This package provides a consistent, unified and extensible framework for estimation of parameters for probability distributions, including parameter estimation procedures that allow for weighted samples; the current set of distributions included are: the standard beta, The four-parameter beta, Burr, gamma, Gumbel, Johnson SB and SU, Laplace, logistic, normal, symmetric truncated normal, truncated normal, symmetric-reflected truncated beta, standard symmetric-reflected truncated beta, triangular, uniform, and Weibull distributions; decision criteria and selections based on these decision criteria.

Evaluate a function over a data frame of expressions.

Generates feature matrix outputs from R object inputs using a variety of expansion functions. The generated feature matrices have applications as inputs for a variety of machine learning algorithms. The expansion functions are based on coercing the input to a matrix, treating the columns as features and converting individual columns or combinations into blocks of columns. Currently these include expansion of columns by efficient sparse embedding by vectors of lags, quadratic expansion into squares and unique products, powers by vectors of degree, vectors of orthogonal polynomials functions, and block random affine projection transformations (RAPTs). The transformations are magrittr- and cbind-friendly, and can be used in a building block fashion. For instance, taking the cos() of the output of the RAPT transformation generates a stationary kernel expansion via Bochner's theorem, and this expansion can then be cbind-ed with other features. Additionally, there are utilities for replacing features, removing rows with NAs, creating matrix samples of a given distribution, a simple wrapper for LASSO with CV, a Freeman-Tukey transform, generalizations of the outer function, matrix size-preserving discrete difference by row, plotting, etc.

The peak fitting of spectral data is performed by using the frame work of EM algorithm. We adapted the EM algorithm for the peak fitting of spectral data set by considering the weight of the intensity corresponding to the measurement energy steps (Matsumura, T., Nagamura, N., Akaho, S., Nagata, K., & Ando, Y. (2019, 2021 and 2023) <doi:10.1080/14686996.2019.1620123>, <doi:10.1080/27660400.2021.1899449> <doi:10.1080/27660400.2022.2159753>. The package efficiently estimates the parameters of Gaussian mixture model during iterative calculation between E-step and M-step, and the parameters are converged to a local optimal solution. This package can support the investigation of peak shift with two advantages: (1) a large amount of data can be processed at high speed; and (2) stable and automatic calculation can be easily performed.

Implementation of a modular framework for ecosystem risk assessments, combining existing risk assessment approaches tailored to semi-quantitative and quantitative analyses.

The EQ-5D is a widely-used standarized instrument for measuring Health Related Quality Of Life (HRQOL), developed by the EuroQol group <https://euroqol.org/>. It assesses five dimensions; mobility, self-care, usual activities, pain/discomfort, and anxiety/depression, using either a three-level (EQ-5D-3L) or five-level (EQ-5D-5L) scale. Scores from these dimensions are commonly converted into a single utility index using country-specific value sets, which are critical in clinical and economic evaluations of healthcare and in population health surveys. The eq5dsuite package enables users to calculate utility index values for the EQ-5D instruments, including crosswalk utilities using the original crosswalk developed by van Hout et al. (2012) <doi:10.1016/j.jval.2012.02.008> (mapping EQ-5D-5L responses to EQ-5D-3L index values), or the recently developed reverse crosswalk by van Hout et al. (2021) <doi:10.1016/j.jval.2021.03.009> (mapping EQ-5D-3L responses to EQ-5D-5L index values). Users are allowed to add and/or remove user-defined value sets. Additionally, the package provides tools to analyze EQ-5D data according to the recommended guidelines outlined in "Methods for Analyzing and Reporting EQ-5D data" by Devlin et al. (2020) <doi:10.1007/978-3-030-47622-9>.

The EpiSimR package provides an interactive shiny app based on deterministic compartmental mathematical modeling for simulating and visualizing the dynamics of epidemic and endemic disease spread. It allows users to explore various intervention strategies, including vaccination and isolation, by adjusting key epidemiological parameters. The methodology follows the approach described by Brauer (2008) <doi:10.1007/978-3-540-78911-6_2>. Thanks to shiny package.

For multiple full/partial ranking lists, R package ExtMallows can (1) detect whether the input ranking lists are over-correlated, and (2) use the Mallows model or extended Mallows model to integrate the ranking lists, and (3) use hierarchical extended Mallows model for rank integration if there are groups of over-correlated ranking lists.

Genotyping the population using next generation sequencing data is essentially important for the rare variant detection. In order to distinguish the genomic structural variation from sequencing error, we propose a statistical model which involves the genotype effect through a latent variable to depict the distribution of non-reference allele frequency data among different samples and different genome loci, while decomposing the sequencing error into sample effect and positional effect. An ECM algorithm is implemented to estimate the model parameters, and then the genotypes and SNPs are inferred based on the empirical Bayes method.

The goal of this package is to provide an easy to use, fast and scalable exhaustive search framework. Exhaustive feature selections typically require a very large number of models to be fitted and evaluated. Execution speed and memory management are crucial factors here. This package provides solutions for both. Execution speed is optimized by using a multi-threaded C++ backend, and memory issues are solved by by only storing the best results during execution and thus keeping memory usage constant.

This package provides tools for training and practicing epidemiologists including methods for two-way and multi-way contingency tables.

Provide the EMU Speech Database Management System (EMU-SDMS) with database management, data extraction, data preparation and data visualization facilities. See <https://ips-lmu.github.io/The-EMU-SDMS-Manual/> for more details.

Genetic predisposition for complex traits is often manifested through multiple tissues of interest at different time points in the development. As an example, the genetic predisposition for obesity could be manifested through inherited variants that control metabolism through regulation of genes expressed in the brain and/or through the control of fat storage in the adipose tissue by dysregulation of genes expressed in adipose tissue. We present a method eGST (eQTL-based genetic subtyper) that integrates tissue-specific eQTLs with GWAS data for a complex trait to probabilistically assign a tissue of interest to the phenotype of each individual in the study. eGST estimates the posterior probability that an individual's phenotype can be assigned to a tissue based on individual-level genotype data of tissue-specific eQTLs and marginal phenotype data in a genome-wide association study (GWAS) cohort. Under a Bayesian framework of mixture model, eGST employs a maximum a posteriori (MAP) expectation-maximization (EM) algorithm to estimate the tissue-specific posterior probability across individuals. Methodology is available from: A Majumdar, C Giambartolomei, N Cai, MK Freund, T Haldar, T Schwarz, J Flint, B Pasaniuc (2019) <doi:10.1101/674226>.

The encompassing test is developed based on multi-step-ahead predictions of two nested models as in Pitarakis, J. (2023) <doi:10.48550/arXiv.2312.16099>. The statistics are standardised to a normal distribution, and the null hypothesis is that the larger model contains no additional useful information. P-values will be provided in the output.

Implementation of method for estimating excess mortality and other health related outcomes from weekly or daily count data described in Acosta and Irizarry (2021) "A Flexible Statistical Framework for Estimating Excess Mortality".

Fit model for datasets with easy-to-interpret Gaussian process modeling, predict responses for new inputs. The input variables of the datasets can be quantitative, qualitative/categorical or mixed. The output variable of the datasets is a scalar (quantitative). The optimization of the likelihood function can be chosen by the users (see the documentation of EzGP_fit()). The modeling method is published in "EzGP: Easy-to-Interpret Gaussian Process Models for Computer Experiments with Both Quantitative and Qualitative Factors" by Qian Xiao, Abhyuday Mandal, C. Devon Lin, and Xinwei Deng (2022) <doi:10.1137/19M1288462>.

In agricultural, post-harvest and processing, engineering and industrial experiments factors are often differentiated with ease with which they can change from experimental run to experimental run. This is due to the fact that one or more factors may be expensive or time consuming to change i.e. hard-to-change factors. These factors restrict the use of complete randomization as it may make the experiment expensive and time consuming. Split plot designs can be used for such situations. In general model estimation of split plot designs require the use of generalized least squares (GLS). However for some split-plot designs ordinary least squares (OLS) estimates are equivalent to generalized least squares (GLS) estimates. These types of designs are known in literature as equivalent-estimation split-plot design. For method details see, Macharia, H. and Goos, P.(2010) <doi:10.1080/00224065.2010.11917833>.Balanced split plot designs are designs which have an equal number of subplots within every whole plot. This package used to construct equivalent estimation balanced split plot designs for different experimental set ups along with different statistical criteria to measure the performance of these designs. It consist of the function equivalent_BSPD().

Routines for Bayesian estimation and analysis of dynamic quantile linear models utilizing the extended asymmetric Laplace error distribution, also known as extended dynamic quantile linear models (exDQLM) described in Barata et al (2020) <doi:10.1214/21-AOAS1497>.

Detects sustained change in digital bio-marker data using simultaneous confidence bands. Accounts for noise using an auto-regressive model. Based on Buehlmann (1998) "Sieve bootstrap for smoothing in nonstationary time series" <doi:10.1214/aos/1030563978>.

Import gaze data from edf files generated by the SR Research <https://www.sr-research.com/> EyeLink eye tracker. Gaze data, both recorded events and samples, is imported per trial. The package allows to extract events of interest, such as saccades, blinks, etc. as well as recorded variables and custom events (areas of interest, triggers) into separate tables. The package requires EDF API library that can be obtained at <https://www.sr-research.com/support/>.

Fast and memory-less computation of the energy statistics related quantities for vectors and matrices. References include: Szekely G. J. and Rizzo M. L. (2014), <doi:10.1214/14-AOS1255>. Szekely G. J. and Rizzo M. L. (2023), <ISBN:9781482242744>. Tsagris M. and Papadakis M. (2025). <doi:10.48550/arXiv.2501.02849>.

Digital simulation of electrochemical processes. Each function allows for implicit and explicit solution of the differential equation using methods like Euler, Backwards implicit, Runge Kutta 4, Crank Nicholson and Backward differentiation formula as well as different number of points for derivative approximation. Several electrochemical processes can be simulated such as: Chronoamperometry, Potential Step, Linear Sweep, Cyclic Voltammetry, Cyclic Voltammetry with electrochemical reaction followed by chemical reaction (EC mechanism) and CV with two following electrochemical reaction (EE mechanism). In update 1.1.0 has been added a general purpose CV function that allow to simulate up to 4 EE mechanism combined with chemical reaction for each species.Update 1.2.0 improved the accuracy of the measurements and allow personalized data resolution for simulation. Bibliography regarding this methods can be found in the following texts. Dieter Britz, Jorg Strutwolf (2016) <ISBN:978-3-319-30292-8>. Allen J. Bard, Larry R. Faulkner (2000) <ISBN:978-0-471-04372-0>.

Training and prediction functions are provided for the Extreme Learning Machine algorithm (ELM). The ELM use a Single Hidden Layer Feedforward Neural Network (SLFN) with random generated weights and no gradient-based backpropagation. The training time is very short and the online version allows to update the model using small chunk of the training set at each iteration. The only parameter to tune is the hidden layer size and the learning function.

This package provides measures to characterize the complexity of classification and regression problems based on aspects that quantify the linearity of the data, the presence of informative feature, the sparsity and dimensionality of the datasets. This package provides bug fixes, generalizations and implementations of many state of the art measures. The measures are described in the papers: Lorena et al. (2019) <doi:10.1145/3347711> and Lorena et al. (2018) <doi:10.1007/s10994-017-5681-1>.