library. Provides a unified crawler with a deduplicating, resumable request queue, content-type aware handlers, structured storage backends and rich console logging via cli'. Supports crawling HTML pages, sitemaps, RSS and Atom feeds and PDF documents, with optional headless-browser rendering and helpers for retrieval-augmented generation.

Perform evaluation of automatic subject indexing methods. The main focus of the package is to enable efficient computation of set retrieval and ranked retrieval metrics across multiple dimensions of a dataset, e.g. document strata or subsets of the label set. The package also provides the possibility of computing bootstrap confidence intervals for all major metrics, with seamless integration of parallel computation and propensity scored variants of standard metrics.

Coalescent simulators can rapidly simulate biological sequences evolving according to a given model of evolution. You can use this package to specify such models, to conduct the simulations and to calculate additional statistics from the results (Staab, Metzler, 2016 <doi:10.1093/bioinformatics/btw098>). It relies on existing simulators for doing the simulation, and currently supports the programs ms', msms and scrm'. It also supports finite-sites mutation models by combining the simulators with the program seq-gen'. Coala provides functions for calculating certain summary statistics, which can also be applied to actual biological data. One possibility to import data is through the PopGenome package (<https://github.com/pievos101/PopGenome>).

Create an addin in Rstudio to do fill-in-the-middle (FIM) and chat with latest Mistral AI models for coding, Codestral and Codestral Mamba'. For more details about Mistral AI API': <https://docs.mistral.ai/getting-started/quickstart/> and <https://docs.mistral.ai/api/>. For more details about Codestral model: <https://mistral.ai/news/codestral>; about Codestral Mamba': <https://mistral.ai/news/codestral-mamba>.

This package provides a set of tools to read, analyze and write lists of click sequences on websites (i.e., clickstream). A click can be represented by a number, character or string. Clickstreams can be modeled as zero- (only computes occurrence probabilities), first- or higher-order Markov chains.

Simulates parameterized single- and double-directional stem deformations in tree point clouds derived from terrestrial or mobile laser scanning, enabling the generation of realistic synthetic datasets for training and validating machine learning models in wood defect detection, quality assessment, and precision forestry. For more details see Pires (2025) <doi:10.54612/a.7hln0kr0ta>.

This package provides interactive 3D visualization for large-scale Cayley graphs. Specifically designed for analyzing state spaces of the TopSpin puzzle. Leverages the Datoviz library and Vulkan-based GPU rendering for smooth real-time exploration of large graphs and complex state transitions. Implements efficient coordinate mapping for high-dimensional permutation groups, allowing users to visualize the connectivity and structural properties of the puzzle's state space. The rendering engine provides high-performance visuals and interactive camera controls, making it suitable for mathematical analysis of group-theoretic puzzles within the R environment.