This package provides a versatile interior point solver that solves linear programs (LPs), quadratic programs (QPs), second-order cone programs (SOCPs), semidefinite programs (SDPs), and problems with exponential and power cone constraints (https://clarabel.org/stable/). For quadratic objectives, unlike interior point solvers based on the standard homogeneous self-dual embedding (HSDE) model, Clarabel handles quadratic objective without requiring any epigraphical reformulation of its objective function. It can therefore be significantly faster than other HSDE-based solvers for problems with quadratic objective functions. Infeasible problems are detected using using a homogeneous embedding technique.

This package makes the qhull library available in R, in a similar manner as in Octave. Qhull computes convex hulls, Delaunay triangulations, halfspace intersections about a point, Voronoi diagrams, furthest-site Delaunay triangulations, and furthest-site Voronoi diagrams. It runs in 2-d, 3-d, 4-d, and higher dimensions. It implements the Quickhull algorithm for computing the convex hull. Qhull does not support constrained Delaunay triangulations, or mesh generation of non-convex objects, but the package does include some R functions that allow for this. Currently the package only gives access to Delaunay triangulation and convex hull computation.

This package provides an interface to build a unified database of genomic annotations and their coordinates (gene, transcript and exon levels). It is aimed to be used when simple tab-delimited annotations (or simple GRanges objects) are required instead of the more complex annotation Bioconductor packages. Also useful when combinatorial annotation elements are reuired, such as RefSeq coordinates with Ensembl biotypes. Finally, it can download, construct and handle annotations with versioned genes and transcripts (where available, e.g. RefSeq and latest Ensembl). This is particularly useful in precision medicine applications where the latter must be reported.

The real-life time series data are hardly pure linear or nonlinear. Merging a linear time series model like the autoregressive moving average (ARMA) model with a nonlinear neural network model such as the Long Short-Term Memory (LSTM) model can be used as a hybrid model for more accurate modeling purposes. Both the autoregressive integrated moving average (ARIMA) and autoregressive fractionally integrated moving average (ARFIMA) models can be implemented. Details can be found in Box et al. (2015, ISBN: 978-1-118-67502-1) and Hochreiter and Schmidhuber (1997) <doi:10.1162/neco.1997.9.8.1735>.

Computes the center of gravity (COG) of character-like binary images using three different methods. This package provides functions for estimating stroke-based, contour-based, and potential energy-based COG. It is useful for analyzing glyph structure in areas such as visual cognition research and font development. The contour-based method was originally proposed by Kotani et al. (2004) <https://ipsj.ixsq.nii.ac.jp/records/36793> and Kotani (2011) <https://shonan-it.repo.nii.ac.jp/records/2000243>, while the potential energy-based method was introduced by Kotani et al. (2006) <doi:10.11371/iieej.35.296>.

Generates simulated data representing the LOX drop testing process (also known as impact testing). A simulated process allows for accelerated study of test behavior. Functions are provided to simulate trials, test series, and groups of test series. Functions for creating plots specific to this process are also included. Test attributes and criteria can be set arbitrarily. This work is not endorsed by or affiliated with NASA. See "ASTM G86-17, Standard Test Method for Determining Ignition Sensitivity of Materials to Mechanical Impact in Ambient Liquid Oxygen and Pressurized Liquid and Gaseous Oxygen Environments" <doi:10.1520/G0086-17>.

It allows you to automatically monitor trends of social media messages by time, place and topic aiming at detecting public health threats early through the detection of signals (i.e., an unusual increase in the number of messages per time, topic and location). It was designed to focus on infectious diseases, and it can be extended to all hazards or other fields of study by modifying the topics and keywords. More information on the original package epitweetr is available in the peer-review publication Espinosa et al. (2022) <doi:10.2807/1560-7917.ES.2022.27.39.2200177>.

This package provides a small subset of plots throughout the U.S. are sampled and assessed "on-the-ground" as forested or non-forested by the U.S. Department of Agriculture, Forest Service, Forest Inventory and Analysis (FIA) Program, but the FIA also has access to remotely sensed data for all land in the country. The forested package contains data frames intended for use in predictive modeling applications where the more easily-accessible remotely sensed data can be used to predict whether a plot is forested or non-forested. Currently, the package provides data for Washington and Georgia.

An implementation of SPRE (standardised predicted random-effects) statistics in R to explore heterogeneity in genetic association meta- analyses, as described by Magosi et al. (2019) <doi:10.1093/bioinformatics/btz590>. SPRE statistics are precision weighted residuals that indicate the direction and extent with which individual study-effects in a meta-analysis deviate from the average genetic effect. Overly influential positive outliers have the potential to inflate average genetic effects in a meta-analysis whilst negative outliers might lower or change the direction of effect. See the getspres website for documentation and examples <https://magosil86.github.io/getspres/>.

Generalizes application of gray-level co-occurrence matrix (GLCM) metrics to objects outside of images. The current focus is to apply GLCM metrics to the study of biological networks and fitness landscapes that are used in studying evolutionary medicine and biology, particularly the evolution of cancer resistance. The package was developed as part of the author's publication in Physics in Medicine and Biology Barker-Clarke et al. (2023) <doi:10.1088/1361-6560/ace305>. A general reference to learn more about mathematical oncology can be found at Rockne et al. (2019) <doi:10.1088/1478-3975/ab1a09>.

This package provides a lightweight framework for creating high quality, complex heatmaps using base graphics. Supports hierarchical clustering with dendrograms, column and row scaling, cluster sub-divisions, customizable cell colours, shapes and sizes, legends, and flexible layouts for arranging multiple heatmaps. Designed to return plot objects that can be easily arranged with other plots without sacrificing resolution. Methods for hierarchical clustering and distance computations are described in Murtagh and Contreras (2012) <doi:10.1002/wics.53>. Dendrogram visualisation methods are based on the ggdendro package by de Vries and Ripley (2020) <https://CRAN.R-project.org/package=ggdendro>.

Fits the joint model proposed by Henderson and colleagues (2000) <doi:10.1093/biostatistics/1.4.465>, but extended to the case of multiple continuous longitudinal measures. The time-to-event data is modelled using a Cox proportional hazards regression model with time-varying covariates. The multiple longitudinal outcomes are modelled using a multivariate version of the Laird and Ware linear mixed model. The association is captured by a multivariate latent Gaussian process. The model is estimated using a Monte Carlo Expectation Maximization algorithm. This project was funded by the Medical Research Council (Grant number MR/M013227/1).

The Cauchy distribution is a special case of the t distribution when the degrees of freedom are equal to 1. The functions are related to the multivariate Cauchy distribution and include simulation, computation of the density, maximum likelihood estimation, contour plot of the bivariate Cauchy distribution, and discriminant analysis. References include: Nadarajah S. and Kotz S. (2008). "Estimation methods for the multivariate t distribution". Acta Applicandae Mathematicae, 102(1): 99--118. <doi:10.1007/s10440-008-9212-8>, and Kanti V. Mardia, John T. Kent and John M. Bibby (1979). "Multivariate analysis", ISBN:978-0124712522. Academic Press, London.

This package provides functions for the design process of survey sampling, with specific tools for multi-wave and multi-phase designs. Perform optimum allocation using Neyman (1934) <doi:10.2307/2342192> or Wright (2012) <doi:10.1080/00031305.2012.733679> allocation, split strata based on quantiles or values of known variables, randomly select samples from strata, allocate sampling waves iteratively, and organize a complex survey design. Also includes a Shiny application for observing the effects of different strata splits. A paper on this package was published in the Journal of Statistical Software <doi:10.18637/jss.v114.i10>.

This package provides tools for exploratory process data analysis. Process data refers to the data describing participants problem-solving processes in computer-based assessments. It is often recorded in computer log files. This package provides functions to read, process, and write process data. It also implements two feature extraction methods to compress the information stored in process data into standard numerical vectors. This package also provides recurrent neural network based models that relate response processes with other binary or scale variables of interest. The functions that involve training and evaluating neural networks are wrappers of functions in keras'.

This package provides a set of concise and efficient tools for statistical production. Can also be used for data management. In statistical production, you deal with complex data and need to control your process at each step of your work. Concise functions are very helpful, because you do not hesitate to use them. The following functions are included in the package. dup checks duplicates. miss checks missing values. tac computes contingency table of all columns. toc compares two tables, spotting significant deviations. chi2_find compares columns within a data.frame, spotting related categories of (a more complex function).

This takes spatial single-cell-type RNA-seq data (specifically designed for Slide-seq v2) that calls copy number alterations (CNAs) using pseudo-spatial binning, clusters cellular units (e.g. beads) based on CNA profile, and visualizes spatial CNA patterns. Documentation about SlideCNA is included in the the pre-print by Zhang et al. (2022, <doi:10.1101/2022.11.25.517982>). The package enrichR (>= 3.0), conditionally used to annotate SlideCNA-determined clusters with gene ontology terms, can be installed at <https://github.com/wjawaid/enrichR> or with install_github("wjawaid/enrichR").

This package provides a unified workflow for choosing, running, and interpreting common statistical tests, from group comparisons and analysis of variance to regression, survival analysis, and diagnostic and agreement statistics. The package combines assumption checks, test selection, effect sizes, formatted results, plain-language interpretation, and a sample-size planning module covering continuous, binary, survival, ordinal, bioequivalence, and precision-based designs. Implemented methods follow standard references including Casella and Berger (2002, ISBN:9780534243128), Hollander et al. (2013, ISBN:9781118553299), Agresti (2013, ISBN:9780470463635), Cohen (1988, ISBN:9780805802832), Hosmer, Lemeshow and Sturdivant (2013, ISBN:9780470582473), and Julious (2010, ISBN:9781584887393).

MiDAS is a R package for immunogenetics data transformation and statistical analysis. MiDAS accepts input data in the form of HLA alleles and KIR types, and can transform it into biologically meaningful variables, enabling HLA amino acid fine mapping, analyses of HLA evolutionary divergence, KIR gene presence, as well as validated HLA-KIR interactions. Further, it allows comprehensive statistical association analysis workflows with phenotypes of diverse measurement scales. MiDAS closes a gap between the inference of immunogenetic variation and its efficient utilization to make relevant discoveries related to T cell, Natural Killer cell, and disease biology.

Estimation and inference methods for bounding average treatment effects (on the treated) that are valid under an unconfoundedness assumption. The bounds are designed to be robust in challenging situations, for example, when the conditioning variables take on a large number of different values in the observed sample, or when the overlap condition is violated. This robustness is achieved by only using limited "pooling" of information across observations. For more details, see the paper by Lee and Weidner, "Bounding Treatment Effects by Pooling Limited Information across Observations," forthcoming at the Journal of Econometrics, <doi:10.48550/arXiv.2111.05243>.

Supports the standardized analysis of Mediterranean International Bottom Trawl Survey (MEDITS) data and the calculation of biological indicators for selected species and population components. The package provides functions to estimate abundance and biomass indices, analyse size structure and length frequency distributions, derive sex ratio and maturity related metrics, explore spatial patterns, and assess temporal trends across surveys. Developed for integration within the Regional Database for Fisheries (RDBFIS) framework, it is intended to work on quality checked input data and to produce reproducible outputs that can support monitoring, comparative analyses among Geographical Sub-Areas (GSAs) and countries, and fishery management.

Estimation of functional spaces based on traits of organisms. The package includes functions to impute missing trait values (with or without considering phylogenetic information), and to create, represent and analyse two dimensional functional spaces based on principal components analysis, other ordination methods, or raw traits. It also allows for mapping a third variable onto the functional space. See Carmona et al. (2021) <doi:10.1038/s41586-021-03871-y>, Puglielli et al. (2021) <doi:10.1111/nph.16952>, Carmona et al. (2021) <doi:10.1126/sciadv.abf2675>, Carmona et al. (2019) <doi:10.1002/ecy.2876> for more information.

This package provides ggplot2 geoms that render with a hand-drawn, sketchy aesthetic: roughened strokes, double-pass lines, and hachure, cross-hatch, zigzag, and dots fill patterns. Implemented as pure-R grid grobs wrapped in ggproto geoms, composable with aes(), stats, scales, and faceting. Works on every R graphics device (PDF, PNG, SVG, screen) with no browser dependency. Algorithms are reimplemented from the published rough.js algorithm description (Shihn, 2020, <https://shihn.ca/posts/2020/roughjs-algorithms/>) and Wood and others (2012, <doi:10.1109/TVCG.2012.262>); see the NOTICE file in the package sources for attribution.

This package provides a general-purpose workflow for image segmentation using TensorFlow models based on the U-Net architecture by Ronneberger et al. (2015) <doi:10.48550/arXiv.1505.04597> and the U-Net++ architecture by Zhou et al. (2018) <doi:10.48550/arXiv.1807.10165>. We provide pre-trained models for assessing canopy density and understory vegetation density from vegetation photos. In addition, the package provides a workflow for easily creating model input and model architectures for general-purpose image segmentation based on grayscale or color images, both for binary and multi-class image segmentation.